Intracranial Hemorrhages

Also known as: Intracranial Hemorrhage / Hemorrhage, Intracranial / Intracranial hemorrhage, unspecified / Unspecified intracranial hemorrhage / Intracranial haemorrhage / Bleeding intracranial / Intracranial haemorrhage, unspecified / Unspecified intracranial haemorrhage / Haemorrhage intracranial / Intracranial haemorrhage NOS / Hemorrhage intracranial / Intracranial hemorrhage NOS

DrugDrug NameDrug Description
DB11330Factor IX Complex (Human)Factor IX Complex is a sterile, lyophilized concentrate composed of a number of Vitamin K-dependent clotting factors found in functioning human plasma. Also known as prothrombin complex concentrate, products containing this complex often include Factor IX (antihemophilic factor B), Factor II (prothrombin), Factor X (Stuart-Prower Factor), and low levels of Factor VII (proconvertin) derived from human plasma. Many commercially available products also contain low levels of other antithrombotic proteins. For example, Kcentra (FDA) also contains the antithrombotic proteins C and S, while Bebulin VH (FDA) contains heparin. Coagulation factors are purified from pooled human plasma and subsequently sterilized and treated. Although Factor IX Complex products contain many different coagulation components, Factor IX is the lead component for potency and efficacy, particularly when used for the treatment of bleeding associated with Hemophilia B (Factor IX deficiency). As the product Kcentra, Factor IX Complex is also indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients experiencing acute major bleeding or requiring rapid reversal of therapy.
DB00622NicardipineA potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [PubChem]
DrugDrug NameTargetType
DB00622NicardipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00622NicardipineCytochrome P450 3A4enzyme
DB00622NicardipineCytochrome P450 2C19enzyme
DB00622NicardipineCytochrome P450 2C8enzyme
DB00622NicardipineCytochrome P450 2D6enzyme
DB00622NicardipineCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1Btarget
DB00622NicardipineCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1Atarget
DB00622NicardipineAlpha-1A adrenergic receptortarget
DB00622NicardipineAlpha-1D adrenergic receptortarget
DB00622NicardipineAlpha-1B adrenergic receptortarget
DB00622NicardipineMuscarinic acetylcholine receptor M1target
DB00622NicardipineMuscarinic acetylcholine receptor M2target
DB00622NicardipineMuscarinic acetylcholine receptor M3target
DB00622NicardipineMuscarinic acetylcholine receptor M4target
DB00622NicardipineMuscarinic acetylcholine receptor M5target
DB00622NicardipineVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00622NicardipineVoltage-dependent L-type calcium channel subunit beta-2target
DB00622NicardipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB00622NicardipineCalmodulintarget
DB00622NicardipineMultidrug resistance protein 1transporter
DB00622NicardipineCytochrome P450 2B6enzyme
DB00622NicardipineCytochrome P450 2E1enzyme
DB00622NicardipineCytochrome P450 3A5enzyme
DB00622NicardipineSolute carrier organic anion transporter family member 1B1transporter
DB00622NicardipineBile salt export pumptransporter
DrugDrug NamePhaseStatusCount
DB00036Coagulation factor VIIa Recombinant Human1Terminated1
DB11330Factor IX Complex (Human)1Terminated1
DB00163Vitamin E1Completed1
DB00633Dexmedetomidine2Unknown Status1
DB00016Erythropoietin2Completed1
DB00813Fentanyl2Unknown Status1
DB00683Midazolam2Unknown Status1
DB09153Sodium chloride2Completed1
DB00169Cholecalciferol2 / 3Active Not Recruiting1
DB01418Acenocoumarol3Recruiting1
DB06605Apixaban3Recruiting1
DB06695Dabigatran etexilate3Recruiting1
DB09075Edoxaban3Recruiting1
DB00016Erythropoietin3Recruiting1
DB00498Phenindione3Recruiting1
DB01174Phenobarbital3Completed1
DB06228Rivaroxaban3Recruiting1
DB09153Sodium chloride3Completed1
DB00682Warfarin3Recruiting1
DB00945Acetylsalicylic acid4Active Not Recruiting2
DB01166Cilostazol4Active Not Recruiting2
DB04920Clevidipine4Withdrawn1
DB11330Factor IX Complex (Human)4Recruiting1
DB00030Insulin Human4Unknown Status1
DB01378Magnesium cation4Completed1
DB01599Probucol4Active Not Recruiting2
DB00575ClonidineNot AvailableCompleted1
DB09477EnalaprilatNot AvailableCompleted1
DB00187EsmololNot AvailableCompleted1
DB01275HydralazineNot AvailableCompleted1
DB00598LabetalolNot AvailableCompleted1
DB00264MetoprololNot AvailableCompleted1
DB00622NicardipineNot AvailableCompleted1
DB00727NitroglycerinNot AvailableCompleted1
DB00325NitroprussideNot AvailableCompleted1
DB00692PhentolamineNot AvailableCompleted1
DB06228RivaroxabanNot AvailableNot Yet Recruiting1
DB12661UrapidilNot AvailableCompleted1