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Identification
NameGemfibrozil
Accession NumberDB01241  (APRD00293)
TypeSmall Molecule
GroupsApproved
DescriptionA lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol. These decreases occur primarily in the VLDL fraction and less frequently in the LDL fraction. Gemfibrozil increases HDL subfractions HDL2 and HDL3 as well as apolipoproteins A-I and A-II. Its mechanism of action has not been definitely established. [PubChem]
Structure
Thumb
Synonyms
2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure
2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure
2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid
Gemfibrozil
Gemfibrozilo
Gemfibrozilum
Lopid
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Dom-gemfibrozilTablet600 mgOralDominion Pharmacal1998-10-222013-04-05Canada
Dom-gemfibrozilCapsule300 mgOralDominion Pharmacal2000-03-10Not applicableCanada
Gemfibrozil Cap 300mgCapsule300 mgOralOmni Laboratories Division, Warner Lambert Canada Inc.1990-12-312003-07-04Canada
Gemfibrozil Tab 600mgTablet600 mgOralOmni Laboratories Division, Warner Lambert Canada Inc.1991-12-312003-07-04Canada
Gemfibrozil-300 - CapCapsule300 mgOralPro Doc Limitee1995-12-312010-07-13Canada
Gemfibrozil-600 - Tab 600mgTablet600 mgOralPro Doc Limitee1995-12-312015-07-10Canada
LopidTablet, film coated600 mg/1OralParke Davis Div Of Pfizer Inc2004-03-30Not applicableUs
Lopid 600mgTablet600 mgOralPfizer Canada Inc1987-12-312013-07-18Canada
Lopid Cap 300mgCapsule300 mgOralPfizer Canada Inc1984-12-312013-07-18Canada
Mylan-gemfibrozilCapsule300 mgOralMylan Pharmaceuticals Ulc1997-01-10Not applicableCanada
Mylan-gemfibrozilTablet600 mgOralMylan Pharmaceuticals Ulc1997-01-14Not applicableCanada
Nu-gemfibrozil Cap 300mgCapsule300 mgOralNu Pharm Inc1994-12-312012-09-04Canada
Nu-gemfibrozil Tab 600mgTablet600 mgOralNu Pharm Inc1994-12-312012-09-04Canada
Penta-gemfibrozilTablet600 mgOralPentapharm Ltd.Not applicableNot applicableCanada
PHL-gemfibrozilTablet600 mgOralPharmel Inc2004-08-042013-04-05Canada
PHL-gemfibrozilCapsule300 mgOralPharmel Inc2004-08-042016-10-25Canada
PMS-gemfibrozilTablet600 mgOralPharmascience Inc1996-12-31Not applicableCanada
PMS-gemfibrozilCapsule300 mgOralPharmascience Inc1999-05-04Not applicableCanada
Riva-gemfibrozilTablet600 mgOralLaboratoire Riva Inc2000-05-152013-07-31Canada
Scheinpharm GemfibrozilCapsule300 mgOralSchein Pharmaceutical Canada Inc.2000-09-132003-11-13Canada
Teva-gemfibrozilTablet600 mgOralTeva Canada Limited1995-12-31Not applicableCanada
Teva-gemfibrozilCapsule300 mgOralTeva Canada Limited2000-02-29Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo-gemfibrozilTablet600 mgOralApotex Inc1993-12-31Not applicableCanada
Apo-gemfibrozil Cap 300mg USPCapsule300 mgOralApotex Inc1993-12-31Not applicableCanada
GemfibrozilTablet600 mg/1OralNorthwind Pharmaceuticals, LLC2014-10-23Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralGolden State Medical Supply, Inc.2006-07-26Not applicableUs
GemfibrozilTablet600 mg/1OralLake Erie Medical DBA Quality Care Products LLC2011-01-01Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralMajor Pharmaceuticals2010-03-12Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralAurobindo Pharma Limited2015-09-16Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralAphena Pharma Solutions Tennessee, Inc.2011-04-01Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralPhysicians Total Care, Inc.2004-08-10Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralAmerican Health Packaging2011-06-01Not applicableUs
GemfibrozilTablet, coated600 mg/1OralGlobal Pharmaceuticals, Division of Impax Laboratories Inc.2009-10-012016-11-29Us
GemfibrozilTablet600 mg/1OralA S Medication Solutions2011-01-01Not applicableUs
GemfibrozilTablet600 mg/1OralAv Pak2014-07-10Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralBlu Pharmaceuticals, LLC2011-04-01Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
GemfibrozilTablet, film coated600 mg/1Oralbryant ranch prepack1998-10-01Not applicableUs
GemfibrozilTablet600 mg/1OralClinical Solutions Wholesale, Llc2011-01-01Not applicableUs
GemfibrozilTablet, coated600 mg/1OralKAISER FOUNDATION HOSPITALS2010-01-27Not applicableUs
GemfibrozilTablet600 mg/1OralPreferred Pharmaceuticals Inc.2016-08-02Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralUnit Dose Services1998-10-01Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralBlenheim Pharmacal, Inc.2013-12-17Not applicableUs
GemfibrozilTablet600 mg/1OralProficient Rx LP2016-07-08Not applicableUs
GemfibrozilTablet600 mg/1OralREMEDYREPACK INC.2012-09-21Not applicableUs
GemfibrozilTablet600 mg/1OralSt Marys Medical Park Pharmacy2014-04-21Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralCardinal Health2011-06-01Not applicableUs
GemfibrozilTablet600 mg/1OralPreferred Pharmaceuticals, Inc2011-01-01Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralWest ward Pharmaceutical Corp2006-07-27Not applicableUs
GemfibrozilTablet600 mg/1OralAmerican Health Packaging2016-08-08Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralREMEDYREPACK INC.2011-06-092016-10-13Us
GemfibrozilTablet, film coated600 mg/1OralCardinal Health2010-03-12Not applicableUs
GemfibrozilTablet600 mg/1OralDispensing Solutions, Inc.2006-07-27Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralCitron Pharma LLC2015-09-16Not applicableUs
GemfibrozilTablet600 mg/1OralCamber Pharmaceuticals2011-01-01Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralHikma Pharmaceutical2010-08-16Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralNcs Health Care Of Ky, Inc Dba Vangard Labs1993-11-24Not applicableUs
GemfibrozilTablet600 mg/1OralCipla USA Inc.2016-07-08Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralMylan Institutional Inc.1996-02-01Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralTeva Pharmaceuticals USA Inc1993-11-24Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralRebel Distributors Corp2010-11-09Not applicableUs
GemfibrozilTablet600 mg/1OralClinical Solutions Wholesale2011-01-01Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
GemfibrozilTablet600 mg/1OralDIRECT RX2015-12-03Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralMc Kesson Contract Packaging2011-09-19Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralWest ward Pharmaceutical Corp2010-08-16Not applicableUs
GemfibrozilTablet600 mg/1OralREMEDYREPACK INC.2016-08-30Not applicableUs
GemfibrozilTablet600 mg/1OralREMEDYREPACK INC.2011-06-222016-10-28Us
GemfibrozilTablet, film coated600 mg/1OralPd Rx Pharmaceuticals, Inc.2011-08-17Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralContract Pharmacy Services Pa2010-04-05Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralApotex Corp.1998-10-01Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralAidarex Pharmaceuticals LLC1998-10-01Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralState of Florida DOH Central Pharmacy2013-01-01Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralGolden State Medical Supply, Inc.1993-09-27Not applicableUs
GemfibrozilTablet600 mg/1OralCarilion Materials Management2011-01-01Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralMajor Pharmaceuticals2004-02-06Not applicableUs
GemfibrozilTablet600 mg/1OralClinical Solutions Wholesale, Llc2016-07-08Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralMed Health Pharma, LLC2011-07-04Not applicableUs
GemfibrozilTablet600 mg/1OralNorthstar Rx LLC2010-12-20Not applicableUs
GemfibrozilTablet600 mg/1OralBlu Pharmaceuticals, LLC2007-01-02Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralState of Florida DOH Central Pharmacy2009-07-01Not applicableUs
GemfibrozilTablet600 mg/1OralProficient Rx LP2011-01-01Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralExelan Pharmaceuticals, Inc.2006-10-20Not applicableUs
GemfibrozilTablet, coated600 mg/1OralKAISER FOUNDATION HOSPITALS2009-10-30Not applicableUs
GemfibrozilTablet600 mg/1OralCadila Pharmaceuticals Limited2016-06-17Not applicableUs
GemfibrozilTablet600 mg/1OralREMEDYREPACK INC.2011-07-192016-10-28Us
GemfibrozilTablet, film coated600 mg/1OralCaraco Pharmaceutical Laboratories, Ltd.2009-07-01Not applicableUs
GemfibrozilTablet600 mg/1OralA S Medication Solutions Llc2011-01-01Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralContract Pharmacy Services Pa2010-11-09Not applicableUs
GemfibrozilTablet, film coated600 mg/1OralDAVA Pharmaceuticals, Inc.1993-09-272018-03-31Us
GemfibrozilTablet, film coated600 mg/1OralAphena Pharma Solutions Tennessee, Llc2010-03-12Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
GemlipidFarmellas Enterprises
Gen-FibroNot Available
GenlipTeofarma
JezilNot Available
LipurPfizer
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIQ8X02027X3
CAS number25812-30-0
WeightAverage: 250.3334
Monoisotopic: 250.15689457
Chemical FormulaC15H22O3
InChI KeyHEMJJKBWTPKOJG-UHFFFAOYSA-N
InChI
InChI=1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)
IUPAC Name
5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
SMILES
CC1=CC(OCCCC(C)(C)C(O)=O)=C(C)C=C1
Pharmacology
IndicationFor treatment of adult patients with very high elevations of serum triglyceride levels (types IV and V hyperlipidemia) who are at risk of developing pancreatitis (inflammation of the pancreas) and who do not respond adequately to a strict diet.
Structured Indications
PharmacodynamicsGemfibrozil, a fibric acid antilipemic agent similar to clofibrate, is used to treat hyperlipoproteinemia and as a second-line therapy for type IIb hypercholesterolemia. It acts to reduce triglyceride levels, reduce VLDL levels, reduce LDL levels (moderately), and increase HDL levels (moderately).
Mechanism of actionGemfibrozil increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. It does so by activating Peroxisome proliferator-activated receptor-alpha (PPARα) 'transcription factor ligand', a receptor that is involved in metabolism of carbohydrates and fats, as well as adipose tissue differentiation. This increase in the synthesis of lipoprotein lipase thereby increases the clearance of triglycerides. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. This is accompanied by a slight increase in secretion of lipids into the bile and ultimately the intestine. Gemfibrozil also inhibits the synthesis and increases the clearance of apolipoprotein B, a carrier molecule for VLDL.
TargetKindPharmacological actionActionsOrganismUniProt ID
Peroxisome proliferator-activated receptor alphaProteinyes
agonist
HumanQ07869 details
Related Articles
AbsorptionWell absorbed from gastrointestinal tract (within 1-2 hours).
Volume of distributionNot Available
Protein binding95%
Metabolism

Hepatic. Gemfibrozil mainly undergoes oxidation of a ring methyl group to successively form a hydroxymethyl and a carboxyl metabolite.

SubstrateEnzymesProduct
Gemfibrozil
Gemfibrozil 1-beta-glucuronideDetails
Route of eliminationApproximately seventy percent of the administered human dose is excreted in the urine, mostly as the glucuronide conjugate, with less than 2% excreted as unchanged gemfibrozil.
Half life1.5 hours
ClearanceNot Available
ToxicityOral, mouse: LD50 = 3162 mg/kg. Symptoms of overdose include abdominal cramps, diarrhea, joint and muscle pain, nausea, and vomiting.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
AceclofenacThe metabolism of Aceclofenac can be decreased when combined with Gemfibrozil.Approved
AcenocoumarolThe metabolism of Acenocoumarol can be decreased when combined with Gemfibrozil.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Gemfibrozil.Approved
AcetohexamideGemfibrozil may increase the hypoglycemic activities of Acetohexamide.Withdrawn
Acetylsalicylic acidThe metabolism of Acetylsalicylic acid can be decreased when combined with Gemfibrozil.Approved, Vet Approved
AcipimoxAcipimox may increase the myopathic rhabdomyolysis activities of Gemfibrozil.Approved
AdinazolamThe metabolism of Adinazolam can be decreased when combined with Gemfibrozil.Approved
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Gemfibrozil.Approved, Investigational
AlosetronThe metabolism of Alosetron can be decreased when combined with Gemfibrozil.Approved, Withdrawn
AlprazolamThe metabolism of Alprazolam can be decreased when combined with Gemfibrozil.Approved, Illicit, Investigational
AmbrisentanThe metabolism of Ambrisentan can be decreased when combined with Gemfibrozil.Approved, Investigational
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Gemfibrozil.Approved, Withdrawn
AmiodaroneThe metabolism of Gemfibrozil can be decreased when combined with Amiodarone.Approved, Investigational
AmitriptylineThe metabolism of Amitriptyline can be decreased when combined with Gemfibrozil.Approved
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Gemfibrozil.Approved
AmoxicillinThe metabolism of Amoxicillin can be decreased when combined with Gemfibrozil.Approved, Vet Approved
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Gemfibrozil.Approved
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Gemfibrozil.Approved
ApixabanThe metabolism of Apixaban can be decreased when combined with Gemfibrozil.Approved
AprepitantThe serum concentration of Gemfibrozil can be increased when it is combined with Aprepitant.Approved, Investigational
Arachidonic AcidThe metabolism of Arachidonic Acid can be decreased when combined with Gemfibrozil.Experimental
ArformoterolThe metabolism of Arformoterol can be decreased when combined with Gemfibrozil.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be decreased when it is combined with Gemfibrozil.Approved, Investigational
ArtemetherThe metabolism of Artemether can be decreased when combined with Gemfibrozil.Approved
AtazanavirThe metabolism of Gemfibrozil can be decreased when combined with Atazanavir.Approved, Investigational
AtomoxetineThe metabolism of Atomoxetine can be decreased when combined with Gemfibrozil.Approved
AtorvastatinGemfibrozil may increase the myopathic rhabdomyolysis activities of Atorvastatin.Approved
AxitinibThe metabolism of Axitinib can be decreased when combined with Gemfibrozil.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Gemfibrozil.Approved
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Gemfibrozil.Approved
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Gemfibrozil.Approved
BeraprostThe metabolism of Beraprost can be decreased when combined with Gemfibrozil.Investigational
BexaroteneThe serum concentration of Bexarotene can be increased when it is combined with Gemfibrozil.Approved, Investigational
BexaroteneThe metabolism of Bexarotene can be decreased when combined with Gemfibrozil.Approved, Investigational
BoceprevirThe metabolism of Gemfibrozil can be decreased when combined with Boceprevir.Approved
BortezomibThe metabolism of Bortezomib can be decreased when combined with Gemfibrozil.Approved, Investigational
BosentanThe serum concentration of Bosentan can be increased when it is combined with Gemfibrozil.Approved, Investigational
BromazepamThe metabolism of Bromazepam can be decreased when combined with Gemfibrozil.Approved, Illicit
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Gemfibrozil.Approved
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Gemfibrozil.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Gemfibrozil.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Gemfibrozil.Approved
CabazitaxelThe metabolism of Cabazitaxel can be decreased when combined with Gemfibrozil.Approved
CabozantinibThe metabolism of Cabozantinib can be decreased when combined with Gemfibrozil.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Gemfibrozil.Approved
CandesartanThe metabolism of Candesartan can be decreased when combined with Gemfibrozil.Approved
CarbamazepineThe metabolism of Gemfibrozil can be increased when combined with Carbamazepine.Approved, Investigational
CarbinoxamineThe metabolism of Carbinoxamine can be decreased when combined with Gemfibrozil.Approved
CarisoprodolThe metabolism of Carisoprodol can be decreased when combined with Gemfibrozil.Approved
CarvedilolThe serum concentration of Carvedilol can be increased when it is combined with Gemfibrozil.Approved, Investigational
CelecoxibThe metabolism of Celecoxib can be decreased when combined with Gemfibrozil.Approved, Investigational
CeritinibThe serum concentration of Gemfibrozil can be increased when it is combined with Ceritinib.Approved
CerivastatinThe metabolism of Cerivastatin can be decreased when combined with Gemfibrozil.Withdrawn
Chenodeoxycholic acidThe therapeutic efficacy of Chenodeoxycholic acid can be decreased when used in combination with Gemfibrozil.Approved
ChloramphenicolThe metabolism of Chloramphenicol can be decreased when combined with Gemfibrozil.Approved, Vet Approved
ChloroquineThe metabolism of Chloroquine can be decreased when combined with Gemfibrozil.Approved, Vet Approved
ChlorpropamideThe metabolism of Chlorpropamide can be decreased when combined with Gemfibrozil.Approved
CholestyramineCholestyramine can cause a decrease in the absorption of Gemfibrozil resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
CilostazolThe serum concentration of Cilostazol can be increased when it is combined with Gemfibrozil.Approved
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Gemfibrozil.Approved
CiprofibrateThe risk or severity of adverse effects can be increased when Ciprofibrate is combined with Gemfibrozil.Approved
CisaprideThe metabolism of Cisapride can be decreased when combined with Gemfibrozil.Approved, Investigational, Withdrawn
CitalopramThe serum concentration of Citalopram can be increased when it is combined with Gemfibrozil.Approved
ClarithromycinThe metabolism of Gemfibrozil can be decreased when combined with Clarithromycin.Approved
ClemastineThe metabolism of Gemfibrozil can be decreased when combined with Clemastine.Approved
ClobazamThe metabolism of Clobazam can be decreased when combined with Gemfibrozil.Approved, Illicit
clomethiazoleThe metabolism of clomethiazole can be decreased when combined with Gemfibrozil.Investigational
ClomipramineThe metabolism of Clomipramine can be decreased when combined with Gemfibrozil.Approved, Vet Approved
ClopidogrelThe serum concentration of the active metabolites of Clopidogrel can be reduced when Clopidogrel is used in combination with Gemfibrozil resulting in a loss in efficacy.Approved, Nutraceutical
ClotiazepamThe metabolism of Clotiazepam can be decreased when combined with Gemfibrozil.Approved, Illicit
ClotrimazoleThe metabolism of Gemfibrozil can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineThe metabolism of Clozapine can be decreased when combined with Gemfibrozil.Approved
CobicistatThe metabolism of Gemfibrozil can be decreased when combined with Cobicistat.Approved
ColchicineGemfibrozil may increase the myopathic rhabdomyolysis activities of Colchicine.Approved
ColesevelamColesevelam can cause a decrease in the absorption of Gemfibrozil resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ColestipolColestipol can cause a decrease in the absorption of Gemfibrozil resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ConivaptanThe serum concentration of Gemfibrozil can be increased when it is combined with Conivaptan.Approved, Investigational
CrizotinibThe metabolism of Gemfibrozil can be decreased when combined with Crizotinib.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Gemfibrozil.Approved, Investigational
CyclosporineCyclosporine may increase the nephrotoxic activities of Gemfibrozil.Approved, Investigational, Vet Approved
CyclosporineThe metabolism of Gemfibrozil can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
DabrafenibThe serum concentration of Gemfibrozil can be decreased when it is combined with Dabrafenib.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Gemfibrozil.Approved
DapsoneThe metabolism of Dapsone can be decreased when combined with Gemfibrozil.Approved, Investigational
DarunavirThe metabolism of Gemfibrozil can be decreased when combined with Darunavir.Approved
DasabuvirThe serum concentration of Dasabuvir can be increased when it is combined with Gemfibrozil.Approved
DasatinibThe serum concentration of Gemfibrozil can be increased when it is combined with Dasatinib.Approved, Investigational
DeferasiroxThe serum concentration of Gemfibrozil can be decreased when it is combined with Deferasirox.Approved, Investigational
DelavirdineThe metabolism of Gemfibrozil can be decreased when combined with Delavirdine.Approved
DesipramineThe metabolism of Desipramine can be decreased when combined with Gemfibrozil.Approved
DexamethasoneThe serum concentration of Gemfibrozil can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DextromethorphanThe metabolism of Dextromethorphan can be decreased when combined with Gemfibrozil.Approved
DiazepamThe metabolism of Diazepam can be decreased when combined with Gemfibrozil.Approved, Illicit, Vet Approved
DiclofenacThe metabolism of Diclofenac can be decreased when combined with Gemfibrozil.Approved, Vet Approved
DiclofenacThe serum concentration of Diclofenac can be increased when it is combined with Gemfibrozil.Approved, Vet Approved
DicoumarolGemfibrozil may increase the anticoagulant activities of Dicoumarol.Approved
DihydroergotamineThe metabolism of Gemfibrozil can be decreased when combined with Dihydroergotamine.Approved
DiltiazemThe metabolism of Diltiazem can be decreased when combined with Gemfibrozil.Approved
DiphenhydramineThe metabolism of Diphenhydramine can be decreased when combined with Gemfibrozil.Approved
DolasetronThe metabolism of Dolasetron can be decreased when combined with Gemfibrozil.Approved
DomperidoneThe metabolism of Domperidone can be decreased when combined with Gemfibrozil.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Gemfibrozil.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Gemfibrozil.Approved
DorzolamideThe metabolism of Dorzolamide can be decreased when combined with Gemfibrozil.Approved
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Gemfibrozil.Approved
DoxepinThe metabolism of Doxepin can be decreased when combined with Gemfibrozil.Approved
DoxycyclineThe metabolism of Gemfibrozil can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DronabinolThe serum concentration of Dronabinol can be increased when it is combined with Gemfibrozil.Approved, Illicit
DronedaroneThe metabolism of Gemfibrozil can be decreased when combined with Dronedarone.Approved
EfavirenzThe serum concentration of Gemfibrozil can be decreased when it is combined with Efavirenz.Approved, Investigational
EletriptanThe metabolism of Eletriptan can be decreased when combined with Gemfibrozil.Approved, Investigational
EltrombopagThe metabolism of Eltrombopag can be decreased when combined with Gemfibrozil.Approved
EluxadolineThe serum concentration of Eluxadoline can be increased when it is combined with Gemfibrozil.Approved
EnfuvirtideThe metabolism of Enfuvirtide can be decreased when combined with Gemfibrozil.Approved, Investigational
EnzalutamideThe serum concentration of Enzalutamide can be increased when it is combined with Gemfibrozil.Approved
EpoprostenolThe metabolism of Epoprostenol can be decreased when combined with Gemfibrozil.Approved
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Gemfibrozil.Approved, Investigational
ErythromycinThe metabolism of Gemfibrozil can be decreased when combined with Erythromycin.Approved, Vet Approved
EscitalopramThe metabolism of Escitalopram can be decreased when combined with Gemfibrozil.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Gemfibrozil can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsomeprazoleThe metabolism of Esomeprazole can be decreased when combined with Gemfibrozil.Approved, Investigational
EstradiolThe metabolism of Estradiol can be decreased when combined with Gemfibrozil.Approved, Investigational, Vet Approved
EstroneThe metabolism of Estrone can be decreased when combined with Gemfibrozil.Approved
EszopicloneThe metabolism of Eszopiclone can be decreased when combined with Gemfibrozil.Approved
Ethyl biscoumacetateGemfibrozil may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
EtodolacThe metabolism of Etodolac can be decreased when combined with Gemfibrozil.Approved, Investigational, Vet Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Gemfibrozil.Approved, Investigational
EtravirineThe metabolism of Etravirine can be decreased when combined with Gemfibrozil.Approved
EzetimibeThe risk or severity of adverse effects can be increased when Gemfibrozil is combined with Ezetimibe.Approved
FamotidineThe metabolism of Famotidine can be decreased when combined with Gemfibrozil.Approved
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Gemfibrozil.Approved
FluconazoleThe metabolism of Gemfibrozil can be decreased when combined with Fluconazole.Approved
FluindioneGemfibrozil may increase the anticoagulant activities of Fluindione.Investigational
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Gemfibrozil.Approved
FlunitrazepamThe metabolism of Flunitrazepam can be decreased when combined with Gemfibrozil.Approved, Illicit
FluorouracilThe metabolism of Fluorouracil can be decreased when combined with Gemfibrozil.Approved
FluoxetineThe metabolism of Fluoxetine can be decreased when combined with Gemfibrozil.Approved, Vet Approved
FlurbiprofenThe metabolism of Flurbiprofen can be decreased when combined with Gemfibrozil.Approved, Investigational
FlutamideThe metabolism of Flutamide can be decreased when combined with Gemfibrozil.Approved
FluvastatinGemfibrozil may increase the myopathic rhabdomyolysis activities of Fluvastatin.Approved
FluvoxamineThe metabolism of Gemfibrozil can be decreased when combined with Fluvoxamine.Approved, Investigational
FormoterolThe metabolism of Formoterol can be decreased when combined with Gemfibrozil.Approved, Investigational
FosamprenavirThe metabolism of Gemfibrozil can be decreased when combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Gemfibrozil can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe metabolism of Gemfibrozil can be increased when combined with Fosphenytoin.Approved
Fusidic AcidThe serum concentration of Gemfibrozil can be increased when it is combined with Fusidic Acid.Approved
GavestinelThe metabolism of Gavestinel can be decreased when combined with Gemfibrozil.Investigational
GlibornurideGemfibrozil may increase the hypoglycemic activities of Glibornuride.Withdrawn
GliclazideThe metabolism of Gliclazide can be decreased when combined with Gemfibrozil.Approved
GlimepirideThe metabolism of Glimepiride can be decreased when combined with Gemfibrozil.Approved
GlipizideThe metabolism of Glipizide can be decreased when combined with Gemfibrozil.Approved
GliquidoneGemfibrozil may increase the hypoglycemic activities of Gliquidone.Approved
GlisoxepideGemfibrozil may increase the hypoglycemic activities of Glisoxepide.Approved
GlucosamineThe metabolism of Glucosamine can be decreased when combined with Gemfibrozil.Approved
GlyburideThe metabolism of Glyburide can be decreased when combined with Gemfibrozil.Approved
GuanfacineThe metabolism of Guanfacine can be decreased when combined with Gemfibrozil.Approved, Investigational
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Gemfibrozil.Approved
HaloperidolThe metabolism of Haloperidol can be decreased when combined with Gemfibrozil.Approved
HalothaneThe metabolism of Halothane can be decreased when combined with Gemfibrozil.Approved, Vet Approved
HexobarbitalThe metabolism of Hexobarbital can be decreased when combined with Gemfibrozil.Approved
Histamine PhosphateThe metabolism of Histamine Phosphate can be decreased when combined with Gemfibrozil.Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Gemfibrozil.Approved, Illicit
IbuprofenThe metabolism of Ibuprofen can be decreased when combined with Gemfibrozil.Approved
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Gemfibrozil.Approved
IdelalisibThe serum concentration of Gemfibrozil can be increased when it is combined with Idelalisib.Approved
IfosfamideThe metabolism of Ifosfamide can be decreased when combined with Gemfibrozil.Approved
ImatinibThe serum concentration of the active metabolites of Imatinib can be reduced when Imatinib is used in combination with Gemfibrozil resulting in a loss in efficacy.Approved
ImipramineThe metabolism of Imipramine can be decreased when combined with Gemfibrozil.Approved
IndinavirThe metabolism of Gemfibrozil can be decreased when combined with Indinavir.Approved
indisulamThe metabolism of indisulam can be decreased when combined with Gemfibrozil.Investigational
IndomethacinThe metabolism of Indomethacin can be decreased when combined with Gemfibrozil.Approved, Investigational
IrbesartanThe metabolism of Irbesartan can be decreased when combined with Gemfibrozil.Approved, Investigational
IrinotecanThe serum concentration of the active metabolites of Irinotecan can be increased when Irinotecan is used in combination with Gemfibrozil.Approved, Investigational
IsavuconazoniumThe metabolism of Gemfibrozil can be decreased when combined with Isavuconazonium.Approved, Investigational
IsradipineThe metabolism of Gemfibrozil can be decreased when combined with Isradipine.Approved
ItraconazoleThe metabolism of Gemfibrozil can be decreased when combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Gemfibrozil can be increased when it is combined with Ivacaftor.Approved
IxazomibThe metabolism of Ixazomib can be decreased when combined with Gemfibrozil.Approved
KetamineThe metabolism of Ketamine can be decreased when combined with Gemfibrozil.Approved, Vet Approved
KetobemidoneThe metabolism of Ketobemidone can be decreased when combined with Gemfibrozil.Approved
KetoconazoleThe metabolism of Gemfibrozil can be decreased when combined with Ketoconazole.Approved, Investigational
KetoprofenThe metabolism of Ketoprofen can be decreased when combined with Gemfibrozil.Approved, Vet Approved
LacosamideThe serum concentration of Lacosamide can be increased when it is combined with Gemfibrozil.Approved
LansoprazoleThe metabolism of Lansoprazole can be decreased when combined with Gemfibrozil.Approved, Investigational
LapatinibThe metabolism of Lapatinib can be decreased when combined with Gemfibrozil.Approved, Investigational
LeflunomideThe metabolism of Leflunomide can be decreased when combined with Gemfibrozil.Approved, Investigational
LesinuradThe metabolism of Lesinurad can be decreased when combined with Gemfibrozil.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Gemfibrozil.Approved
LicofeloneThe metabolism of Licofelone can be decreased when combined with Gemfibrozil.Investigational
LidocaineThe metabolism of Lidocaine can be decreased when combined with Gemfibrozil.Approved, Vet Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Gemfibrozil.Approved
LopinavirThe metabolism of Gemfibrozil can be decreased when combined with Lopinavir.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Gemfibrozil.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Gemfibrozil.Approved
LornoxicamThe metabolism of Lornoxicam can be decreased when combined with Gemfibrozil.Approved
LosartanThe metabolism of Losartan can be decreased when combined with Gemfibrozil.Approved
LovastatinGemfibrozil may increase the myopathic rhabdomyolysis activities of Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Gemfibrozil can be increased when it is combined with Luliconazole.Approved
LumacaftorThe metabolism of Gemfibrozil can be increased when combined with Lumacaftor.Approved
LumiracoxibThe metabolism of Lumiracoxib can be decreased when combined with Gemfibrozil.Approved, Investigational
MacitentanThe metabolism of Macitentan can be decreased when combined with Gemfibrozil.Approved
Mefenamic acidThe metabolism of Mefenamic acid can be decreased when combined with Gemfibrozil.Approved
MelatoninThe metabolism of Melatonin can be decreased when combined with Gemfibrozil.Approved, Nutraceutical, Vet Approved
MeloxicamThe metabolism of Meloxicam can be decreased when combined with Gemfibrozil.Approved, Vet Approved
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Gemfibrozil.Investigational, Withdrawn
MeprobamateThe metabolism of Meprobamate can be decreased when combined with Gemfibrozil.Approved, Illicit
MestranolThe metabolism of Mestranol can be decreased when combined with Gemfibrozil.Approved
MethadoneThe metabolism of Methadone can be decreased when combined with Gemfibrozil.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Gemfibrozil.Approved, Vet Approved
MethsuximideThe metabolism of Methsuximide can be decreased when combined with Gemfibrozil.Approved
MethylphenobarbitalThe metabolism of Methylphenobarbital can be decreased when combined with Gemfibrozil.Approved
MetoprololThe metabolism of Metoprolol can be decreased when combined with Gemfibrozil.Approved, Investigational
MetronidazoleThe metabolism of Metronidazole can be decreased when combined with Gemfibrozil.Approved
MifepristoneThe serum concentration of Gemfibrozil can be increased when it is combined with Mifepristone.Approved, Investigational
MirtazapineThe metabolism of Mirtazapine can be decreased when combined with Gemfibrozil.Approved
MitotaneThe serum concentration of Gemfibrozil can be decreased when it is combined with Mitotane.Approved
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Gemfibrozil.Approved
ModafinilThe serum concentration of Gemfibrozil can be decreased when it is combined with Modafinil.Approved, Investigational
MontelukastThe serum concentration of Montelukast can be increased when it is combined with Gemfibrozil.Approved
MorphineThe metabolism of Morphine can be decreased when combined with Gemfibrozil.Approved, Investigational
muraglitazarThe metabolism of muraglitazar can be decreased when combined with Gemfibrozil.Investigational
Mycophenolate mofetilThe metabolism of Mycophenolate mofetil can be decreased when combined with Gemfibrozil.Approved, Investigational
NafcillinThe serum concentration of Gemfibrozil can be decreased when it is combined with Nafcillin.Approved
NaloxoneThe metabolism of Naloxone can be decreased when combined with Gemfibrozil.Approved, Vet Approved
NaproxenThe metabolism of Naproxen can be decreased when combined with Gemfibrozil.Approved, Vet Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Gemfibrozil.Approved, Investigational
NefazodoneThe metabolism of Gemfibrozil can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe metabolism of Gemfibrozil can be decreased when combined with Nelfinavir.Approved
NetupitantThe serum concentration of Gemfibrozil can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Gemfibrozil can be increased when combined with Nevirapine.Approved
NicardipineThe metabolism of Nicardipine can be decreased when combined with Gemfibrozil.Approved
NiclosamideThe metabolism of Niclosamide can be decreased when combined with Gemfibrozil.Approved, Vet Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Gemfibrozil.Approved
NilotinibThe metabolism of Gemfibrozil can be decreased when combined with Nilotinib.Approved, Investigational
NilutamideThe metabolism of Nilutamide can be decreased when combined with Gemfibrozil.Approved
NortriptylineThe metabolism of Nortriptyline can be decreased when combined with Gemfibrozil.Approved
OlaparibThe metabolism of Gemfibrozil can be decreased when combined with Olaparib.Approved
OlodaterolThe metabolism of Olodaterol can be decreased when combined with Gemfibrozil.Approved
OmbitasvirThe serum concentration of Ombitasvir can be increased when it is combined with Gemfibrozil.Approved
OmeprazoleThe metabolism of Omeprazole can be decreased when combined with Gemfibrozil.Approved, Investigational, Vet Approved
OndansetronThe metabolism of Ondansetron can be decreased when combined with Gemfibrozil.Approved
OsimertinibThe serum concentration of Gemfibrozil can be increased when it is combined with Osimertinib.Approved
OspemifeneThe serum concentration of Ospemifene can be increased when it is combined with Gemfibrozil.Approved
OxaprozinThe metabolism of Oxaprozin can be decreased when combined with Gemfibrozil.Approved
OxiconazoleThe metabolism of Oxiconazole can be decreased when combined with Gemfibrozil.Approved
PaclitaxelThe metabolism of Paclitaxel can be decreased when combined with Gemfibrozil.Approved, Vet Approved
PalbociclibThe serum concentration of Gemfibrozil can be increased when it is combined with Palbociclib.Approved
PantoprazoleThe metabolism of Pantoprazole can be decreased when combined with Gemfibrozil.Approved
ParamethadioneThe metabolism of Paramethadione can be decreased when combined with Gemfibrozil.Approved
ParecoxibThe serum concentration of Parecoxib can be increased when it is combined with Gemfibrozil.Approved
ParitaprevirThe serum concentration of Paritaprevir can be increased when it is combined with Gemfibrozil.Approved
PazopanibThe metabolism of Pazopanib can be decreased when combined with Gemfibrozil.Approved
PentamidineThe metabolism of Pentamidine can be decreased when combined with Gemfibrozil.Approved
PentobarbitalThe metabolism of Gemfibrozil can be increased when combined with Pentobarbital.Approved, Vet Approved
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Gemfibrozil.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Gemfibrozil.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Gemfibrozil.Withdrawn
PhenindioneGemfibrozil may increase the anticoagulant activities of Phenindione.Approved
PhenobarbitalThe metabolism of Gemfibrozil can be increased when combined with Phenobarbital.Approved
PhenprocoumonGemfibrozil may increase the anticoagulant activities of Phenprocoumon.Approved
PhenylbutazoneThe metabolism of Phenylbutazone can be decreased when combined with Gemfibrozil.Approved, Vet Approved
PhenytoinThe metabolism of Gemfibrozil can be increased when combined with Phenytoin.Approved, Vet Approved
PioglitazoneThe metabolism of Pioglitazone can be decreased when combined with Gemfibrozil.Approved, Investigational
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Gemfibrozil.Approved
PiroxicamThe metabolism of Piroxicam can be decreased when combined with Gemfibrozil.Approved, Investigational
PitavastatinGemfibrozil may increase the myopathic rhabdomyolysis activities of Pitavastatin.Approved
PodofiloxThe metabolism of Podofilox can be decreased when combined with Gemfibrozil.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Gemfibrozil.Approved
PosaconazoleThe metabolism of Gemfibrozil can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
PrasugrelThe metabolism of Prasugrel can be decreased when combined with Gemfibrozil.Approved
PravastatinGemfibrozil may increase the myopathic rhabdomyolysis activities of Pravastatin.Approved
PraziquantelThe metabolism of Praziquantel can be decreased when combined with Gemfibrozil.Approved, Vet Approved
PrimidoneThe metabolism of Gemfibrozil can be increased when combined with Primidone.Approved, Vet Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Gemfibrozil.Approved, Vet Approved
ProguanilThe metabolism of Proguanil can be decreased when combined with Gemfibrozil.Approved
PromazineThe metabolism of Promazine can be decreased when combined with Gemfibrozil.Approved, Vet Approved
PropofolThe metabolism of Propofol can be decreased when combined with Gemfibrozil.Approved, Investigational, Vet Approved
PropranololThe metabolism of Propranolol can be decreased when combined with Gemfibrozil.Approved, Investigational
QuazepamThe metabolism of Quazepam can be decreased when combined with Gemfibrozil.Approved, Illicit
QuetiapineThe metabolism of Quetiapine can be decreased when combined with Gemfibrozil.Approved
QuinidineThe metabolism of Quinidine can be decreased when combined with Gemfibrozil.Approved
QuinineThe metabolism of Quinine can be decreased when combined with Gemfibrozil.Approved
RabeprazoleThe metabolism of Rabeprazole can be decreased when combined with Gemfibrozil.Approved, Investigational
RaltegravirRaltegravir may increase the myopathic rhabdomyolysis activities of Gemfibrozil.Approved
RamelteonThe serum concentration of Ramelteon can be increased when it is combined with Gemfibrozil.Approved, Investigational
RanitidineThe metabolism of Ranitidine can be decreased when combined with Gemfibrozil.Approved
RanolazineThe metabolism of Gemfibrozil can be decreased when combined with Ranolazine.Approved, Investigational
RepaglinideThe serum concentration of Repaglinide can be increased when it is combined with Gemfibrozil.Approved, Investigational
RifabutinThe metabolism of Gemfibrozil can be increased when combined with Rifabutin.Approved
RifampicinThe metabolism of Gemfibrozil can be increased when combined with Rifampicin.Approved
RifapentineThe metabolism of Gemfibrozil can be increased when combined with Rifapentine.Approved
RiociguatThe metabolism of Riociguat can be decreased when combined with Gemfibrozil.Approved
RitonavirThe serum concentration of Ritonavir can be increased when it is combined with Gemfibrozil.Approved, Investigational
RofecoxibThe metabolism of Rofecoxib can be decreased when combined with Gemfibrozil.Investigational, Withdrawn
RomidepsinThe metabolism of Romidepsin can be decreased when combined with Gemfibrozil.Approved, Investigational
RosiglitazoneThe metabolism of Rosiglitazone can be decreased when combined with Gemfibrozil.Approved, Investigational
RosuvastatinGemfibrozil may increase the myopathic rhabdomyolysis activities of Rosuvastatin.Approved
Salicylic acidThe metabolism of Salicylic acid can be decreased when combined with Gemfibrozil.Approved, Vet Approved
SaquinavirThe metabolism of Gemfibrozil can be decreased when combined with Saquinavir.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Gemfibrozil.Approved
SelegilineThe metabolism of Selegiline can be decreased when combined with Gemfibrozil.Approved, Investigational, Vet Approved
SelexipagThe metabolism of Selexipag can be decreased when combined with Gemfibrozil.Approved
SeratrodastThe metabolism of Seratrodast can be decreased when combined with Gemfibrozil.Approved, Investigational
SertralineThe metabolism of Sertraline can be decreased when combined with Gemfibrozil.Approved
SildenafilThe metabolism of Sildenafil can be decreased when combined with Gemfibrozil.Approved, Investigational
SiltuximabThe serum concentration of Gemfibrozil can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Gemfibrozil can be increased when it is combined with Simeprevir.Approved
SimvastatinGemfibrozil may increase the myopathic rhabdomyolysis activities of Simvastatin.Approved
SitagliptinThe metabolism of Sitagliptin can be decreased when combined with Gemfibrozil.Approved, Investigational
SitaxentanThe metabolism of Sitaxentan can be decreased when combined with Gemfibrozil.Approved, Investigational, Withdrawn
SorafenibThe metabolism of Sorafenib can be decreased when combined with Gemfibrozil.Approved, Investigational
St. John's WortThe serum concentration of Gemfibrozil can be decreased when it is combined with St. John's Wort.Nutraceutical
StiripentolThe serum concentration of Gemfibrozil can be increased when it is combined with Stiripentol.Approved
SulfadiazineThe metabolism of Sulfadiazine can be decreased when combined with Gemfibrozil.Approved, Vet Approved
SulfamethoxazoleThe metabolism of Sulfamethoxazole can be decreased when combined with Gemfibrozil.Approved
SulfamoxoleThe metabolism of Sulfamoxole can be decreased when combined with Gemfibrozil.Approved
SulfinpyrazoneThe metabolism of Sulfinpyrazone can be decreased when combined with Gemfibrozil.Approved
SulfisoxazoleThe metabolism of Sulfisoxazole can be decreased when combined with Gemfibrozil.Approved, Vet Approved
SuprofenThe metabolism of Suprofen can be decreased when combined with Gemfibrozil.Approved, Withdrawn
TamoxifenThe metabolism of Tamoxifen can be decreased when combined with Gemfibrozil.Approved
TapentadolThe metabolism of Tapentadol can be decreased when combined with Gemfibrozil.Approved
TazaroteneThe metabolism of Tazarotene can be decreased when combined with Gemfibrozil.Approved, Investigational
TelaprevirThe metabolism of Gemfibrozil can be decreased when combined with Telaprevir.Approved
TelithromycinThe metabolism of Gemfibrozil can be decreased when combined with Telithromycin.Approved
TemazepamThe metabolism of Temazepam can be decreased when combined with Gemfibrozil.Approved
TeniposideThe metabolism of Teniposide can be decreased when combined with Gemfibrozil.Approved
TenoxicamThe metabolism of Tenoxicam can be decreased when combined with Gemfibrozil.Approved
TerbinafineThe metabolism of Terbinafine can be decreased when combined with Gemfibrozil.Approved, Investigational, Vet Approved
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Gemfibrozil.Withdrawn
TestosteroneThe metabolism of Testosterone can be decreased when combined with Gemfibrozil.Approved, Investigational
ThalidomideThe metabolism of Thalidomide can be decreased when combined with Gemfibrozil.Approved, Investigational, Withdrawn
TheophyllineThe metabolism of Theophylline can be decreased when combined with Gemfibrozil.Approved
ThiamylalThe metabolism of Thiamylal can be decreased when combined with Gemfibrozil.Approved, Vet Approved
ThioridazineThe metabolism of Thioridazine can be decreased when combined with Gemfibrozil.Approved
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Gemfibrozil.Approved
TimololThe metabolism of Timolol can be decreased when combined with Gemfibrozil.Approved
TipranavirThe metabolism of Tipranavir can be decreased when combined with Gemfibrozil.Approved, Investigational
TocilizumabThe serum concentration of Gemfibrozil can be decreased when it is combined with Tocilizumab.Approved
TofacitinibThe metabolism of Tofacitinib can be decreased when combined with Gemfibrozil.Approved, Investigational
TolazamideGemfibrozil may increase the hypoglycemic activities of Tolazamide.Approved
TolbutamideThe metabolism of Tolbutamide can be decreased when combined with Gemfibrozil.Approved
TolterodineThe metabolism of Tolterodine can be decreased when combined with Gemfibrozil.Approved, Investigational
TorasemideThe metabolism of Torasemide can be decreased when combined with Gemfibrozil.Approved
TrabectedinThe metabolism of Trabectedin can be decreased when combined with Gemfibrozil.Approved, Investigational
TreprostinilThe serum concentration of Treprostinil can be increased when it is combined with Gemfibrozil.Approved, Investigational
TretinoinThe metabolism of Tretinoin can be decreased when combined with Gemfibrozil.Approved, Investigational, Nutraceutical
TrimethadioneThe metabolism of Trimethadione can be decreased when combined with Gemfibrozil.Approved
TrimethoprimThe metabolism of Trimethoprim can be decreased when combined with Gemfibrozil.Approved, Vet Approved
TrimipramineThe metabolism of Trimipramine can be decreased when combined with Gemfibrozil.Approved
TroglitazoneThe metabolism of Troglitazone can be decreased when combined with Gemfibrozil.Withdrawn
Ursodeoxycholic acidThe therapeutic efficacy of Ursodeoxycholic acid can be decreased when used in combination with Gemfibrozil.Approved, Investigational
ValdecoxibThe metabolism of Valdecoxib can be decreased when combined with Gemfibrozil.Investigational, Withdrawn
Valproic AcidThe metabolism of Valproic Acid can be decreased when combined with Gemfibrozil.Approved, Investigational
ValsartanThe metabolism of Valsartan can be decreased when combined with Gemfibrozil.Approved, Investigational
VenlafaxineThe metabolism of Venlafaxine can be decreased when combined with Gemfibrozil.Approved
VerapamilThe metabolism of Verapamil can be decreased when combined with Gemfibrozil.Approved
VicrivirocThe metabolism of Vicriviroc can be decreased when combined with Gemfibrozil.Investigational
VismodegibThe metabolism of Vismodegib can be decreased when combined with Gemfibrozil.Approved
VoriconazoleThe metabolism of Gemfibrozil can be decreased when combined with Voriconazole.Approved, Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Gemfibrozil.Approved
WarfarinThe metabolism of Warfarin can be decreased when combined with Gemfibrozil.Approved
XimelagatranThe metabolism of Ximelagatran can be decreased when combined with Gemfibrozil.Approved, Investigational, Withdrawn
ZafirlukastThe metabolism of Zafirlukast can be decreased when combined with Gemfibrozil.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Gemfibrozil.Approved
ZaltoprofenThe metabolism of Zaltoprofen can be decreased when combined with Gemfibrozil.Approved
ZidovudineThe metabolism of Zidovudine can be decreased when combined with Gemfibrozil.Approved
ZileutonThe metabolism of Zileuton can be decreased when combined with Gemfibrozil.Approved, Investigational, Withdrawn
ZiprasidoneThe metabolism of Gemfibrozil can be decreased when combined with Ziprasidone.Approved
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Gemfibrozil.Approved
ZopicloneThe metabolism of Zopiclone can be decreased when combined with Gemfibrozil.Approved
Food Interactions
  • Take 30 minutes before meals.
References
Synthesis Reference

Gianfranco Piccoli, Antonio Tarquini, Giovanni Frare, “Process for the preparation of gemfibrozil.” U.S. Patent US5654476, issued May, 1980.

US5654476
General ReferencesNot Available
External Links
ATC CodesC10AB04
AHFS Codes
  • 24:06.06
PDB EntriesNot Available
FDA labelDownload (260 KB)
MSDSDownload (74.3 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.977
Blood Brain Barrier+0.9213
Caco-2 permeable+0.7918
P-glycoprotein substrateSubstrate0.5597
P-glycoprotein inhibitor INon-inhibitor0.8943
P-glycoprotein inhibitor IINon-inhibitor0.8839
Renal organic cation transporterNon-inhibitor0.8177
CYP450 2C9 substrateNon-substrate0.7512
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.6973
CYP450 1A2 substrateInhibitor0.9106
CYP450 2C9 inhibitorInhibitor0.8949
CYP450 2D6 inhibitorNon-inhibitor0.9231
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8234
Ames testNon AMES toxic0.7822
CarcinogenicityNon-carcinogens0.8314
BiodegradationNot ready biodegradable0.6759
Rat acute toxicity2.2167 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9774
hERG inhibition (predictor II)Non-inhibitor0.8701
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
TabletOral600 mg
CapsuleOral300 mg
TabletOral600 mg/1
Tablet, coatedOral600 mg/1
Tablet, film coatedOral600 mg/1
Prices
Unit descriptionCostUnit
Gemfibrozil powder2.88USD g
Lopid 600 mg tablet2.07USD tablet
Gemfibrozil 600 mg tablet1.8USD tablet
Apo-Gemfibrozil 600 mg Tablet0.65USD tablet
Mylan-Gemfibrozil 600 mg Tablet0.65USD tablet
Novo-Gemfibrozil 600 mg Tablet0.65USD tablet
Nu-Gemfibrozil 600 mg Tablet0.65USD tablet
Pms-Gemfibrozil 600 mg Tablet0.65USD tablet
Lopid 300 mg Capsule0.58USD capsule
Apo-Gemfibrozil 300 mg Capsule0.31USD capsule
Mylan-Gemfibrozil 300 mg Capsule0.31USD capsule
Novo-Gemfibrozil 300 mg Capsule0.31USD capsule
Nu-Gemfibrozil 300 mg Capsule0.31USD capsule
Pms-Gemfibrozil 300 mg Capsule0.31USD capsule
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point62 °CPhysProp
boiling point158.5 °C at 2.00E-02 mm HgPhysProp
water solubility10 mg/mL (in base)Not Available
logP3.4Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0278 mg/mLALOGPS
logP3.61ALOGPS
logP4.39ChemAxon
logS-4ALOGPS
pKa (Strongest Acidic)4.42ChemAxon
pKa (Strongest Basic)-4.8ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area46.53 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity71.82 m3·mol-1ChemAxon
Polarizability28.9 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
1D NMR1H NMR SpectrumNot Available
1D NMR13C NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring.
KingdomOrganic compounds
Super ClassBenzenoids
ClassBenzene and substituted derivatives
Sub ClassPhenol ethers
Direct ParentPhenol ethers
Alternative Parents
Substituents
  • Phenol ether
  • Alkyl aryl ether
  • Monocarboxylic acid or derivatives
  • Ether
  • Carboxylic acid
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aromatic homomonocyclic compound
Molecular FrameworkAromatic homomonocyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Zinc ion binding
Specific Function:
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fa...
Gene Name:
PPARA
Uniprot ID:
Q07869
Molecular Weight:
52224.595 Da
References
  1. Clavey V, Copin C, Mariotte MC, Bauge E, Chinetti G, Fruchart J, Fruchart JC, Dallongeville J, Staels B: Cell culture conditions determine apolipoprotein CIII secretion and regulation by fibrates in human hepatoma HepG2 cells. Cell Physiol Biochem. 1999;9(3):139-49. [PubMed:10494028 ]
  2. Bosse Y, Pascot A, Dumont M, Brochu M, Prud'homme D, Bergeron J, Despres JP, Vohl MC: Influences of the PPAR alpha-L162V polymorphism on plasma HDL(2)-cholesterol response of abdominally obese men treated with gemfibrozil. Genet Med. 2002 Jul-Aug;4(4):311-5. [PubMed:12172398 ]
  3. Pahan K, Jana M, Liu X, Taylor BS, Wood C, Fischer SM: Gemfibrozil, a lipid-lowering drug, inhibits the induction of nitric-oxide synthase in human astrocytes. J Biol Chem. 2002 Nov 29;277(48):45984-91. Epub 2002 Sep 18. [PubMed:12244038 ]
  4. Shoji Y, Sanekata A, Sato M, Imaizumi K: Preparation of antiserum against rat delta6-desaturase and its use to evaluate the desaturase protein levels in rats treated with gemfibrozil, a ligand for peroxisome proliferator-activated receptor alpha. Biosci Biotechnol Biochem. 2003 May;67(5):1177-8. [PubMed:12834305 ]
  5. Rizvi F, Iftikhar M, George JP: Beneficial effects of fish liver preparations of sea bass (Lates calcarifer) versus gemfibrozil in high fat diet-induced lipid-intolerant rats. J Med Food. 2003 Summer;6(2):123-8. [PubMed:12935323 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitorinducer
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Honkalammi J, Niemi M, Neuvonen PJ, Backman JT: Gemfibrozil is a strong inactivator of CYP2C8 in very small multiple doses. Clin Pharmacol Ther. 2012 May;91(5):846-55. doi: 10.1038/clpt.2011.313. [PubMed:22472994 ]
  3. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular Weight:
55930.545 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular Weight:
76447.99 Da
References
  1. Sharma P, Holmes VE, Elsby R, Lambert C, Surry D: Validation of cell-based OATP1B1 assays to assess drug transport and the potential for drug-drug interaction to support regulatory submissions. Xenobiotica. 2010 Jan;40(1):24-37. doi: 10.3109/00498250903351013. [PubMed:19919292 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23