Epilepsies

Also known as: Epilepsy / (Epilepsy) or (epileptic attack) / Epilepsy, unspecified / Epileptic fit / Epilepsy NOS / Epileptic seizure

DrugDrug NameDrug Description
DB00313Valproic AcidValproic acid, supplied as the sodium salt valproate semisodium or divalproex sodium, is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing gamma-aminobutyric acid levels in the brain or by altering the properties of voltage dependent sodium channels. Typically supplied in the sodium salt form (CAS number: 76584-70-8). Valproic Acid is also a histone deacetylase inhibitor and is under investigation for treatment of HIV and various cancers.
DB00909ZonisamideZonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures. Zonisamide may be a carbonic anhydrase inhibitor although this is not one of the primary mechanisms of action. Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels leading to a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. This latter action may inhibit the uptake of the inhibitory neurotransmitter GABA while enhancing the uptake of the excitatory neurotransmitter glutamate.
DrugDrug NameTargetType
DB00313Valproic Acid4-aminobutyrate aminotransferase, mitochondrialtarget
DB00313Valproic AcidHistone deacetylase 9target
DB00313Valproic AcidShort/branched chain specific acyl-CoA dehydrogenase, mitochondrialtarget
DB00313Valproic AcidCytochrome P450 2A6enzyme
DB00313Valproic AcidCytochrome P450 2B6enzyme
DB00313Valproic AcidCytochrome P450 2C9enzyme
DB00313Valproic AcidSolute carrier family 22 member 5transporter
DB00313Valproic AcidSolute carrier family 22 member 6transporter
DB00313Valproic AcidSolute carrier family 22 member 8transporter
DB00313Valproic AcidMonocarboxylate transporter 1transporter
DB00313Valproic AcidSolute carrier family 22 member 7transporter
DB00313Valproic AcidCytochrome P450 3A5enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-9enzyme
DB00313Valproic AcidProstaglandin G/H synthase 1enzyme
DB00313Valproic AcidCytochrome P450 1A2enzyme
DB00313Valproic AcidCytochrome P450 2C18enzyme
DB00313Valproic AcidCytochrome P450 2C19enzyme
DB00313Valproic AcidCytochrome P450 2C8enzyme
DB00313Valproic AcidCytochrome P450 3A4enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-4enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-8enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-10enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-6enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 1-3enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 2B7enzyme
DB00313Valproic AcidUDP-glucuronosyltransferase 2B15enzyme
DB00313Valproic Acid2-oxoglutarate dehydrogenase, mitochondrialtarget
DB00313Valproic AcidSuccinate-semialdehyde dehydrogenase, mitochondrialtarget
DB00313Valproic AcidSodium channel proteintarget
DB00313Valproic AcidHistone deacetylase 2target
DB00313Valproic AcidPeroxisome proliferator-activated receptor alphatarget
DB00313Valproic AcidPeroxisome proliferator-activated receptor deltatarget
DB00313Valproic AcidPeroxisome proliferator-activated receptor gammatarget
DB00313Valproic AcidSerum albumincarrier
DB00909ZonisamideSodium channel protein type 1 subunit alphatarget
DB00909ZonisamideCarbonic anhydrase 1target
DB00909ZonisamideVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
DB00909ZonisamideCytochrome P450 3A4enzyme
DB00909ZonisamideAldehyde oxidaseenzyme
DB00909ZonisamideAmine oxidase [flavin-containing] Btarget
DB00909ZonisamideCarbonic anhydrase 2target
DB00909ZonisamideCarbonic anhydrase 3target
DB00909ZonisamideCarbonic anhydrase 4target
DB00909ZonisamideCarbonic anhydrase 5A, mitochondrialtarget
DB00909ZonisamideCarbonic anhydrase 5B, mitochondrialtarget
DB00909ZonisamideCarbonic anhydrase 6target
DB00909ZonisamideCarbonic anhydrase 7target
DB00909ZonisamideCarbonic anhydrase-related proteintarget
DB00909ZonisamideCarbonic anhydrase 9target
DB00909ZonisamideCarbonic anhydrase-related protein 10target
DB00909ZonisamideCarbonic anhydrase-related protein 11target
DB00909ZonisamideCarbonic anhydrase 12target
DB00909ZonisamideCarbonic anhydrase 13target
DB00909ZonisamideCarbonic anhydrase 14target
DB00909ZonisamideVoltage-dependent T-type calcium channel subunit alpha-1Htarget
DB00909ZonisamideVoltage-dependent T-type calcium channel subunit alpha-1Itarget
DB00909ZonisamideSodium channel protein type 2 subunit alphatarget
DB00909ZonisamideSodium channel protein type 3 subunit alphatarget
DB00909ZonisamideSodium channel protein type 4 subunit alphatarget
DB00909ZonisamideSodium channel protein type 5 subunit alphatarget
DB00909ZonisamideSodium channel protein type 9 subunit alphatarget
DB00909ZonisamideSodium channel protein type 11 subunit alphatarget
DB00909ZonisamideSodium channel subunit beta-1target
DB00909ZonisamideSodium channel subunit beta-2target
DB00909ZonisamideSodium channel subunit beta-3target
DB00909ZonisamideSodium channel subunit beta-4target
DB00909ZonisamideAmine oxidase [flavin-containing] Atarget
DB00909ZonisamideCytochrome P450 2C19enzyme
DrugDrug NamePhaseStatusCount
DB00252Phenytoin0Terminated1
DB00273Topiramate0Terminated1
DB01076Atorvastatin1Completed1
DB05541Brivaracetam1Completed2
DB09061Cannabidiol1Active Not Recruiting1
DB09061Cannabidiol1Recruiting1
DB00564Carbamazepine1Completed2
DB00829Diazepam1Completed1
DB00390Digoxin1Completed2
DB09119Eslicarbazepine acetate1Completed25
DB09119Eslicarbazepine acetate1Terminated2
DB04953Ezogabine1Completed3
DB00996Gabapentin1Completed1
DB01120Gliclazide1Completed1
DB06218Lacosamide1Completed1
DB00555Lamotrigine1Completed8
DB01202Levetiracetam1Completed1
DB00186Lorazepam1Completed1
DB06796Mangafodipir1Suspended1
DB00683Midazolam1Terminated1
DB00218Moxifloxacin1Completed1
DB12458Muscimol1Terminated1
DB00776Oxcarbazepine1Completed3
DB01267Paliperidone1Completed1
DB00252Phenytoin1Completed2
DB00252Phenytoin1Terminated1
DB00641Simvastatin1Completed1
DB00273Topiramate1Completed3
DB11677Triheptanoin1Recruiting1
DB00313Valproic Acid1Completed1
DB00313Valproic Acid1Unknown Status1
DB00682Warfarin1Completed1
DB01590Everolimus1 / 2Completed1
DB00555Lamotrigine1 / 2Completed1
DB01202Levetiracetam1 / 2Completed1
DB00313Valproic Acid1 / 2Recruiting1
DB12131Vinpocetine1 / 2Recruiting1
DB00945Acetylsalicylic acid2Recruiting1
DB00173Adenine2Completed1
DB05016Ataluren2Recruiting1
DB05541Brivaracetam2Completed3
DB05541Brivaracetam2Recruiting1
DB00490Buspirone2Terminated1
DB09061Cannabidiol2Completed3
DB09061Cannabidiol2Enrolling by Invitation1
DB09061Cannabidiol2Recruiting1
DB00564Carbamazepine2Completed1
DB11121Chloroxylenol2Recruiting1
DB00349Clobazam2Completed1
DB01068Clonazepam2Completed1
DB00286Conjugated estrogens2Completed1
DB01285Corticotropin2Completed1
DB00829Diazepam2Completed1
DB09119Eslicarbazepine acetate2Completed3
DB01590Everolimus2Recruiting1
DB04953Ezogabine2Terminated1
DB00574Fenfluramine2Active Not Recruiting1
DB00472Fluoxetine2Recruiting1
DB05087Ganaxolone2Not Yet Recruiting1
DB05087Ganaxolone2Recruiting1
DB06089ICA-1056652Terminated1
DB06218Lacosamide2Active Not Recruiting1
DB06218Lacosamide2Completed4
DB06218Lacosamide2Enrolling by Invitation1
DB00555Lamotrigine2Completed2
DB01202Levetiracetam2Completed9
DB00186Lorazepam2Recruiting1
DB00603Medroxyprogesterone acetate2Completed1
DB01065Melatonin2Completed1
DB01595Nitrazepam2Completed1
DB11133Omega-3 fatty acids2Recruiting1
DB08883Perampanel2Completed3
DB08883Perampanel2Recruiting1
DB08883Perampanel2Unknown Status1
DB00165Pyridoxine2Completed1
DB12367Selurampanel2Completed1
DB04982Talampanel2Completed1
DB00273Topiramate2Completed5
DB11677Triheptanoin2Not Yet Recruiting1
DB00313Valproic Acid2Completed1
DB00518Albendazole2 / 3Completed1
DB06218Lacosamide2 / 3Recruiting1
DB01058Praziquantel2 / 3Completed1
DB05541Brivaracetam3Active Not Recruiting2
DB05541Brivaracetam3Completed9
DB05541Brivaracetam3Enrolling by Invitation2
DB05541Brivaracetam3Recruiting1
DB05541Brivaracetam3Terminated2
DB09061Cannabidiol3Completed3
DB09061Cannabidiol3Enrolling by Invitation1
DB09061Cannabidiol3Not Yet Recruiting1
DB09061Cannabidiol3Recruiting1
DB00564Carbamazepine3Completed5
DB12338Carisbamate3Completed1
DB12338Carisbamate3Terminated1
DB01563Chloral hydrate3Completed1
DB00349Clobazam3Completed1
DB00349Clobazam3Unknown Status1
DB01068Clonazepam3Recruiting1
DB01068Clonazepam3Unknown Status1
DB00829Diazepam3Completed1
DB09119Eslicarbazepine acetate3Completed3
DB09119Eslicarbazepine acetate3Enrolling by Invitation1
DB09119Eslicarbazepine acetate3Terminated1
DB00593Ethosuximide3Completed1
DB04953Ezogabine3Active Not Recruiting1
DB04953Ezogabine3Completed5
DB04953Ezogabine3Terminated2
DB00472Fluoxetine3Completed1
DB00158Folic Acid3Unknown Status1
DB01320Fosphenytoin3Completed1
DB01320Fosphenytoin3Recruiting1
DB09341Glucose3Completed1
DB01221Ketamine3Withdrawn1
DB00125L-Arginine3Completed1
DB06218Lacosamide3Active Not Recruiting2
DB06218Lacosamide3Completed12
DB06218Lacosamide3Enrolling by Invitation2
DB06218Lacosamide3Recruiting1
DB06218Lacosamide3Unknown Status1
DB06218Lacosamide3Withdrawn1
DB00555Lamotrigine3Completed7
DB00555Lamotrigine3Terminated1
DB01202Levetiracetam3Completed15
DB01202Levetiracetam3Recruiting1
DB01202Levetiracetam3Terminated2
DB01202Levetiracetam3Unknown Status1
DB01202Levetiracetam3Withdrawn1
DB01627Lincomycin3Active Not Recruiting1
DB01627Lincomycin3Completed1
DB00186Lorazepam3Recruiting1
DB00186Lorazepam3Unknown Status1
DB00683Midazolam3Completed1
DB00683Midazolam3Terminated1
DB01183Naloxone3Recruiting1
DB00776Oxcarbazepine3Completed3
DB08883Perampanel3Completed2
DB01174Phenobarbital3Completed1
DB01174Phenobarbital3Withdrawn1
DB00252Phenytoin3Completed1
DB00230Pregabalin3Completed1
DB00230Pregabalin3Terminated1
DB06201Rufinamide3Completed1
DB12175Seletracetam3Withdrawn2
DB01104Sertraline3Completed1
DB00273Topiramate3Completed13
DB00273Topiramate3Recruiting1
DB00273Topiramate3Terminated1
DB00313Valproic Acid3Completed3
DB00909Zonisamide3Completed3
DB00909Zonisamide3Terminated2
DB01373Calcium4Completed1
DB00564Carbamazepine4Completed4
DB00564Carbamazepine4Enrolling by Invitation1
DB00564Carbamazepine4Recruiting3
DB00169Cholecalciferol4Completed1
DB04920Clevidipine4Completed1
DB00349Clobazam4Recruiting2
DB01068Clonazepam4Recruiting1
DB00153Ergocalciferol4Completed1
DB01175Escitalopram4Terminated1
DB09119Eslicarbazepine acetate4Completed1
DB09119Eslicarbazepine acetate4Recruiting1
DB00593Ethosuximide4Recruiting1
DB04953Ezogabine4Terminated1
DB00996Gabapentin4Completed1
DB00996Gabapentin4Recruiting1
DB00602Ivermectin4Not Yet Recruiting1
DB06218Lacosamide4Completed2
DB00555Lamotrigine4Completed6
DB00555Lamotrigine4Enrolling by Invitation1
DB00555Lamotrigine4Not Yet Recruiting1
DB00555Lamotrigine4Recruiting2
DB00555Lamotrigine4Unknown Status1
DB01202Levetiracetam4Completed10
DB01202Levetiracetam4Enrolling by Invitation1
DB01202Levetiracetam4Recruiting2
DB00367Levonorgestrel4Completed1
DB00422Methylphenidate4Completed2
DB00683Midazolam4Active Not Recruiting1
DB01595Nitrazepam4Recruiting1
DB00776Oxcarbazepine4Completed1
DB08883Perampanel4Active Not Recruiting1
DB08883Perampanel4Terminated1
DB00252Phenytoin4Enrolling by Invitation1
DB00252Phenytoin4Recruiting1
DB00252Phenytoin4Terminated1
DB00230Pregabalin4Completed2
DB00230Pregabalin4Terminated1
DB01032Probenecid4Terminated1
DB00884Risedronate4Completed1
DB06201Rufinamide4Recruiting1
DB01104Sertraline4Terminated1
DB09118Stiripentol4Recruiting1
DB00273Topiramate4Completed6
DB00273Topiramate4Enrolling by Invitation1
DB00273Topiramate4Recruiting2
DB00273Topiramate4Unknown Status1
DB00313Valproic Acid4Completed4
DB00313Valproic Acid4Enrolling by Invitation1
DB00313Valproic Acid4Recruiting2
DB00313Valproic Acid4Unknown Status1
DB01080Vigabatrin4Recruiting1
DB11094Vitamin D4Completed1
DB00163Vitamin E4Completed1
DB00909Zonisamide4Completed6
DB00909Zonisamide4Enrolling by Invitation1
DB00909Zonisamide4Recruiting1
DB00909Zonisamide4Terminated1
DB00518AlbendazoleNot AvailableCompleted1
DB00802AlfentanilNot AvailableRecruiting1
DB01238AripiprazoleNot AvailableRecruiting1
DB00297BupivacaineNot AvailableCompleted1
DB09061CannabidiolNot AvailableAvailable3
DB00564CarbamazepineNot AvailableCompleted1
DB00564CarbamazepineNot AvailableRecruiting1
DB00438CeftazidimeNot AvailableRecruiting1
DB00369CidofovirNot AvailableRecruiting1
DB00537CiprofloxacinNot AvailableRecruiting1
DB00349ClobazamNot AvailableRecruiting1
DB00363ClozapineNot AvailableRecruiting1
DB01234DexamethasoneNot AvailableCompleted1
DB01234DexamethasoneNot AvailableRecruiting1
DB00633DexmedetomidineNot AvailableCompleted1
DB00829DiazepamNot AvailableRecruiting1
DB00668EpinephrineNot AvailableCompleted1
DB09119Eslicarbazepine acetateNot AvailableCompleted2
DB04953EzogabineNot AvailableCompleted2
DB09150Fludeoxyglucose F-18Not AvailableCompleted1
DB01320FosphenytoinNot AvailableRecruiting1
DB00502HaloperidolNot AvailableRecruiting1
DB01109HeparinNot AvailableRecruiting1
DB00327HydromorphoneNot AvailableRecruiting1
DB06218LacosamideNot AvailableCompleted2
DB00555LamotrigineNot AvailableCompleted4
DB00555LamotrigineNot AvailableRecruiting1
DB00555LamotrigineNot AvailableUnknown Status1
DB01202LevetiracetamNot AvailableCompleted2
DB01202LevetiracetamNot AvailableRecruiting2
DB01202LevetiracetamNot AvailableUnknown Status2
DB00281LidocaineNot AvailableCompleted1
DB08815LurasidoneNot AvailableRecruiting1
DB01043MemantineNot AvailableCompleted1
DB01043MemantineNot AvailableWithdrawn1
DB00760MeropenemNot AvailableRecruiting1
DB00959MethylprednisoloneNot AvailableRecruiting1
DB00683MidazolamNot AvailableRecruiting1
DB01618MolindoneNot AvailableRecruiting1
DB00295MorphineNot AvailableRecruiting1
DB00622NicardipineNot AvailableRecruiting1
DB00334OlanzapineNot AvailableRecruiting1
DB00198OseltamivirNot AvailableRecruiting1
DB00776OxcarbazepineNot AvailableCompleted3
DB00776OxcarbazepineNot AvailableRecruiting1
DB00312PentobarbitalNot AvailableRecruiting1
DB08883PerampanelNot AvailableNot Yet Recruiting1
DB08883PerampanelNot AvailableRecruiting1
DB01174PhenobarbitalNot AvailableCompleted1
DB01174PhenobarbitalNot AvailableRecruiting1
DB01174PhenobarbitalNot AvailableWithdrawn1
DB00252PhenytoinNot AvailableCompleted1
DB00252PhenytoinNot AvailableRecruiting1
DB00230PregabalinNot AvailableCompleted3
DB00818PropofolNot AvailableCompleted1
DB00818PropofolNot AvailableRecruiting1
DB01224QuetiapineNot AvailableRecruiting1
DB00899RemifentanilNot AvailableCompleted1
DB00734RisperidoneNot AvailableRecruiting1
DB09118StiripentolNot AvailableRecruiting1
DB00373TimololNot AvailableRecruiting1
DB00684TobramycinNot AvailableRecruiting1
DB00273TopiramateNot AvailableCompleted1
DB00273TopiramateNot AvailableRecruiting2
DB00313Valproic AcidNot AvailableCompleted4
DB00313Valproic AcidNot AvailableRecruiting2
DB00313Valproic AcidNot AvailableUnknown Status1
DB00661VerapamilNot AvailableUnknown Status1
DB00682WarfarinNot AvailableRecruiting1
DB00246ZiprasidoneNot AvailableRecruiting1
DB00909ZonisamideNot AvailableCompleted1