Selenic acid

Identification

Name
Selenic acid
Accession Number
DB11068
Description

Selenic acid is an organic compound with the chemical formula H2SeO4. It may be found in over-the-counter daily dietary supplements as a source of Selenium, an essential trace mineral for human health.

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 144.97
Monoisotopic: 145.91183038
Chemical Formula
H2O4Se
Synonyms
Not Available
External IDs
  • UN-1905
  • UN1905

Pharmacology

Indication

Indicated for use as a nutritional supplement.

Associated Therapies
Contraindications & Blackbox Warnings
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Pharmacodynamics

Selenium is an essential trace mineral that plays a critical role in antioxidant actions, anti-inflammatory effects, immune function, and the production of active thyroid hormone 1.

Mechanism of action

Selenium is a constituent of selenoproteins thus has structural and enzymatic roles. It acts as an antioxidant via the actions of selenoproteins for protection against oxidative stress, and acts as a catayst for the production of active thyroid hormone []. It may also play a role in sperm motility 2.

Absorption

Following single oral administration of sodium selenate concentrations ranging from 1 mg Se/kg to 4 mg Se/kg in lambs, the peak plasma concentrations ranged from 0.79 mg Se/L to 2.54 mg Se/L 3. The time to reach peak plasma concentrations ranged from 7 to 12 hours 3.

Volume of distribution

No pharmacokinetic data available.

Protein binding

No pharmacokinetic data available.

Metabolism

No pharmacokinetic data available.

Route of elimination
Not Available
Half-life

Following single oral administration of 1 mg Se/kg of sodium selenate in lambs, the elimination half life was 313 hours. The elimination half life was 142 hours following a single oral dosing of 4 mg Se/kg as sodium selenate 3.

Clearance

No pharmacokinetic data available.

Adverse Effects
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Toxicity

Injectable selenium is more acutely toxic than oral administration, with an intramuscular LD50 of 0.5 mg/kg BW in lambs 3.

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
EltrombopagThe bioavailability of Selenic acid can be decreased when combined with Eltrombopag.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
No interactions found.

Products

Product Ingredients
IngredientUNIICASInChI Key
Sodium selenate5DQP25600A13410-01-0MHQOTKLEMKRJIR-UHFFFAOYSA-L
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Balance Ace - CapSodium selenate (15 mcg) + Ascorbic acid (250 mg) + Beta carotene (10000 unit) + Cupric oxide (1 mg) + DL-alpha tocopheryl acetate (200 unit) + Manganese (1.5 mg) + Zinc (7.5 mg)CapsuleOralPharmavite1996-09-062002-07-25Canada
Cell-wise Natural SourceSodium selenate (25 mcg) + Ascorbic acid (200 mg) + Beta carotene (5000 unit) + Calcium (82.5 mg) + Cupric oxide (1 mg) + Manganese (1.5 mg) + Vitamin E (200 unit) + Zinc (7.5 mg)TabletOralMelaleuca, Inc.1998-05-262005-06-28Canada
High Potency Multivitamins & Minerals CapletsSodium selenate (50 mcg) + Ascorbic acid (100 mg) + Beta carotene (2500 unit) + Biotin (45 mcg) + Calcium (175 mg) + Calcium phosphate, dibasic (125 mg) + Cholecalciferol (400 unit) + Chromic chloride (50 mcg) + Cupric sulfate (2 mg) + Cyanocobalamin (9 mcg) + Ferrous fumarate (10 mg) + Folic acid (0.4 mg) + Magnesium (100 mg) + Manganese (5 mg) + Nickel sulfate (5 mcg) + Nicotinamide (40 mg) + Pantothenic acid (10 mg) + Potassium (55 mg) + Potassium Iodide (0.15 mg) + Potassium chloride (50 mg) + Pyridoxine hydrochloride (4 mg) + Riboflavin (3.4 mg) + Silicon (0.01 mg) + Sodium metavanadate (10 mcg) + Sodium molybdate (50 mcg) + Stannous chloride (0.01 mg) + Thiamine mononitrate (3 mg) + Vitamin A (3500 unit) + Zinc (20 mg) + alpha-Tocopherol acetate (50 unit)TabletOralAshbury Research CorporationNot applicableNot applicableCanada
K.L. Vitamin-mineralSodium selenate (24.5 mcg) + Ascorbic acid (21 mg) + Biotin (105 mcg) + Calcium (250 mg) + Calcium Phosphate (150 mg) + Cholecalciferol (140 unit) + Chromium (42 mcg) + Copper (0.7 mg) + Cyanocobalamin (2.1 mcg) + Ferrous sulfate (6.3 mg) + Folic acid (0.140 mg) + Magnesium (80 mg) + Manganese (0.7 mg) + Nicotinamide (7 mg) + Calcium pantothenate (3.5 mg) + Potassium Iodide (0.0525 mg) + Pyridoxine hydrochloride (0.7 mg) + Riboflavin (0.6 mg) + Sodium molybdate (25 mcg) + Thiamine (0.5 mg) + Vitamin A palmitate (1750 unit) + Zinc (5.25 mg) + alpha-Tocopherol acetate (10.5 unit)PowderOralAbundance Naturally LtdNot applicableNot applicableCanada
MaternaSodium selenate (25 mcg) + Ascorbic acid (100 mg) + Beta carotene (1500 unit) + Biotin (30 mcg) + Calcium (250 mg) + Cholecalciferol (250 unit) + Chromic chloride (25 mcg) + Cupric oxide (2 mg) + Cyanocobalamin (12 mcg) + Ferrous fumarate (27 mg) + Folic acid (1 mg) + Magnesium (50 mg) + Manganese (5 mg) + Nicotinamide (20 mg) + Calcium pantothenate (10 mg) + Potassium Iodide (0.15 mg) + Pyridoxine hydrochloride (10 mg) + Riboflavin (3.4 mg) + Sodium molybdate (25 mcg) + Thiamine mononitrate (3 mg) + Vitamin A (1500 unit) + Zinc (25 mg) + alpha-Tocopherol acetate (30 unit)TabletOralWyeth Ltd.2004-05-172006-07-24Canada
Ocuvite TabSodium selenate (40 mcg) + Ascorbic acid (60 mg) + Beta carotene (5000 unit) + Cupric oxide (2 mg) + DL-alpha tocopheryl acetate (30 unit) + Zinc (40 mg)TabletOralBausch & Lomb Inc1992-12-312002-07-29Canada
One Daily Vitamin and Mineral Dietary SupplementSodium selenate (10 mcg) + Ascorbic acid (60 mg) + Beta carotene (5000 unit) + Biotin (30 mcg) + Calcium (130 mg) + Cholecalciferol (400 unit) + Chromium (10 mcg) + Copper (2 mg) + Cyanocobalamin (6 mcg) + Ferrous fumarate (18 mg) + Folic acid (0.4 mg) + Magnesium (100 mg) + Manganese (2.5 mg) + Nicotinamide (20 mg) + Pantothenic acid (10 mg) + Potassium (37.5 mg) + Potassium Iodide (0.15 mg) + Potassium chloride (34 mg) + Pyridoxine hydrochloride (2 mg) + Riboflavin (1.7 mg) + Sodium molybdate (10 mcg) + Thiamine hydrochloride (1.5 mg) + Vitamin A (1500 unit) + Zinc (15 mg) + alpha-Tocopherol acetate (30 unit)TabletOralGarden State Nutritionals1998-09-252000-06-07Canada
One Tablet Daily Mens FormulaSodium selenate (87.5 mcg) + Ascorbic acid (90 mg) + Beta carotene (1000 unit) + Chromic chloride (150 mcg) + Cupric oxide (2 mg) + Cyanocobalamin (9 mcg) + Folic acid (0.4 mg) + Magnesium (100 mg) + Manganese (3.5 mg) + Nicotinamide (20 mg) + Calcium pantothenate (10 mg) + Potassium (37.5 mg) + Potassium Iodide (0.15 mg) + Potassium chloride (34 mg) + Pyridoxine hydrochloride (3 mg) + Riboflavin (2.55 mg) + Sodium molybdate (42 mcg) + Thiamine mononitrate (2.25 mg) + Vitamin A (4000 unit) + Vitamin D (400 unit) + Vitamin E (45 unit) + Zinc (15 mg)TabletOralVita Health Products Inc2003-05-162008-08-05Canada
One-A-day Advance Men'sSodium selenate (87.5 mcg) + Ascorbic acid (90 mg) + Beta carotene (1000 unit) + Chromic chloride (150 mcg) + Cupric sulfate (2 mg) + Cyanocobalamin (9 mcg) + Folic acid (0.4 mg) + Magnesium (100 mg) + Manganese (3.3 mg) + Niacin (20 mg) + Calcium pantothenate (10 mg) + Potassium (37.5 mg) + Potassium Iodide (0.15 mg) + Potassium chloride (34 mg) + Pyridoxine (3 mg) + Riboflavin (2.55 mg) + Sodium molybdate (41.7 mcg) + Thiamine mononitrate (2.25 mg) + Vitamin A (4000 unit) + Vitamin D (400 unit) + Zinc (15 mg) + alpha-Tocopherol acetate (45 unit)TabletOralBayer Inc Consumer Care2000-08-012002-02-06Canada
Optivite Vitamin and Mineral Supplement TabletSodium selenate (40 mcg) + Ascorbic acid (60 mg) + Beta carotene (5000 unit) + Cupric oxide (2 mg) + Zinc (40 mg) + alpha-Tocopherol acetate (30 unit)TabletOralPharmetics (2011) Inc.1998-11-102005-08-04Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Cavan Heme OBSodium selenate (65 ug/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Iron (28 mg/1) + Niacin (17 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (175 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (15 mg/1) + alpha-Tocopherol succinate (10 [iU]/1)TabletOralSeton Pharmaceuticals2010-08-032012-06-10Us
Duet DHA BalancedSodium selenate (65 ug/1) + Ascorbic acid (120 mg/1) + Beta carotene (2800 [iU]/1) + Calcium carbonate (215 mg/1) + Cholecalciferol (640 [iU]/1) + Choline (55 mg/1) + Cupric oxide (1.8 mg/1) + Cyanocobalamin (12 ug/1) + D-alpha-Tocopherol acetate (15 mg/1) + Folic acid (1 mg/1) + Iodine (210 ug/1) + Iron (25 mg/1) + Magnesium (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (267 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (2 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (25 mg/1)OralEckson Labs, LLC2012-10-30Not applicableUs
HemeNatal OBSodium selenate (65 ug/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Heme iron polypeptide (6 mg/1) + Iron sucrose (28 mg/1) + Nicotinamide (17 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (250 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (4.5 mg/1) + alpha-Tocopherol succinate (10 [iU]/1)TabletOralWh Nutritionals, Llc2012-03-082018-06-30Us
HemeNatal OB plus DHASodium selenate (65 ug/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + Doconexent (200 mg/1) + Folic acid (1 mg/1) + Heme iron polypeptide (6 mg/1) + Iron sucrose (28 mg/1) + Nicotinamide (17 mg/1) + Osbond acid (2.5 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (250 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (4.5 mg/1) + alpha-Linolenic acid (0.5 mg/1) + alpha-Tocopherol succinate (10 [iU]/1)KitOralWh Nutritionals, Llc2012-03-082019-04-30Us
Paire OB Plus DHASodium selenate (65 ug/1) + Biotin (30 ug/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + D-alpha-Tocopherol acetate (10 [iU]/1) + Doconexent (200 mg/1) + Ferrous asparto glycinate (6 mg/1) + Folic acid (1 mg/1) + Iron (22 mg/1) + Nicotinamide (17 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (175 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Thiamine mononitrate (1.5 mg/1) + Vitamin D (400 [iU]/1) + Zinc oxide (15 mg/1)KitOralCentrix Pharmaceutical2010-10-132015-07-31Us
PreferaOBSodium selenate (65 ug/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Heme iron polypeptide (6 mg/1) + Iron sucrose (28 mg/1) + Nicotinamide (17 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (250 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (4.5 mg/1) + alpha-Tocopherol succinate (10 [iU]/1)Tablet, coatedOralMEDA Pharmaceuticals2015-04-282018-08-31Us
PreferaOB plus DHASodium selenate (65 ug/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Heme iron polypeptide (6 mg/1) + Iron sucrose (28 mg/1) + Nicotinamide (17 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (250 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Schizochytrium DHA oil (200 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (4.5 mg/1) + alpha-Tocopherol succinate (10 [iU]/1)OralMEDA Pharmaceuticals2015-02-012018-08-31Us
Vp-heme ObSodium selenate (65 mg/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Copper gluconate (0.8 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Heme iron polypeptide (6 mg/1) + Iron sucrose (28 mg/1) + Nicotinamide (17 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (250 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (4.5 mg/1) + alpha-Tocopherol succinate (10 [iU]/1)Tablet, film coatedOralVirtus Pharmaceuticals2013-10-142016-05-31Us
Vp-heme Ob DHASodium selenate (65 mg/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (0.80 mg/1) + Cyanocobalamin (12 ug/1) + Folic acid (1 mg/1) + Heme iron polypeptide (6 mg/1) + Iron sucrose (28 mg/1) + Niacin (17 mg/1) + Omega-3 fatty acids (203 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (250 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (4.5 mg/1) + alpha-Tocopherol succinate (10 [iU]/1)KitOralVirtus Pharmaceuticals2013-12-012016-02-05Us

Categories

ATC Codes
A12CE01 — Sodium selenate
Drug Categories
Classification
Not classified

Chemical Identifiers

UNII
HV0Y51NC4J
CAS number
7783-08-6
InChI Key
QYHFIVBSNOWOCQ-UHFFFAOYSA-N
InChI
InChI=1S/H2O4Se/c1-5(2,3)4/h(H2,1,2,3,4)
IUPAC Name
selenic acid
SMILES
O[Se](O)(=O)=O

References

General References
  1. Rayman MP: Selenium and human health. Lancet. 2012 Mar 31;379(9822):1256-68. doi: 10.1016/S0140-6736(11)61452-9. Epub 2012 Feb 29. [PubMed:22381456]
  2. Rayman MP: The importance of selenium to human health. Lancet. 2000 Jul 15;356(9225):233-41. doi: 10.1016/S0140-6736(00)02490-9. [PubMed:10963212]
  3. Davis TZ, Stegelmeier BL, Welch KD, Pfister JA, Panter KE, Hall JO: Comparative oral dose toxicokinetics of selenium compounds commonly found in selenium accumulator plants. J Anim Sci. 2013 Sep;91(9):4501-9. doi: 10.2527/jas.2012-6101. Epub 2013 Jul 3. [PubMed:23825349]
Human Metabolome Database
HMDB0062761
KEGG Compound
C05697
PubChem Compound
1089
PubChem Substance
347827883
ChemSpider
1058
BindingDB
50147596
ChEBI
18170
ChEMBL
CHEMBL2097002
PDBe Ligand
SE4
Wikipedia
Selenic_acid
MSDS
Download (48 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1, 2CompletedPreventionDeficiency, Vitamin D / Prophylaxis of preeclampsia1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CapsuleOral
TabletOral
PowderOral
KitOral
Tablet, coatedOral
Tablet, film coatedOral
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)70MSDS
boiling point (°C)DecomposesMSDS
water solubilitySolubleMSDS
Predicted Properties
PropertyValueSource
logP-1.6ChemAxon
pKa (Strongest Acidic)-3.8ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area74.6 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity21.13 m3·mol-1ChemAxon
Polarizability6.65 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0002-0900000000-ce27aa482e96edc8d2c3
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0002-0900000000-a8b1c495851747f01491
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0002-1900000000-5aea84da45d6f46389b1
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-0900000000-b27e0c5103000de8e548
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-1900000000-5e615f49bdaf4a1a74a7
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-0900000000-30844102eaffa8a1b188

Drug created on December 03, 2015 09:51 / Updated on June 12, 2020 10:53

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