Identification

Name
Primidone
Accession Number
DB00794  (APRD00549)
Type
Small Molecule
Groups
Approved, Vet Approved
Description

An antiepileptic agent related to the barbiturates; it is partly metabolized to phenobarbital in the body and owes some of its actions to this metabolite. Adverse effects are reported to be more frequent than with phenobarbital. (From Martindale, The Extra Pharmacopoeia, 30th ed, p309)

Structure
Thumb
Synonyms
  • 5-Phenyl-5-ethyl-hexahydropyrimidine-4,6-dione
  • Desoxyphenobarbital
  • Primaclone
  • Primidon
  • Primidona
  • Primidone
  • Primidonum
External IDs
NSC-41701 / Rö 101
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
MysolineTablet50 mg/1OralValeant Pharmaceuticals North America2009-06-24Not applicableUs
MysolineTablet250 mg/1OralValeant Pharmaceuticals North America2009-06-24Not applicableUs
Mysoline 250mg TabTablet250 mgOralElan Pharmaceuticals1994-12-312004-08-05Canada
Mysoline Pediatric Chewable Tablets 125mgTablet125 mgOralElan Pharmaceuticals1994-12-312004-08-05Canada
Mysoline Tab 125mgTablet125 mgOralAyerst Laboratories1963-12-311996-09-10Canada
Mysoline Tab 250mgTablet250 mgOralAyerst Laboratories1965-12-311997-08-15Canada
PrimidoneTablet250 mgOralAa Pharma Inc1977-12-31Not applicableCanada
PrimidoneTablet125 mgOralAa Pharma Inc1977-12-31Not applicableCanada
Primidone 125 TabTablet125 mgOralPro Doc Limitee1982-12-311999-08-12Canada
Primidone 250 TabTablet250 mgOralPro Doc Limitee1982-12-311999-08-12Canada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
PrimidoneTablet50 mg/1OralAmerincan Health Packaging2007-06-14Not applicableUs
PrimidoneTablet50 mg/1OralMajor2005-04-07Not applicableUs
PrimidoneTablet50 mg/1OralPhysicians Total Care, Inc.2009-01-29Not applicableUs
PrimidoneTablet250 mg/1OralA S Medication Solutions2010-06-192017-06-20Us
PrimidoneTablet50 mg/1OralLannett Company, Inc.2001-05-24Not applicableUs
PrimidoneTablet50 mg/1OralGlobal Pharmaceuticals2008-02-122016-11-29Us
PrimidoneTablet250 mg/1OralAvera Mc Kennan Hospital2015-04-14Not applicableUs
PrimidoneTablet50 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs2001-05-24Not applicableUs
PrimidoneTablet50 mg/1OralAv Pak2011-05-19Not applicableUs
PrimidoneTablet250 mg/1OralA S Medication Solutions2005-02-242017-06-20Us
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
PrimidoneTablet50 mg/1OralAphena Pharma Solutions Tennessee, Inc.2005-02-24Not applicableUs
International/Other Brands
Liskantin (Desitin) / Mizodin (Unia) / Mylepsinum / Mysoline / Pridona (Psicofarma) / Primid (Apsen) / Prysoline (Rekah) / Sertan (Alkaloida)
Categories
UNII
13AFD7670Q
CAS number
125-33-7
Weight
Average: 218.2518
Monoisotopic: 218.105527702
Chemical Formula
C12H14N2O2
InChI Key
DQMZLTXERSFNPB-UHFFFAOYSA-N
InChI
InChI=1S/C12H14N2O2/c1-2-12(9-6-4-3-5-7-9)10(15)13-8-14-11(12)16/h3-7H,2,8H2,1H3,(H,13,15)(H,14,16)
IUPAC Name
5-ethyl-5-phenyl-1,3-diazinane-4,6-dione
SMILES
CCC1(C(=O)NCNC1=O)C1=CC=CC=C1

Pharmacology

Indication

For the treatment of epilepsy

Structured Indications
Pharmacodynamics

Primidone is a barbiturate with anticonvulsant properties. Primidone, either alone or used concomitantly with other anticonvulsants, is indicated in the control of grand mal, psychomotor, and focal epileptic seizures. It may control grand mal seizures refractory to other anticonvulsant therapy. Primidone raises electro- or chemoshock seizure thresholds or alters seizure patterns in experimental animals. Primidone per se has anticonvulsant activity as do its two metabolites, phenobarbital and phenylethylmalonamide (PEMA). In addition to its anticonvulsant activity, Primidone potentiates that of phenobarbital in experimental animals.

Mechanism of action

Primidone is a GABA receptor agonist. The mechanism of Primidone's antiepileptic action is not known.

TargetActionsOrganism
AGamma-aminobutyric acid receptor subunit alpha-1
potentiator
Human
AGamma-aminobutyric acid receptor subunit alpha-2
potentiator
Human
AGamma-aminobutyric acid receptor subunit alpha-3
potentiator
Human
AGamma-aminobutyric acid receptor subunit alpha-4
potentiator
Human
AGamma-aminobutyric acid receptor subunit alpha-5
potentiator
Human
AGamma-aminobutyric acid receptor subunit alpha-6
potentiator
Human
UNeuronal acetylcholine receptor subunit alpha-4
antagonist
Human
UNeuronal acetylcholine receptor subunit alpha-7
antagonist
Human
UGlutamate receptor 2
antagonist
Human
UGlutamate receptor ionotropic, kainate 2
antagonist
Human
AGABA-A receptor (anion channel)
positive allosteric modulator
Human
Absorption

90 to 100%

Volume of distribution
Not Available
Protein binding

70%

Metabolism

Hepatic

Route of elimination
Not Available
Half life

3-23 hours

Clearance
Not Available
Toxicity

Symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgment, drowsiness or coma, shallow breathing, staggering, and in severe cases coma and death.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
16-BromoepiandrosteroneThe serum concentration of 16-Bromoepiandrosterone can be decreased when it is combined with Primidone.Investigational
19-norandrostenedioneThe serum concentration of 19-norandrostenedione can be decreased when it is combined with Primidone.Experimental, Illicit
5-androstenedioneThe serum concentration of 5-androstenedione can be decreased when it is combined with Primidone.Experimental, Illicit
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Primidone.Experimental
AbemaciclibThe serum concentration of Abemaciclib can be decreased when it is combined with Primidone.Approved
AbirateroneThe serum concentration of Abiraterone can be decreased when it is combined with Primidone.Approved
AcebutololPrimidone may increase the hypotensive activities of Acebutolol.Approved
AceclofenacThe metabolism of Aceclofenac can be increased when combined with Primidone.Approved, Investigational
AcenocoumarolThe metabolism of Acenocoumarol can be increased when combined with Primidone.Approved
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Primidone.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Primidone.Approved
AcetaminophenThe metabolism of Acetaminophen can be increased when combined with Primidone.Approved
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Primidone.Approved, Vet Approved
Acetylsalicylic acidThe metabolism of Acetylsalicylic acid can be increased when combined with Primidone.Approved, Vet Approved
AdinazolamThe metabolism of Adinazolam can be increased when combined with Primidone.Approved
AdipiplonThe risk or severity of adverse effects can be increased when Adipiplon is combined with Primidone.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Primidone.Approved, Investigational
AlaproclateThe risk or severity of adverse effects can be increased when Primidone is combined with Alaproclate.Experimental
AlbendazoleThe metabolism of Albendazole can be increased when combined with Primidone.Approved, Vet Approved
AlclometasoneThe metabolism of Alclometasone can be increased when combined with Primidone.Approved
AldesleukinPrimidone may increase the hypotensive activities of Aldesleukin.Approved
AldosteroneThe serum concentration of Aldosterone can be decreased when it is combined with Primidone.Experimental, Investigational
AlfaxaloneThe risk or severity of adverse effects can be increased when Alfaxalone is combined with Primidone.Vet Approved
AlfentanilThe metabolism of Alfentanil can be increased when combined with Primidone.Approved, Illicit
AlfuzosinThe metabolism of Alfuzosin can be increased when combined with Primidone.Approved, Investigational
AliskirenThe metabolism of Aliskiren can be increased when combined with Primidone.Approved, Investigational
AllopregnanoloneThe risk or severity of adverse effects can be increased when Allopregnanolone is combined with Primidone.Investigational
AllylestrenolThe metabolism of Allylestrenol can be increased when combined with Primidone.Approved
AlmotriptanThe metabolism of Almotriptan can be increased when combined with Primidone.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be increased when combined with Primidone.Approved
AlosetronThe metabolism of Alosetron can be increased when combined with Primidone.Approved, Withdrawn
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Primidone.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Alphaprodine is combined with Primidone.Illicit
AlprazolamThe metabolism of Alprazolam can be increased when combined with Primidone.Approved, Illicit, Investigational
AlprenololThe serum concentration of Alprenolol can be decreased when it is combined with Primidone.Approved, Withdrawn
AmbrisentanThe metabolism of Ambrisentan can be increased when combined with Primidone.Approved, Investigational
AmbroxolThe metabolism of Ambroxol can be increased when combined with Primidone.Approved, Investigational
Ambroxol acefyllinateThe serum concentration of Ambroxol acefyllinate can be decreased when it is combined with Primidone.Experimental, Investigational
AmcinonideThe serum concentration of Amcinonide can be decreased when it is combined with Primidone.Approved
AmifostinePrimidone may increase the hypotensive activities of Amifostine.Approved, Investigational
AmiloridePrimidone may increase the hypotensive activities of Amiloride.Approved
AmineptineThe metabolism of Amineptine can be increased when combined with Primidone.Illicit, Withdrawn
AminophenazoneThe metabolism of Aminophenazone can be increased when combined with Primidone.Approved, Withdrawn
AminophyllineThe metabolism of Aminophylline can be increased when combined with Primidone.Approved
AmiodaroneThe metabolism of Amiodarone can be increased when combined with Primidone.Approved, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Primidone.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be increased when combined with Primidone.Approved
AmlodipineThe metabolism of Amlodipine can be increased when combined with Primidone.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Primidone is combined with Amobarbital.Approved, Illicit
AmodiaquineThe metabolism of Amodiaquine can be increased when combined with Primidone.Approved, Investigational
AmoxapineThe metabolism of Amoxapine can be increased when combined with Primidone.Approved
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Primidone.Experimental
Amphotericin BPrimidone may increase the hypotensive activities of Amphotericin B.Approved, Investigational
AmprenavirThe metabolism of Amprenavir can be increased when combined with Primidone.Approved
AmrinoneThe metabolism of Amrinone can be increased when combined with Primidone.Approved
Amyl NitritePrimidone may increase the hypotensive activities of Amyl Nitrite.Approved
AndrostenedioneThe serum concentration of Androstenedione can be decreased when it is combined with Primidone.Experimental, Illicit
AnecortaveThe serum concentration of Anecortave can be decreased when it is combined with Primidone.Investigational
anecortave acetateThe serum concentration of anecortave acetate can be decreased when it is combined with Primidone.Investigational
AntipyrineThe metabolism of Antipyrine can be increased when combined with Primidone.Approved
ApixabanThe serum concentration of Apixaban can be decreased when it is combined with Primidone.Approved
ApomorphinePrimidone may increase the hypotensive activities of Apomorphine.Approved, Investigational
ApraclonidinePrimidone may increase the hypotensive activities of Apraclonidine.Approved
ApremilastThe serum concentration of Apremilast can be decreased when it is combined with Primidone.Approved, Investigational
AprepitantThe metabolism of Aprepitant can be increased when combined with Primidone.Approved, Investigational
Arachidonic AcidThe metabolism of Arachidonic Acid can be increased when combined with Primidone.Experimental
ArformoterolThe metabolism of Arformoterol can be increased when combined with Primidone.Approved, Investigational
ArgatrobanThe metabolism of Argatroban can be increased when combined with Primidone.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Primidone.Approved, Investigational
ArmodafinilThe metabolism of Primidone can be decreased when combined with Armodafinil.Approved, Investigational
ArotinololThe serum concentration of Arotinolol can be decreased when it is combined with Primidone.Approved, Investigational
Arsenic trioxidePrimidone may increase the hypotensive activities of Arsenic trioxide.Approved, Investigational
ArtemetherThe serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Primidone resulting in a loss in efficacy.Approved
ArticaineThe risk or severity of adverse effects can be increased when Articaine is combined with Primidone.Approved
AsenapineThe metabolism of Asenapine can be increased when combined with Primidone.Approved
AstemizoleThe metabolism of Astemizole can be increased when combined with Primidone.Approved, Withdrawn
AtamestaneThe serum concentration of Atamestane can be decreased when it is combined with Primidone.Investigational
AtazanavirThe metabolism of Atazanavir can be increased when combined with Primidone.Approved, Investigational
AtenololPrimidone may increase the hypotensive activities of Atenolol.Approved
AtorvastatinThe metabolism of Atorvastatin can be increased when combined with Primidone.Approved
AvanafilThe metabolism of Avanafil can be increased when combined with Primidone.Approved
AxitinibThe serum concentration of Axitinib can be decreased when it is combined with Primidone.Approved, Investigational
AzaperoneThe risk or severity of adverse effects can be increased when Azaperone is combined with Primidone.Investigational, Vet Approved
AzelastinePrimidone may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelnidipineThe metabolism of Azelnidipine can be increased when combined with Primidone.Approved, Investigational
Azilsartan medoxomilPrimidone may increase the hypotensive activities of Azilsartan medoxomil.Approved
AzimilideThe metabolism of Azimilide can be increased when combined with Primidone.Investigational
AzithromycinThe metabolism of Azithromycin can be increased when combined with Primidone.Approved
BaclofenThe risk or severity of adverse effects can be increased when Baclofen is combined with Primidone.Approved
BanoxantroneThe metabolism of Banoxantrone can be increased when combined with Primidone.Investigational
BarbexacloneThe risk or severity of adverse effects can be increased when Primidone is combined with Barbexaclone.Experimental
BarbitalThe risk or severity of adverse effects can be increased when Primidone is combined with Barbital.Illicit
BarnidipineThe metabolism of Barnidipine can be increased when combined with Primidone.Approved
BazedoxifeneThe serum concentration of Bazedoxifene can be decreased when it is combined with Primidone.Approved, Investigational
Beclomethasone dipropionateThe serum concentration of Beclomethasone dipropionate can be decreased when it is combined with Primidone.Approved, Investigational
BedaquilineThe serum concentration of Bedaquiline can be decreased when it is combined with Primidone.Approved
BefunololThe serum concentration of Befunolol can be decreased when it is combined with Primidone.Experimental
BenazeprilPrimidone may increase the hypotensive activities of Benazepril.Approved, Investigational
BencyclaneThe metabolism of Bencyclane can be increased when combined with Primidone.Experimental
BendroflumethiazidePrimidone may increase the orthostatic hypotensive activities of Bendroflumethiazide.Approved
BenidipineThe metabolism of Benidipine can be increased when combined with Primidone.Approved, Investigational
BenperidolThe risk or severity of adverse effects can be increased when Benperidol is combined with Primidone.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Primidone.Approved
BenzphetamineThe metabolism of Benzphetamine can be increased when combined with Primidone.Approved, Illicit
Benzyl alcoholThe metabolism of Benzyl alcohol can be increased when combined with Primidone.Approved
BepridilThe metabolism of Bepridil can be increased when combined with Primidone.Approved, Withdrawn
BeraprostThe metabolism of Beraprost can be increased when combined with Primidone.Investigational
BetamethasoneThe serum concentration of Betamethasone can be decreased when it is combined with Primidone.Approved, Vet Approved
BetaxololPrimidone may increase the hypotensive activities of Betaxolol.Approved
BevantololThe serum concentration of Bevantolol can be decreased when it is combined with Primidone.Approved
BexaroteneThe metabolism of Bexarotene can be increased when combined with Primidone.Approved, Investigational
BezafibrateThe metabolism of Bezafibrate can be increased when combined with Primidone.Approved
BicalutamideThe metabolism of Bicalutamide can be increased when combined with Primidone.Approved
BisoprololThe metabolism of Bisoprolol can be increased when combined with Primidone.Approved
BoceprevirThe serum concentration of Boceprevir can be decreased when it is combined with Primidone.Approved, Withdrawn
BopindololThe serum concentration of Bopindolol can be decreased when it is combined with Primidone.Approved
BortezomibThe serum concentration of Bortezomib can be decreased when it is combined with Primidone.Approved, Investigational
BosentanThe metabolism of Bosentan can be increased when combined with Primidone.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be decreased when it is combined with Primidone.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be decreased when it is combined with Primidone.Approved
BretyliumPrimidone may increase the hypotensive activities of Bretylium.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be decreased when it is combined with Primidone.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Primidone.Approved
BrinzolamideThe risk or severity of adverse effects can be increased when Brinzolamide is combined with Primidone.Approved
BrivaracetamThe metabolism of Brivaracetam can be increased when combined with Primidone.Approved, Investigational
BromazepamThe metabolism of Bromazepam can be increased when combined with Primidone.Approved, Illicit
BromisovalThe risk or severity of adverse effects can be increased when Bromisoval is combined with Primidone.Experimental
BromocriptineThe metabolism of Bromocriptine can be increased when combined with Primidone.Approved, Investigational
BromperidolThe risk or severity of adverse effects can be increased when Bromperidol is combined with Primidone.Investigational
BrompheniramineThe metabolism of Brompheniramine can be increased when combined with Primidone.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Brotizolam is combined with Primidone.Approved, Investigational, Withdrawn
BucindololThe serum concentration of Bucindolol can be decreased when it is combined with Primidone.Investigational
BudesonideThe metabolism of Budesonide can be increased when combined with Primidone.Approved
BufuralolThe serum concentration of Bufuralol can be decreased when it is combined with Primidone.Experimental, Investigational
BumetanidePrimidone may increase the hypotensive activities of Bumetanide.Approved
BupivacaineThe metabolism of Bupivacaine can be increased when combined with Primidone.Approved, Investigational
BupranololThe serum concentration of Bupranolol can be decreased when it is combined with Primidone.Approved
BuprenorphinePrimidone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be increased when combined with Primidone.Approved
BuspironeThe metabolism of Buspirone can be increased when combined with Primidone.Approved, Investigational
BusulfanThe metabolism of Busulfan can be increased when combined with Primidone.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Primidone.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Butacaine is combined with Primidone.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Butalbital is combined with Primidone.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Butamben is combined with Primidone.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Primidone.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Primidone.Approved, Illicit, Vet Approved
CabazitaxelThe metabolism of Cabazitaxel can be increased when combined with Primidone.Approved
CabergolineThe metabolism of Cabergoline can be increased when combined with Primidone.Approved
CabozantinibThe serum concentration of Cabozantinib can be decreased when it is combined with Primidone.Approved
CaffeineThe metabolism of Caffeine can be increased when combined with Primidone.Approved
CalcitriolThe metabolism of Calcitriol can be increased when combined with Primidone.Approved, Nutraceutical
CanagliflozinThe serum concentration of Canagliflozin can be decreased when it is combined with Primidone.Approved
CandesartanThe metabolism of Candesartan can be increased when combined with Primidone.Experimental
Candesartan cilexetilThe metabolism of Candesartan cilexetil can be increased when combined with Primidone.Approved
CanertinibThe risk or severity of adverse effects can be increased when Canertinib is combined with Primidone.Investigational
CannabidiolThe serum concentration of Cannabidiol can be decreased when it is combined with Primidone.Approved, Investigational
CaptoprilPrimidone may increase the hypotensive activities of Captopril.Approved
CarbamazepineThe metabolism of Carbamazepine can be increased when combined with Primidone.Approved, Investigational
CarbetocinPrimidone may increase the hypotensive activities of Carbetocin.Approved
CarbinoxamineThe metabolism of Carbinoxamine can be increased when combined with Primidone.Approved
CarboxyamidotriazoleThe metabolism of Carboxyamidotriazole can be increased when combined with Primidone.Investigational
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Primidone.Illicit, Investigational, Vet Approved
CariprazineThe metabolism of Cariprazine can be increased when combined with Primidone.Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Carisoprodol is combined with Primidone.Approved
CaroverineThe metabolism of Caroverine can be increased when combined with Primidone.Experimental
CarteololPrimidone may increase the hypotensive activities of Carteolol.Approved
CarvedilolThe metabolism of Carvedilol can be increased when combined with Primidone.Approved, Investigational
CelecoxibThe metabolism of Celecoxib can be increased when combined with Primidone.Approved, Investigational
CeliprololThe metabolism of Celiprolol can be increased when combined with Primidone.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be increased when combined with Primidone.Approved, Vet Approved
CeritinibThe serum concentration of Ceritinib can be decreased when it is combined with Primidone.Approved
CerivastatinThe metabolism of Cerivastatin can be increased when combined with Primidone.Withdrawn
CetirizineThe risk or severity of adverse effects can be increased when Cetirizine is combined with Primidone.Approved
CevimelineThe metabolism of Cevimeline can be increased when combined with Primidone.Approved
Chenodeoxycholic acidThe metabolism of Chenodeoxycholic acid can be increased when combined with Primidone.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Primidone.Approved, Illicit, Vet Approved
ChloramphenicolThe metabolism of Primidone can be decreased when combined with Chloramphenicol.Approved, Vet Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be increased when combined with Primidone.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Primidone.Approved, Investigational, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Primidone.Approved
ChloroquineThe metabolism of Chloroquine can be increased when combined with Primidone.Approved, Vet Approved
ChlorothiazidePrimidone may increase the orthostatic hypotensive activities of Chlorothiazide.Approved, Vet Approved
ChlorotrianiseneThe therapeutic efficacy of Chlorotrianisene can be decreased when used in combination with Primidone.Investigational, Withdrawn
ChlorphenamineThe metabolism of Chlorphenamine can be increased when combined with Primidone.Approved
ChlorpromazineThe metabolism of Chlorpromazine can be increased when combined with Primidone.Approved, Vet Approved
ChlorpropamideThe metabolism of Chlorpropamide can be increased when combined with Primidone.Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Primidone.Approved, Investigational, Withdrawn
ChlorthalidonePrimidone may increase the orthostatic hypotensive activities of Chlorthalidone.Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be increased when combined with Primidone.Approved
CholecalciferolThe metabolism of Cholecalciferol can be increased when combined with Primidone.Approved, Nutraceutical
CiclesonideThe metabolism of Ciclesonide can be increased when combined with Primidone.Approved, Investigational
CilazaprilPrimidone may increase the hypotensive activities of Cilazapril.Approved
CilnidipineThe metabolism of Cilnidipine can be increased when combined with Primidone.Approved, Investigational
CilostazolThe metabolism of Cilostazol can be increased when combined with Primidone.Approved
CimetidineThe metabolism of Primidone can be decreased when combined with Cimetidine.Approved
CinacalcetThe metabolism of Cinacalcet can be increased when combined with Primidone.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Primidone.Approved, Vet Approved
CinnarizineThe metabolism of Cinnarizine can be increased when combined with Primidone.Approved, Investigational
CisaprideThe metabolism of Cisapride can be increased when combined with Primidone.Approved, Investigational, Withdrawn
CitalopramThe metabolism of Citalopram can be increased when combined with Primidone.Approved
ClarithromycinThe serum concentration of the active metabolites of Clarithromycin can be increased when Clarithromycin is used in combination with Primidone.Approved
ClemastineThe risk or severity of adverse effects can be increased when Clemastine is combined with Primidone.Approved
ClevidipinePrimidone may increase the hypotensive activities of Clevidipine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Clidinium is combined with Primidone.Approved
ClindamycinThe metabolism of Clindamycin can be increased when combined with Primidone.Approved, Vet Approved
ClobazamThe metabolism of Clobazam can be increased when combined with Primidone.Approved, Illicit
ClobetasolThe serum concentration of Clobetasol can be decreased when it is combined with Primidone.Investigational
Clobetasol propionateThe serum concentration of Clobetasol propionate can be decreased when it is combined with Primidone.Approved
ClobetasoneThe serum concentration of Clobetasone can be decreased when it is combined with Primidone.Approved
ClocortoloneThe serum concentration of Clocortolone can be decreased when it is combined with Primidone.Approved
ClofarabinePrimidone may increase the hypotensive activities of Clofarabine.Approved, Investigational
ClofazimineThe metabolism of Clofazimine can be increased when combined with Primidone.Approved, Investigational
ClofibrateThe metabolism of Clofibrate can be increased when combined with Primidone.Approved, Investigational
clomethiazoleThe metabolism of clomethiazole can be increased when combined with Primidone.Investigational
ClomipramineThe metabolism of Clomipramine can be increased when combined with Primidone.Approved, Vet Approved
ClonazepamThe metabolism of Clonazepam can be increased when combined with Primidone.Approved, Illicit
ClonidineThe metabolism of Clonidine can be increased when combined with Primidone.Approved
ClopenthixolThe risk or severity of adverse effects can be increased when Clopenthixol is combined with Primidone.Experimental
ClopidogrelThe metabolism of Clopidogrel can be increased when combined with Primidone.Approved, Nutraceutical
CloranololThe serum concentration of Cloranolol can be decreased when it is combined with Primidone.Experimental
ClorazepateThe metabolism of Clorazepate can be increased when combined with Primidone.Approved, Illicit
ClorindioneThe metabolism of Clorindione can be increased when combined with Primidone.Experimental
ClothiapineThe risk or severity of adverse effects can be increased when Clothiapine is combined with Primidone.Experimental
ClotiazepamThe metabolism of Clotiazepam can be increased when combined with Primidone.Approved, Illicit
ClotrimazoleThe metabolism of Primidone can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe serum concentration of Clozapine can be decreased when it is combined with Primidone.Approved
CobicistatThe serum concentration of Cobicistat can be decreased when it is combined with Primidone.Approved
CobimetinibThe serum concentration of Cobimetinib can be decreased when it is combined with Primidone.Approved
CocaineThe metabolism of Cocaine can be increased when combined with Primidone.Approved, Illicit
CodeineThe metabolism of Codeine can be increased when combined with Primidone.Approved, Illicit
ColchicineThe metabolism of Colchicine can be increased when combined with Primidone.Approved
ConivaptanThe metabolism of Conivaptan can be increased when combined with Primidone.Approved, Investigational
Conjugated estrogensThe metabolism of Conjugated estrogens can be increased when combined with Primidone.Approved
CopanlisibThe metabolism of Copanlisib can be increased when combined with Primidone.Approved
Cortexolone 17α-propionateThe serum concentration of Cortexolone 17α-propionate can be decreased when it is combined with Primidone.Investigational
CorticosteroneThe serum concentration of Corticosterone can be decreased when it is combined with Primidone.Experimental
Cortisone acetateThe metabolism of Cortisone acetate can be increased when combined with Primidone.Approved
CrizotinibThe serum concentration of Crizotinib can be decreased when it is combined with Primidone.Approved
CyclizineThe risk or severity of adverse effects can be increased when Primidone is combined with Cyclizine.Approved
CyclobenzaprineThe metabolism of Cyclobenzaprine can be increased when combined with Primidone.Approved
CyclopenthiazidePrimidone may increase the orthostatic hypotensive activities of Cyclopenthiazide.Experimental
CyclophosphamideThe metabolism of Cyclophosphamide can be increased when combined with Primidone.Approved, Investigational
CyclosporineThe metabolism of Cyclosporine can be increased when combined with Primidone.Approved, Investigational, Vet Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Cyproheptadine is combined with Primidone.Approved
CytarabineThe metabolism of Cytarabine can be increased when combined with Primidone.Approved, Investigational
DabrafenibThe serum concentration of Primidone can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Daclatasvir can be decreased when it is combined with Primidone.Approved
DantroleneThe metabolism of Dantrolene can be increased when combined with Primidone.Approved
DapagliflozinThe metabolism of Dapagliflozin can be increased when combined with Primidone.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Primidone.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Primidone is combined with Dapoxetine.Investigational
DapsoneThe metabolism of Dapsone can be increased when combined with Primidone.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be increased when combined with Primidone.Approved, Investigational
DarodipineThe metabolism of Darodipine can be increased when combined with Primidone.Experimental
DarunavirThe metabolism of Darunavir can be increased when combined with Primidone.Approved
DasabuvirThe metabolism of Dasabuvir can be increased when combined with Primidone.Approved
DasatinibThe serum concentration of Dasatinib can be decreased when it is combined with Primidone.Approved, Investigational
DaunorubicinThe metabolism of Daunorubicin can be increased when combined with Primidone.Approved
DeflazacortThe metabolism of Deflazacort can be increased when combined with Primidone.Approved
DelavirdineThe metabolism of Delavirdine can be increased when combined with Primidone.Approved
DeramciclaneThe risk or severity of adverse effects can be increased when Deramciclane is combined with Primidone.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Primidone.Approved
DesipramineThe metabolism of Desipramine can be increased when combined with Primidone.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Primidone is combined with Desloratadine.Approved, Investigational
DesogestrelThe therapeutic efficacy of Desogestrel can be decreased when used in combination with Primidone.Approved
DesonideThe serum concentration of Desonide can be decreased when it is combined with Primidone.Approved, Investigational
DesoximetasoneThe serum concentration of Desoximetasone can be decreased when it is combined with Primidone.Approved
Desoxycorticosterone acetateThe serum concentration of Desoxycorticosterone acetate can be decreased when it is combined with Primidone.Approved
Desoxycorticosterone PivalateThe serum concentration of Desoxycorticosterone Pivalate can be decreased when it is combined with Primidone.Experimental, Vet Approved
DesvenlafaxineThe metabolism of Desvenlafaxine can be increased when combined with Primidone.Approved
DetomidineThe risk or severity of adverse effects can be increased when Detomidine is combined with Primidone.Vet Approved
DeutetrabenazineThe metabolism of Deutetrabenazine can be increased when combined with Primidone.Approved, Investigational
DexamethasoneThe serum concentration of Dexamethasone can be decreased when it is combined with Primidone.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateThe serum concentration of Dexamethasone isonicotinate can be decreased when it is combined with Primidone.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Primidone.Approved
Dexchlorpheniramine maleateThe metabolism of Dexchlorpheniramine maleate can be increased when combined with Primidone.Approved
DexlansoprazoleThe metabolism of Dexlansoprazole can be increased when combined with Primidone.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Primidone.Approved, Vet Approved
DexmethylphenidateThe serum concentration of the active metabolites of Primidone can be increased when Primidone is used in combination with Dexmethylphenidate.Approved
DextromethorphanThe metabolism of Dextromethorphan can be increased when combined with Primidone.Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Primidone.Experimental, Illicit
DextropropoxypheneThe metabolism of Dextropropoxyphene can be increased when combined with Primidone.Approved, Illicit, Investigational, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Primidone.Approved, Investigational
DiazepamThe metabolism of Diazepam can be increased when combined with Primidone.Approved, Illicit, Vet Approved
DibenzepinThe metabolism of Dibenzepin can be increased when combined with Primidone.Experimental
DiclofenacThe serum concentration of Diclofenac can be decreased when it is combined with Primidone.Approved, Vet Approved
DiclofenamideThe risk or severity of adverse effects can be increased when Diclofenamide is combined with Primidone.Approved
DicoumarolThe metabolism of Dicoumarol can be increased when combined with Primidone.Approved
DienestrolThe therapeutic efficacy of Dienestrol can be decreased when used in combination with Primidone.Approved, Investigational
DienogestThe therapeutic efficacy of Dienogest can be decreased when used in combination with Primidone.Approved
Diethyl etherThe risk or severity of adverse effects can be increased when Diethyl ether is combined with Primidone.Experimental
DiethylstilbestrolThe therapeutic efficacy of Diethylstilbestrol can be decreased when used in combination with Primidone.Approved, Investigational
DifenoxinThe risk or severity of adverse effects can be increased when Primidone is combined with Difenoxin.Approved, Illicit
DiflorasoneThe serum concentration of Diflorasone can be decreased when it is combined with Primidone.Approved
DifluocortoloneThe serum concentration of Difluocortolone can be decreased when it is combined with Primidone.Approved, Investigational
DifluprednateThe serum concentration of Difluprednate can be decreased when it is combined with Primidone.Approved
DigitoxinThe metabolism of Digitoxin can be increased when combined with Primidone.Approved, Investigational
DigoxinThe metabolism of Digoxin can be increased when combined with Primidone.Approved
DihydrocodeineThe metabolism of Dihydrocodeine can be increased when combined with Primidone.Approved, Illicit
DihydroergotamineThe metabolism of Dihydroergotamine can be increased when combined with Primidone.Approved
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Primidone.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Primidone.Experimental, Illicit
DiltiazemThe metabolism of Diltiazem can be increased when combined with Primidone.Approved
DimenhydrinateThe risk or severity of adverse effects can be increased when Primidone is combined with Dimenhydrinate.Approved
DinutuximabPrimidone may increase the hypotensive activities of Dinutuximab.Approved
DiphenadioneThe metabolism of Diphenadione can be increased when combined with Primidone.Experimental
DiphenhydramineThe metabolism of Diphenhydramine can be increased when combined with Primidone.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Primidone.Approved, Illicit
DipyridamolePrimidone may increase the hypotensive activities of Dipyridamole.Approved
DisopyramideThe metabolism of Disopyramide can be increased when combined with Primidone.Approved
DisulfiramThe metabolism of Disulfiram can be increased when combined with Primidone.Approved
DixyrazineThe risk or severity of adverse effects can be increased when Dixyrazine is combined with Primidone.Experimental
DocetaxelThe metabolism of Docetaxel can be increased when combined with Primidone.Approved, Investigational
DoconexentThe metabolism of Doconexent can be increased when combined with Primidone.Approved, Investigational
DofetilideThe metabolism of Dofetilide can be increased when combined with Primidone.Approved
DolasetronThe metabolism of Dolasetron can be increased when combined with Primidone.Approved
DomperidoneThe metabolism of Domperidone can be increased when combined with Primidone.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be increased when combined with Primidone.Approved
DopamineThe metabolism of Dopamine can be increased when combined with Primidone.Approved
DoramectinThe risk or severity of adverse effects can be increased when Doramectin is combined with Primidone.Vet Approved
DorzolamideThe risk or severity of adverse effects can be increased when Dorzolamide is combined with Primidone.Approved
DosulepinThe metabolism of Dosulepin can be increased when combined with Primidone.Approved
DotarizineThe metabolism of Dotarizine can be increased when combined with Primidone.Investigational
DoxazosinPrimidone may increase the hypotensive activities of Doxazosin.Approved
DoxepinThe metabolism of Doxepin can be increased when combined with Primidone.Approved
DoxorubicinThe serum concentration of Doxorubicin can be decreased when it is combined with Primidone.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be increased when combined with Primidone.Approved, Investigational
DoxycyclineThe serum concentration of Doxycycline can be decreased when it is combined with Primidone.Approved, Investigational, Vet Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Primidone.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Primidone.Experimental
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Primidone.Approved, Illicit
DronedaroneThe serum concentration of Dronedarone can be decreased when it is combined with Primidone.Approved
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Primidone.Approved, Vet Approved
DrospirenoneThe therapeutic efficacy of Drospirenone can be decreased when used in combination with Primidone.Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Primidone.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Primidone is combined with Duloxetine.Approved
DutasterideThe metabolism of Dutasteride can be increased when combined with Primidone.Approved, Investigational
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Primidone.Approved
DyphyllineThe serum concentration of Dyphylline can be decreased when it is combined with Primidone.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Primidone.Experimental, Illicit
EcopipamThe risk or severity of adverse effects can be increased when Ecopipam is combined with Primidone.Investigational
EfavirenzThe metabolism of Efavirenz can be increased when combined with Primidone.Approved, Investigational
EfonidipineThe metabolism of Efonidipine can be increased when combined with Primidone.Approved, Investigational
ElbasvirThe metabolism of Elbasvir can be increased when combined with Primidone.Approved
EletriptanThe metabolism of Eletriptan can be increased when combined with Primidone.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be decreased when it is combined with Primidone.Approved
EltanoloneThe risk or severity of adverse effects can be increased when Eltanolone is combined with Primidone.Investigational
EltrombopagThe metabolism of Eltrombopag can be increased when combined with Primidone.Approved
ElvitegravirThe metabolism of Elvitegravir can be increased when combined with Primidone.Approved
EmpagliflozinPrimidone may increase the hypotensive activities of Empagliflozin.Approved
EnalaprilThe metabolism of Enalapril can be increased when combined with Primidone.Approved, Vet Approved
EnalaprilatPrimidone may increase the hypotensive activities of Enalaprilat.Approved
EnasidenibThe metabolism of Enasidenib can be increased when combined with Primidone.Approved
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Primidone.Approved, Investigational, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Primidone.Approved, Investigational
EnzalutamideThe serum concentration of Enzalutamide can be decreased when it is combined with Primidone.Approved
EpanololThe serum concentration of Epanolol can be decreased when it is combined with Primidone.Experimental
EperisoneThe metabolism of Eperisone can be increased when combined with Primidone.Approved, Investigational
EpinastineThe metabolism of Epinastine can be increased when combined with Primidone.Approved, Investigational
EplerenoneThe metabolism of Eplerenone can be increased when combined with Primidone.Approved
EpoprostenolThe metabolism of Epoprostenol can be increased when combined with Primidone.Approved
EprosartanPrimidone may increase the hypotensive activities of Eprosartan.Approved
EquileninThe serum concentration of Equilenin can be decreased when it is combined with Primidone.Experimental
EquilinThe serum concentration of Equilin can be decreased when it is combined with Primidone.Approved
ErgocalciferolThe metabolism of Ergocalciferol can be increased when combined with Primidone.Approved, Nutraceutical
Ergoloid mesylateThe metabolism of Ergoloid mesylate can be increased when combined with Primidone.Approved
ErgonovineThe metabolism of Ergonovine can be increased when combined with Primidone.Approved
ErgotamineThe metabolism of Ergotamine can be increased when combined with Primidone.Approved
ErlotinibThe serum concentration of Erlotinib can be decreased when it is combined with Primidone.Approved, Investigational
ErythromycinThe metabolism of Erythromycin can be increased when combined with Primidone.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be increased when combined with Primidone.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Eslicarbazepine acetate can be decreased when it is combined with Primidone.Approved
EsmirtazapineThe metabolism of Esmirtazapine can be increased when combined with Primidone.Investigational
EsmololPrimidone may increase the hypotensive activities of Esmolol.Approved
EsomeprazoleThe metabolism of Esomeprazole can be increased when combined with Primidone.Approved, Investigational
EstazolamThe metabolism of Estazolam can be increased when combined with Primidone.Approved, Illicit
EstradiolThe metabolism of Estradiol can be increased when combined with Primidone.Approved, Investigational, Vet Approved
Estradiol valerate/DienogestThe metabolism of Estradiol valerate/Dienogest can be increased when combined with Primidone.Approved, Investigational
EstramustineThe metabolism of Estramustine can be increased when combined with Primidone.Approved
Estrogens, esterifiedThe therapeutic efficacy of Estrogens, esterified can be decreased when used in combination with Primidone.Approved
EstroneThe metabolism of Estrone can be increased when combined with Primidone.Approved
Estrone sulfateThe metabolism of Estrone sulfate can be increased when combined with Primidone.Approved
EszopicloneThe metabolism of Eszopiclone can be increased when combined with Primidone.Approved
Etacrynic acidPrimidone may increase the hypotensive activities of Etacrynic acid.Approved
EthanolPrimidone may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Primidone.Approved, Illicit, Withdrawn
Ethinyl EstradiolThe metabolism of Ethinyl Estradiol can be increased when combined with Primidone.Approved
EthosuximideThe metabolism of Ethosuximide can be increased when combined with Primidone.Approved
EthotoinThe risk or severity of adverse effects can be increased when Ethotoin is combined with Primidone.Approved
EthoxzolamideThe risk or severity of adverse effects can be increased when Ethoxzolamide is combined with Primidone.Withdrawn
Ethyl biscoumacetateThe metabolism of Ethyl biscoumacetate can be increased when combined with Primidone.Withdrawn
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Primidone.Withdrawn
Ethyl chlorideThe risk or severity of adverse effects can be increased when Ethyl chloride is combined with Primidone.Experimental, Investigational
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Primidone.Approved, Illicit
EthylmorphineThe metabolism of Ethylmorphine can be increased when combined with Primidone.Approved, Illicit
Ethynodiol diacetateThe therapeutic efficacy of Ethynodiol diacetate can be decreased when used in combination with Primidone.Approved
EtidocaineThe risk or severity of adverse effects can be increased when Etidocaine is combined with Primidone.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Primidone.Investigational, Withdrawn
EtizolamThe metabolism of Etizolam can be increased when combined with Primidone.Approved
EtodolacThe metabolism of Etodolac can be increased when combined with Primidone.Approved, Investigational, Vet Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Primidone.Approved
EtonogestrelThe therapeutic efficacy of Etonogestrel can be decreased when used in combination with Primidone.Approved, Investigational
EtoperidoneThe risk or severity of adverse effects can be increased when Primidone is combined with Etoperidone.Withdrawn
EtoposideThe serum concentration of Etoposide can be decreased when it is combined with Primidone.Approved
EtoricoxibThe metabolism of Etoricoxib can be increased when combined with Primidone.Approved, Investigational
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Primidone.Illicit, Vet Approved
EtravirineThe serum concentration of Etravirine can be decreased when it is combined with Primidone.Approved
EverolimusThe serum concentration of Everolimus can be decreased when it is combined with Primidone.Approved
ExemestaneThe serum concentration of Exemestane can be decreased when it is combined with Primidone.Approved, Investigational
EzogabineThe risk or severity of adverse effects can be increased when Primidone is combined with Ezogabine.Approved
FamciclovirThe metabolism of Famciclovir can be increased when combined with Primidone.Approved
FelbamateThe serum concentration of the active metabolites of Primidone can be increased when Primidone is used in combination with Felbamate.Approved
FelodipineThe metabolism of Felodipine can be increased when combined with Primidone.Approved, Investigational
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Primidone.Approved, Illicit, Withdrawn
FendilineThe metabolism of Fendiline can be increased when combined with Primidone.Withdrawn
FenofibrateThe metabolism of Fenofibrate can be increased when combined with Primidone.Approved
FenoldopamPrimidone may increase the hypotensive activities of Fenoldopam.Approved
FentanylThe serum concentration of Fentanyl can be decreased when it is combined with Primidone.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe metabolism of Fesoterodine can be increased when combined with Primidone.Approved
FexofenadineThe risk or severity of adverse effects can be increased when Primidone is combined with Fexofenadine.Approved
FimasartanPrimidone may increase the hypotensive activities of Fimasartan.Approved, Investigational
FinasterideThe metabolism of Finasteride can be increased when combined with Primidone.Approved
FingolimodThe metabolism of Fingolimod can be increased when combined with Primidone.Approved, Investigational
FlibanserinThe serum concentration of Flibanserin can be decreased when it is combined with Primidone.Approved
FluanisoneThe risk or severity of adverse effects can be increased when Fluanisone is combined with Primidone.Experimental
fluasteroneThe serum concentration of fluasterone can be decreased when it is combined with Primidone.Investigational
FluconazoleThe metabolism of Primidone can be decreased when combined with Fluconazole.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Primidone.Approved, Illicit
FludrocortisoneThe serum concentration of Fludrocortisone can be decreased when it is combined with Primidone.Approved
FluindioneThe metabolism of Fluindione can be increased when combined with Primidone.Investigational
FlumethasoneThe serum concentration of Flumethasone can be decreased when it is combined with Primidone.Approved, Vet Approved
FlunarizineThe metabolism of Flunarizine can be increased when combined with Primidone.Approved
FlunisolideThe metabolism of Flunisolide can be increased when combined with Primidone.Approved, Investigational
FlunitrazepamThe metabolism of Flunitrazepam can be increased when combined with Primidone.Approved, Illicit
Fluocinolone AcetonideThe serum concentration of Fluocinolone Acetonide can be decreased when it is combined with Primidone.Approved, Investigational, Vet Approved
FluocinonideThe serum concentration of Fluocinonide can be decreased when it is combined with Primidone.Approved, Investigational
FluocortoloneThe serum concentration of Fluocortolone can be decreased when it is combined with Primidone.Approved, Withdrawn
FluorometholoneThe metabolism of Fluorometholone can be increased when combined with Primidone.Approved
FluorouracilThe metabolism of Fluorouracil can be increased when combined with Primidone.Approved
FluoxetineThe metabolism of Fluoxetine can be increased when combined with Primidone.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Primidone.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Primidone.Approved
FluprednideneThe serum concentration of Fluprednidene can be decreased when it is combined with Primidone.Approved, Withdrawn
FluprednisoloneThe serum concentration of Fluprednisolone can be decreased when it is combined with Primidone.Approved
FlurandrenolideThe serum concentration of Flurandrenolide can be decreased when it is combined with Primidone.Approved
FlurazepamThe metabolism of Flurazepam can be increased when combined with Primidone.Approved, Illicit
FlurbiprofenThe metabolism of Flurbiprofen can be increased when combined with Primidone.Approved, Investigational
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Primidone.Approved, Investigational
FlutamideThe metabolism of Flutamide can be increased when combined with Primidone.Approved
Fluticasone furoateThe metabolism of Fluticasone furoate can be increased when combined with Primidone.Approved
Fluticasone propionateThe metabolism of Fluticasone propionate can be increased when combined with Primidone.Approved
FluvastatinThe metabolism of Fluvastatin can be increased when combined with Primidone.Approved
FluvoxamineThe metabolism of Primidone can be decreased when combined with Fluvoxamine.Approved, Investigational
Folic AcidThe serum concentration of Primidone can be decreased when it is combined with Folic Acid.Approved, Nutraceutical, Vet Approved
FormestaneThe serum concentration of Formestane can be decreased when it is combined with Primidone.Approved, Investigational, Withdrawn
FormoterolThe metabolism of Formoterol can be increased when combined with Primidone.Approved, Investigational
FosamprenavirThe metabolism of Fosamprenavir can be increased when combined with Primidone.Approved
FosinoprilPrimidone may increase the hypotensive activities of Fosinopril.Approved
FosphenytoinThe metabolism of Primidone can be increased when combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Primidone.Approved, Illicit, Investigational
FulvestrantThe metabolism of Fulvestrant can be increased when combined with Primidone.Approved, Investigational
FurosemidePrimidone may increase the hypotensive activities of Furosemide.Approved, Vet Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Primidone.Approved, Investigational
Gabapentin EnacarbilThe risk or severity of adverse effects can be increased when Primidone is combined with Gabapentin Enacarbil.Approved
GalantamineThe metabolism of Galantamine can be increased when combined with Primidone.Approved
GallopamilThe metabolism of Gallopamil can be increased when combined with Primidone.Investigational
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Primidone.Approved, Illicit, Investigational
GavestinelThe metabolism of Gavestinel can be increased when combined with Primidone.Investigational
GefitinibThe serum concentration of Gefitinib can be decreased when it is combined with Primidone.Approved, Investigational
GemfibrozilThe metabolism of Gemfibrozil can be increased when combined with Primidone.Approved
GepironeThe risk or severity of adverse effects can be increased when Gepirone is combined with Primidone.Investigational
GestodeneThe therapeutic efficacy of Gestodene can be decreased when used in combination with Primidone.Approved, Investigational
GliclazideThe metabolism of Gliclazide can be increased when combined with Primidone.Approved
GlimepirideThe metabolism of Glimepiride can be increased when combined with Primidone.Approved
GlipizideThe metabolism of Glipizide can be increased when combined with Primidone.Approved
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Primidone.Approved, Illicit
GlyburideThe metabolism of Glyburide can be increased when combined with Primidone.Approved
GranisetronThe metabolism of Granisetron can be increased when combined with Primidone.Approved, Investigational
GrazoprevirThe metabolism of Grazoprevir can be increased when combined with Primidone.Approved
GrepafloxacinThe metabolism of Grepafloxacin can be increased when combined with Primidone.Investigational, Withdrawn
GriseofulvinThe serum concentration of Griseofulvin can be decreased when it is combined with Primidone.Approved, Vet Approved
GuanfacineThe serum concentration of Guanfacine can be decreased when it is combined with Primidone.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Primidone.Approved, Illicit, Withdrawn
HalcinonideThe serum concentration of Halcinonide can be decreased when it is combined with Primidone.Approved, Investigational, Withdrawn
HalofantrineThe metabolism of Halofantrine can be increased when combined with Primidone.Approved
HaloperidolThe metabolism of Haloperidol can be increased when combined with Primidone.Approved
HalothaneThe metabolism of Halothane can be increased when combined with Primidone.Approved, Vet Approved
HE3286The serum concentration of HE3286 can be decreased when it is combined with Primidone.Investigational
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Primidone.Approved, Illicit, Investigational
HexestrolThe therapeutic efficacy of Hexestrol can be decreased when used in combination with Primidone.Withdrawn
HexobarbitalThe risk or severity of adverse effects can be increased when Primidone is combined with Hexobarbital.Approved
HistamineThe metabolism of Histamine can be increased when combined with Primidone.Approved, Investigational
HydralazinePrimidone may increase the hypotensive activities of Hydralazine.Approved
HydrochlorothiazidePrimidone may increase the orthostatic hypotensive activities of Hydrochlorothiazide.Approved, Vet Approved
HydrocodonePrimidone may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be decreased when it is combined with Primidone.Approved, Vet Approved
HydroflumethiazidePrimidone may increase the orthostatic hypotensive activities of Hydroflumethiazide.Approved, Investigational
HydromorphoneThe metabolism of Hydromorphone can be increased when combined with Primidone.Approved, Illicit
Hydroxyprogesterone caproateThe metabolism of Hydroxyprogesterone caproate can be increased when combined with Primidone.Approved
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Primidone.Approved
IbrutinibThe serum concentration of Ibrutinib can be decreased when it is combined with Primidone.Approved
IbuprofenThe metabolism of Ibuprofen can be increased when combined with Primidone.Approved
IcotinibThe metabolism of Icotinib can be increased when combined with Primidone.Approved, Investigational
IdarubicinThe metabolism of Idarubicin can be increased when combined with Primidone.Approved
IdelalisibThe serum concentration of Idelalisib can be decreased when it is combined with Primidone.Approved
IfosfamideThe serum concentration of the active metabolites of Ifosfamide can be increased when Ifosfamide is used in combination with Primidone.Approved
IloperidoneThe metabolism of Iloperidone can be increased when combined with Primidone.Approved
IloprostPrimidone may increase the hypotensive activities of Iloprost.Approved, Investigational
ImatinibThe serum concentration of Imatinib can be decreased when it is combined with Primidone.Approved
ImidafenacinThe metabolism of Imidafenacin can be increased when combined with Primidone.Approved, Investigational
ImidaprilPrimidone may increase the hypotensive activities of Imidapril.Investigational
ImipramineThe metabolism of Imipramine can be increased when combined with Primidone.Approved
ImiquimodThe metabolism of Imiquimod can be increased when combined with Primidone.Approved, Investigational
IndacaterolThe metabolism of Indacaterol can be increased when combined with Primidone.Approved
IndalpineThe risk or severity of adverse effects can be increased when Primidone is combined with Indalpine.Investigational, Withdrawn
IndapamideThe metabolism of Indapamide can be increased when combined with Primidone.Approved
IndenololThe serum concentration of Indenolol can be decreased when it is combined with Primidone.Withdrawn
IndinavirThe metabolism of Indinavir can be increased when combined with Primidone.Approved
IndiplonThe risk or severity of adverse effects can be increased when Indiplon is combined with Primidone.Investigational
indisulamThe metabolism of indisulam can be increased when combined with Primidone.Investigational
IndomethacinThe metabolism of Indomethacin can be increased when combined with Primidone.Approved, Investigational
IndoraminPrimidone may increase the hypotensive activities of Indoramin.Withdrawn
Ipratropium bromideThe metabolism of Ipratropium bromide can be increased when combined with Primidone.Approved
IprindoleThe metabolism of Iprindole can be increased when combined with Primidone.Experimental
IrbesartanThe metabolism of Irbesartan can be increased when combined with Primidone.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be decreased when it is combined with Primidone.Approved, Investigational
IsavuconazoniumThe serum concentration of the active metabolites of Isavuconazonium can be reduced when Isavuconazonium is used in combination with Primidone resulting in a loss in efficacy.Approved, Investigational
IsocarboxazidPrimidone may increase the hypotensive activities of Isocarboxazid.Approved
IsofluraneThe metabolism of Isoflurane can be increased when combined with Primidone.Approved, Vet Approved
IsoniazidThe metabolism of Primidone can be decreased when combined with Isoniazid.Approved
Isosorbide DinitrateThe metabolism of Isosorbide Dinitrate can be increased when combined with Primidone.Approved
Isosorbide MononitrateThe metabolism of Isosorbide Mononitrate can be increased when combined with Primidone.Approved
IsoxsuprinePrimidone may increase the hypotensive activities of Isoxsuprine.Approved, Withdrawn
IsradipineThe metabolism of Isradipine can be increased when combined with Primidone.Approved
IstaroximeThe serum concentration of Istaroxime can be decreased when it is combined with Primidone.Investigational
ItraconazoleThe serum concentration of Itraconazole can be decreased when it is combined with Primidone.Approved, Investigational
IvabradineThe serum concentration of Ivabradine can be decreased when it is combined with Primidone.Approved
IvacaftorThe serum concentration of Ivacaftor can be decreased when it is combined with Primidone.Approved
IvermectinThe metabolism of Ivermectin can be increased when combined with Primidone.Approved, Vet Approved
IxabepiloneThe serum concentration of Ixabepilone can be decreased when it is combined with Primidone.Approved, Investigational
IxazomibThe serum concentration of Ixazomib can be decreased when it is combined with Primidone.Approved
KetamineThe metabolism of Ketamine can be increased when combined with Primidone.Approved, Vet Approved
KetazolamThe metabolism of Ketazolam can be increased when combined with Primidone.Approved
KetobemidoneThe metabolism of Ketobemidone can be increased when combined with Primidone.Approved, Investigational
KetoconazoleThe metabolism of Ketoconazole can be increased when combined with Primidone.Approved, Investigational
KetoprofenThe metabolism of Ketoprofen can be increased when combined with Primidone.Approved, Vet Approved
LabetalolPrimidone may increase the hypotensive activities of Labetalol.Approved
LacidipineThe metabolism of Lacidipine can be increased when combined with Primidone.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be decreased when it is combined with Primidone.Approved, Investigational
LandiololThe serum concentration of Landiolol can be decreased when it is combined with Primidone.Investigational
LansoprazoleThe metabolism of Lansoprazole can be increased when combined with Primidone.Approved, Investigational
LapatinibThe serum concentration of Lapatinib can be decreased when it is combined with Primidone.Approved, Investigational
LaquinimodThe metabolism of Laquinimod can be increased when combined with Primidone.Investigational
LeflunomideThe metabolism of Leflunomide can be increased when combined with Primidone.Approved, Investigational
LenvatinibThe metabolism of Lenvatinib can be increased when combined with Primidone.Approved
LercanidipineThe metabolism of Lercanidipine can be increased when combined with Primidone.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be increased when combined with Primidone.Approved
LetrozoleThe metabolism of Letrozole can be increased when combined with Primidone.Approved, Investigational
LeucovorinThe serum concentration of Primidone can be decreased when it is combined with Leucovorin.Approved
LevetiracetamThe risk or severity of adverse effects can be increased when Primidone is combined with Levetiracetam.Approved, Investigational
LevobunololPrimidone may increase the hypotensive activities of Levobunolol.Approved
LevobupivacaineThe metabolism of Levobupivacaine can be increased when combined with Primidone.Approved, Investigational
LevocabastineThe risk or severity of adverse effects can be increased when Primidone is combined with Levocabastine.Approved
LevocetirizineThe metabolism of Levocetirizine can be increased when combined with Primidone.Approved
LevodopaThe risk or severity of adverse effects can be increased when Primidone is combined with Levodopa.Approved
LevoleucovorinThe serum concentration of Primidone can be decreased when it is combined with Levoleucovorin.Approved
Levomefolic acidThe serum concentration of the active metabolites of Primidone can be reduced when Primidone is used in combination with Levomefolic acid resulting in a loss in efficacy.Approved
Levomethadyl AcetateThe metabolism of Levomethadyl Acetate can be increased when combined with Primidone.Approved, Investigational
LevomilnacipranThe metabolism of Levomilnacipran can be increased when combined with Primidone.Approved
LevonorgestrelThe therapeutic efficacy of Levonorgestrel can be decreased when used in combination with Primidone.Approved, Investigational
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Primidone.Approved
LevosimendanPrimidone may increase the hypotensive activities of Levosimendan.Approved, Investigational
LevothyroxineThe metabolism of Levothyroxine can be increased when combined with Primidone.Approved
LicofeloneThe metabolism of Licofelone can be increased when combined with Primidone.Investigational
LidocaineThe metabolism of Lidocaine can be increased when combined with Primidone.Approved, Vet Approved
LidoflazineThe metabolism of Lidoflazine can be increased when combined with Primidone.Experimental
LinagliptinThe serum concentration of Linagliptin can be decreased when it is combined with Primidone.Approved
LisinoprilPrimidone may increase the hypotensive activities of Lisinopril.Approved, Investigational
LisurideThe metabolism of Lisuride can be increased when combined with Primidone.Approved, Investigational
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Primidone.Approved
LobeglitazoneThe metabolism of Primidone can be decreased when combined with Lobeglitazone.Approved, Investigational
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Primidone.Illicit
LofepramineThe metabolism of Lofepramine can be increased when combined with Primidone.Experimental
LofexidinePrimidone may increase the hypotensive activities of Lofexidine.Approved, Investigational
LomitapideThe metabolism of Lomitapide can be increased when combined with Primidone.Approved
LoperamideThe metabolism of Loperamide can be increased when combined with Primidone.Approved
LopinavirThe metabolism of Lopinavir can be increased when combined with Primidone.Approved
LoprazolamThe risk or severity of adverse effects can be increased when Loprazolam is combined with Primidone.Experimental
LoratadineThe metabolism of Loratadine can be increased when combined with Primidone.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Primidone.Approved
LorcaserinThe metabolism of Lorcaserin can be increased when combined with Primidone.Approved
LormetazepamThe risk or severity of adverse effects can be increased when Lormetazepam is combined with Primidone.Approved
LornoxicamThe metabolism of Lornoxicam can be increased when combined with Primidone.Approved, Investigational
LosartanThe metabolism of Losartan can be increased when combined with Primidone.Approved
LoteprednolThe serum concentration of Loteprednol can be decreased when it is combined with Primidone.Approved
LovastatinThe metabolism of Lovastatin can be increased when combined with Primidone.Approved, Investigational
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Primidone.Approved
LuliconazoleThe serum concentration of Primidone can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Primidone can be decreased when it is combined with Lumacaftor.Approved
LumefantrineThe serum concentration of Lumefantrine can be decreased when it is combined with Primidone.Approved
LumiracoxibThe metabolism of Lumiracoxib can be increased when combined with Primidone.Approved, Investigational
LurasidoneThe serum concentration of Lurasidone can be decreased when it is combined with Primidone.Approved
LynestrenolThe therapeutic efficacy of Lynestrenol can be decreased when used in combination with Primidone.Investigational
MacitentanThe serum concentration of Macitentan can be decreased when it is combined with Primidone.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Primidone.Approved, Vet Approved
MalathionThe metabolism of Malathion can be increased when combined with Primidone.Approved, Investigational
ManidipineThe metabolism of Manidipine can be increased when combined with Primidone.Approved, Investigational
MannitolPrimidone may increase the hypotensive activities of Mannitol.Approved, Investigational
MaprotilineThe risk or severity of adverse effects can be increased when Primidone is combined with Maprotiline.Approved
MaravirocThe serum concentration of Maraviroc can be decreased when it is combined with Primidone.Approved, Investigational
ME-609The serum concentration of ME-609 can be decreased when it is combined with Primidone.Investigational
MebendazoleThe metabolism of Mebendazole can be increased when combined with Primidone.Approved, Vet Approved
MebicarThe risk or severity of adverse effects can be increased when Mebicar is combined with Primidone.Experimental
MecamylaminePrimidone may increase the hypotensive activities of Mecamylamine.Approved
MeclizineThe risk or severity of adverse effects can be increased when Meclizine is combined with Primidone.Approved
MedazepamThe risk or severity of adverse effects can be increased when Medazepam is combined with Primidone.Experimental
MedetomidineThe risk or severity of adverse effects can be increased when Medetomidine is combined with Primidone.Vet Approved
Medroxyprogesterone acetateThe therapeutic efficacy of Medroxyprogesterone acetate can be decreased when used in combination with Primidone.Approved, Investigational
MedrysoneThe serum concentration of Medrysone can be decreased when it is combined with Primidone.Approved
Mefenamic acidThe metabolism of Mefenamic acid can be increased when combined with Primidone.Approved
MefloquineThe therapeutic efficacy of Primidone can be decreased when used in combination with Mefloquine.Approved
MelatoninThe metabolism of Melatonin can be increased when combined with Primidone.Approved, Nutraceutical, Vet Approved
MelengestrolThe serum concentration of Melengestrol can be decreased when it is combined with Primidone.Vet Approved
MeloxicamThe metabolism of Meloxicam can be increased when combined with Primidone.Approved, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Melperone is combined with Primidone.Approved, Investigational
MephenytoinThe metabolism of Mephenytoin can be increased when combined with Primidone.Investigational, Withdrawn
MepindololThe serum concentration of Mepindolol can be decreased when it is combined with Primidone.Experimental
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Primidone.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Primidone.Approved, Illicit
MeptazinolThe risk or severity of adverse effects can be increased when Meptazinol is combined with Primidone.Experimental
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Primidone.Approved, Investigational
MestranolThe metabolism of Mestranol can be increased when combined with Primidone.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Metaxalone is combined with Primidone.Approved
MethadoneThe serum concentration of Methadone can be decreased when it is combined with Primidone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Primidone.Approved, Illicit
MethallenestrilThe therapeutic efficacy of Methallenestril can be decreased when used in combination with Primidone.Experimental
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Primidone.Withdrawn
MethaqualoneThe metabolism of Methaqualone can be increased when combined with Primidone.Illicit, Withdrawn
MethazolamideThe risk or severity of adverse effects can be increased when Methazolamide is combined with Primidone.Approved
MethocarbamolThe risk or severity of adverse effects can be increased when Methocarbamol is combined with Primidone.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Primidone is combined with Methohexital.Approved
MethotrimeprazinePrimidone may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxsalenThe metabolism of Methoxsalen can be increased when combined with Primidone.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be increased when combined with Primidone.Approved, Investigational, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Primidone is combined with Methsuximide.Approved
MethyclothiazidePrimidone may increase the orthostatic hypotensive activities of Methyclothiazide.Approved
MethyldopaPrimidone may increase the hypotensive activities of Methyldopa.Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Methylecgonine is combined with Primidone.Experimental
MethylphenidateThe serum concentration of the active metabolites of Primidone can be increased when Primidone is used in combination with Methylphenidate.Approved, Investigational
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Primidone is combined with Methylphenobarbital.Approved
MethylprednisoloneThe serum concentration of Methylprednisolone can be decreased when it is combined with Primidone.Approved, Vet Approved
MethyltestosteroneThe metabolism of Methyltestosterone can be increased when combined with Primidone.Approved
MetipranololPrimidone may increase the hypotensive activities of Metipranolol.Approved
MetolazonePrimidone may increase the orthostatic hypotensive activities of Metolazone.Approved
MetoprololPrimidone may increase the hypotensive activities of Metoprolol.Approved, Investigational
MetronidazoleThe serum concentration of Metronidazole can be decreased when it is combined with Primidone.Approved
MetyrosinePrimidone may increase the sedative activities of Metyrosine.Approved
MexiletineThe metabolism of Mexiletine can be increased when combined with Primidone.Approved
MianserinThe therapeutic efficacy of Primidone can be decreased when used in combination with Mianserin.Approved, Investigational
MibefradilThe metabolism of Mibefradil can be increased when combined with Primidone.Investigational, Withdrawn
MiconazoleThe metabolism of Miconazole can be increased when combined with Primidone.Approved, Investigational, Vet Approved
MidazolamThe metabolism of Midazolam can be increased when combined with Primidone.Approved, Illicit
MidostaurinThe metabolism of Midostaurin can be increased when combined with Primidone.Approved
MifepristoneThe serum concentration of Mifepristone can be decreased when it is combined with Primidone.Approved, Investigational
MilnacipranThe risk or severity of adverse effects can be increased when Primidone is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Primidone.Approved, Investigational
MinoxidilPrimidone may increase the hypotensive activities of Minoxidil.Approved
MirabegronThe metabolism of Mirabegron can be increased when combined with Primidone.Approved
MirtazapinePrimidone may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MoclobemideThe metabolism of Moclobemide can be increased when combined with Primidone.Approved
ModafinilThe metabolism of Modafinil can be increased when combined with Primidone.Approved, Investigational
MoexiprilPrimidone may increase the hypotensive activities of Moexipril.Approved
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Primidone.Approved
MometasoneThe serum concentration of Mometasone can be decreased when it is combined with Primidone.Approved, Vet Approved
MontelukastThe metabolism of Montelukast can be increased when combined with Primidone.Approved
MorphineThe metabolism of Morphine can be increased when combined with Primidone.Approved, Investigational
MoxonidinePrimidone may increase the hypotensive activities of Moxonidine.Approved, Investigational
muraglitazarThe metabolism of muraglitazar can be increased when combined with Primidone.Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be increased when combined with Primidone.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Primidone.Approved, Investigational
NadololPrimidone may increase the hypotensive activities of Nadolol.Approved
NaftopidilThe metabolism of Naftopidil can be increased when combined with Primidone.Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Primidone.Approved
NaloxegolThe serum concentration of Naloxegol can be decreased when it is combined with Primidone.Approved
NaloxoneThe metabolism of Naloxone can be increased when combined with Primidone.Approved, Vet Approved
NaproxenThe metabolism of Naproxen can be increased when combined with Primidone.Approved, Vet Approved
NateglinideThe metabolism of Nateglinide can be increased when combined with Primidone.Approved, Investigational
NCX 1022The serum concentration of NCX 1022 can be decreased when it is combined with Primidone.Investigational
NebivololPrimidone may increase the hypotensive activities of Nebivolol.Approved, Investigational
NefazodoneThe metabolism of Nefazodone can be increased when combined with Primidone.Approved, Withdrawn
NelfinavirThe metabolism of Nelfinavir can be increased when combined with Primidone.Approved
NeratinibThe metabolism of Neratinib can be increased when combined with Primidone.Approved, Investigational
NesiritidePrimidone may increase the hypotensive activities of Nesiritide.Approved, Investigational
NetupitantThe serum concentration of Netupitant can be decreased when it is combined with Primidone.Approved
NevirapineThe metabolism of Nevirapine can be increased when combined with Primidone.Approved
NicardipineThe metabolism of Nicardipine can be increased when combined with Primidone.Approved
NiclosamideThe metabolism of Niclosamide can be increased when combined with Primidone.Approved, Investigational, Vet Approved
NicotineThe metabolism of Nicotine can be increased when combined with Primidone.Approved
NifedipineThe serum concentration of Nifedipine can be decreased when it is combined with Primidone.Approved
NiguldipineThe metabolism of Niguldipine can be increased when combined with Primidone.Experimental
NilotinibThe serum concentration of Nilotinib can be decreased when it is combined with Primidone.Approved, Investigational
NiludipineThe metabolism of Niludipine can be increased when combined with Primidone.Experimental
NilvadipineThe metabolism of Nilvadipine can be increased when combined with Primidone.Approved, Investigational
NimesulideThe metabolism of Nimesulide can be increased when combined with Primidone.Approved, Investigational, Withdrawn
NimodipineThe serum concentration of Nimodipine can be decreased when it is combined with Primidone.Approved
NisoldipineThe serum concentration of Nisoldipine can be decreased when it is combined with Primidone.Approved
NitrazepamThe metabolism of Nitrazepam can be increased when combined with Primidone.Approved
NitrendipineThe metabolism of Nitrendipine can be increased when combined with Primidone.Approved, Investigational
Nitric OxidePrimidone may increase the hypotensive activities of Nitric Oxide.Approved
NitroglycerinPrimidone may increase the hypotensive activities of Nitroglycerin.Approved, Investigational
NitroprussidePrimidone may increase the hypotensive activities of Nitroprusside.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Primidone.Approved, Vet Approved
NorelgestrominThe therapeutic efficacy of Norelgestromin can be decreased when used in combination with Primidone.Approved
NorethisteroneThe metabolism of Norethisterone can be increased when combined with Primidone.Approved
NorfluraneThe risk or severity of adverse effects can be increased when Norflurane is combined with Primidone.Investigational
NorgestimateThe therapeutic efficacy of Norgestimate can be decreased when used in combination with Primidone.Approved
NorgestrelThe therapeutic efficacy of Norgestrel can be decreased when used in combination with Primidone.Approved
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Primidone.Approved, Illicit
NortriptylineThe metabolism of Nortriptyline can be increased when combined with Primidone.Approved
ObinutuzumabPrimidone may increase the hypotensive activities of Obinutuzumab.Approved
OdanacatibThe metabolism of Odanacatib can be increased when combined with Primidone.Investigational
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Primidone.Approved, Investigational
OlaparibThe serum concentration of Olaparib can be decreased when it is combined with Primidone.Approved
Oleoyl-estroneThe serum concentration of Oleoyl-estrone can be decreased when it is combined with Primidone.Investigational
OlmesartanPrimidone may increase the hypotensive activities of Olmesartan.Approved, Investigational
OlodaterolThe metabolism of Olodaterol can be increased when combined with Primidone.Approved
OlopatadineThe metabolism of Olopatadine can be increased when combined with Primidone.Approved
OmbitasvirThe metabolism of Ombitasvir can be increased when combined with Primidone.Approved
OmeprazoleThe metabolism of Omeprazole can be increased when combined with Primidone.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be increased when combined with Primidone.Approved
OpipramolThe metabolism of Opipramol can be increased when combined with Primidone.Investigational
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Primidone.Approved, Illicit
OrlistatThe serum concentration of Primidone can be decreased when it is combined with Orlistat.Approved, Investigational
OrphenadrinePrimidone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Primidone.Investigational
OsimertinibThe serum concentration of Osimertinib can be decreased when it is combined with Primidone.Approved
OspemifeneThe metabolism of Ospemifene can be increased when combined with Primidone.Approved
OtiloniumThe metabolism of Otilonium can be increased when combined with Primidone.Experimental, Investigational
OxaprozinThe metabolism of Oxaprozin can be increased when combined with Primidone.Approved
OxazepamThe metabolism of Oxazepam can be increased when combined with Primidone.Approved
OxethazaineThe risk or severity of adverse effects can be increased when Oxethazaine is combined with Primidone.Approved, Investigational
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Primidone.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Primidone.Approved
OxybutyninThe metabolism of Oxybutynin can be increased when combined with Primidone.Approved, Investigational
OxycodoneThe metabolism of Oxycodone can be increased when combined with Primidone.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be increased when combined with Primidone.Approved, Investigational, Vet Approved
PaclitaxelThe metabolism of Paclitaxel can be increased when combined with Primidone.Approved, Vet Approved
PalbociclibThe serum concentration of Palbociclib can be decreased when it is combined with Primidone.Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Primidone.Approved
PalonosetronThe metabolism of Palonosetron can be increased when combined with Primidone.Approved, Investigational
PanobinostatThe serum concentration of Panobinostat can be decreased when it is combined with Primidone.Approved, Investigational
PantoprazoleThe metabolism of Pantoprazole can be increased when combined with Primidone.Approved
PapaverinePrimidone may increase the hypotensive activities of Papaverine.Approved
ParaldehydePrimidone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
ParamethadioneThe metabolism of Paramethadione can be increased when combined with Primidone.Approved
ParamethasoneThe metabolism of Paramethasone can be increased when combined with Primidone.Approved
ParecoxibThe metabolism of Parecoxib can be increased when combined with Primidone.Approved
ParicalcitolThe metabolism of Paricalcitol can be increased when combined with Primidone.Approved, Investigational
ParitaprevirThe metabolism of Paritaprevir can be increased when combined with Primidone.Approved
ParoxetineThe risk or severity of adverse effects can be increased when Primidone is combined with Paroxetine.Approved, Investigational
PazopanibThe serum concentration of Pazopanib can be decreased when it is combined with Primidone.Approved
PenbutololPrimidone may increase the hypotensive activities of Penbutolol.Approved, Investigational
PenfluridolThe risk or severity of adverse effects can be increased when Penfluridol is combined with Primidone.Experimental
PentamidineThe metabolism of Pentamidine can be increased when combined with Primidone.Approved
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Primidone.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Primidone is combined with Pentobarbital.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Primidone.Approved
PerazineThe risk or severity of adverse effects can be increased when Perazine is combined with Primidone.Investigational
PergolideThe metabolism of Pergolide can be increased when combined with Primidone.Approved, Investigational, Vet Approved, Withdrawn
PerhexilineThe metabolism of Perhexiline can be increased when combined with Primidone.Approved, Investigational
PerindoprilPrimidone may increase the hypotensive activities of Perindopril.Approved
PermethrinThe metabolism of Permethrin can be increased when combined with Primidone.Approved, Investigational
PerospironeThe metabolism of Perospirone can be increased when combined with Primidone.Approved
PerphenazineThe metabolism of Perphenazine can be increased when combined with Primidone.Approved
PethidinePrimidone may increase the central nervous system depressant (CNS depressant) activities of Pethidine.Approved
PhenacetinThe metabolism of Phenacetin can be increased when combined with Primidone.Withdrawn
PhenazocineThe risk or severity of adverse effects can be increased when Phenazocine is combined with Primidone.Experimental
PhenelzinePrimidone may increase the hypotensive activities of Phenelzine.Approved
PhenibutThe risk or severity of adverse effects can be increased when Phenibut is combined with Primidone.Experimental
PhenindioneThe metabolism of Phenindione can be increased when combined with Primidone.Approved, Investigational
PhenobarbitalThe risk or severity of adverse effects can be increased when Primidone is combined with Phenobarbital.Approved
PhenoperidineThe risk or severity of adverse effects can be increased when Phenoperidine is combined with Primidone.Experimental
PhenoxybenzamineThe metabolism of Phenoxybenzamine can be increased when combined with Primidone.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Phenoxyethanol is combined with Primidone.Approved
PhenprocoumonThe metabolism of Phenprocoumon can be increased when combined with Primidone.Approved, Investigational
PhentolaminePrimidone may increase the hypotensive activities of Phentolamine.Approved
PhenylbutazoneThe metabolism of Phenylbutazone can be increased when combined with Primidone.Approved, Vet Approved
PhenytoinThe metabolism of Primidone can be increased when combined with Phenytoin.Approved, Vet Approved
PilocarpineThe metabolism of Pilocarpine can be increased when combined with Primidone.Approved
PimecrolimusThe metabolism of Pimecrolimus can be increased when combined with Primidone.Approved, Investigational
PimozideThe metabolism of Pimozide can be increased when combined with Primidone.Approved
PinacidilThe metabolism of Pinacidil can be increased when combined with Primidone.Withdrawn
PinaveriumThe metabolism of Pinaverium can be increased when combined with Primidone.Approved
PindololPrimidone may increase the hypotensive activities of Pindolol.Approved
PioglitazoneThe metabolism of Pioglitazone can be increased when combined with Primidone.Approved, Investigational
PipamperoneThe risk or severity of adverse effects can be increased when Pipamperone is combined with Primidone.Approved, Investigational
PipotiazineThe metabolism of Pipotiazine can be increased when combined with Primidone.Approved, Investigational
PiritramideThe risk or severity of adverse effects can be increased when Piritramide is combined with Primidone.Investigational
PiroxicamThe metabolism of Piroxicam can be increased when combined with Primidone.Approved, Investigational
PitavastatinThe metabolism of Pitavastatin can be increased when combined with Primidone.Approved
PizotifenThe risk or severity of adverse effects can be increased when Primidone is combined with Pizotifen.Approved
Platelet Activating FactorThe serum concentration of Platelet Activating Factor can be decreased when it is combined with Primidone.Experimental
PodofiloxThe metabolism of Podofilox can be increased when combined with Primidone.Approved
PolythiazidePrimidone may increase the orthostatic hypotensive activities of Polythiazide.Approved
PomalidomideThe metabolism of Pomalidomide can be increased when combined with Primidone.Approved
PonatinibThe serum concentration of Ponatinib can be decreased when it is combined with Primidone.Approved
PosaconazoleThe metabolism of Posaconazole can be increased when combined with Primidone.Approved, Investigational, Vet Approved
PractololThe serum concentration of Practolol can be decreased when it is combined with Primidone.Approved
PramipexolePrimidone may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Pramocaine is combined with Primidone.Approved
PrasteroneThe metabolism of Prasterone can be increased when combined with Primidone.Approved, Nutraceutical
Prasterone sulfateThe serum concentration of Prasterone sulfate can be decreased when it is combined with Primidone.Investigational
PrasugrelThe metabolism of Prasugrel can be increased when combined with Primidone.Approved
PravastatinThe metabolism of Pravastatin can be increased when combined with Primidone.Approved
PrazepamThe metabolism of Prazepam can be increased when combined with Primidone.Approved, Illicit
PraziquantelThe serum concentration of Praziquantel can be decreased when it is combined with Primidone.Approved, Vet Approved
PrazosinPrimidone may increase the hypotensive activities of Prazosin.Approved
PrednicarbateThe serum concentration of Prednicarbate can be decreased when it is combined with Primidone.Approved
PrednisoloneThe serum concentration of Prednisolone can be decreased when it is combined with Primidone.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be decreased when it is combined with Primidone.Approved, Vet Approved
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Primidone.Approved, Illicit, Investigational
PregnenoloneThe serum concentration of Pregnenolone can be decreased when it is combined with Primidone.Experimental, Investigational
PrenylamineThe metabolism of Prenylamine can be increased when combined with Primidone.Withdrawn
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Primidone.Approved
PrimaquineThe metabolism of Primaquine can be increased when combined with Primidone.Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Primidone.Approved, Investigational, Vet Approved
ProchlorperazineThe metabolism of Prochlorperazine can be increased when combined with Primidone.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be increased when combined with Primidone.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be increased when combined with Primidone.Approved
PromazineThe metabolism of Promazine can be increased when combined with Primidone.Approved, Vet Approved
PromethazineThe metabolism of Promethazine can be increased when combined with Primidone.Approved
PropacetamolThe metabolism of Propacetamol can be increased when combined with Primidone.Approved, Investigational
PropafenoneThe serum concentration of Propafenone can be decreased when it is combined with Primidone.Approved
PropanididThe risk or severity of adverse effects can be increased when Propanidid is combined with Primidone.Experimental
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Primidone.Approved, Vet Approved
PropofolThe metabolism of Propofol can be increased when combined with Primidone.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Propoxycaine is combined with Primidone.Approved
Propoxyphene napsylateThe metabolism of Propoxyphene napsylate can be increased when combined with Primidone.Approved
PropranololThe metabolism of Propranolol can be increased when combined with Primidone.Approved, Investigational
ProtriptylineThe metabolism of Protriptyline can be increased when combined with Primidone.Approved
ProxibarbalThe risk or severity of adverse effects can be increased when Proxibarbal is combined with Primidone.Experimental
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Primidone.Investigational
PyrazinamideThe metabolism of Pyrazinamide can be increased when combined with Primidone.Approved
PyridoxineThe metabolism of Primidone can be increased when combined with Pyridoxine.Approved, Nutraceutical, Vet Approved
QuazepamThe metabolism of Quazepam can be increased when combined with Primidone.Approved, Illicit
QuetiapineThe serum concentration of Quetiapine can be decreased when it is combined with Primidone.Approved
QuinacrineThe metabolism of Quinacrine can be increased when combined with Primidone.Approved, Investigational
QuinaprilPrimidone may increase the hypotensive activities of Quinapril.Approved, Investigational
QuinethazonePrimidone may increase the orthostatic hypotensive activities of Quinethazone.Approved
QuinidineThe serum concentration of Quinidine can be decreased when it is combined with Primidone.Approved
QuinineThe metabolism of Quinine can be increased when combined with Primidone.Approved
QuinisocaineThe risk or severity of adverse effects can be increased when Quinisocaine is combined with Primidone.Experimental
RabeprazoleThe metabolism of Rabeprazole can be increased when combined with Primidone.Approved, Investigational
RacloprideThe risk or severity of adverse effects can be increased when Raclopride is combined with Primidone.Investigational
RaloxifeneThe metabolism of Raloxifene can be increased when combined with Primidone.Approved, Investigational
RamelteonThe metabolism of Ramelteon can be increased when combined with Primidone.Approved, Investigational
RamiprilPrimidone may increase the hypotensive activities of Ramipril.Approved
RanolazineThe serum concentration of Ranolazine can be decreased when it is combined with Primidone.Approved, Investigational
RasagilinePrimidone may increase the hypotensive activities of Rasagiline.Approved
ReboxetineThe metabolism of Reboxetine can be increased when combined with Primidone.Approved, Investigational
RegorafenibThe serum concentration of Regorafenib can be decreased when it is combined with Primidone.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Primidone.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Primidone.Approved, Withdrawn
RepaglinideThe metabolism of Repaglinide can be increased when combined with Primidone.Approved, Investigational
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Primidone.Approved, Investigational
RetapamulinThe metabolism of Retapamulin can be increased when combined with Primidone.Approved
RibociclibThe serum concentration of Ribociclib can be decreased when it is combined with Primidone.Approved
RifabutinThe metabolism of Rifabutin can be increased when combined with Primidone.Approved
RifampicinThe metabolism of Rifampicin can be increased when combined with Primidone.Approved
RifapentineThe metabolism of Primidone can be increased when combined with Rifapentine.Approved
RifaximinThe metabolism of Primidone can be increased when combined with Rifaximin.Approved, Investigational
RilpivirineThe serum concentration of Rilpivirine can be decreased when it is combined with Primidone.Approved
RimexoloneThe serum concentration of Rimexolone can be decreased when it is combined with Primidone.Approved
RimonabantThe metabolism of Rimonabant can be increased when combined with Primidone.Approved, Investigational
RiociguatThe metabolism of Riociguat can be increased when combined with Primidone.Approved
RisedronateThe metabolism of Risedronate can be increased when combined with Primidone.Approved, Investigational
RisperidoneThe metabolism of Risperidone can be increased when combined with Primidone.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Ritanserin is combined with Primidone.Investigational
RitonavirThe metabolism of Ritonavir can be increased when combined with Primidone.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be decreased when it is combined with Primidone.Approved
RofecoxibThe metabolism of Rofecoxib can be increased when combined with Primidone.Investigational, Withdrawn
RoflumilastThe serum concentration of Roflumilast can be decreased when it is combined with Primidone.Approved
RolapitantThe serum concentration of Rolapitant can be decreased when it is combined with Primidone.Approved
RomidepsinThe serum concentration of Romidepsin can be decreased when it is combined with Primidone.Approved, Investigational
RomifidineThe risk or severity of adverse effects can be increased when Romifidine is combined with Primidone.Vet Approved
RopinirolePrimidone may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be increased when combined with Primidone.Approved
RosiglitazoneThe metabolism of Rosiglitazone can be increased when combined with Primidone.Approved, Investigational
RosuvastatinThe metabolism of Rosuvastatin can be increased when combined with Primidone.Approved
RotigotinePrimidone may increase the sedative activities of Rotigotine.Approved
RoxithromycinThe metabolism of Roxithromycin can be increased when combined with Primidone.Approved, Investigational, Withdrawn
RucaparibThe metabolism of Rucaparib can be increased when combined with Primidone.Approved, Investigational
RufinamideThe serum concentration of Rufinamide can be decreased when it is combined with Primidone.Approved
RupatadineThe metabolism of Rupatadine can be increased when combined with Primidone.Approved
RuxolitinibThe metabolism of Ruxolitinib can be increased when combined with Primidone.Approved
SacubitrilPrimidone may increase the hypotensive activities of Sacubitril.Approved
SafinamideThe metabolism of Safinamide can be increased when combined with Primidone.Approved
Salicylic acidThe metabolism of Salicylic acid can be increased when combined with Primidone.Approved, Vet Approved
SalmeterolThe metabolism of Salmeterol can be increased when combined with Primidone.Approved
SaquinavirThe metabolism of Saquinavir can be increased when combined with Primidone.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Primidone.Approved
ScopolamineThe risk or severity of adverse effects can be increased when Scopolamine is combined with Primidone.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Primidone is combined with Secobarbital.Approved, Vet Approved
SelegilineThe metabolism of Selegiline can be increased when combined with Primidone.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be increased when combined with Primidone.Approved
SepranoloneThe risk or severity of adverse effects can be increased when Sepranolone is combined with Primidone.Investigational
SeratrodastThe metabolism of Seratrodast can be increased when combined with Primidone.Approved
SertindoleThe metabolism of Sertindole can be increased when combined with Primidone.Approved, Investigational, Withdrawn
SertralineThe metabolism of Sertraline can be increased when combined with Primidone.Approved
SevofluraneThe metabolism of Sevoflurane can be increased when combined with Primidone.Approved, Vet Approved
SibutramineThe metabolism of Sibutramine can be increased when combined with Primidone.Approved, Illicit, Investigational, Withdrawn
SildenafilThe metabolism of Sildenafil can be increased when combined with Primidone.Approved, Investigational
SilodosinThe metabolism of Silodosin can be increased when combined with Primidone.Approved
SimeprevirThe serum concentration of Simeprevir can be decreased when it is combined with Primidone.Approved
SimvastatinThe metabolism of Simvastatin can be increased when combined with Primidone.Approved
SirolimusThe metabolism of Sirolimus can be increased when combined with Primidone.Approved, Investigational
SitagliptinThe metabolism of Sitagliptin can be increased when combined with Primidone.Approved, Investigational
SitaxentanThe metabolism of Sitaxentan can be increased when combined with Primidone.Approved, Investigational, Withdrawn
Sodium NitritePrimidone may increase the hypotensive activities of Sodium Nitrite.Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Primidone.Approved
SolifenacinThe metabolism of Solifenacin can be increased when combined with Primidone.Approved
SomatostatinThe risk or severity of adverse effects can be increased when Somatostatin is combined with Primidone.Approved, Investigational
SonidegibThe serum concentration of Sonidegib can be decreased when it is combined with Primidone.Approved, Investigational
SorafenibThe serum concentration of Sorafenib can be decreased when it is combined with Primidone.Approved, Investigational
SotalolPrimidone may increase the hypotensive activities of Sotalol.Approved
SpiramycinThe metabolism of Spiramycin can be increased when combined with Primidone.Approved
SpironolactonePrimidone may increase the hypotensive activities of Spironolactone.Approved
StiripentolThe metabolism of Primidone can be decreased when combined with Stiripentol.Approved
StreptokinasePrimidone may increase the hypotensive activities of Streptokinase.Approved, Investigational
SufentanilThe metabolism of Sufentanil can be increased when combined with Primidone.Approved, Investigational
SulfadiazineThe metabolism of Sulfadiazine can be increased when combined with Primidone.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be increased when combined with Primidone.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be increased when combined with Primidone.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be increased when combined with Primidone.Approved
SulfisoxazoleThe metabolism of Sulfisoxazole can be increased when combined with Primidone.Approved, Vet Approved
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Primidone.Approved, Investigational
SultoprideThe risk or severity of adverse effects can be increased when Sultopride is combined with Primidone.Experimental
SunitinibThe serum concentration of Sunitinib can be decreased when it is combined with Primidone.Approved, Investigational
SuprofenThe metabolism of Suprofen can be increased when combined with Primidone.Approved, Withdrawn
SuvorexantPrimidone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
Synthetic Conjugated Estrogens, AThe metabolism of Synthetic Conjugated Estrogens, A can be increased when combined with Primidone.Approved
Synthetic Conjugated Estrogens, BThe metabolism of Synthetic Conjugated Estrogens, B can be increased when combined with Primidone.Approved
TacrolimusThe metabolism of Tacrolimus can be increased when combined with Primidone.Approved, Investigational
TadalafilThe serum concentration of Tadalafil can be decreased when it is combined with Primidone.Approved, Investigational
TalinololThe serum concentration of Talinolol can be decreased when it is combined with Primidone.Investigational
TamoxifenThe metabolism of Tamoxifen can be increased when combined with Primidone.Approved
TamsulosinThe metabolism of Tamsulosin can be increased when combined with Primidone.Approved, Investigational
TandospironeThe risk or severity of adverse effects can be increased when Tandospirone is combined with Primidone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Primidone.Approved
TasimelteonThe serum concentration of Tasimelteon can be decreased when it is combined with Primidone.Approved
TasosartanThe metabolism of Tasosartan can be increased when combined with Primidone.Approved
Taurochenodeoxycholic acidThe metabolism of Taurochenodeoxycholic acid can be increased when combined with Primidone.Experimental
TazaroteneThe metabolism of Tazarotene can be increased when combined with Primidone.Approved, Investigational
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Primidone.Approved, Withdrawn
TelithromycinThe metabolism of Telithromycin can be increased when combined with Primidone.Approved
TelmisartanPrimidone may increase the hypotensive activities of Telmisartan.Approved, Investigational
TemazepamThe metabolism of Temazepam can be increased when combined with Primidone.Approved
TemsirolimusThe metabolism of Temsirolimus can be increased when combined with Primidone.Approved
TeniposideThe serum concentration of Teniposide can be decreased when it is combined with Primidone.Approved
TenoxicamThe metabolism of Tenoxicam can be increased when combined with Primidone.Approved
TerazosinPrimidone may increase the hypotensive activities of Terazosin.Approved
TerbinafineThe metabolism of Terbinafine can be increased when combined with Primidone.Approved, Investigational, Vet Approved
TerfenadineThe metabolism of Terfenadine can be increased when combined with Primidone.Withdrawn
TerodilineThe metabolism of Terodiline can be increased when combined with Primidone.Experimental
TertatololThe serum concentration of Tertatolol can be decreased when it is combined with Primidone.Experimental
TesmilifeneThe metabolism of Tesmilifene can be increased when combined with Primidone.Investigational
TestosteroneThe metabolism of Testosterone can be increased when combined with Primidone.Approved, Investigational
TetrabenazineThe risk or severity of adverse effects can be increased when Primidone is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Tetracaine is combined with Primidone.Approved, Vet Approved
TetracosactideTetracosactide may increase the hepatotoxic activities of Primidone.Approved
TetracyclineThe metabolism of Tetracycline can be increased when combined with Primidone.Approved, Vet Approved
TetrahydropalmatineThe risk or severity of adverse effects can be increased when Tetrahydropalmatine is combined with Primidone.Investigational
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Primidone.Investigational
ThalidomidePrimidone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
TheophyllineThe metabolism of Theophylline can be increased when combined with Primidone.Approved
ThiamylalThe risk or severity of adverse effects can be increased when Primidone is combined with Thiamylal.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Primidone is combined with Thiopental.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Primidone.Approved, Withdrawn
ThiotepaThe metabolism of Thiotepa can be increased when combined with Primidone.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Primidone.Approved
TiagabineThe metabolism of Tiagabine can be increased when combined with Primidone.Approved
TianeptineThe metabolism of Tianeptine can be increased when combined with Primidone.Approved, Investigational
TiaprideThe risk or severity of adverse effects can be increased when Tiapride is combined with Primidone.Approved, Investigational
TicagrelorThe serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Primidone resulting in a loss in efficacy.Approved
TiclopidineThe metabolism of Ticlopidine can be increased when combined with Primidone.Approved
TiletamineThe risk or severity of adverse effects can be increased when Tiletamine is combined with Primidone.Vet Approved
TilidineThe risk or severity of adverse effects can be increased when Tilidine is combined with Primidone.Experimental
TimololPrimidone may increase the hypotensive activities of Timolol.Approved
TinidazoleThe metabolism of Tinidazole can be increased when combined with Primidone.Approved, Investigational
TioclomarolThe metabolism of Tioclomarol can be increased when combined with Primidone.Experimental
TiotropiumThe metabolism of Tiotropium can be increased when combined with Primidone.Approved
TipranavirThe metabolism of Tipranavir can be increased when combined with Primidone.Approved, Investigational
TixocortolThe serum concentration of Tixocortol can be decreased when it is combined with Primidone.Approved
TizanidineThe risk or severity of adverse effects can be increased when Tizanidine is combined with Primidone.Approved
TofacitinibThe serum concentration of Tofacitinib can be decreased when it is combined with Primidone.Approved, Investigational
TolazolinePrimidone may increase the hypotensive activities of Tolazoline.Approved, Vet Approved
TolbutamideThe metabolism of Tolbutamide can be increased when combined with Primidone.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Primidone.Approved, Withdrawn
Tolfenamic AcidThe metabolism of Tolfenamic Acid can be increased when combined with Primidone.Approved
TolterodineThe metabolism of Tolterodine can be increased when combined with Primidone.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be decreased when it is combined with Primidone.Approved
TopiramateThe risk or severity of adverse effects can be increased when Topiramate is combined with Primidone.Approved
TorasemideThe metabolism of Torasemide can be increased when combined with Primidone.Approved
ToremifeneThe serum concentration of Toremifene can be decreased when it is combined with Primidone.Approved, Investigational
TrabectedinThe serum concentration of Trabectedin can be decreased when it is combined with Primidone.Approved, Investigational
TramadolThe metabolism of Tramadol can be increased when combined with Primidone.Approved, Investigational
TrandolaprilPrimidone may increase the hypotensive activities of Trandolapril.Approved
TranilastThe metabolism of Tranilast can be increased when combined with Primidone.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Primidone.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Primidone.Approved
Trastuzumab emtansineThe metabolism of Trastuzumab emtansine can be increased when combined with Primidone.Approved
TrazodoneThe metabolism of Trazodone can be increased when combined with Primidone.Approved, Investigational
TreprostinilThe serum concentration of Treprostinil can be decreased when it is combined with Primidone.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be increased when combined with Primidone.Approved, Investigational, Nutraceutical
TriamcinoloneThe metabolism of Triamcinolone can be increased when combined with Primidone.Approved, Vet Approved
TriamterenePrimidone may increase the hypotensive activities of Triamterene.Approved
TriazolamThe metabolism of Triazolam can be increased when combined with Primidone.Approved
Tricaine methanesulfonateThe risk or severity of adverse effects can be increased when Tricaine methanesulfonate is combined with Primidone.Vet Approved
TrichlormethiazidePrimidone may increase the orthostatic hypotensive activities of Trichlormethiazide.Approved, Vet Approved
TrichloroethyleneThe risk or severity of adverse effects can be increased when Trichloroethylene is combined with Primidone.Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Primidone.Approved
TrifluperidolThe risk or severity of adverse effects can be increased when Trifluperidol is combined with Primidone.Experimental
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Primidone.Approved, Vet Approved
TrimethadioneThe metabolism of Trimethadione can be increased when combined with Primidone.Approved
TrimethoprimThe metabolism of Trimethoprim can be increased when combined with Primidone.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be increased when combined with Primidone.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Triprolidine is combined with Primidone.Approved
TroglitazoneThe metabolism of Troglitazone can be increased when combined with Primidone.Investigational, Withdrawn
TroleandomycinThe metabolism of Troleandomycin can be increased when combined with Primidone.Approved
UdenafilThe metabolism of Udenafil can be increased when combined with Primidone.Approved, Investigational
UlipristalThe serum concentration of Ulipristal can be decreased when it is combined with Primidone.Approved
UlobetasolThe serum concentration of Ulobetasol can be decreased when it is combined with Primidone.Approved
ValbenazineThe metabolism of Valbenazine can be increased when combined with Primidone.Approved, Investigational
ValdecoxibThe metabolism of Valdecoxib can be increased when combined with Primidone.Investigational, Withdrawn
Valproic AcidThe metabolism of Primidone can be decreased when combined with Valproic Acid.Approved, Investigational
ValsartanThe metabolism of Valsartan can be increased when combined with Primidone.Approved, Investigational
VandetanibThe serum concentration of Vandetanib can be decreased when it is combined with Primidone.Approved
VanoxerineThe metabolism of Vanoxerine can be increased when combined with Primidone.Investigational
VardenafilThe metabolism of Vardenafil can be increased when combined with Primidone.Approved
VelpatasvirThe metabolism of Velpatasvir can be increased when combined with Primidone.Approved
VenetoclaxThe metabolism of Venetoclax can be increased when combined with Primidone.Approved
VenlafaxineThe metabolism of Venlafaxine can be increased when combined with Primidone.Approved
VeraliprideThe risk or severity of adverse effects can be increased when Veralipride is combined with Primidone.Experimental
VerapamilThe metabolism of Verapamil can be increased when combined with Primidone.Approved
VicrivirocThe metabolism of Vicriviroc can be increased when combined with Primidone.Investigational
VigabatrinThe risk or severity of adverse effects can be increased when Primidone is combined with Vigabatrin.Approved
VilanterolThe metabolism of Vilanterol can be increased when combined with Primidone.Approved
VilazodoneThe serum concentration of Vilazodone can be decreased when it is combined with Primidone.Approved
VinblastineThe metabolism of Vinblastine can be increased when combined with Primidone.Approved
VincristineThe serum concentration of Vincristine can be decreased when it is combined with Primidone.Approved, Investigational
VincristineThe metabolism of Vincristine can be increased when combined with Primidone.Approved, Investigational
VindesineThe metabolism of Vindesine can be increased when combined with Primidone.Approved, Investigational
VinorelbineThe metabolism of Vinorelbine can be increased when combined with Primidone.Approved, Investigational
VinpocetineThe metabolism of Vinpocetine can be increased when combined with Primidone.Investigational
Vinyl etherThe risk or severity of adverse effects can be increased when Vinyl ether is combined with Primidone.Experimental
VismodegibThe metabolism of Vismodegib can be increased when combined with Primidone.Approved
VorapaxarThe serum concentration of Vorapaxar can be decreased when it is combined with Primidone.Approved
VoriconazoleThe serum concentration of Voriconazole can be decreased when it is combined with Primidone.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be decreased when it is combined with Primidone.Approved
VoxilaprevirThe metabolism of Voxilaprevir can be increased when combined with Primidone.Approved
WarfarinThe metabolism of Warfarin can be increased when combined with Primidone.Approved
XenonThe risk or severity of adverse effects can be increased when Xenon is combined with Primidone.Experimental
XimelagatranThe metabolism of Ximelagatran can be increased when combined with Primidone.Approved, Investigational, Withdrawn
XylazineThe risk or severity of adverse effects can be increased when Xylazine is combined with Primidone.Vet Approved
XylometazolineThe metabolism of Xylometazoline can be increased when combined with Primidone.Approved
YohimbineThe metabolism of Yohimbine can be increased when combined with Primidone.Approved, Vet Approved
ZafirlukastThe metabolism of Zafirlukast can be increased when combined with Primidone.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be increased when combined with Primidone.Approved, Investigational
ZaleplonThe serum concentration of Zaleplon can be decreased when it is combined with Primidone.Approved, Illicit, Investigational
ZaltoprofenThe metabolism of Zaltoprofen can be increased when combined with Primidone.Approved, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Primidone is combined with Ziconotide.Approved
ZidovudineThe metabolism of Zidovudine can be increased when combined with Primidone.Approved
ZileutonThe metabolism of Zileuton can be increased when combined with Primidone.Approved, Investigational, Withdrawn
ZimelidineThe risk or severity of adverse effects can be increased when Primidone is combined with Zimelidine.Withdrawn
ZiprasidoneThe metabolism of Ziprasidone can be increased when combined with Primidone.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Zolazepam is combined with Primidone.Vet Approved
ZolpidemPrimidone may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZomepiracThe metabolism of Zomepirac can be increased when combined with Primidone.Withdrawn
ZonisamideThe metabolism of Zonisamide can be increased when combined with Primidone.Approved, Investigational
ZopicloneThe metabolism of Zopiclone can be increased when combined with Primidone.Approved
ZotepineThe risk or severity of adverse effects can be increased when Zotepine is combined with Primidone.Approved, Investigational
ZucapsaicinThe metabolism of Primidone can be decreased when combined with Zucapsaicin.Approved
ZuclopenthixolThe serum concentration of Zuclopenthixol can be decreased when it is combined with Primidone.Approved, Investigational
Food Interactions
  • Avoid alcohol.
  • Avoid high doses of caffeine.
  • Take with food to reduce gastric irritation.

References

General References
  1. Murphy K, Delanty N: Primary Generalized Epilepsies. Curr Treat Options Neurol. 2000 Nov;2(6):527-542. [PubMed:11096777]
  2. Kagitani-Shimono K, Imai K, Okamoto N, Ono J, Okada S: Unverricht-Lundborg disease with cystatin B gene abnormalities. Pediatr Neurol. 2002 Jan;26(1):55-60. [PubMed:11814737]
  3. Brown GM, Stone GH, Rathbone MP: Primidone and rapid cycling affective disorders. Lancet. 1993 Oct 9;342(8876):925. [PubMed:8105181]
  4. Schaffer LC, Schaffer CB, Caretto J: The use of primidone in the treatment of refractory bipolar disorder. Ann Clin Psychiatry. 1999 Jun;11(2):61-6. [PubMed:10440522]
  5. Young MC, Hughes IA: Loss of therapeutic control in congenital adrenal hyperplasia due to interaction between dexamethasone and primidone. Acta Paediatr Scand. 1991 Jan;80(1):120-4. [PubMed:2028784]
External Links
Human Metabolome Database
HMDB14932
KEGG Drug
D00474
KEGG Compound
C07371
PubChem Compound
4909
PubChem Substance
46507775
ChemSpider
4740
ChEBI
8412
ChEMBL
CHEMBL856
Therapeutic Targets Database
DAP000678
PharmGKB
PA451105
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Primidone
ATC Codes
N03AA03 — PrimidoneN05CB01 — Combinations of barbiturates
AHFS Codes
  • 28:12.04 — Barbiturates
FDA label
Download (108 KB)
MSDS
Download (65.5 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedBasic ScienceTherapeutic Equivalency1
1CompletedTreatmentHealthy Volunteers1
2WithdrawnTreatmentClopidogrel Resistance / Secondary Stroke Prevention1

Pharmacoeconomics

Manufacturers
  • Xcel pharmaceuticals
  • Valeant pharmaceuticals international
  • Amneal pharmaceutical
  • Dr reddys laboratories ltd
  • Impax laboratories inc
  • Lannett co inc
  • Mutual pharmaceutical co inc
  • Vintage pharmaceuticals inc
  • Watson laboratories inc
  • West ward pharmaceutical corp
Packagers
Dosage forms
FormRouteStrength
TabletOral125 mg
TabletOral250 mg/1
TabletOral250 mg
TabletOral50 mg/1
Prices
Unit descriptionCostUnit
Primidone powder10.56USD g
Mysoline 250 mg tablet6.52USD tablet
Mysoline 50 mg tablet1.26USD tablet
Primidone 250 mg tablet1.02USD tablet
Primidone 50 mg tablet0.51USD tablet
Apo-Primidone 250 mg Tablet0.09USD tablet
Apo-Primidone 125 mg Tablet0.06USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)281.5 °CPhysProp
water solubility500 mg/L (at 22 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP0.91HANSCH,C ET AL. (1995)
logS-2.64ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility1.04 mg/mLALOGPS
logP0.62ALOGPS
logP1.12ChemAxon
logS-2.3ALOGPS
pKa (Strongest Acidic)11.5ChemAxon
pKa (Strongest Basic)-6.2ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area58.2 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity59.04 m3·mol-1ChemAxon
Polarizability22.44 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9907
Blood Brain Barrier+0.9642
Caco-2 permeable-0.5593
P-glycoprotein substrateSubstrate0.5222
P-glycoprotein inhibitor INon-inhibitor0.536
P-glycoprotein inhibitor IINon-inhibitor0.9048
Renal organic cation transporterNon-inhibitor0.8298
CYP450 2C9 substrateNon-substrate0.7961
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateNon-substrate0.6863
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.924
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8682
Ames testAMES toxic0.9107
CarcinogenicityNon-carcinogens0.7814
BiodegradationNot ready biodegradable0.982
Rat acute toxicity2.1941 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9912
hERG inhibition (predictor II)Non-inhibitor0.8735
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Download (9.01 KB)
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
GC-MS Spectrum - EI-BGC-MSsplash10-014i-8900000000-0e7a89b14902d3718a96
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-03di-0900000000-cd2ff1c9796dadddc1c4
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-03k9-0900000000-2791dd2c8b88ef3746e2
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-014i-0590000000-248d62cc8fce49dbc8ac
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-03xr-1910000000-defb3cb3827732984417
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-01ox-4900000000-2a6eec3c8ff19123ac27
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0006-9800000000-6cf73d06072a870130a9
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0006-9500000000-f9d1e48f1afbc27fce53
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0006-9400000000-ee42f86b57749afa5326
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-014i-0590000000-c6e3ad2d87e33ccd0249
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-03xr-1910000000-4f481052510ee71cb8ae
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-03dl-4900000000-b796d864e3b38d92a1d4
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0006-9700000000-c6a71612fcf884b362c6
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0006-9400000000-2509c88567fd37a64f08
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0006-9400000000-70b4eb639de5cd82206d
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-03k9-0900000000-32676f955580c7b188af
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0gb9-0790000000-85b9730b3c1a612616dd
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0uxr-1950000000-9a26803c7d536d7535be
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-1000-7940000000-13c974e8220bfde7b936
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-0aou-9400000000-e6ac3896e41d100eb94d
LC-MS/MS Spectrum - LC-ESI-QQ , positiveLC-MS/MSsplash10-052f-9000000000-bdd6d5c0f8bd8a00b144
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0006-8900000000-8251f44f80079a017e49
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0006-9500000000-eca07632eb70021d3678
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-03k9-0900000000-104ab34d91923122fa54
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-03k9-0900000000-523cfc5e1d739d54e0f5
MS/MS Spectrum - , positiveLC-MS/MSsplash10-03di-1910000000-bd08d6489b18d57466ef
MS/MS Spectrum - , positiveLC-MS/MSsplash10-03di-2910000000-b7efd09b00e06dbafb8a
MS/MS Spectrum - , positiveLC-MS/MSsplash10-015c-4900000000-628ede89a2ff3a714388
LC-MS/MS Spectrum - LC-ESI-QFT , positiveLC-MS/MSsplash10-03xu-2900000000-c1f7b0b63b199254dd07

Taxonomy

Description
This compound belongs to the class of organic compounds known as hydropyrimidines. These are compounds containing a hydrogenated pyrimidine ring (i.e. containing less than the maximum number of double bonds.).
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Diazines
Sub Class
Pyrimidines and pyrimidine derivatives
Direct Parent
Hydropyrimidines
Alternative Parents
Benzene and substituted derivatives / Cyclic carboximidic acids / Propargyl-type 1,3-dipolar organic compounds / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds / Hydrocarbon derivatives
Substituents
Benzenoid / 2,5-dihydropyrimidine / Hydropyrimidine / Monocyclic benzene moiety / Cyclic carboximidic acid / Azacycle / Organic 1,3-dipolar compound / Propargyl-type 1,3-dipolar organic compound / Organic nitrogen compound / Organic oxygen compound
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
pyrimidone (CHEBI:8412)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Potentiator
General Function
Inhibitory extracellular ligand-gated ion channel activity
Specific Function
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine...
Gene Name
GABRA1
Uniprot ID
P14867
Uniprot Name
Gamma-aminobutyric acid receptor subunit alpha-1
Molecular Weight
51801.395 Da
References
  1. Whiting PJ: The GABAA receptor gene family: new opportunities for drug development. Curr Opin Drug Discov Devel. 2003 Sep;6(5):648-57. [PubMed:14579514]
  2. Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. [PubMed:10209232]
  3. Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. [PubMed:11264449]
  4. Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. [PubMed:10487207]
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]
  6. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  7. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Potentiator
General Function
Inhibitory extracellular ligand-gated ion channel activity
Specific Function
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene Name
GABRA2
Uniprot ID
P47869
Uniprot Name
Gamma-aminobutyric acid receptor subunit alpha-2
Molecular Weight
51325.85 Da
References
  1. Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. [PubMed:11264449]
  2. Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. [PubMed:10209232]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Potentiator
General Function
Inhibitory extracellular ligand-gated ion channel activity
Specific Function
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene Name
GABRA3
Uniprot ID
P34903
Uniprot Name
Gamma-aminobutyric acid receptor subunit alpha-3
Molecular Weight
55164.055 Da
References
  1. Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. [PubMed:11264449]
  2. Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. [PubMed:10209232]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Potentiator
General Function
Inhibitory extracellular ligand-gated ion channel activity
Specific Function
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene Name
GABRA4
Uniprot ID
P48169
Uniprot Name
Gamma-aminobutyric acid receptor subunit alpha-4
Molecular Weight
61622.645 Da
References
  1. Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. [PubMed:10209232]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Potentiator
General Function
Transporter activity
Specific Function
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene Name
GABRA5
Uniprot ID
P31644
Uniprot Name
Gamma-aminobutyric acid receptor subunit alpha-5
Molecular Weight
52145.645 Da
References
  1. Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. [PubMed:11264449]
  2. Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. [PubMed:10209232]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Potentiator
General Function
Inhibitory extracellular ligand-gated ion channel activity
Specific Function
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Gene Name
GABRA6
Uniprot ID
Q16445
Uniprot Name
Gamma-aminobutyric acid receptor subunit alpha-6
Molecular Weight
51023.69 Da
References
  1. Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217. [PubMed:10209232]
  2. Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. [PubMed:11264449]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Ligand-gated ion channel activity
Specific Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeabl...
Gene Name
CHRNA4
Uniprot ID
P43681
Uniprot Name
Neuronal acetylcholine receptor subunit alpha-4
Molecular Weight
69956.47 Da
References
  1. Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. [PubMed:11264449]
  2. Arias HR, Bhumireddy P: Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors. Curr Protein Pept Sci. 2005 Oct;6(5):451-72. [PubMed:16248797]
  3. Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. [PubMed:10487207]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Toxic substance binding
Specific Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The cha...
Gene Name
CHRNA7
Uniprot ID
P36544
Uniprot Name
Neuronal acetylcholine receptor subunit alpha-7
Molecular Weight
56448.925 Da
References
  1. Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. [PubMed:11264449]
  2. Arias HR, Bhumireddy P: Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors. Curr Protein Pept Sci. 2005 Oct;6(5):451-72. [PubMed:16248797]
  3. Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. [PubMed:10487207]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Ionotropic glutamate receptor activity
Specific Function
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory ne...
Gene Name
GRIA2
Uniprot ID
P42262
Uniprot Name
Glutamate receptor 2
Molecular Weight
98820.32 Da
References
  1. Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. [PubMed:11264449]
  2. Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. [PubMed:10487207]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Antagonist
General Function
Kainate selective glutamate receptor activity
Specific Function
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a co...
Gene Name
GRIK2
Uniprot ID
Q13002
Uniprot Name
Glutamate receptor ionotropic, kainate 2
Molecular Weight
102582.475 Da
References
  1. Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51. [PubMed:11264449]
  2. Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303. [PubMed:10487207]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name
CYP2C19
Uniprot ID
P33261
Uniprot Name
Cytochrome P450 2C19
Molecular Weight
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
  3. The P450 Program [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2B6
Uniprot ID
P20813
Uniprot Name
Cytochrome P450 2B6
Molecular Weight
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C8
Uniprot ID
P10632
Uniprot Name
Cytochrome P450 2C8
Molecular Weight
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]

Drug created on June 13, 2005 07:24 / Updated on December 10, 2017 17:18