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targets (143)
for drugs
Identification
Name Nicotinamide-Adenine-Dinucleotide
Accession Number DB01907 (DB03527, EXPT02287)
Type small molecule
Groups experimental
Description Not Available
Structure Thumb
Download: MOL | SDF | SMILES | InChI
Display: 2D Structure | 3D Structure
Synonyms Not Available
Salts Not Available
Brand names Not Available
Brand mixtures Not Available
Categories Not Available
CAS number 53-84-9
Weight Average: 663.4251
Monoisotopic: 663.109121631
Chemical Formula C21H27N7O14P2
InChI Key InChIKey=BAWFJGJZGIEFAR-DQQFMEOOSA-N
InChI
InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11+,13-,14+,15-,16+,20-,21+/m0/s1
Plain Text
IUPAC Name
1-[(2S,3S,4R,5S)-5-({[(S)-({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl phosphonato)]oxy}methyl)-3,4-dihydroxyoxolan-2-yl]-3-carbamoyl-1$l^{5}-pyridin-1-ylium
SMILES
NC(=O)C1=CC=C[N+](=C1)[C@H]1O[C@@H](CO[P@]([O-])(=O)O[P@@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@H](O)[C@@H]1O
Plain Text
Mass Spec Not Available
Taxonomy
Kingdom Not Available
Classes Not Available
Substructures Not Available
Pharmacology
Indication Not Available
Pharmacodynamics Not Available
Mechanism of action Not Available
Absorption Not Available
Volume of distribution Not Available
Protein binding Not Available
Metabolism Not Available
Route of elimination Not Available
Half life Not Available
Clearance Not Available
Toxicity Not Available
Affected organisms Not Available
Pathways Not Available
Pharmacoeconomics
Manufacturers Not Available
Packagers Not Available
Dosage forms Not Available
Prices Not Available
Patents Not Available
Properties
State solid
Experimental Properties Not Available
Predicted Properties
Property Value Source
water solubility 2.14e+00 g/l ALOGPS
logP -1.2 ALOGPS
logP -10 ChemAxon
logS -2.5 ALOGPS
pKa (strongest acidic) 1.86 ChemAxon
pKa (strongest basic) 5 ChemAxon
physiological charge -1 ChemAxon
hydrogen acceptor count 15 ChemAxon
hydrogen donor count 7 ChemAxon
polar surface area 321.09 ChemAxon
rotatable bond count 11 ChemAxon
refractivity 140.88 ChemAxon
polarizability 56.22 ChemAxon
References
Synthesis Reference Not Available
General Reference Not Available
External Links
Resource Link
KEGG Drug D00002 Link_out
KEGG Compound C00003 Link_out
ChEBI 15846 Link_out
ChEMBL 15846 Link_out
HET NAD Link_out
ATC Codes Not Available
AHFS Codes Not Available
PDB Entries
FDA label Not Available
MSDS Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available
Targets

1. dTDP-4-dehydrorhamnose reductase

Pharmacological action: unknown

dTDP-6-deoxy-L-mannose + NADP(+) = dTDP-4- dehydro-6-deoxy-L-mannose + NADPH

Organism class: bacterial
UniProt ID: P26392 Link_out
Gene: rfbD
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

2. UDP-glucose 4-epimerase

Pharmacological action: unknown

UDP-glucose = UDP-galactose

Organism class: bacterial
UniProt ID: P09147 Link_out
Gene: galE
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

3. GDP-mannose 6-dehydrogenase

Pharmacological action: unknown

Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics

Organism class: bacterial
UniProt ID: P11759 Link_out
Gene: algD
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

4. Dihydrodipicolinate reductase

Pharmacological action: unknown

2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) = 2,3-dihydrodipicolinate + NAD(P)H

Organism class: bacterial
UniProt ID: P72024 Link_out
Gene: dapB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

5. NH(3)-dependent NAD(+) synthetase

Pharmacological action: unknown

Catalyzes a key step in NAD biosynthesis, transforming deamido-NAD into NAD by a two-step reaction

Organism class: bacterial
UniProt ID: P08164 Link_out
Gene: nadE
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

6. Malate dehydrogenase

Pharmacological action: unknown

Catalyzes the reversible oxidation of malate to oxaloacetate

Organism class: bacterial
UniProt ID: Q9ZF99 Link_out
Gene: mdh
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

7. D-2-hydroxyisocaproate dehydrogenase

Pharmacological action: unknown

Catalyzes the NAD dependent reversible, stereospecific interconversion between 2-ketocarboxylic acids and D-2-hydroxy- carboxylic acids

Organism class: bacterial
UniProt ID: P17584 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

8. Histidinol dehydrogenase

Pharmacological action: unknown

Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

Organism class: bacterial
UniProt ID: P06988 Link_out
Gene: hisD
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

9. CDP-paratose 2-epimerase

Pharmacological action: unknown

Catalyzes the isomeration of CDP-paratose to CDP- tyvelose

Organism class: bacterial
UniProt ID: P14169 Link_out
Gene: rfbE
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

10. NADP-dependent malic enzyme, mitochondrial

Pharmacological action: unknown
Organism class: human
UniProt ID: Q16798 Link_out
Gene: ME3 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

11. Adenosylhomocysteinase

Pharmacological action: unknown

Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine

Organism class: human
UniProt ID: P23526 Link_out
Gene: AHCY Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

12. dTDP-glucose 4,6-dehydratase

Pharmacological action: unknown

dTDP-glucose = dTDP-4-dehydro-6-deoxy-D- glucose + H(2)O

Organism class: bacterial
UniProt ID: P26391 Link_out
Gene: rfbB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

13. 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase

Pharmacological action: unknown

Androstan-3-alpha,17-beta-diol + NAD(+) = 17- beta-hydroxyandrostan-3-one + NADH

Organism class: bacterial
UniProt ID: P69167 Link_out
Gene: fabG3
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

14. Gamma-aminobutyraldehyde dehydrogenase

Pharmacological action: unknown

Catalyzes the oxidation of 1-pyrroline, which is spontaneously formed from 4-aminobutanal, leading to 4- aminobutanoate (GABA). Can also oxidize n-alkyl medium-chain aldehydes, but with a lower catalytic efficiency

Organism class: bacterial
UniProt ID: P77674 Link_out
Gene: prr
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

15. D-lactate dehydrogenase

Pharmacological action: unknown

(R)-lactate + NAD(+) = pyruvate + NADH

Organism class: bacterial
UniProt ID: P30901 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

16. 3-dehydroquinate synthase

Pharmacological action: unknown

3-deoxy-arabino-heptulonate 7-phosphate = 3- dehydroquinate + phosphate

Organism class: bacterial
UniProt ID: Q6GGU4 Link_out
Gene: aroB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

17. AGR_L_3209p

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q7CRW4 Link_out
Gene: AGR_L_3209
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

18. Dihydrodipicolinate reductase

Pharmacological action: unknown

2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) = 2,3-dihydrodipicolinate + NAD(P)H

Organism class: bacterial
UniProt ID: P04036 Link_out
Gene: dapB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

19. Glutamate dehydrogenase 1, mitochondrial

Pharmacological action: unknown

May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate

Organism class: human
UniProt ID: P00367 Link_out
Gene: GLUD1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

20. Malate dehydrogenase

Pharmacological action: unknown

Catalyzes the reversible oxidation of malate to oxaloacetate

Organism class: bacterial
UniProt ID: P80039 Link_out
Gene: mdh
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

21. Retinal dehydrogenase 1

Pharmacological action: unknown

Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid

Organism class: human
UniProt ID: P00352 Link_out
Gene: ALDH1A1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

22. Alcohol dehydrogenase 4

Pharmacological action: unknown
Organism class: human
UniProt ID: P08319 Link_out
Gene: ADH4 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

23. Biliverdin reductase A

Pharmacological action: unknown

Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor

Organism class: human
UniProt ID: P53004 Link_out
Gene: BLVRA Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

24. Nicotinamide mononucleotide adenylyltransferase 3

Pharmacological action: unknown

ATP + nicotinamide ribonucleotide = diphosphate + NAD(+)

Organism class: human
UniProt ID: Q96T66 Link_out
Gene: NMNAT3 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

25. Levodione reductase

Pharmacological action: unknown

Catalyzes the regio- and stereoselective reversible NAD- dependent reduction of (6R)-2,2,6-trimethyl-1,4-cyclohexanedione (levodione) to (4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexanone (actinol)

Organism class: bacterial
UniProt ID: Q9LBG2 Link_out
Gene: lvr
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

26. Enoyl-[acyl-carrier-protein] reductase [NADH]

Pharmacological action: unknown

Acyl-[acyl-carrier-protein] + NAD(+) = trans- 2,3-dehydroacyl-[acyl-carrier-protein] + NADH

Organism class: bacterial
UniProt ID: O24990 Link_out
Gene: fabI
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

27. Adenosylhomocysteinase

Pharmacological action: unknown

Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine (By similarity)

Organism class: parasitic
UniProt ID: P50250 Link_out
Gene: PFE1050w
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

28. L-lactate dehydrogenase A chain

Pharmacological action: unknown
Organism class: human
UniProt ID: P00338 Link_out
Gene: LDHA Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

29. Nicotinamide mononucleotide adenylyltransferase 1

Pharmacological action: unknown

ATP + nicotinamide ribonucleotide = diphosphate + NAD(+)

Organism class: human
UniProt ID: Q9HAN9 Link_out
Gene: NMNAT1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

30. 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Pharmacological action: unknown

P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA

Organism class: bacterial
UniProt ID: P13702 Link_out
Gene: mvaA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

31. Dehydrogenase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q746L8 Link_out
Gene: TT_P0035
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

32. Glyceraldehyde-3-phosphate dehydrogenase

Pharmacological action: unknown

D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH

Organism class: bacterial
UniProt ID: P17721 Link_out
Gene: gap
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

33. TDP-glucose-4,6-dehydratase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9ZGH3 Link_out
Gene: desIV
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

34. Redox-sensing transcriptional repressor rex

Pharmacological action: unknown

Modulates transcription in response to changes in cellular NADH/NAD(+) redox state (By similarity)

Organism class: bacterial
UniProt ID: Q9X2V5 Link_out
Gene: rex
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

35. Glutamate dehydrogenase 2, mitochondrial

Pharmacological action: unknown

Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission

Organism class: human
UniProt ID: P49448 Link_out
Gene: GLUD2 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

36. 2,4-dienoyl-CoA reductase, mitochondrial

Pharmacological action: unknown

Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA

Organism class: human
UniProt ID: Q16698 Link_out
Gene: DECR1
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

37. Dihydrolipoyl dehydrogenase, mitochondrial

Pharmacological action: unknown

Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes

Organism class: human
UniProt ID: P09622 Link_out
Gene: DLD Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

38. L-aspartate dehydrogenase

Pharmacological action: unknown

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. Does not show aspartate oxidase activity. Is also able to catalyze the reverse reaction, i.e. the reductive amination of oxaloacetate

Organism class: bacterial
UniProt ID: Q9X1X6 Link_out
Gene: nadX
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

39. Glyceraldehyde 3-phosphate dehydrogenase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: P84125 Link_out
Gene: tthHB8IM
Protein Sequence: FASTA
SNPs: SNPJam Report Link_out

40. L-lactate dehydrogenase

Pharmacological action: unknown

(S)-lactate + NAD(+) = pyruvate + NADH

Organism class: bacterial
UniProt ID: P56511 Link_out
Gene: ldh
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

41. Malate dehydrogenase

Pharmacological action: unknown

Catalyzes the reversible oxidation of malate to oxaloacetate

Organism class: bacterial
UniProt ID: P10584 Link_out
Gene: mdh
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

42. Ferredoxin reductase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q52437 Link_out
Gene: bphA4
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

43. NADH peroxidase

Pharmacological action: unknown

Peroxidase whose active site is a redox-active cysteine- sulfenic acid

Organism class: bacterial
UniProt ID: P37062 Link_out
Gene: npr
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

44. L-lactate dehydrogenase

Pharmacological action: unknown

(S)-lactate + NAD(+) = pyruvate + NADH

Organism class: bacterial
UniProt ID: P00344 Link_out
Gene: ldh
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

45. Quinate/shikimate dehydrogenase

Pharmacological action: unknown

The physiological substrate is not known

Organism class: bacterial
UniProt ID: P0A6D5 Link_out
Gene: ydiB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

46. Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

Pharmacological action: unknown

May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility

Organism class: human
UniProt ID: O14556 Link_out
Gene: GAPDHS Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

47. Aldehyde dehydrogenase, dimeric NADP-preferring

Pharmacological action: unknown

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes

Organism class: human
UniProt ID: P30838 Link_out
Gene: ALDH3A1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

48. 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9ZFY9 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA

49. Hypothetical protein yhfP

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: O07615 Link_out
Gene: yhfP
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

50. L-2-hydroxyisocaproate dehydrogenase

Pharmacological action: unknown

Catalyzes the NADP dependent reversible and stereospecific interconversion between 2-ketocarboxylic acids and L-2-hydroxy-carboxylic acids. 2-ketoacids with medium chain length (five to six C-atoms) are the best substrates

Organism class: bacterial
UniProt ID: P14295 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA

51. ADP-ribosyltransferase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9ADS9 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA

52. Iota toxin component Ia

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q46220 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA

53. Vip2Ac

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q844J9 Link_out
Gene: vip2Ac
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

54. Glyceraldehyde-3-phosphate dehydrogenase

Pharmacological action: unknown

D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH

Organism class: bacterial
UniProt ID: P00362 Link_out
Gene: gap
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

55. Glycerol dehydrogenase

Pharmacological action: unknown

Glycerol + NAD(+) = glycerone + NADH

Organism class: bacterial
UniProt ID: P32816 Link_out
Gene: gldA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

56. Inorganic polyphosphate/ATP-NAD kinase

Pharmacological action: unknown

Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus

Organism class: bacterial
UniProt ID: P0A5S6 Link_out
Gene: ppnK
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

57. Alcohol dehydrogenase [NADP+]

Pharmacological action: unknown

Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN)

Organism class: human
UniProt ID: P14550 Link_out
Gene: AKR1A1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

58. D-3-phosphoglycerate dehydrogenase

Pharmacological action: unknown

3-phospho-D-glycerate + NAD(+) = 3- phosphonooxypyruvate + NADH

Organism class: bacterial
UniProt ID: P0A9T0 Link_out
Gene: serA
Protein Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

59. Citrate synthase

Pharmacological action: unknown

Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA

Organism class: bacterial
UniProt ID: P0ABH7 Link_out
Gene: gltA
Protein Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

60. Glyceraldehyde-3-phosphate dehydrogenase A

Pharmacological action: unknown

D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH

Organism class: bacterial
UniProt ID: P0A9B2 Link_out
Gene: gapA
Protein Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

61. NAD(P) transhydrogenase subunit alpha part 1

Pharmacological action: unknown

The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane

Organism class: bacterial
UniProt ID: P0C186 Link_out
Gene: pntAA
Protein Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

62. Dihydrodipicolinate reductase

Pharmacological action: unknown

2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) = 2,3-dihydrodipicolinate + NAD(P)H

Organism class: bacterial
UniProt ID: Q9X1K8 Link_out
Gene: dapB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

63. Glutathione-independent formaldehyde dehydrogenase

Pharmacological action: unknown

Catalyzes the oxidation of long-chain alcohols but is inactive against ethanol

Organism class: bacterial
UniProt ID: P46154 Link_out
Gene: fdhA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

64. Alpha-glucosidase, putative

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9WZL1 Link_out
Gene: TM_0752
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

65. Alpha-glucosidase

Pharmacological action: unknown

Alpha-glycosidase with a very broad specificity. Hydrolyzes maltose and other small maltooligosaccharides but is inactive against the polymeric substrate starch. AglA is not specific with respect to the configuration at the C-4 position of its substrates because glycosidic derivatives of D-galactose are also hydrolyzed. Does not cleave beta-glycosidic bonds

Organism class: bacterial
UniProt ID: O33830 Link_out
Gene: aglA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

66. Nicotinate-nucleotide adenylyltransferase

Pharmacological action: unknown

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)

Organism class: bacterial
UniProt ID: P0A753 Link_out
Gene: nadD
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

67. CDP-D-glucose-4,6-dehydratase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q57329 Link_out
Gene: ascB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

68. Glucose 1-dehydrogenase

Pharmacological action: unknown

Beta-D-glucose + NAD(P)(+) = D-glucono-1,5- lactone + NAD(P)H

Organism class: bacterial
UniProt ID: P40288 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA

69. 4-trimethylaminobutyraldehyde dehydrogenase

Pharmacological action: unknown

Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction

Organism class: human
UniProt ID: P49189 Link_out
Gene: ALDH9A1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

70. Hypothetical protein Rv0046c/MT0052

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: P71703 Link_out
Gene: ino1
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

71. Mannitol dehydrogenase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: O08355 Link_out
Gene: mtlD
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

72. Dihydrolipoyl dehydrogenase

Pharmacological action: unknown

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3)

Organism class: bacterial
UniProt ID: P09063 Link_out
Gene: lpdV
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

73. Malate dehydrogenase, cytoplasmic

Pharmacological action: unknown
Organism class: human
UniProt ID: P40925 Link_out
Gene: MDH1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

74. Retinal dehydrogenase 2

Pharmacological action: unknown

Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently

Organism class: human
UniProt ID: O94788 Link_out
Gene: ALDH1A2 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

75. UDP-galactose 4-epimerase

Pharmacological action: unknown
Organism class: parasitic
UniProt ID: Q8T8E9 Link_out
Gene: galE
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

76. 2,5-diketo-D-gluconic acid reductase A

Pharmacological action: unknown

Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates. 25DKGR-A exhibits a greater selectivity for the substrate and higher thermal stability than 25DKGR-B

Organism class: bacterial
UniProt ID: P06632 Link_out
Gene: dkgA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

77. Phenol 2-hydroxylase component B

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9LAG2 Link_out
Gene: pheA2
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

78. Transcriptional regulator nadR

Pharmacological action: unknown

NadR is bifunctional; it interacts with pnuC at low internal NAD levels, permitting transport of NMN intact into the cell. As NAD levels increase within the cell, the affinity of nadR for the operator regions of some genes increases, repressing the transcription of these genes (By similarity)

Organism class: bacterial
UniProt ID: P44308 Link_out
Gene: nadR
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

79. NADH-cytochrome b5 reductase 3

Pharmacological action: unknown

Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction

Organism class: human
UniProt ID: P00387 Link_out
Gene: CYB5R3 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

80. Glyceraldehyde-3-phosphate dehydrogenase

Pharmacological action: unknown

D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH

Organism class: bacterial
UniProt ID: P00361 Link_out
Gene: gap
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

81. DNA ligase, NAD-dependent

Pharmacological action: unknown

NAD(+) + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + nicotinamide nucleotide + (deoxyribonucleotide)(n+m)

Organism class: bacterial
UniProt ID: Q837V6 Link_out
Gene: ligA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

82. 3-oxoacyl-(Acyl carrier protein) reductase

Pharmacological action: unknown

Acyl-[acyl-carrier-protein] + NAD(+) = trans- 2,3-dehydroacyl-[acyl-carrier-protein] + NADH

Organism class: bacterial
UniProt ID: Q9X0Q1 Link_out
Gene: TM_1169
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

83. C-terminal-binding protein 1

Pharmacological action: unknown

Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex (By similarity). Co- repressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity

Organism class: human
UniProt ID: Q13363 Link_out
Gene: CTBP1
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

84. Benzyl alcohol dehydrogenase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q59096 Link_out
Gene: xylB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

85. Ornithine cyclodeaminase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q88H32 Link_out
Gene: PP3533
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

86. dTDP-glucose 4,6-dehydratase

Pharmacological action: unknown

dTDP-glucose = dTDP-4-dehydro-6-deoxy-D- glucose + H(2)O

Organism class: bacterial
UniProt ID: P95780 Link_out
Gene: rmlB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

87. L-lactate dehydrogenase 2

Pharmacological action: unknown

(S)-lactate + NAD(+) = pyruvate + NADH

Organism class: bacterial
UniProt ID: P19869 Link_out
Gene: ldh2
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

88. Siroheme synthase

Pharmacological action: unknown

Multifunctional enzyme that catalyze the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consist of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme

Organism class: bacterial
UniProt ID: P25924 Link_out
Gene: cysG
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

89. Formate dehydrogenase

Pharmacological action: unknown

Formate + NAD(+) = CO(2) + NADH

Organism class: bacterial
UniProt ID: P33160 Link_out
Protein Sequence: FASTA

90. NADPH-flavin oxidoreductase

Pharmacological action: unknown

Involved in bioluminescence. It is a good supplier of reduced flavin mononucleotide (FMNH2) to the bioluminescence reaction

Organism class: bacterial
UniProt ID: Q56691 Link_out
Gene: frp
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

91. WbpP

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q8KN66 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA

92. Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase

Pharmacological action: unknown

Cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) = biphenyl-2,3-diol + NADH

Organism class: bacterial
UniProt ID: P47227 Link_out
Gene: bphB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

93. Myo-inositol-1-phosphate synthase-related protein

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9X1D6 Link_out
Gene: TM_1419
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

94. Alanine dehydrogenase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: O52942 Link_out
Gene: ald
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

95. Alcohol dehydrogenase

Pharmacological action: unknown
Organism class: bacterial
UniProt ID: Q9HTD9 Link_out
Gene: adhA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

96. Acetoin(diacetyl) reductase

Pharmacological action: unknown

Catalyzes the reversible reduction of acetoin to 2,3- butanediol in the presence of NADH

Organism class: bacterial
UniProt ID: Q48436 Link_out
Gene: budC
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

97. D-lactate dehydrogenase

Pharmacological action: unknown

(R)-lactate + NAD(+) = pyruvate + NADH

Organism class: bacterial
UniProt ID: P26297 Link_out
Gene: ldhA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

98. UDP-glucose 6-dehydrogenase

Pharmacological action: unknown

Catalyzes the formation of UDP-glucuronic acid which is required for capsular hyaluronic acid synthesis

Organism class: bacterial
UniProt ID: P0C0F4 Link_out
Gene: hasB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

99. Enoyl-[acyl-carrier-protein] reductase [NADH]

Pharmacological action: unknown

Acyl-[acyl-carrier-protein] + NAD(+) = trans- 2,3-dehydroacyl-[acyl-carrier-protein] + NADH

Organism class: bacterial
UniProt ID: P0AEK4 Link_out
Gene: fabI
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

100. 7-alpha-hydroxysteroid dehydrogenase

Pharmacological action: unknown

7-alpha-dehydroxylation of cholic acid, yielding deoxycholic acid and lithocholic acid, respectively. Highest affinity with taurochenodeoxycholic acid

Organism class: bacterial
UniProt ID: P0AET8 Link_out
Gene: hdhA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

101. 3-isopropylmalate dehydrogenase

Pharmacological action: unknown

Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate

Organism class: bacterial
UniProt ID: Q5SIY4 Link_out
Gene: leuB
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

102. Alcohol dehydrogenase 1C

Pharmacological action: unknown
Organism class: human
UniProt ID: P00326 Link_out
Gene: ADH1C Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

103. NH(3)-dependent NAD(+) synthetase

Pharmacological action: unknown

Catalyzes a key step in NAD biosynthesis, transforming deamido-NAD into NAD by a two-step reaction

Organism class: bacterial
UniProt ID: P18843 Link_out
Gene: nadE
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

104. L-lactate dehydrogenase

Pharmacological action: unknown

(S)-lactate + NAD(+) = pyruvate + NADH

Organism class: bacterial
UniProt ID: P16115 Link_out
Gene: ldh
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

105. Inositol-3-phosphate synthase 1

Pharmacological action: unknown
Organism class: human
UniProt ID: Q9NPH2 Link_out
Gene: ISYNA1
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

106. Glyceraldehyde-3-phosphate dehydrogenase

Pharmacological action: unknown
Organism class: human
UniProt ID: P04406 Link_out
Gene: GAPDH Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

107. Alcohol dehydrogenase 1B

Pharmacological action: unknown
Organism class: human
UniProt ID: P00325 Link_out
Gene: ADH1B Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

108. Sorbitol dehydrogenase

Pharmacological action: unknown
Organism class: human
UniProt ID: Q00796 Link_out
Gene: SORD Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

109. Enoyl-[acyl-carrier-protein] reductase [NADH]

Pharmacological action: unknown

Involved in the resistance against the antituberculosis drugs isoniazid and ethionamide

Organism class: bacterial
UniProt ID: P0A5Y6 Link_out
Gene: inhA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

110. Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

Pharmacological action: unknown

Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA

Organism class: human
UniProt ID: Q16836 Link_out
Gene: HADH Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

111. L-lactate dehydrogenase

Pharmacological action: unknown

(S)-lactate + NAD(+) = pyruvate + NADH

Organism class: parasitic
UniProt ID: Q27743 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

112. Deoxyhypusine synthase

Pharmacological action: unknown

Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue

Organism class: human
UniProt ID: P49366 Link_out
Gene: DHPS Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

113. Inosine-5'-monophosphate dehydrogenase 2

Pharmacological action: unknown

Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors

Organism class: human
UniProt ID: P12268 Link_out
Gene: IMPDH2 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

114. Nitric oxide synthase oxygenase

Pharmacological action: unknown

Catalyzes the production of nitric oxide

Organism class: bacterial
UniProt ID: P0A094 Link_out
Gene: nos
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

115. UDP-glucose 4-epimerase

Pharmacological action: unknown

Catalyzes two distinct but analogous reactions:the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine

Organism class: human
UniProt ID: Q14376 Link_out
Gene: GALE Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

116. Glutathione reductase

Pharmacological action: unknown

Maintains high levels of reduced glutathione in the cytosol

Organism class: bacterial
UniProt ID: P06715 Link_out
Gene: gor
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

117. Alcohol dehydrogenase class 3

Pharmacological action: unknown

Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione

Organism class: human
UniProt ID: P11766 Link_out
Gene: ADH5 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

118. Glutathione reductase, mitochondrial

Pharmacological action: unknown

Maintains high levels of reduced glutathione in the cytosol

Organism class: human
UniProt ID: P00390 Link_out
Gene: GSR Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

119. Isocitrate dehydrogenase [NADP]

Pharmacological action: unknown

Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH

Organism class: bacterial
UniProt ID: P08200 Link_out
Gene: icd
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

120. Malate dehydrogenase

Pharmacological action: unknown

Catalyzes the reversible oxidation of malate to oxaloacetate

Organism class: bacterial
UniProt ID: P80040 Link_out
Gene: mdh
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

121. Peroxisomal multifunctional enzyme type 2

Pharmacological action: unknown

Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids

Organism class: human
UniProt ID: P51659 Link_out
Gene: HSD17B4 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

122. Urocanate hydratase

Pharmacological action: unknown

3-(5-oxo-4,5-dihydro-3H-imidazol-4- yl)propanoate = urocanate + H(2)O

Organism class: bacterial
UniProt ID: Q88CZ6 Link_out
Gene: hutU
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

123. Estradiol 17-beta-dehydrogenase 1

Pharmacological action: unknown

Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH

Organism class: human
UniProt ID: P14061 Link_out
Gene: HSD17B1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

124. NAD-dependent malic enzyme, mitochondrial

Pharmacological action: unknown
Organism class: human
UniProt ID: P23368 Link_out
Gene: ME2 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

125. Glucose-6-phosphate 1-dehydrogenase

Pharmacological action: unknown

D-glucose 6-phosphate + NADP(+) = D-glucono- 1,5-lactone 6-phosphate + NADPH

Organism class: bacterial
UniProt ID: P11411 Link_out
Gene: zwf
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

126. Aldehyde dehydrogenase, mitochondrial

Pharmacological action: unknown
Organism class: human
UniProt ID: P05091 Link_out
Gene: ALDH2 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

127. Glyceraldehyde-3-phosphate dehydrogenase, glycosomal

Pharmacological action: unknown

D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH

Organism class: parasitic
UniProt ID: P22513 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

128. Alcohol dehydrogenase class 4 mu/sigma chain

Pharmacological action: unknown

Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism

Organism class: human
UniProt ID: P40394 Link_out
Gene: ADH7 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

129. Maltose-6'-phosphate glucosidase

Pharmacological action: unknown

Hydrolyzes maltose-6'P and trehalose-6'P. Is involved in the catabolism of alpha-glycosides accumulated via a phosphoenolpyruvate-dependent maltose phosphotransferase system (PEP-PTS)

Organism class: bacterial
UniProt ID: P54716 Link_out
Gene: glvA
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

130. Diphtheria toxin

Pharmacological action: unknown

Diphtheria toxin, produced by a phage infecting corynebacterium diphtheriae, is a proenzyme that, after activation, catalyzes the covalent attachment of the ADP ribose moiety of NAD to elongation factor 2. Fragment A is responsible for enzymatic ADP-ribosylation of elongation factor 2, while fragment B is responsible for binding of toxin to cell receptors and entry of fragment A

Organism class: viral
UniProt ID: P00587 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

131. GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1

Pharmacological action: unknown

NAD(P)(+) + protein-L-arginine = nicotinamide + omega-N-(ADP-D-ribosyl)-protein-L-arginine

Organism class: human
UniProt ID: P52961 Link_out
Gene: ART1 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

132. 6-phospho-beta-glucosidase bglT

Pharmacological action: unknown

Hydrolyzes cellobiose 6'-phosphate into glucose 6- phosphate (Glc6P) and glucose

Organism class: bacterial
UniProt ID: Q9X108 Link_out
Gene: bglT
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

133. Glucose--fructose oxidoreductase

Pharmacological action: unknown

D-glucose + D-fructose = D-gluconolactone + D- glucitol

Organism class: bacterial
UniProt ID: Q07982 Link_out
Gene: gfo
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

134. Alcohol dehydrogenase 1A

Pharmacological action: unknown
Organism class: human
UniProt ID: P07327 Link_out
Gene: ADH1A Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

135. Dihydropteridine reductase

Pharmacological action: unknown

The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases

Organism class: human
UniProt ID: P09417 Link_out
Gene: QDPR Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

136. Malate dehydrogenase

Pharmacological action: unknown

Catalyzes the reversible oxidation of malate to oxaloacetate

Organism class: bacterial
UniProt ID: P61889 Link_out
Gene: mdh
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

137. 3-hydroxyacyl-CoA dehydrogenase type-2

Pharmacological action: unknown

Binds intracellular amyloid-beta. By interacting with amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD)

Organism class: human
UniProt ID: Q99714 Link_out
Gene: HSD17B10 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

138. L-lactate dehydrogenase B chain

Pharmacological action: unknown
Organism class: human
UniProt ID: P07195 Link_out
Gene: LDHB Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

139. 2,3-diketo-L-gulonate reductase

Pharmacological action: unknown

Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate

Organism class: bacterial
UniProt ID: P37672 Link_out
Gene: dlgD
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

140. 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase

Pharmacological action: unknown

Androstan-3-alpha,17-beta-diol + NAD(+) = 17- beta-hydroxyandrostan-3-one + NADH

Organism class: bacterial
UniProt ID: P19992 Link_out
Protein Sequence: FASTA

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

141. NAD-dependent deacetylase sirtuin-5

Pharmacological action: unknown

Probable NAD-dependent deacetylase (By similarity)

Organism class: human
UniProt ID: Q9NXA8 Link_out
Gene: SIRT5
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed

142. Mono-ADP-ribosyltransferase C3

Pharmacological action: unknown

ADP-ribosylates eukaryotic Rho and Rac proteins on an asparagine residue

Organism class: viral
UniProt ID: P15879 Link_out
Gene: C3
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. Pubmed
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. Pubmed

143. Dehydrogenase/reductase SDR family member 4-like 2

Pharmacological action: unknown

Probable oxidoreductase (By similarity)

Organism class: human
UniProt ID: Q6PKH6 Link_out
Gene: DHRS4L2 Link_out
Protein Sequence: FASTA
Gene Sequence: FASTA
SNPs: SNPJam Report Link_out

References:
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. Pubmed
Comments
Drug created on June 13, 2005 07:24 / Updated on February 08, 2013 16:20