Stannous chloride

Identification

Name
Stannous chloride
Accession Number
DB11056
Type
Small Molecule
Groups
Approved
Description

Stannous chloride is used as a source of tin in radiopharmaceutical kits. Tin reduces technetium-99m, the active radiological agent, allowing it to form a complex with phosphate-containing moeities [1]. These complexes localize primarily in bone (40-50%) and infracted myocardium (0.01-0.02%/g of tissue) allowing for imaging of areas of altered osteogenesis or necrotic heart tissue [Label].

Structure
Thumb
Synonyms
  • Stannous chloride anhydrous
  • Stannous chloride,anhydrous
  • Tin dichloride
Product Ingredients
IngredientUNIICASInChI Key
Stannous chloride dihydrate1BQV3749L510025-69-1FWPIDFUJEMBDLS-UHFFFAOYSA-L
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ultratag RBCKit0.05 mg/9.5mgMallinckrodt Nuclear Medicine Llc1991-06-10Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
High Potency Multivitamins & Minerals CapletsStannous chloride (0.01 mg) + Ascorbic acid (100 mg) + Beta carotene (2500 unit) + Biotin (45 mcg) + Calcium (175 mg) + Calcium phosphate, dibasic (125 mg) + Cholecalciferol (400 unit) + Chromic chloride (50 mcg) + Cupric sulfate (2 mg) + Cyanocobalamin (9 mcg) + Ferrous fumarate (10 mg) + Folic Acid (0.4 mg) + Magnesium (100 mg) + Manganese (5 mg) + Nickel sulfate (5 mcg) + Nicotinamide (40 mg) + Pantothenic acid (10 mg) + Potassium (55 mg) + Potassium Chloride (50 mg) + Potassium Iodide (0.15 mg) + Pyridoxine hydrochloride (4 mg) + Riboflavin (3.4 mg) + Sodium selenate (50 mcg) + Silicon (0.01 mg) + Sodium metavanadate (10 mcg) + Sodium molybdate (50 mcg) + Thiamine mononitrate (3 mg) + Vitamin A (3500 unit) + Zinc (20 mg) + alpha-Tocopherol acetate (50 unit)TabletOralAshbury Research CorporationNot applicableNot applicableCanada
Multivitamins and Minerals TabletsStannous chloride (0.010 mg) + Ascorbic acid (120 mg) + Beta carotene (1000 unit) + Biotin (40 mcg) + Calcium (162 mg) + Calcium Phosphate (125 mg) + Cholecalciferol (400 unit) + Chromic chloride (120 mcg) + Cupric sulfate (2 mg) + Cyanocobalamin (18 mcg) + Ferrous fumarate (15 mg) + Folic Acid (0.4 mg) + Magnesium (50 mg) + Manganese (4 mg) + Nickel sulfate (5 mcg) + Nicotinamide (40 mg) + Calcium pantothenate (10 mg) + Potassium (80 mg) + Potassium Chloride (72 mg) + Potassium Iodide (0.150 mg) + Pyridoxine hydrochloride (6 mg) + Riboflavin (5.1 mg) + Sodium selenite (70 mcg) + Silicon (4 mg) + Sodium metavanadate (10 mcg) + Sodium molybdate (50 mcg) + Thiamine mononitrate (4.5 mg) + Vitamin A (4000 unit) + Zinc (15 mg) + alpha-Tocopherol acetate (60 unit)TabletOralPharmetics (2011) Inc.2004-06-032009-07-30Canada
Spectrum Performa Multivitamins and Minerals TabletsStannous chloride (0.01 mg) + Ascorbic acid (120 mg) + Beta carotene (1000 unit) + Biotin (40 mcg) + Calcium (162 mg) + Calcium Phosphate (125 mg) + Cholecalciferol (400 unit) + Chromic chloride (120 mcg) + Cupric sulfate (2 mg) + Cyanocobalamin (18 mcg) + Ferrous fumarate (18 mg) + Folic Acid (0.4 mg) + Magnesium (50 mg) + Manganese (4 mg) + Nickel sulfate (5 mcg) + Nicotinamide (40 mg) + Calcium pantothenate (10 mg) + Potassium (80 mg) + Potassium Chloride (72 mg) + Potassium Iodide (0.15 mg) + Pyridoxine hydrochloride (6 mg) + Riboflavin (5.1 mg) + Sodium selenite (70 mcg) + Silicon (4 mg) + Sodium metavanadate (10 mcg) + Sodium molybdate (50 mcg) + Thiamine mononitrate (4.5 mg) + Vitamin A (4000 unit) + Zinc (15 mg) + alpha-Tocopherol acetate (60 unit)TabletOralPharmetics (2011) Inc.2003-03-122009-07-30Canada
Technescan PYPStannous chloride dihydrate (3.2 mg/10mL) + Technetium Tc-99m pyrophosphate (11.9 mg/10mL)Injection, powder, lyophilized, for solutionIntravenousMallinckrodt2009-03-202017-07-01Us
Technescan PYPStannous chloride dihydrate (3.2 mg/10mL) + Sodium pyrophosphate (11.9 mg/10mL)Injection, powder, lyophilized, for solutionIntravenousMallinckrodt Nuclear Medicine Llc2015-10-14Not applicableUs
Categories
Not Available
UNII
R30H55TN67
CAS number
7772-99-8
Weight
Average: 189.62
Monoisotopic: 189.839901985
Chemical Formula
Cl2Sn
InChI Key
AXZWODMDQAVCJE-UHFFFAOYSA-L
InChI
InChI=1S/2ClH.Sn/h2*1H;/q;;+2/p-2
IUPAC Name
λ²-tin(2+) ion dichloride
SMILES
[Cl-].[Cl-].[Sn++]

Pharmacology

Indication

Stannous chloride is a component of technetium-99m agents indicated for imaging of the skeleton for areas of altered osteogenesis or in the detection of infarcted heart tissue [Label].

Associated Conditions
Pharmacodynamics

Stannous chloride itself is not known to produce a pharmacological effect at the dosages used clinically.

Mechanism of action

Stannous chloride acts as a reducing agent for technetium-99m allowing formation of a Tc99m-Sn-pyrophosphate complex in combination sodium pyrophosphate [1]. See Technetium Tc-99m pyrophosphate for information on the active agent.

Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. Thrall JH: Technetium-99m labeled agents for skeletal imaging. CRC Crit Rev Clin Radiol Nucl Med. 1976;8(1):1-31. [PubMed:789010]
External Links
ChemSpider
22887
ChEBI
78067
Wikipedia
Tin(II)_chloride
FDA label
Download (105 KB)
MSDS
Download (50.4 KB)

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
TabletOral
Injection, powder, lyophilized, for solutionIntravenous
Kit0.05 mg/9.5mg
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)38MSDS
water solubilityFreely solubleMSDS
Predicted Properties
PropertyValueSource
Water Solubility65.4 mg/mLALOGPS
logP0.66ALOGPS
logP0.61ChemAxon
logS-0.46ALOGPS
pKa (Strongest Acidic)-7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity5.62 m3·mol-1ChemAxon
Polarizability2.39 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as post-transition metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is a post-transition metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Post-transition metal salts
Sub Class
Post-transition metal chlorides
Direct Parent
Post-transition metal chlorides
Alternative Parents
Inorganic tin salts / Inorganic chloride salts
Substituents
Post-transition metal chloride / Inorganic chloride salt / Inorganic tin salt / Inorganic salt
Molecular Framework
Not Available
External Descriptors
inorganic chloride, tin molecular entity (CHEBI:78067)

Drug created on December 03, 2015 09:51 / Updated on November 02, 2018 09:12