Inflammatory Reaction

Also known as: Inflammations / Inflammation / Inflammatory processes / Inflammation NOS

DrugDrug NameDrug Description
DB00945Acetylsalicylic acidThe prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Acetylsalicylic acid also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
DB00288AmcinonideAmcinonide is a corticosteroid.
DB13501BendazacBendazac is an oxyacetic acid [A39863, A39869]. Despite possessing anti-inflammatory, anti-necrotic, choleretic, and anti-lipidemic characteristics, most research has revolved around studying and demonstrating the agent's principal action in inhibiting the denaturation of proteins - an effect that has primarily proven useful in managing and delaying the progression of ocular cataracts [A39863. A39863]. Bendazac, however, has since been withdrawn or discontinued in various international regions due to its capability or risk for eliciting hepatotoxicity [A39891, A39892, A39893, L4778] in patients although a small handful of regions may continue to have the medication available for purchase and use either as a topical anti-inflammatory/analgesic cream or eye drop formulation.
DB01380Cortisone acetateCortisone acetate is a steroid hormone that has both glucocoriticoid and mineral corticoid activities. Corticosteroids are used to provide relief for inflamed areas of the body. They lessen swelling, redness, itching, and allergic reactions. They are often used as part of the treatment for a number of different diseases, such as severe allergies or skin problems, asthma, or arthritis. Endogenous glucocorticoids and some synthetic corticoids have high affinity to the protein transcortin (also called CBG, corticosteroid-binding protein), whereas all of them bind albumin. Glucocorticoids also bind to the cytosolic glucocorticoid receptor.
DB01234DexamethasoneAn anti-inflammatory 9-fluoro-glucocorticoid.
DB01047FluocinonideA topical glucocorticoid used in the treatment of eczema.
DB14545Hydrocortisone succinateNot Available
DB14544Hydrocortisone valerateNot Available
DB00465KetorolacKetorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet and as an injectable. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis [F3952].
DB14104Linoleic acidNot Available
DB00873LoteprednolNot Available
DB00959MethylprednisoloneA prednisolone derivative with similar anti-inflammatory action.
DB06802NepafenacNepafenac is a non-steroidal anti-inflammatory prodrug (NSAID) usually sold as a prescription eye drop. It is used to treat pain and inflammation associated with cataract surgery.
DrugDrug NameTargetType
DB00945Acetylsalicylic acidProstaglandin G/H synthase 1target
DB00945Acetylsalicylic acidProstaglandin G/H synthase 2target
DB00945Acetylsalicylic acidSerum albumincarrier
DB00945Acetylsalicylic acidAldo-keto reductase family 1 member C1target
DB00945Acetylsalicylic acidSolute carrier family 22 member 6transporter
DB00945Acetylsalicylic acidMultidrug resistance protein 1transporter
DB00945Acetylsalicylic acidSolute carrier family 22 member 7transporter
DB00945Acetylsalicylic acidCytochrome P450 2C19enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C8enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acid5'-AMP-activated protein kinasetarget
DB00945Acetylsalicylic acidEndothelin-1 receptortarget
DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00945Acetylsalicylic acidCellular tumor antigen p53target
DB00945Acetylsalicylic acid78 kDa glucose-regulated proteintarget
DB00945Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
DB00945Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
DB00945Acetylsalicylic acidNuclear factor NF-kappa-Btarget
DB00288AmcinonideGlucocorticoid receptortarget
DB00288AmcinonideAnnexin A1target
DB00288AmcinonideCytochrome P450 3A4enzyme
DB13501BendazacFree radicalstarget
DB13501BendazacProstaglandin G/H synthase 1target
DB13501BendazacProstaglandin G/H synthase 2target
DB01380Cortisone acetateGlucocorticoid receptortarget
DB01380Cortisone acetateCytochrome P450 3A4enzyme
DB01234DexamethasoneGlucocorticoid receptortarget
DB01234DexamethasoneAnnexin A1target
DB01234DexamethasoneNitric oxide synthase, inducibletarget
DB01234DexamethasoneNuclear receptor subfamily 0 group B member 1target
DB01234DexamethasoneCytochrome P450 3A4enzyme
DB01234DexamethasoneCytochrome P450 3A5enzyme
DB01234DexamethasoneCytochrome P450 3A7enzyme
DB01234DexamethasoneBile salt export pumptransporter
DB01234DexamethasoneMultidrug resistance protein 1transporter
DB01234DexamethasoneCanalicular multispecific organic anion transporter 1transporter
DB01234DexamethasoneSolute carrier organic anion transporter family member 1A2transporter
DB01234DexamethasoneATP-binding cassette sub-family G member 2transporter
DB01234DexamethasoneCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB01234DexamethasoneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB01234DexamethasoneCytochrome P450 19A1enzyme
DB01234DexamethasoneCytochrome P450 1A1enzyme
DB01234DexamethasoneCytochrome P450 1B1enzyme
DB01234DexamethasoneCytochrome P450 2A6enzyme
DB01234DexamethasoneCytochrome P450 2B6enzyme
DB01234DexamethasoneCytochrome P450 2C19enzyme
DB01234DexamethasoneCytochrome P450 2C8enzyme
DB01234DexamethasoneCytochrome P450 2D6enzyme
DB01234DexamethasoneCytochrome P450 2E1enzyme
DB01234DexamethasoneCytochrome P450 3A43enzyme
DB01234DexamethasoneCytochrome P450 4A11enzyme
DB01234DexamethasoneNuclear receptor subfamily 1 group I member 2target
DB01047FluocinonideCorticosteroid-binding globulincarrier
DB01047FluocinonideGlucocorticoid receptortarget
DB01047FluocinonideSmoothened homologtarget
DB01047FluocinonideCytochrome P450 3A4enzyme
DB14545Hydrocortisone succinateCytochrome P450 3A4enzyme
DB14545Hydrocortisone succinateCytochrome P450 3A5enzyme
DB14545Hydrocortisone succinateCytochrome P450 3A7enzyme
DB14545Hydrocortisone succinateCytochrome P450 2C8enzyme
DB14545Hydrocortisone succinateCytochrome P450 11B1, mitochondrialenzyme
DB14545Hydrocortisone succinateCytochrome P450 11B2, mitochondrialenzyme
DB14544Hydrocortisone valerateAnnexin A1target
DB14544Hydrocortisone valerateGlucocorticoid receptortarget
DB14544Hydrocortisone valerateSex hormone-binding globulincarrier
DB14544Hydrocortisone valerateCytochrome P450 3A4enzyme
DB14544Hydrocortisone valerateCytochrome P450 3A5enzyme
DB14544Hydrocortisone valerateCytochrome P450 3A7enzyme
DB14544Hydrocortisone valerateMultidrug resistance protein 1transporter
DB14544Hydrocortisone valerateSolute carrier organic anion transporter family member 1A2transporter
DB14544Hydrocortisone valerateATP-binding cassette sub-family G member 2transporter
DB14544Hydrocortisone valerateCytochrome P450 11B1, mitochondrialenzyme
DB14544Hydrocortisone valerateCytochrome P450 11B2, mitochondrialenzyme
DB14544Hydrocortisone valerateCytochrome P450 2C8enzyme
DB14544Hydrocortisone valerateCorticosteroid-binding globulincarrier
DB14544Hydrocortisone valerateCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB14544Hydrocortisone valerate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB14544Hydrocortisone valerateSolute carrier family 22 member 8transporter
DB00465KetorolacProstaglandin G/H synthase 1target
DB00465KetorolacProstaglandin G/H synthase 2target
DB00959MethylprednisoloneGlucocorticoid receptortarget
DB00959MethylprednisoloneCytochrome P450 3A4enzyme
DB00959MethylprednisoloneMultidrug resistance protein 1transporter
DB06802NepafenacProstaglandin G/H synthase 1target
DB06802NepafenacProstaglandin G/H synthase 2target
DrugDrug NamePhaseStatusCount
DB00945Acetylsalicylic acid0Recruiting1
DB00758Clopidogrel0Recruiting1
DB00798Gentamicin0Completed1
DB00760Meropenem0Completed1
DB00788Naproxen0Not Yet Recruiting1
DB08816Ticagrelor0Recruiting1
DB00512Vancomycin0Completed1
DB00945Acetylsalicylic acid1Completed1
DB00640Adenosine1Terminated1
DB04630Aldosterone1Completed1
DB01076Atorvastatin1Completed1
DB00207Azithromycin1Completed1
DB12328Cantharidin1Completed1
DB00482Celecoxib1Terminated1
DB00115Cyanocobalamin1Completed1
DB00586Diclofenac1Completed1
DB12140Dilmapimod1Completed1
DB00153Ergocalciferol1Completed1
DB06414Etravirine1Completed1
DB12356Fletikumab1Completed2
DB12356Fletikumab1Terminated1
DB00158Folic Acid1Completed1
DB11903GW8421661Completed1
DB00741Hydrocortisone1Completed1
DB01050Ibuprofen1Completed2
DB00465Ketorolac1Completed1
DB00465Ketorolac1Withdrawn1
DB12578Lexaptepid Pegol1Completed1
DB01065Melatonin1Not Yet Recruiting1
DB00563Methotrexate1Completed1
DB00325Nitroprusside1Terminated1
DB09140Oxygen1Completed1
DB00860Prednisolone1Completed1
DB00818Propofol1Completed2
DB00165Pyridoxine1Completed1
DB10803Salmonella typhi ty2 vi polysaccharide antigen1Completed1
DB01236Sevoflurane1Completed2
DB00641Simvastatin1Unknown Status1
DB06151Acetylcysteine1 / 2Completed1
DB00626Bacitracin1 / 2Withdrawn1
DB01276Exenatide1 / 2Withdrawn1
DB12583Maltodextrin1 / 2Recruiting1
DB01017Minocycline1 / 2Withdrawn1
DB00994Neomycin1 / 2Withdrawn1
DB00781Polymyxin B1 / 2Withdrawn1
DB00073Rituximab1 / 2Recruiting1
DB00945Acetylsalicylic acid2Completed2
DB00945Acetylsalicylic acid2Not Yet Recruiting2
DB00051Adalimumab2Withdrawn1
DB00026Anakinra2Recruiting1
DB01076Atorvastatin2Completed1
DB00207Azithromycin2Recruiting1
DB09310Catridecacog2Terminated1
DB00608Chloroquine2Recruiting1
DB00758Clopidogrel2Completed1
DB01394Colchicine2Recruiting1
DB09028Cytisine2Not Yet Recruiting1
DB06781Difluprednate2Completed2
DB00005Etanercept2Completed1
DB08868Fingolimod2Not Yet Recruiting1
DB01095Fluvastatin2Terminated1
DB01611Hydroxychloroquine2Recruiting1
DB04335Inosine2Completed1
DB00046Insulin Lispro2Recruiting1
DB00125L-Arginine2Active Not Recruiting1
DB00678Losartan2Completed1
DB12041Mapracorat2Completed1
DB00331Metformin2Recruiting1
DB00563Methotrexate2Completed1
DB00563Methotrexate2Withdrawn1
DB14158Microcrystalline cellulose2Withdrawn1
DB00704Naltrexone2Completed1
DB02701Nicotinamide2Recruiting1
DB01132Pioglitazone2Completed1
DB01708Prasterone2Completed1
DB00635Prednisone2Completed1
DB00178Ramipril2Completed1
DB06372Rilonacept2Completed1
DB01399Salsalate2Completed1
DB01261Sitagliptin2Recruiting1
DB00605Sulindac2Active Not Recruiting1
DB00945Acetylsalicylic acid2 / 3Completed1
DB00513Aminocaproic Acid2 / 3Completed1
DB00254Doxycycline2 / 3Unknown Status1
DB13961Fish oil2 / 3Completed1
DB06196Icatibant2 / 3Completed1
DB00159Icosapent2 / 3Active Not Recruiting1
DB00331Metformin2 / 3Completed1
DB00435Nitric Oxide2 / 3Recruiting1
DB00412Rosiglitazone2 / 3Withdrawn1
DB01399Salsalate2 / 3Completed1
DB12131Vinpocetine2 / 3Completed1
DB06151Acetylcysteine3Unknown Status1
DB01076Atorvastatin3Completed1
DB01076Atorvastatin3Terminated1
DB00207Azithromycin3Unknown Status1
DB00112Bevacizumab3Unknown Status1
DB00963Bromfenac3Completed3
DB00835Brompheniramine3Withdrawn1
DB00878Chlorhexidine3Unknown Status1
DB01234Dexamethasone3Completed1
DB06781Difluprednate3Completed6
DB01075Diphenhydramine3Withdrawn1
DB00005Etanercept3Completed1
DB00973Ezetimibe3Unknown Status1
DB00159Icosapent3Completed1
DB01221Ketamine3Recruiting1
DB00465Ketorolac3Completed1
DB00130L-Glutamine3Completed1
DB00873Loteprednol3Completed4
DB12041Mapracorat3Completed2
DB12041Mapracorat3Terminated1
DB04835Maraviroc3Completed1
DB00683Midazolam3Recruiting1
DB11133Omega-3 fatty acids3Completed1
DB09528Phylloquinone3Completed1
DB00860Prednisolone3Completed1
DB00852Pseudoephedrine3Withdrawn1
DB00641Simvastatin3Unknown Status1
DB01261Sitagliptin3Completed1
DB09153Sodium chloride3Recruiting1
DB00126Ascorbic acid4Completed2
DB01076Atorvastatin4Completed3
DB01076Atorvastatin4Unknown Status1
DB00963Bromfenac4Completed1
DB01164Calcium Chloride4Completed1
DB00796Candesartan cilexetil4Completed1
DB00482Celecoxib4Completed2
DB00482Celecoxib4Recruiting1
DB11121Chloroxylenol4Completed1
DB00122Choline4Terminated1
DB00091Ciclosporin4Completed1
DB00758Clopidogrel4Not Yet Recruiting1
DB01234Dexamethasone4Completed1
DB01234Dexamethasone4Recruiting2
DB05351Dexlansoprazole4Completed1
DB00514Dextromethorphan4Completed1
DB00254Doxycycline4Unknown Status1
DB01225Enoxaparin4Completed1
DB01175Escitalopram4Recruiting1
DB00005Etanercept4Completed2
DB00973Ezetimibe4Completed1
DB06215Ferumoxytol4Completed1
DB00324Fluorometholone4Recruiting1
DB11242Gelatin4Terminated1
DB01611Hydroxychloroquine4Recruiting1
DB00328Indometacin4Completed1
DB01221Ketamine4Recruiting1
DB00465Ketorolac4Completed2
DB11579Light Mineral Oil4Completed1
DB06655Liraglutide4Recruiting1
DB00873Loteprednol4Active Not Recruiting1
DB00873Loteprednol4Completed1
DB09407Magnesium chloride4Completed1
DB04835Maraviroc4Completed1
DB00331Metformin4Completed1
DB09107Methoxy polyethylene glycol-epoetin beta4Completed1
DB14158Microcrystalline cellulose4Completed1
DB11057Mineral oil4Completed1
DB00688Mycophenolate mofetil4Completed1
DB06802Nepafenac4Completed1
DB00338Omeprazole4Completed1
DB08439Parecoxib4Completed1
DB00806Pentoxifylline4Completed1
DB01132Pioglitazone4Completed1
DB01132Pioglitazone4Unknown Status1
DB08860Pitavastatin4Completed1
DB00761Potassium chloride4Completed1
DB00860Prednisolone4Active Not Recruiting1
DB00818Propofol4Completed1
DB00571Propranolol4Completed1
DB06817Raltegravir4Completed1
DB00178Ramipril4Completed1
DB00740Riluzole4Recruiting1
DB13131Serrapeptase4Not Yet Recruiting1
DB00641Simvastatin4Completed1
DB00877Sirolimus4Completed1
DB09154Sodium Citrate4Completed1
DB09395Sodium acetate4Completed1
DB09153Sodium chloride4Completed1
DB09422Soybean oil4Completed1
DB09034Suvorexant4Not Yet Recruiting1
DB00864Tacrolimus4Recruiting1
DB00966Telmisartan4Completed1
DB08816Ticagrelor4Not Yet Recruiting1
DB00684Tobramycin4Completed1
DB00620Triamcinolone4Recruiting1
DB047895-methyltetrahydrofolic acidNot AvailableCompleted1
DB03128AcetylcholineNot AvailableUnknown Status1
DB00459AcitretinNot AvailableCompleted1
DB00051AdalimumabNot AvailableCompleted1
DB00640AdenosineNot AvailableUnknown Status1
DB00802AlfentanilNot AvailableRecruiting1
DB00026AnakinraNot AvailableCompleted1
DB00026AnakinraNot AvailableUnknown Status1
DB01238AripiprazoleNot AvailableRecruiting1
DB01072AtazanavirNot AvailableCompleted1
DB01076AtorvastatinNot AvailableCompleted3
DB00963BromfenacNot AvailableCompleted1
DB00297BupivacaineNot AvailableCompleted1
DB00438CeftazidimeNot AvailableRecruiting1
DB00369CidofovirNot AvailableRecruiting1
DB00537CiprofloxacinNot AvailableRecruiting1
DB00363ClozapineNot AvailableRecruiting1
DB01234DexamethasoneNot AvailableCompleted1
DB01234DexamethasoneNot AvailableRecruiting1
DB01234DexamethasoneNot AvailableTerminated1
DB00633DexmedetomidineNot AvailableNot Yet Recruiting1
DB00829DiazepamNot AvailableRecruiting1
DB00586DiclofenacNot AvailableCompleted1
DB00153ErgocalciferolNot AvailableCompleted1
DB00005EtanerceptNot AvailableCompleted1
DB00973EzetimibeNot AvailableCompleted1
DB01039FenofibrateNot AvailableUnknown Status1
DB13961Fish oilNot AvailableEnrolling by Invitation1
DB00158Folic AcidNot AvailableCompleted2
DB01320FosphenytoinNot AvailableRecruiting1
DB00502HaloperidolNot AvailableRecruiting1
DB01109HeparinNot AvailableRecruiting1
DB01109HeparinNot AvailableTerminated1
DB00327HydromorphoneNot AvailableRecruiting1
DB01202LevetiracetamNot AvailableRecruiting1
DB00281LidocaineNot AvailableCompleted1
DB00873LoteprednolNot AvailableCompleted1
DB08815LurasidoneNot AvailableRecruiting1
DB14009Medical CannabisNot AvailableRecruiting1
DB00814MeloxicamNot AvailableCompleted2
DB00760MeropenemNot AvailableRecruiting1
DB00563MethotrexateNot AvailableCompleted2
DB00959MethylprednisoloneNot AvailableCompleted1
DB00959MethylprednisoloneNot AvailableRecruiting1
DB00683MidazolamNot AvailableRecruiting1
DB01618MolindoneNot AvailableRecruiting1
DB00471MontelukastNot AvailableCompleted1
DB00295MorphineNot AvailableRecruiting1
DB00295MorphineNot AvailableTerminated1
DB00788NaproxenNot AvailableRecruiting1
DB06802NepafenacNot AvailableCompleted1
DB00627NiacinNot AvailableTerminated1
DB00622NicardipineNot AvailableRecruiting1
DB00334OlanzapineNot AvailableRecruiting1
DB11133Omega-3 fatty acidsNot AvailableCompleted1
DB00198OseltamivirNot AvailableRecruiting1
DB00910ParicalcitolNot AvailableCompleted1
DB06154Pentaerythritol tetranitrateNot AvailableRecruiting1
DB00312PentobarbitalNot AvailableRecruiting1
DB01132PioglitazoneNot AvailableCompleted1
DB01132PioglitazoneNot AvailableTerminated1
DB11090Potassium nitrateNot AvailableCompleted1
DB00635PrednisoneNot AvailableCompleted1
DB00818PropofolNot AvailableNot Yet Recruiting1
DB00818PropofolNot AvailableRecruiting1
DB01224QuetiapineNot AvailableRecruiting1
DB00734RisperidoneNot AvailableRecruiting1
DB00073RituximabNot AvailableCompleted1
DB00020SargramostimNot AvailableCompleted1
DB00658SevelamerNot AvailableRecruiting1
DB00641SimvastatinNot AvailableCompleted2
DB09153Sodium chlorideNot AvailableUnknown Status1
DB09422Soybean oilNot AvailableCompleted1
DB11626TasonerminNot AvailableCompleted1
DB00373TimololNot AvailableRecruiting1
DB06822TinzaparinNot AvailableTerminated1
DB00684TobramycinNot AvailableRecruiting1
DB06273TocilizumabNot AvailableRecruiting1
DB00273TopiramateNot AvailableRecruiting1
DB05679UstekinumabNot AvailableCompleted1
DB00313Valproic AcidNot AvailableRecruiting1
DB00682WarfarinNot AvailableRecruiting1
DB09145WaterNot AvailableCompleted1
DB00246ZiprasidoneNot AvailableRecruiting1