Ankylosing Spondylitis (AS)

Also known as: Spondylitis, Ankylosing / Ankylosing Spondylitis / Ankylosing Spondylitis(AS) / Rheumatoid spondylitis / Spondylitis ankylopoietica / Rheumatoid arthritis of spine / Spondylitis ankylosing / Ank spond / Bechterew's disease / Bekhterev's disease

DrugDrug NameDrug Description
DB00443BetamethasoneA glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)
DB00297BupivacaineA widely used local anesthetic agent. [PubChem]
DB00482Celecoxib_Celecoxib_ is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and is also used to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis. It is marketed by Pfizer under the brand name _Celebrex_. Celecoxib is available by prescription in capsule form [A34124]. By inhibiting prostaglandin synthesis, non-steroidal anti-inflammatory drugs (NSAIDs) cause mucosal damage, ulceration and ulcer complication throughout the gastrointestinal tract. Celecoxib, however, poses less of an ulceration risk, owing to its decreased effect on gastric mucosal prostaglandin synthesis, when compared to placebo [A34152]. Interestingly, selective COX-2 inhibitors (especially _celecoxib_), have been evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of malignancies [A34124].
DB01285CorticotropinCorticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis.
DB01380Cortisone acetateCortisone acetate is a steroid hormone that has both glucocoriticoid and mineral corticoid activities. Corticosteroids are used to provide relief for inflamed areas of the body. They lessen swelling, redness, itching, and allergic reactions. They are often used as part of the treatment for a number of different diseases, such as severe allergies or skin problems, asthma, or arthritis. Endogenous glucocorticoids and some synthetic corticoids have high affinity to the protein transcortin (also called CBG, corticosteroid-binding protein), whereas all of them bind albumin. Glucocorticoids also bind to the cytosolic glucocorticoid receptor.
DB01234DexamethasoneAn anti-inflammatory 9-fluoro-glucocorticoid.
DB00586DiclofenacA non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
DB00005EtanerceptDimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of IgG1. Etanercept is produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian cell expression system. It consists of 934 amino acids.
DB00712FlurbiprofenFlurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen.
DB00741HydrocortisoneThe main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
DB01050IbuprofenIbuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics.[A39074] The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin.[A39075] Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID.[A39076] On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer _in vivo_ by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.[A39194]
DB00328IndometacinIndometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlorobenzoyl)25-methoxy-2-methylindole-3-acetic acid.[A177871] The pharmacological effect of indometacin is not fully understood, however, it is thought to be mediated through potent and nonselective inhibition of the enzyme cyclooxygenase (COX), which is the main enzyme responsible for catalyzes the rate-limiting step in prostaglandin and thromboxane biosynthesis via the arachidonic acid (AA) pathway. Indometacin was first discovered in 1963 and it was first approved for use in the U.S. by the Food and Drug Administration in 1965, [A486] along with other acetic acid derivatives such as [diclofenac] and [sulindac] that were also developed during the 1960s.[A177871] Since then, indometacin has been extensively studied in clinical trials as one of the most potent NSAIDs in blocking prostaglandin synthesis and was among the first NSAIDs to be used in the symptomatic treatment of migraine and for headaches that eventually became known as “indomethacin-responsive” headache disorders.[A177871] Most commonly used in rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, acute shoulder pains, and acute gouty arthritis, indometacin is currently available as oral capsules as well as other methods of administration, including rectal and intravenous formulations. Intravenous indometacin is administered to close a hemodynamically significant patent ductus arteriosus, as indicated by clinical evidence, in premature infants.[F4600] Ophthalmic indometacin has been studied and used in the symptomatic treatment of postoperative ocular inflammation and pain and/or complications after cataract surgery. Although deemed effective in reducing ocular inflammation in clinical studies, topical NSAIDs were also associated with a potential reduction in corneal sensitivity accompanied by an increased risk of superficial punctate keratitis and subjective symptoms of discomfort, including pain, burning or pricking, or a tingling sensation after instillation into the cul‐de‐sac.[A177949]
DB00065InfliximabInfliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions [A31469]. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory cytokine involved in chronic inflammatory diseases [A31469]. Its hyperactivity and enhanced signalling pathways can be observed in inflammatory diseases where it activates further pro-inflammatory cascades. By binding to both the soluble subunit and the membrane-bound precursor of TNF-α [A106], infliximab disrupts the interaction of TNF-α with its receptors and may also cause lysis of cells that produce TNF-α [A106]. Infliximab was first approved by the FDA in 1998 under the market name Remicade as an intravenous injection. It is indicated for the treatment of various inflammatory disorders such as adult or pediatric Chron's disease, adult or pediatric ulcerative colitis, rheumatoid arthritis in combination with methotrexate, ankylosing spondyliti, psoriatic arthritis, and plaque psoriasis [FDA Label]. In clinical trials, multiple infusions of infliximab displayed in a reduction of signs and symptoms of inflammatory diseases and induction of remission in patients who have had an inadequate response to alternative first-line therapies for that disorder [FDA Label]. There are currently two biosilimars of infliximab available in the US market that demonstrate a high degree of similarity to the reference product, Remicade. They are approved for all eligible indications of the reference product. Inflectra, a first biosimilar drug product, was approved in 2016. In December 2017, Ixifi, a second biosimilar that was developed by Pfizer, was granted approval by the FDA.
DB01009KetoprofenKetoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
DB00939Meclofenamic acidA non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
DB00959MethylprednisoloneA prednisolone derivative with similar anti-inflammatory action.
DB00788NaproxenNaproxen is classified as a nonsteroidal anti-inflammatory dug (NSAID) and was initially approved for prescription use in 1976 and then for over-the-counter (OTC) use in 1994.[A178975]
DB00554PiroxicamA cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.
DB00860PrednisoloneA glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
DB00635PrednisoneA synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver.
DB00863RanitidineRanitidine is a commonly used drug, classified as a _histamine H2-receptor antagonist_. This drug helps to prevent and treat gastric-acid related conditions, including ulcers, because of its ability to decrease gastric acid secretion [A176759], [FDA label]. It is often referred to as _Zantac_, and is available in various forms, including a regular tablet, injection, and effervescent tablet [FDA label], [F4253]. One common use of this drug is to relieve the symptoms of gastric esophageal reflux disease (GERD) [FDA label], which often leads to heartburn symptoms and acid regurgitation. The prevalence of GERD is thought to be 10-20% in western countries [A176843]. Ranitidine has proven to be an effective agent in relieving the above symptoms and is therefore widely used in GERD and other gastric-acid related conditions [A176849], [FDA label].
DB09029SecukinumabSecukinumab (Cosentyx) is a human monoclonal antibody designed for the treatment of uveitis, rheumatoid arthritis, ankylosing spondylitis, and psoriasis. Secukinumab is an interleukin-17A (IL-17A) inhibitor marketed by Novartis. IL-17 is a group of proinflammatory cytokines released by cells of the immune system and and exist in higher levels in many immune conditions associated with chronic inflammation. By targeting IL-17A, secukinumab has shown excellent efficacy in psoriasis by normalizing skin histology and was approved by the United States Food and Drug Administration on January 21, 2015 to treat adults with moderate-to-severe plaque psoriasis.
DB00605SulindacSulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril. Like other NSAIDs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that is converted _in vivo_ to an active sulfide compound by liver enzymes. There is evidence from some studies that sulindac may be associated with fewer gastrointestinal side effects than other NSAIDs, except for the cyclooxygenase-2 (COX-2) inhibitor drug class. This may be due to the sulfide metabolite undergoing enterohepatic circulation thus maintaining constant blood levels of the compound without inducing gastrointestinal effects, where the drug is excreted in the bile and then reabsorbed from the intestines. While its full mechanism of action is not fully understood, sulindac is thought to primarily mediate its action by inhibiting prostaglandin synthesis by inhibiting COX-1 and COX-2.
DB01284TetracosactideTetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticosteroids in the adrenal cortex. Tetracosactide exhibits the same activity as natural ACTH with regard to all its biological activities. The complex results in a product whose absorption in man is effected over a longer period of time as compared to corticotropin. Therefore, therapy may be maintained with less frequent administration.
DB00500TolmetinA non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin.
DB00620TriamcinoloneA glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)
DrugDrug NameTargetType
DB00443BetamethasoneGlucocorticoid receptortarget
DB00443BetamethasoneCytochrome P450 3A4enzyme
DB00443BetamethasoneMultidrug resistance protein 1transporter
DB00443BetamethasoneCytochrome P450 19A1enzyme
DB00297BupivacaineSodium channel protein type 10 subunit alphatarget
DB00297BupivacaineProstaglandin E2 receptor EP1 subtypetarget
DB00297BupivacaineCytochrome P450 3A4enzyme
DB00297BupivacaineCytochrome P450 2C19enzyme
DB00297BupivacaineCytochrome P450 2D6enzyme
DB00482CelecoxibProstaglandin G/H synthase 2target
DB00482Celecoxib3-phosphoinositide-dependent protein kinase 1target
DB00482CelecoxibCytochrome P450 2C9enzyme
DB00482CelecoxibCytochrome P450 2D6enzyme
DB00482CelecoxibMultidrug resistance-associated protein 4transporter
DB00482CelecoxibCytochrome P450 3A4enzyme
DB00482CelecoxibCytochrome P450 2C8enzyme
DB00482CelecoxibCarbonic anhydrase 2target
DB00482CelecoxibCarbonic anhydrase 3target
DB00482CelecoxibATP-binding cassette sub-family B member 5target
DB00482CelecoxibATP-binding cassette sub-family G member 2target
DB00482CelecoxibMultidrug resistance protein 1target
DB00482CelecoxibBile salt export pumptransporter
DB01285CorticotropinAdrenocorticotropic hormone receptortarget
DB01285CorticotropinCorticoliberintarget
DB01285Corticotropin3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
DB01285Corticotropin25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialenzyme
DB01285Corticotropin1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
DB01285CorticotropinCytochrome P450 3A4enzyme
DB01380Cortisone acetateGlucocorticoid receptortarget
DB01380Cortisone acetateCytochrome P450 3A4enzyme
DB01234DexamethasoneGlucocorticoid receptortarget
DB01234DexamethasoneAnnexin A1target
DB01234DexamethasoneNitric oxide synthase, inducibletarget
DB01234DexamethasoneNuclear receptor subfamily 0 group B member 1target
DB01234DexamethasoneCytochrome P450 3A4enzyme
DB01234DexamethasoneCytochrome P450 3A5enzyme
DB01234DexamethasoneCytochrome P450 3A7enzyme
DB01234DexamethasoneBile salt export pumptransporter
DB01234DexamethasoneMultidrug resistance protein 1transporter
DB01234DexamethasoneCanalicular multispecific organic anion transporter 1transporter
DB01234DexamethasoneSolute carrier organic anion transporter family member 1A2transporter
DB01234DexamethasoneATP-binding cassette sub-family G member 2transporter
DB01234DexamethasoneCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB01234DexamethasoneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB01234DexamethasoneCytochrome P450 19A1enzyme
DB01234DexamethasoneCytochrome P450 1A1enzyme
DB01234DexamethasoneCytochrome P450 1B1enzyme
DB01234DexamethasoneCytochrome P450 2A6enzyme
DB01234DexamethasoneCytochrome P450 2B6enzyme
DB01234DexamethasoneCytochrome P450 2C19enzyme
DB01234DexamethasoneCytochrome P450 2C8enzyme
DB01234DexamethasoneCytochrome P450 2D6enzyme
DB01234DexamethasoneCytochrome P450 2E1enzyme
DB01234DexamethasoneCytochrome P450 3A43enzyme
DB01234DexamethasoneCytochrome P450 4A11enzyme
DB01234DexamethasoneNuclear receptor subfamily 1 group I member 2target
DB00586DiclofenacProstaglandin G/H synthase 1target
DB00586DiclofenacProstaglandin G/H synthase 2target
DB00586DiclofenacTransthyretincarrier
DB00586DiclofenacCytochrome P450 2C9enzyme
DB00586DiclofenacCytochrome P450 2C19enzyme
DB00586DiclofenacCytochrome P450 1A2enzyme
DB00586DiclofenacCytochrome P450 2C8enzyme
DB00586DiclofenacUDP-glucuronosyltransferase 1-1enzyme
DB00586DiclofenacSerum albumincarrier
DB00586DiclofenacMultidrug resistance-associated protein 4transporter
DB00586DiclofenacMultidrug resistance protein 1transporter
DB00586DiclofenacMultidrug resistance-associated protein 1transporter
DB00586DiclofenacSolute carrier family 22 member 6transporter
DB00586DiclofenacSolute carrier family 22 member 8transporter
DB00586DiclofenacSolute carrier organic anion transporter family member 1C1transporter
DB00586DiclofenacSolute carrier family 22 member 11transporter
DB00586DiclofenacUDP-glucuronosyltransferase 2B7enzyme
DB00586DiclofenacProstaglandin G/H synthase 1enzyme
DB00586DiclofenacCytochrome P450 3A4enzyme
DB00586DiclofenacCytochrome P450 1A1enzyme
DB00586DiclofenacCytochrome P450 2B6enzyme
DB00586DiclofenacCytochrome P450 2C18enzyme
DB00586DiclofenacCytochrome P450 2E1enzyme
DB00586DiclofenacArachidonate 5-lipoxygenasetarget
DB00586DiclofenacSodium channel protein type 4 subunit alphatarget
DB00586DiclofenacAcid-sensing ion channel 1target
DB00586DiclofenacPotassium voltage-gated channel subfamily KQT member 2target
DB00586DiclofenacPotassium voltage-gated channel subfamily KQT member 3target
DB00586DiclofenacPhospholipase A2, membrane associatedtarget
DB00586DiclofenacSolute carrier organic anion transporter family member 1B1transporter
DB00586DiclofenacBile salt export pumptransporter
DB00005EtanerceptTumor necrosis factortarget
DB00005EtanerceptLymphotoxin-alphatarget
DB00005EtanerceptLow affinity immunoglobulin gamma Fc region receptor III-Btarget
DB00005EtanerceptComplement C1r subcomponenttarget
DB00005EtanerceptComplement C1q subcomponent subunit Atarget
DB00005EtanerceptComplement C1q subcomponent subunit Btarget
DB00005EtanerceptComplement C1q subcomponent subunit Ctarget
DB00005EtanerceptLow affinity immunoglobulin gamma Fc region receptor III-Atarget
DB00005EtanerceptComplement C1s subcomponenttarget
DB00005EtanerceptHigh affinity immunoglobulin gamma Fc receptor Itarget
DB00005EtanerceptLow affinity immunoglobulin gamma Fc region receptor II-atarget
DB00005EtanerceptLow affinity immunoglobulin gamma Fc region receptor II-btarget
DB00005EtanerceptLow affinity immunoglobulin gamma Fc region receptor II-ctarget
DB00005EtanerceptTumor necrosis factor receptor superfamily member 1Btarget
DB00712FlurbiprofenProstaglandin G/H synthase 2target
DB00712FlurbiprofenProstaglandin G/H synthase 1target
DB00712FlurbiprofenCytochrome P450 2C9enzyme
DB00712FlurbiprofenSerum albumincarrier
DB00712FlurbiprofenMultidrug resistance-associated protein 4transporter
DB00712FlurbiprofenSolute carrier family 22 member 6transporter
DB00712FlurbiprofenUDP-glucuronosyltransferase 2B7enzyme
DB00712FlurbiprofenUDP-glucuronosyltransferase 1-1enzyme
DB00712FlurbiprofenUDP-glucuronosyltransferase 1-3enzyme
DB00712FlurbiprofenUDP-glucuronosyltransferase 1-9enzyme
DB00712FlurbiprofenUDP-glucuronosyltransferase 2B4enzyme
DB00741HydrocortisoneAnnexin A1target
DB00741HydrocortisoneGlucocorticoid receptortarget
DB00741HydrocortisoneSex hormone-binding globulincarrier
DB00741HydrocortisoneCytochrome P450 3A4enzyme
DB00741HydrocortisoneCytochrome P450 3A5enzyme
DB00741HydrocortisoneCytochrome P450 3A7enzyme
DB00741HydrocortisoneMultidrug resistance protein 1transporter
DB00741HydrocortisoneSolute carrier organic anion transporter family member 1A2transporter
DB00741HydrocortisoneATP-binding cassette sub-family G member 2transporter
DB00741HydrocortisoneCytochrome P450 11B1, mitochondrialenzyme
DB00741HydrocortisoneCytochrome P450 11B2, mitochondrialenzyme
DB00741HydrocortisoneCytochrome P450 2C8enzyme
DB00741HydrocortisoneCorticosteroid-binding globulincarrier
DB00741HydrocortisoneCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB00741Hydrocortisone3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB00741HydrocortisoneSolute carrier family 22 member 8transporter
DB01050IbuprofenProstaglandin G/H synthase 1target
DB01050IbuprofenProstaglandin G/H synthase 2target
DB01050IbuprofenCytochrome P450 2C9enzyme
DB01050IbuprofenSerum albumincarrier
DB01050IbuprofenMultidrug resistance-associated protein 4transporter
DB01050IbuprofenMultidrug resistance-associated protein 1transporter
DB01050IbuprofenSolute carrier organic anion transporter family member 1A2transporter
DB01050IbuprofenSolute carrier family 22 member 6transporter
DB01050IbuprofenSolute carrier family 22 member 8transporter
DB01050IbuprofenSolute carrier family 22 member 11transporter
DB01050IbuprofenSolute carrier organic anion transporter family member 2B1transporter
DB01050IbuprofenMultidrug resistance protein 1transporter
DB01050IbuprofenUDP-glucuronosyltransferase 1-3enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 1-9enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 2B4enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 2B7enzyme
DB01050IbuprofenCytochrome P450 2C8enzyme
DB01050IbuprofenCytochrome P450 2C19enzyme
DB01050IbuprofenApoptosis regulator Bcl-2target
DB01050IbuprofenThrombomodulintarget
DB01050IbuprofenFatty acid-binding protein, intestinaltarget
DB01050IbuprofenPeroxisome proliferator-activated receptor gammatarget
DB01050IbuprofenCystic fibrosis transmembrane conductance regulatortarget
DB01050IbuprofenPeroxisome proliferator-activated receptor alphatarget
DB01050IbuprofenPlatelet glycoprotein Ib alpha chaintarget
DB01050IbuprofenProtein S100-A7target
DB01050IbuprofenAlpha-methylacyl-CoA racemaseenzyme
DB00328IndometacinProstaglandin G/H synthase 1target
DB00328IndometacinProstaglandin G/H synthase 2target
DB00328IndometacinCytochrome P450 2C19enzyme
DB00328IndometacinUDP-glucuronosyltransferase 1-9enzyme
DB00328IndometacinPhospholipase A2, membrane associatedtarget
DB00328IndometacinProstaglandin reductase 2target
DB00328IndometacinLactoylglutathione lyasetarget
DB00328IndometacinProstaglandin D2 receptor 2target
DB00328IndometacinPeroxisome proliferator-activated receptor gammatarget
DB00328IndometacinSerum albumincarrier
DB00328IndometacinCanalicular multispecific organic anion transporter 2transporter
DB00328IndometacinMultidrug resistance-associated protein 4transporter
DB00328IndometacinMultidrug resistance-associated protein 6transporter
DB00328IndometacinMultidrug resistance protein 1transporter
DB00328IndometacinMultidrug resistance-associated protein 1transporter
DB00328IndometacinSolute carrier organic anion transporter family member 1A2transporter
DB00328IndometacinSolute carrier family 22 member 6transporter
DB00328IndometacinSolute carrier family 22 member 8transporter
DB00328IndometacinCanalicular multispecific organic anion transporter 1transporter
DB00328IndometacinATP-binding cassette sub-family C member 11transporter
DB00328IndometacinSolute carrier family 22 member 11transporter
DB00328IndometacinSodium/bile acid cotransportertransporter
DB00328IndometacinSolute carrier family 22 member 7transporter
DB00328IndometacinCytochrome P450 2C9enzyme
DB00328IndometacinUDP-glucuronosyltransferase 1-1enzyme
DB00328IndometacinLiver carboxylesterase 1enzyme
DB00328IndometacinUDP-glucuronosyltransferase 2B7enzyme
DB00328IndometacinPeroxisome proliferator-activated receptor alphatarget
DB00328IndometacinAldo-keto reductase family 1 member C3target
DB00328IndometacinSolute carrier organic anion transporter family member 1B1transporter
DB00328IndometacinBile salt export pumptransporter
DB00065InfliximabTumor necrosis factortarget
DB01009KetoprofenProstaglandin G/H synthase 1target
DB01009KetoprofenProstaglandin G/H synthase 2target
DB01009KetoprofenC-X-C chemokine receptor type 1target
DB01009KetoprofenSerum albumincarrier
DB01009KetoprofenMultidrug resistance-associated protein 4transporter
DB01009KetoprofenSolute carrier organic anion transporter family member 1A2transporter
DB01009KetoprofenSolute carrier family 22 member 6transporter
DB01009KetoprofenSolute carrier family 22 member 8transporter
DB01009KetoprofenSolute carrier family 22 member 11transporter
DB01009KetoprofenSolute carrier family 22 member 7transporter
DB01009KetoprofenCytochrome P450 2C9enzyme
DB01009KetoprofenCytochrome P450 2C8enzyme
DB01009KetoprofenUDP-glucuronosyltransferase 1-1enzyme
DB00939Meclofenamic acidProstaglandin G/H synthase 1target
DB00939Meclofenamic acidProstaglandin G/H synthase 2target
DB00939Meclofenamic acidArachidonate 5-lipoxygenasetarget
DB00939Meclofenamic acidSolute carrier family 22 member 6transporter
DB00939Meclofenamic acidSolute carrier organic anion transporter family member 1C1transporter
DB00939Meclofenamic acidPotassium voltage-gated channel subfamily KQT member 2target
DB00939Meclofenamic acidPotassium voltage-gated channel subfamily KQT member 3target
DB00939Meclofenamic acidThyroxine-binding globulincarrier
DB00959MethylprednisoloneGlucocorticoid receptortarget
DB00959MethylprednisoloneCytochrome P450 3A4enzyme
DB00959MethylprednisoloneMultidrug resistance protein 1transporter
DB00788NaproxenProstaglandin G/H synthase 1target
DB00788NaproxenProstaglandin G/H synthase 2target
DB00788NaproxenSerum albumincarrier
DB00788NaproxenCytochrome P450 2C9enzyme
DB00788NaproxenCytochrome P450 1A2enzyme
DB00788NaproxenSolute carrier organic anion transporter family member 1A2transporter
DB00788NaproxenSolute carrier family 22 member 6transporter
DB00788NaproxenCytochrome P450 2C8enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-1enzyme
DB00788NaproxenUDP-glucuronosyltransferase 2B7enzyme
DB00788NaproxenPeptostreptococcal albumin-binding proteintarget
DB00788NaproxenBile salt export pumptransporter
DB00788NaproxenMultidrug resistance protein 1transporter
DB00554PiroxicamProstaglandin G/H synthase 1target
DB00554PiroxicamProstaglandin G/H synthase 2target
DB00554PiroxicamSerum albumincarrier
DB00554PiroxicamCytochrome P450 2C9enzyme
DB00554PiroxicamSolute carrier family 22 member 6transporter
DB00554PiroxicamSolute carrier family 22 member 8transporter
DB00554PiroxicamSolute carrier family 22 member 11transporter
DB00554PiroxicamCytochrome P450 2C8enzyme
DB00554PiroxicamSolute carrier organic anion transporter family member 2B1transporter
DB00860PrednisoloneCorticosteroid-binding globulincarrier
DB00860PrednisoloneCytochrome P450 3A4enzyme
DB00860PrednisoloneGlucocorticoid receptortarget
DB00860PrednisoloneSolute carrier organic anion transporter family member 1A2transporter
DB00860PrednisoloneMultidrug resistance protein 1transporter
DB00635PrednisoneGlucocorticoid receptortarget
DB00635PrednisoneCytochrome P450 3A4enzyme
DB00635PrednisoneMultidrug resistance protein 1transporter
DB00635PrednisoneSolute carrier organic anion transporter family member 1A2transporter
DB00635PrednisoneCytochrome P450 2C19enzyme
DB00635PrednisoneSerum albumincarrier
DB00635PrednisoneCorticosteroid 11-beta-dehydrogenase isozyme 1target
DB00863RanitidineHistamine H2 receptortarget
DB00863RanitidineCytochrome P450 1A2enzyme
DB00863RanitidineCytochrome P450 2D6enzyme
DB00863RanitidineSolute carrier family 22 member 1transporter
DB00863RanitidineMultidrug resistance protein 1transporter
DB00863RanitidineSolute carrier family 22 member 8transporter
DB00863RanitidineCytochrome P450 3A4enzyme
DB00863RanitidineAcetylcholinesterasetarget
DB00863RanitidineSolute carrier family 22 member 2transporter
DB00863RanitidineCholinesterasetarget
DB09029SecukinumabInterleukin-17Atarget
DB00605SulindacProstaglandin G/H synthase 2target
DB00605SulindacAldose reductasetarget
DB00605SulindacProstaglandin G/H synthase 1target
DB00605SulindacMitogen-activated protein kinase 3target
DB00605SulindacPeroxisome proliferator-activated receptor deltatarget
DB00605SulindacProstaglandin D2 receptor 2target
DB00605SulindacSerum albumincarrier
DB00605SulindacSolute carrier family 22 member 6transporter
DB00605SulindacCytochrome P450 1A1enzyme
DB00605SulindacAldo-keto reductase family 1 member B10target
DB01284TetracosactideAdrenocorticotropic hormone receptortarget
DB00500TolmetinProstaglandin G/H synthase 1target
DB00500TolmetinProstaglandin G/H synthase 2target
DB00500TolmetinSolute carrier family 22 member 6transporter
DB00500TolmetinTryptophan 2,3-dioxygenaseenzyme
DB00500TolmetinMyeloperoxidaseenzyme
DB00500TolmetinSerum albumincarrier
DB00620TriamcinoloneCorticosteroid-binding globulincarrier
DB00620TriamcinoloneGlucocorticoid receptortarget
DB00620TriamcinoloneCytochrome P450 3A4enzyme
DB00620TriamcinoloneProstaglandin G/H synthase 2enzyme
DB00620TriamcinoloneCholinesteraseenzyme
DrugDrug NamePhaseStatusCount
DB08904Certolizumab pegol1Completed2
DB00065Infliximab1Completed3
DB01281Abatacept2Unknown Status1
DB00051Adalimumab2Recruiting1
DB05676Apremilast2Completed1
DB12917Bimekizumab2Active Not Recruiting2
DB12917Bimekizumab2Completed1
DB00482Celecoxib2Recruiting1
DB08904Certolizumab pegol2Active Not Recruiting1
DB00005Etanercept2Recruiting1
DB00005Etanercept2Unknown Status1
DB01628Etoricoxib2Recruiting1
DB06674Golimumab2Recruiting1
DB00814Meloxicam2Recruiting1
DB00563Methotrexate2Unknown Status1
DB00959Methylprednisolone2Unknown Status1
DB01250Olsalazine2Completed1
DB14762Risankizumab2Completed1
DB11767Sarilumab2Completed1
DB11767Sarilumab2Terminated1
DB09029Secukinumab2Completed2
DB00795Sulfasalazine2Recruiting1
DB01041Thalidomide2Completed1
DB08895Tofacitinib2Completed1
DB05679Ustekinumab2Completed1
DB10318Varicella Zoster Vaccine (Live/Attenuated)2Active Not Recruiting2
DB09145Water2Unknown Status1
DB00005Etanercept2 / 3Recruiting1
DB00065Infliximab2 / 3Completed1
DB00860Prednisolone2 / 3Unknown Status1
DB00073Rituximab2 / 3Unknown Status1
DB14004Tildrakizumab2 / 3Active Not Recruiting1
DB00051Adalimumab3Completed5
DB00051Adalimumab3Recruiting1
DB00051Adalimumab3Withdrawn1
DB12917Bimekizumab3Not Yet Recruiting1
DB00482Celecoxib3Completed2
DB08904Certolizumab pegol3Active Not Recruiting1
DB00586Diclofenac3Completed2
DB00442Entecavir3Terminated1
DB00005Etanercept3Completed6
DB01628Etoricoxib3Completed2
DB06674Golimumab3Completed4
DB00328Indometacin3Completed1
DB00065Infliximab3Completed5
DB11569Ixekizumab3Withdrawn1
DB00814Meloxicam3Completed1
DB00563Methotrexate3Completed1
DB00929Misoprostol3Completed1
DB00788Naproxen3Completed2
DB00338Omeprazole3Completed1
DB11656Rebamipide3Completed1
DB09029Secukinumab3Completed5
DB09029Secukinumab3Recruiting1
DB06273Tocilizumab3Terminated2
DB08895Tofacitinib3Recruiting1
DB00316Acetaminophen4Completed1
DB00316Acetaminophen4Terminated1
DB00051Adalimumab4Active Not Recruiting1
DB00051Adalimumab4Completed2
DB00051Adalimumab4Recruiting1
DB00051Adalimumab4Unknown Status2
DB00630Alendronic acid4Completed1
DB00482Celecoxib4Active Not Recruiting1
DB00482Celecoxib4Completed1
DB00482Celecoxib4Not Yet Recruiting1
DB00482Celecoxib4Recruiting1
DB08904Certolizumab pegol4Unknown Status1
DB00851Dacarbazine4Recruiting1
DB00586Diclofenac4Recruiting1
DB00586Diclofenac4Terminated1
DB00005Etanercept4Active Not Recruiting2
DB00005Etanercept4Completed12
DB00005Etanercept4Not Yet Recruiting1
DB00005Etanercept4Terminated1
DB00005Etanercept4Unknown Status2
DB01628Etoricoxib4Active Not Recruiting1
DB06674Golimumab4Active Not Recruiting1
DB06674Golimumab4Completed2
DB06674Golimumab4Recruiting1
DB06674Golimumab4Withdrawn1
DB01611Hydroxychloroquine4Recruiting1
DB12354Imrecoxib4Recruiting1
DB00328Indometacin4Recruiting1
DB00065Infliximab4Completed8
DB00065Infliximab4Terminated1
DB00065Infliximab4Unknown Status2
DB00065Infliximab4Withdrawn1
DB09212Loxoprofen4Completed1
DB00814Meloxicam4Recruiting1
DB00563Methotrexate4Completed2
DB00563Methotrexate4Recruiting1
DB00563Methotrexate4Withdrawn1
DB00282Pamidronic acid4Not Yet Recruiting1
DB09029Secukinumab4Active Not Recruiting1
DB09029Secukinumab4Recruiting2
DB00795Sulfasalazine4Completed1
DB00795Sulfasalazine4Not Yet Recruiting1
DB00795Sulfasalazine4Recruiting1
DB00193Tramadol4Completed1
DB00193Tramadol4Terminated1
DB09145Water4Completed3
DB09145Water4Not Yet Recruiting1
DB09145Water4Terminated1
DB01281AbataceptNot AvailableRecruiting1
DB00051AdalimumabNot AvailableCompleted3
DB00051AdalimumabNot AvailableRecruiting2
DB00482CelecoxibNot AvailableCompleted1
DB00005EtanerceptNot AvailableCompleted5
DB00005EtanerceptNot AvailableRecruiting2
DB00005EtanerceptNot AvailableTerminated1
DB01628EtoricoxibNot AvailableCompleted1
DB06674GolimumabNot AvailableActive Not Recruiting2
DB06674GolimumabNot AvailableCompleted1
DB06674GolimumabNot AvailableRecruiting1
DB00065InfliximabNot AvailableCompleted4
DB00065InfliximabNot AvailableRecruiting2
DB00065InfliximabNot AvailableTerminated1
DB00065InfliximabNot AvailableUnknown Status1
DB00563MethotrexateNot AvailableCompleted1
DB00073RituximabNot AvailableRecruiting1
DB01098RosuvastatinNot AvailableCompleted1
DB09029SecukinumabNot AvailableRecruiting1
DB06273TocilizumabNot AvailableRecruiting1
DB05679UstekinumabNot AvailableRecruiting1
DB09145WaterNot AvailableCompleted2
DB09145WaterNot AvailableTerminated1