Upper Respiratory Tract Infections

Also known as: Upper Respiratory Tract Infection / Infections, Upper Respiratory Tract / Upper respiratory tract infections / Upper respiratory infection / Upper resp tract infection / Upper respiratory disease, acute / Infection upper respiratory / Upper respiratory infection NOS / URTI / URTI (upper respiratory tract infection) / URI / Upper respiratory tract infection NOS

DrugDrug NameDrug Description
DB00254DoxycyclineDoxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline [FDA label]. This drug is a second-generation tetracycline, exhibiting lesser toxicity than first-generation tetracyclines [A174034]. Doxycycline may be used to treat a wide range of bacterial infections, depending on the results of antibiotic susceptibility testing.
DB00199ErythromycinErythromycin is an antibiotic drug produced by a strain of Saccharopolyspora erythraea (formerly Streptomyces erythraeus) and belongs to the _macrolide_ group of antibiotics [FDA label]. It was originally discovered in 1952. Erythromycin is widely used for treating a variety of infections, including those caused by gram-positive bacteria, gram-negative bacteria and many other organisms [L5245], [FDA label].
DB01017MinocyclineA tetracycline analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant staphylococcus infections.
DrugDrug NameTargetType
DB00254Doxycycline16S rRNAtarget
DB00254DoxycyclineSolute carrier family 22 member 6transporter
DB00254DoxycyclineCytochrome P450 3A4enzyme
DB00254DoxycyclineATP-binding cassette sub-family B member 5transporter
DB00199Erythromycin23S rRNAtarget
DB00199ErythromycinCytochrome P450 3A4enzyme
DB00199ErythromycinCytochrome P450 3A7enzyme
DB00199ErythromycinMultidrug resistance protein 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1B1transporter
DB00199ErythromycinMotilin receptortarget
DB00199ErythromycinPotassium voltage-gated channel subfamily H member 2target
DB00199ErythromycinCytochrome P450 3A5enzyme
DB00199ErythromycinSolute carrier organic anion transporter family member 1B3transporter
DB00199ErythromycinBile salt export pumptransporter
DB00199ErythromycinBacterial 50S Ribosomal Subunittarget
DB00199ErythromycinCanalicular multispecific organic anion transporter 1transporter
DB00199ErythromycinSolute carrier organic anion transporter family member 1A2transporter
DB01017Minocycline30S ribosomal protein S4target
DB01017Minocycline30S ribosomal protein S9target
DB01017Minocycline16S rRNAtarget
DB01017MinocyclineInterleukin-1 betatarget
DB01017MinocyclineArachidonate 5-lipoxygenasetarget
DB01017MinocyclineMatrix metalloproteinase-9target
DB01017MinocyclineVascular endothelial growth factor Atarget
DB01017MinocyclineCaspase-1target
DB01017MinocyclineCaspase-3target
DB01017MinocyclineCytochrome ctarget
DB01017MinocyclineSolute carrier family 22 member 6transporter
DB01017MinocyclineSolute carrier family 22 member 8transporter
DB01017MinocyclineSolute carrier family 22 member 11transporter
DB01017MinocyclineSolute carrier family 22 member 7transporter
DrugDrug NamePhaseStatusCount
DB05181BTA7982Withdrawn1
DB12862Glucose Oxidase2Completed1
DB00316Acetaminophen3Completed1
DB00169Cholecalciferol3Completed1
DB00471Montelukast3Unknown Status1
DB00198Oseltamivir3Completed1
DB00198Oseltamivir3Terminated1
DB00558Zanamivir3Terminated1
DB04339Carbocisteine4Completed1
DB00514Dextromethorphan4Terminated1
DB00586Diclofenac4Withdrawn1
DB04743Nimesulide4Withdrawn1
DB00635Prednisone4Active Not Recruiting1
DB14240EchinaceaNot AvailableCompleted2
DB14239Echinacea purpureaNot AvailableCompleted1