Gastrointestinal Stromal Tumors

Also known as: Gastrointestinal stromal tumor / Tumors, Gastrointestinal Stromal / GIST / Gastrointestinal stromal tumour

DrugDrug NameDrug Description
DB00398SorafenibSorafenib (rINN), marketed as Nexavar by Bayer, is a drug approved for the treatment of advanced renal cell carcinoma (primary kidney cancer). It has also received "Fast Track" designation by the FDA for the treatment of advanced hepatocellular carcinoma (primary liver cancer), and has since performed well in Phase III trials. Sorafenib is a small molecular inhibitor of Raf kinase, PDGF (platelet-derived growth factor), VEGF receptor 2 & 3 kinases and c Kit the receptor for Stem cell factor. A growing number of drugs target most of these pathways. The originality of Sorafenib lays in its simultaneous targeting of the Raf/Mek/Erk pathway.
DrugDrug NameTargetType
DB00398SorafenibSerine/threonine-protein kinase B-raftarget
DB00398SorafenibReceptor-type tyrosine-protein kinase FLT3target
DB00398SorafenibRAF proto-oncogene serine/threonine-protein kinasetarget
DB00398SorafenibVascular endothelial growth factor receptor 3target
DB00398SorafenibPlatelet-derived growth factor receptor betatarget
DB00398SorafenibMast/stem cell growth factor receptor Kittarget
DB00398SorafenibVascular endothelial growth factor receptor 2target
DB00398SorafenibCytochrome P450 3A4enzyme
DB00398SorafenibUDP-glucuronosyltransferase 1-9enzyme
DB00398SorafenibCytochrome P450 2B6enzyme
DB00398SorafenibCytochrome P450 2C8enzyme
DB00398SorafenibCytochrome P450 3A5enzyme
DB00398SorafenibCytochrome P450 3A7enzyme
DB00398SorafenibCytochrome P450 2C9enzyme
DB00398SorafenibMultidrug resistance-associated protein 4transporter
DB00398SorafenibMultidrug resistance protein 1transporter
DB00398SorafenibCanalicular multispecific organic anion transporter 1transporter
DB00398SorafenibATP-binding cassette sub-family G member 2transporter
DB00398SorafenibCytochrome P450 1A2enzyme
DB00398SorafenibCytochrome P450 2C19enzyme
DB00398SorafenibCytochrome P450 2D6enzyme
DB00398SorafenibUDP-glucuronosyltransferase 1-1enzyme
DB00398SorafenibRalA-binding protein 1transporter
DB00398SorafenibFibroblast growth factor receptor 1target
DB00398SorafenibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB00398SorafenibVascular endothelial growth factor receptor 1target
DB00398SorafenibSolute carrier organic anion transporter family member 1B1transporter
DrugDrug NamePhaseStatusCount
DB019337-Hydroxystaurosporine1Completed1
DB03496Alvocidib1Completed1
DB00002Cetuximab1Completed1
DB01254Dasatinib1Completed1
DB00997Doxorubicin1Completed1
DB00530Erlotinib1Completed1
DB06091Evofosfamide1Unknown Status1
DB00544Fluorouracil1Completed1
DB00619Imatinib1Completed3
DB00619Imatinib1Terminated1
DB06186Ipilimumab1Completed1
DB00762Irinotecan1Completed2
DB00650Leucovorin1Completed1
DB04868Nilotinib1Completed2
DB08896Regorafenib1Active Not Recruiting1
DB05626Retaspimycin1Completed1
DB00020Sargramostim1Completed1
DB01268Sunitinib1Active Not Recruiting1
DB01268Sunitinib1Terminated1
DB01590Everolimus1 / 2Completed1
DB00619Imatinib1 / 2Completed2
DB00619Imatinib1 / 2Not Yet Recruiting1
DB11870RG-47331 / 2Completed1
DB01268Sunitinib1 / 2Completed1
DB01268Sunitinib1 / 2Recruiting1
DB08828Vismodegib1 / 2Completed1
DB11881AUY9222Completed1
DB11881AUY9222Recruiting1
DB06598Brostallicin2Completed1
DB00958Carboplatin2Completed1
DB04849Cediranib2Completed1
DB12033Cediranib2Completed1
DB00515Cisplatin2Completed1
DB01254Dasatinib2Active Not Recruiting1
DB05928Dovitinib2Completed2
DB11717Epacadostat2Recruiting1
DB11741Famitinib2Active Not Recruiting1
DB00322Floxuridine2Completed1
DB12047Ganetespib2Completed1
DB11918Guadecitabine2Recruiting1
DB00619Imatinib2Completed12
DB00619Imatinib2Recruiting1
DB00619Imatinib2Terminated2
DB00619Imatinib2Unknown Status1
DB06186Ipilimumab2Recruiting3
DB06075Linsitinib2Completed1
DB04868Nilotinib2Active Not Recruiting1
DB04868Nilotinib2Completed3
DB04868Nilotinib2Terminated1
DB06132Nivolumab2Recruiting1
DB09035Nivolumab2Recruiting3
DB00104Octreotide2Completed1
DB01229Paclitaxel2Completed1
DB06589Pazopanib2Completed1
DB06589Pazopanib2Withdrawn1
DB09037Pembrolizumab2Recruiting1
DB06641Perifosine2Completed1
DB08896Regorafenib2Active Not Recruiting1
DB08896Regorafenib2Recruiting1
DB06176Romidepsin2Active Not Recruiting1
DB06159Rubitecan2Completed1
DB06436Semaxanib2Completed1
DB00398Sorafenib2Active Not Recruiting1
DB00398Sorafenib2Completed1
DB01268Sunitinib2Completed2
DB00853Temozolomide2Completed1
DB00853Temozolomide2Recruiting1
DB06287Temsirolimus2Completed1
DB05109Trabectedin2Completed1
DB08911Trametinib2Withdrawn1
DB05146XL8202Completed1
DB00619Imatinib2 / 3Completed1
DB00112Bevacizumab3Completed1
DB00619Imatinib3Completed5
DB00619Imatinib3Not Yet Recruiting1
DB00619Imatinib3Recruiting1
DB00619Imatinib3Terminated5
DB00619Imatinib3Unknown Status2
DB11526Masitinib3Unknown Status2
DB04868Nilotinib3Completed2
DB04868Nilotinib3Terminated1
DB08896Regorafenib3Active Not Recruiting1
DB08896Regorafenib3No Longer Available1
DB05626Retaspimycin3Terminated1
DB01268Sunitinib3Completed1
DB01268Sunitinib3Terminated1
DB01268Sunitinib3Unknown Status1
DB00619Imatinib4Completed1
DB00619Imatinib4No Longer Available1
DB04868Nilotinib4Active Not Recruiting1
DB01254DasatinibNot AvailableRecruiting1
DB01590EverolimusNot AvailableAvailable1
DB00693FluoresceinNot AvailableSuspended1
DB00619ImatinibNot AvailableCompleted1
DB09374Indocyanine green acid formNot AvailableSuspended1
DB05296Motexafin lutetiumNot AvailableTerminated1
DB04868NilotinibNot AvailableCompleted1
DB08896RegorafenibNot AvailableNo Longer Available1
DB08896RegorafenibNot AvailableRecruiting1
DB01268SunitinibNot AvailableCompleted3