Identification

Name
Cupric sulfate
Accession Number
DB06778
Type
Small Molecule
Groups
Approved
Description

Cupric sulfate is a salt created by treating cupric oxide with sulfuric acid. This forms as large, bright blue crystals containing five molecules of water (CuSO4∙5H2O) and is also known as blue vitriol. The anhydrous salt is created by heating the hydrate to 150 °C (300 °F). Cupric sulfate is used primarily for agricultural purposes, as a pesticide, germicide, feed additive, and soil additive. Some of its secondary uses are as a raw material in the preparation of other copper compounds, as a reagent in analytic chemistry, as an electrolyte for batteries and electroplating baths, and in medical practice as a locally applied fungicide, bactericide, and astringent [9].

Copper is an essential trace element and an important catalyst for heme synthesis and iron absorption. After zinc and iron, copper is the third most abundant trace element found in the human body. Copper is a noble metal and its properties include high thermal and electrical conductivity, low corrosion, alloying ability, and malleability. Copper is a component of intrauterine contraceptive devices (IUD) and the release of copper is necessary for their important contraceptive effects. The average daily intake of copper in the USA is approximately 1 mg Cu with the diet being a primary source [5].

Interestingly, the dysregulation of copper has been studied with a focus on neurodegenerative diseases, such as Wilson’s disease, Alzheimer’s disease, and Parkinson’s disease. Data from clinical observations of the neurotoxic effects of copper may provide the basis for future treatments affecting copper and its homeostasis [15].

Structure
Thumb
Synonyms
  • Copper monosulfate
  • Copper monosulphate
  • Copper sulfate
  • Copper sulfate (1:1)
  • Copper sulphate
  • Copper(2+) sulfate
  • Copper(II) sulphate
  • Cupric sulfate anhydrous
  • Cupric sulfate, anhydrous
  • Cupric sulphate anhydrous
  • Cupric sulphate, anhydrous
Product Ingredients
IngredientUNIICASInChI Key
Cupric sulfate pentahydrateLRX7AJ16DT7758-99-8JZCCFEFSEZPSOG-UHFFFAOYSA-L
Active Moieties
NameKindUNIICASInChI Key
Copperunknown789U1901C57440-50-8RYGMFSIKBFXOCR-UHFFFAOYSA-N
Sulfate ionionic7IS9N8KPMG14808-79-8QAOWNCQODCNURD-UHFFFAOYSA-L
Cupric cationionicFV4Y0JO2CX15158-11-9JPVYNHNXODAKFH-UHFFFAOYSA-N
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Eau Resolutive SokerCupric sulfate (28.925 mg) + Camphor (.715 mg) + Methylene blue (.1365 mg) + Resorcinol (58.565 mg) + Zinc sulfate (88.4 mg)LiquidTopicalProduits Francais Labs Inc.1930-12-311997-05-30Canada
High Potency Multivitamins & Minerals CapletsCupric sulfate (2 mg) + Ascorbic acid (100 mg) + Beta carotene (2500 unit) + Biotin (45 mcg) + Calcium (175 mg) + Calcium phosphate, dibasic (125 mg) + Cholecalciferol (400 unit) + Chromic chloride (50 mcg) + Cyanocobalamin (9 mcg) + Ferrous fumarate (10 mg) + Folic Acid (0.4 mg) + Magnesium (100 mg) + Manganese (5 mg) + Nickel sulfate (5 mcg) + Nicotinamide (40 mg) + Pantothenic acid (10 mg) + Potassium (55 mg) + Potassium Chloride (50 mg) + Potassium Iodide (0.15 mg) + Pyridoxine hydrochloride (4 mg) + Riboflavin (3.4 mg) + Sodium selenate (50 mcg) + Silicon (0.01 mg) + Sodium metavanadate (10 mcg) + Sodium molybdate (50 mcg) + Stannous chloride (0.01 mg) + Thiamine mononitrate (3 mg) + Vitamin A (3500 unit) + Zinc (20 mg) + alpha-Tocopherol acetate (50 unit)TabletOralAshbury Research CorporationNot applicableNot applicableCanada
Multiple Vitamins & Minerals TabletsCupric sulfate (2 mg) + Ascorbic acid (60 mg) + Calcium (160 mg) + Calcium Phosphate (125 mg) + Cholecalciferol (400 unit) + Cyanocobalamin (6 mcg) + Ferrous fumarate (5 mg) + Folic Acid (0.1 mg) + Magnesium (100 mg) + Nicotinamide (20 mg) + Calcium pantothenate (10 mg) + Pyridoxine hydrochloride (2 mg) + Riboflavin (1.7 mg) + Thiamine mononitrate (1.5 mg) + Vitamin A palmitate (5000 unit) + alpha-Tocopherol acetate (10 unit)TabletOralPharmetics (2011) Inc.2002-12-182006-07-27Canada
Multiple Vitamins With Minerals TabletsCupric sulfate (1 mg) + Ascorbic acid (75 mg) + Calcium (125 mg) + Cyanocobalamin (3 mcg) + Ferrous fumarate (4 mg) + Nicotinamide (25 mg) + Calcium pantothenate (5 mg) + Potassium Iodide (0.15 mg) + Pyridoxine hydrochloride (1 mg) + Riboflavin (5 mg) + Thiamine mononitrate (3 mg) + Vitamin A (10000 unit) + Vitamin D (400 unit)TabletOralPharmetics (2011) Inc.1999-07-162009-07-30Canada
Multivitamines Et MinerauxCupric sulfate (1 mg) + Ascorbic acid (75 mg) + Calcium (125 mg) + Cyanocobalamin (3 mcg) + Ferrous sulfate (5 mg) + Nicotinamide (25 mg) + Pantothenic acid (5 mg) + Potassium Iodide (0.15 mg) + Pyridoxine hydrochloride (1 mg) + Riboflavin (5 mg) + Thiamine mononitrate (3 mg) + Vitamin A (10000 unit) + Vitamin D (400 unit)TabletOralLe Groupe M. Vachon Inc.Not applicableNot applicableCanada
Multivitamins and Minerals TabletsCupric sulfate (2 mg) + Ascorbic acid (120 mg) + Beta carotene (1000 unit) + Biotin (40 mcg) + Calcium (162 mg) + Calcium Phosphate (125 mg) + Cholecalciferol (400 unit) + Chromic chloride (120 mcg) + Cyanocobalamin (18 mcg) + Ferrous fumarate (15 mg) + Folic Acid (0.4 mg) + Magnesium (50 mg) + Manganese (4 mg) + Nickel sulfate (5 mcg) + Nicotinamide (40 mg) + Calcium pantothenate (10 mg) + Potassium (80 mg) + Potassium Chloride (72 mg) + Potassium Iodide (0.150 mg) + Pyridoxine hydrochloride (6 mg) + Riboflavin (5.1 mg) + Sodium selenite (70 mcg) + Silicon (4 mg) + Sodium metavanadate (10 mcg) + Sodium molybdate (50 mcg) + Stannous chloride (0.010 mg) + Thiamine mononitrate (4.5 mg) + Vitamin A (4000 unit) + Zinc (15 mg) + alpha-Tocopherol acetate (60 unit)TabletOralPharmetics (2011) Inc.2004-06-032009-07-30Canada
One A Day Advance AdultsCupric sulfate (2 mg) + Ascorbic acid (60 mg) + Beta carotene (2500 unit) + Biotin (30 mcg) + Calcium (130 mg) + Chromium (10 mcg) + Cyanocobalamin (6 mcg) + Ferrous fumarate (18 mg) + Folic Acid (0.4 mg) + Magnesium (100 mg) + Manganese (2.5 mg) + Molybdenum (10 mcg) + Niacin (20 mg) + Calcium pantothenate (10 mg) + Potassium (37.5 mg) + Potassium Chloride (34 mg) + Potassium Iodide (0.15 mg) + Pyridoxine (2 mg) + Riboflavin (1.7 mg) + Selenium (10 mcg) + Thiamine mononitrate (1.5 mg) + Vitamin A (2500 unit) + Vitamin D (400 unit) + Zinc (15 mg) + alpha-Tocopherol acetate (30 unit)TabletOralBayer Inc Consumer Care2002-09-122007-08-02Canada
One A Day Advance Adults 50+Cupric sulfate (2 mg) + Ascorbic acid (120 mg) + Beta carotene (3000 unit) + Biotin (30 mcg) + Calcium (220 mg) + Chromium (10 mcg) + Cyanocobalamin (25 mcg) + Folic Acid (0.4 mg) + Magnesium (100 mg) + Manganese (2.5 mg) + Molybdenum (10 mcg) + Niacin (20 mg) + Calcium pantothenate (20 mg) + Potassium (37.5 mg) + Potassium Chloride (34 mg) + Potassium Iodide (0.15 mg) + Pyridoxine hydrochloride (6 mg) + Riboflavin (3.4 mg) + Selenium (10 mcg) + Thiamine mononitrate (4.5 mg) + Vitamin A (3000 unit) + Vitamin D (400 unit) + Vitamin E (60 unit) + Zinc (15 mg)TabletOralBayer Inc Consumer Care2002-09-122007-08-02Canada
One-A-day Advance Men'sCupric sulfate (2 mg) + Ascorbic acid (90 mg) + Beta carotene (1000 unit) + Chromic chloride (150 mcg) + Cyanocobalamin (9 mcg) + Folic Acid (0.4 mg) + Magnesium (100 mg) + Manganese (3.3 mg) + Niacin (20 mg) + Calcium pantothenate (10 mg) + Potassium (37.5 mg) + Potassium Chloride (34 mg) + Potassium Iodide (0.15 mg) + Pyridoxine (3 mg) + Riboflavin (2.55 mg) + Sodium selenate (87.5 mcg) + Sodium molybdate (41.7 mcg) + Thiamine mononitrate (2.25 mg) + Vitamin A (4000 unit) + Vitamin D (400 unit) + Zinc (15 mg) + alpha-Tocopherol acetate (45 unit)TabletOralBayer Inc Consumer Care2000-08-012002-02-06Canada
Prenatal Vitamin and Mineral Supplement TabCupric sulfate (2 mg) + Ascorbic acid (100 mg) + Beta carotene (1500 unit) + Biotin (30 mcg) + Calcium Carbonate (250 mg) + Chromic chloride (25 mcg) + Cyanocobalamin (12 mcg) + DL-alpha tocopheryl acetate (30 unit) + Ferrous fumarate (60 mg) + Folic Acid (1 mg) + Manganese sulfate (5 mg) + Nicotinamide (20 mg) + Calcium pantothenate (10 mg) + Potassium Iodide (.15 mg) + Pyridoxine hydrochloride (10 mg) + Riboflavin (3.4 mg) + Sodium molybdate (25 mcg) + Thiamine mononitrate (3 mg) + Vitamin A acetate (1500 unit) + Vitamin D (250 unit) + Zinc sulfate (25 mg)TabletOralKsl Pharmaceuticals1993-12-311996-09-09Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Active OBCupric sulfate pentahydrate (2 mg/1) + Ascorbic acid (100 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (30 ug/1) + D-alpha-Tocopherol acetate (30 [iU]/1) + Doconexent (320 mg/1) + Folic Acid (1 mg/1) + Iron (20 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (4 mg/1) + Thiamine mononitrate (2 mg/1) + Zinc oxide (30 mg/1)Capsule, liquid filledOralGm Pharmaceuticals2013-10-282017-03-31Us
C-Nate DHACupric sulfate pentahydrate (1 mg/1) + Ascorbic acid (100 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (15 ug/1) + Ferrous fumarate (28 mg/1) + Folic Acid (1 mg/1) + Magnesium (30 mg/1) + Omega-3 fatty acids (200 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3 mg/1) + Thiamine mononitrate (3 mg/1) + Vitamin E (30 [iU]/1) + Zinc oxide (20 mg/1)Capsule, gelatin coatedOralCenturion Labs2013-01-01Not applicableUs
Cavan Heme OBCupric sulfate pentahydrate (0.8 mg/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (12 ug/1) + Folic Acid (1 mg/1) + Iron (28 mg/1) + Niacin (17 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (175 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Sodium selenate (65 ug/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (15 mg/1) + alpha-Tocopherol succinate (10 [iU]/1)TabletOralSeton Pharmaceuticals2010-08-032012-06-10Us
CentratexCupric sulfate (0.8 mg/1) + Cyanocobalamin (15 ug/1) + Folic Acid (1 mg/1) + Iron (106 mg/1) + Magnesium sulfate (6.9 mg/1) + Manganese sulfate (1.3 mg/1) + Nicotinamide (30 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (5 mg/1) + Riboflavin (6 mg/1) + Sodium ascorbate (200 mg/1) + Thiamine mononitrate (10 mg/1) + Zinc sulfate, unspecified form (18.2 mg/1)CapsuleOralCenturion Labs2009-06-14Not applicableUs
Concept DHACupric sulfate pentahydrate (2 mg/1) + Ascorbic acid (25 mg/1) + Biotin (300 ug/1) + Cyanocobalamin (12.5 ug/1) + Ferrous fumarate (53.5 mg/1) + Folic Acid (1 mg/1) + Iron (38 mg/1) + Magnesium sulfate (5 mg/1) + Niacin (1.8 mg/1) + Omega-3-acid ethyl esters (200 mg/1) + Calcium pantothenate (5 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (3 mg/1) + Thiamine mononitrate (2 mg/1) + Zinc sulfate, unspecified form (10 mg/1)Capsule, liquid filledOralUs Pharmaceutical Corporation2009-06-24Not applicableUs
Concept OBCupric sulfate pentahydrate (800 ug/1) + Ascorbic acid (210 mg/1) + Biotin (300 ug/1) + Cyanocobalamin (10 ug/1) + Ferrous fumarate (130 mg/1) + Folic Acid (1 mg/1) + Iron (92.4 mg/1) + Magnesium sulfate (6.9 mg/1) + Manganese sulfate (1.3 mg/1) + Niacin (20 mg/1) + Calcium pantothenate (7 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (5 mg/1) + Thiamine mononitrate (5 mg/1) + Zinc sulfate, unspecified form (18.2 mg/1)CapsuleOralUs Pharmaceutical Corporation2009-01-01Not applicableUs
Cupric SulfateCupric sulfate pentahydrate (1.57 mg/1mL)Injection, solutionIntravenousAmerican Regent1990-09-302017-02-28Us
HemeNatal OBCupric sulfate pentahydrate (.8 mg/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (12 ug/1) + Folic Acid (1 mg/1) + Heme iron polypeptide (6 mg/1) + Iron saccharate (28 mg/1) + Nicotinamide (17 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (250 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Sodium selenate (65 ug/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (4.5 mg/1) + alpha-Tocopherol succinate (10 [iU]/1)TabletOralWh Nutritionals, Llc2012-03-08Not applicableUs
HemeNatal OB plus DHACupric sulfate pentahydrate (0.8 mg/1) + Alpha-Linolenic Acid (.5 mg/1) + Biotin (30 ug/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (12 ug/1) + Doconexent (200 mg/1) + Folic Acid (1 mg/1) + Heme iron polypeptide (6 mg/1) + Iron saccharate (28 mg/1) + Nicotinamide (17 mg/1) + Osbond acid (2.5 mg/1) + Calcium pantothenate (10 mg/1) + Potassium Iodide (250 ug/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.6 mg/1) + Sodium selenate (65 ug/1) + Thiamine mononitrate (1.5 mg/1) + Zinc oxide (4.5 mg/1) + alpha-Tocopherol succinate (10 [iU]/1)KitWh Nutritionals, Llc2012-03-08Not applicableUs
Multitrace -4Cupric sulfate pentahydrate (3.93 mg/1mL) + Chromic chloride hexahydrate (51.3 ug/1mL) + Manganese sulfate (1.54 mg/1mL) + Zinc sulfate heptahydrate (22 mg/1mL)Injection, solution, concentrateIntravenousAMERICAN REGENT, INC.1993-12-07Not applicableUs
International/Other Brands
Gynoseptyl / Gynostad / Hi Trace Copper / Intense Copper / M-Care / Zyload
Categories
UNII
KUW2Q3U1VV
CAS number
7758-98-7
Weight
Average: 159.609
Monoisotopic: 158.881330257
Chemical Formula
CuO4S
InChI Key
ARUVKPQLZAKDPS-UHFFFAOYSA-L
InChI
InChI=1S/Cu.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2
IUPAC Name
copper(2+) ion sulfate
SMILES
[Cu++].[O-]S([O-])(=O)=O

Pharmacology

Indication

Elemental use in copper deficiency [11]

Copper and copper containing compounds are broadly used in medical practice. Metallic copper is used already for many years in dental fillings and in copper intrauterine devices (IUD) for reversible contraception. Ointments containing copper, which release copper ions that are absorbed by the skin in the management of cramps, disturbances of renal function, peripheral, venous hypostatic circulatory disturbances, rheumatic disease and swelling associated with trauma. There are also cosmetic facial creams containing copper as their main active ingredient [13].

Pharmacodynamics

Copper is an essential mineral that plays a key role in many physiological processes, including angiogenesis, skin generation and expression and stabilization of skin proteins. Copper is found naturally in many food sources including meats, vegetables, and grains. Copper has potent biocidal properties and is used to eliminate bacteria, viruses and parasites [13], [17].

Copper is one of the nine essential minerals for humans, as it plays an imperative role in various physiological pathways in basically all human tissue, as well as in the health of the dermis and epidermis [13].

In addition to the above, copper is essential in wound healing, as it promotes angiogenesis and skin extracellular matrix formation and stabilization [13].

Mechanism of action

This drug is an essential trace element for the functioning of many metalloenzymes including ceruloplasmin, ferroxidase II, lysyl oxidase, monoamine oxidase, Zn-copper superoxide dismutase, tyrosinase, dopamine-β-hydroxylase, and cytochrome-c-oxidase.

It is involved in erythropoiesis & leukopoiesis, bone mineralization, elastin and collagen cross-linking, oxidative phosphorylation, catecholamine metabolism, melanin formation & antioxidant protection of cells [13].

Cupric sulfate may also have a role in iron turnover, ascorbic acid metabolism, phospholipid metabolism, myelin formation, glucose homeostasis, and cellular immune defense [11].

After the metal passes through the basolateral membrane it is transported to the liver, attached to serum albumin. The liver is the critical organ for the homeostasis of copper. The copper is then prepared for excretion through the bile or incorporation into various proteins. The transport of copper to the peripheral tissues is accomplished through the plasma attached to serum albumin, ceruloplasmin or low-molecular-weight complexes [14].

In the dermis, copper promotes dermal fibroblasts proliferation, upregulates collagen (types I, II, and V) and elastin fiber components (elastin, fibrillins) production by fibroblasts, through the induction of TGF-β, promotes heat shock protein-47, important for collagen fibril formation, serves as a cofactor of LOX enzyme required for extracellular matrix protein cross-linking, stabilizes the skin ECM once formed, as increased crosslinking of collagen and elastin matrices occurs in a copper dose dependant manner, serves as a cofactor of superoxide dismutase, an antioxidant enzyme in the skin, essential for protection against free radicals, inhibits cellular oxidative effects such as membrane damage and lipid peroxidation, acts as a cofactor of tyrosinase, a melanin biosynthesis essential enzyme responsible for skin and hair pigmentation [13].

In reference to its role as a biocide, copper is an essential nutrient for many organisms. It acts as a cofactor in respiration, and therefore copper is required for aerobic metabolism. Accumulation of copper ions or intracellular release of free copper ions from proteins lead to cell damage. Copper catalyzes reactions that result in the production of hydroxyl radicals through the Fenton and Haber-Weiss reactions. The highly reactive oxygen intermediates lead to lipid peroxidation and oxidation of proteins. Free copper ions oxidize sulfhydryl groups, such as cysteine, in proteins or the cellular redox buffer glutathione. In particular, copper ions inactivate proteins by damaging Fe-S clusters in cytoplasmic hydratases [18].

Absorption

Primarily absorbed in the small intestine [11].

Based on studies with radioactive isotopes of copper, most copper is absorbed from the stomach and duodenum of the gastrointestinal tract.

Maximum blood copper levels are observed within 1 to 3 hours following oral administration, and about 50 percent of ingested copper was absorbed. Copper absorption is proposed to occur by two mechanisms, one energy- dependent and the other enzymatic. Factors that can interfere with copper absorption include competition for binding sites with zinc, interactions with molybdenum and sulfates, chelation with phytates, and inhibition by ascorbic acid (vitamin C) [16].

Copper absorbed from the gastrointestinal tract is transported rapidly to blood serum and deposited in the liver bound to metallothionein [16].

From 20 to 60% of the dietary copper is absorbed [8].

Volume of distribution

The body of a 70 kg healthy individual contains approximately 110 mg of copper, 50% of which is found in the bones and muscles, 15% in the skin, 15% in the bone marrow, 10% in the hepatic system, and 8% in the brain [13].

The distribution of copper is affected by sex, age, and the amount of copper in the diet. Brain and liver have the highest tissue levels (about one-third of the total body burden), with lesser concentrations found in the heart, spleen, kidneys, and blood. The iris and choroid of the eye have very high copper levels [16].

Erythrocyte copper levels are generally stable, however, plasma levels fluctuate widely in association with the synthesis and release of ceruloplasmin. Plasma copper levels during gestation may be 2-3 times levels measured before pregnancy, due to the increased synthesis of ceruloplasmin [16].

Protein binding

About 80 percent of the absorbed copper is bound to liver metallothionein; the remainder is incorporated into cytochrome c oxidase or sequestered by lysosomes [16].

The bioavailability of copper from the diet is about 65-70% depending on a variety of factors including chemical form, interaction with other metals, and dietary components [5].

Metabolism

Maximum blood copper levels were observed within 1 to 3 hours following oral administration, and about 50 percent of ingested copper was absorbed. Copper absorption is believed to occur by two mechanisms, one energy- dependent and the other enzymatic. Factors that can interfere with copper absorption include competition for binding sites with zinc, interactions with molybdenum and sulfates, chelation with phytates, and inhibition by ascorbic acid [16]. Copper absorbed from the intestine is transported quickly into blood serum and deposited in the liver bound to metallothionein. It is released and incorporated into ceruloplasmin, a copper-specific transport protein. The remaining copper in the serum binds to albumin or amino acids or is contained in the erythrocytes. About 80 percent of the absorbed copper is bound to liver metallothionein; the remainder is included into cytochrome c oxidase or sequestered by lysosomes [16].

Route of elimination

This drug is 80% eliminated via the liver in bile. Minimal excretion by the kidney [11]. Metabolism studies show that persons with daily intakes of 2-5 mg of copper per day absorbed 0.6 to 1.6 mg (32%), excreted 0.5 to 1.3 mg in the bile, passed 0.1 to 0.3 mg directly into the bowel, and excreted 0.01 to 0.06 mg in the urine. As the data indicate, urinary excretion plays a negligible role in copper clearance, and the main route of excretion is in the bile. Other nonsignificant excretory routes include saliva, sweat, menstrual flow, and excretion into the intestine from the blood [16].

Half life

The biological half-life of copper from the diet is 13-33 days with biliary excretion being the primary route of elimination [5].

Clearance
Not Available
Toxicity

Acute oral toxicity (LD50): 300 mg/kg in rats [MSDS].

Copper sulfate ingestion (accidental or deliberate) is a rare form of poisoning usually limited to the Indian subcontinent. Though the rates are on the decline, it is essential that physicians are aware of its lethal complications and management strategies. The main complications of copper sulfate ingestion include intravascular hemolysis, methemoglobinaemia, acute kidney injury, and rhabdomyolysis [12].

Severe gastrointestinal effects may occur with acute overdosage. In extreme or long-term overdosage, symptoms may be similar to those of Wilson's disease, a disease in which the liver does not filter copper adequately and copper accumulates in the liver, brain, eyes, and other organs. Gradually, high copper levels may cause life-threatening organ damage [11].

Ingestion of more than 15 mg of copper has been reported to be toxic to humans. In a survey of human clinical case studies, 5.3 mg/day was the lowest oral dose at which local gastrointestinal irritation was seen. Ingestion of gram quantities of copper sulfate resulted in death by suicide, whereas less severe effects were reported from estimated copper doses of 40 to 50 mg from ingestion of carbonated beverages in contact with copper containers. Limited data are available on the chronic toxicity of copper. The hazard from dietary intakes of up to 5 mg/day appears to be low [16].

Treatment of cupric sulfate toxicity is symptomatic and may involve the use of a chelating agent (e.g. penicillamine, trientine and zinc) to remove any excessive metal that has been absorbed. In addition, dialysis may be useful [10, 11].

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Cupric sulfate.
AclidiniumThe therapeutic efficacy of Cupric sulfate can be decreased when used in combination with Aclidinium.
AgmatineThe therapeutic efficacy of Cupric sulfate can be decreased when used in combination with Agmatine.
AlcuroniumThe therapeutic efficacy of Cupric sulfate can be decreased when used in combination with Alcuronium.
AlfentanilThe therapeutic efficacy of Cupric sulfate can be decreased when used in combination with Alfentanil.
AlmasilateThe therapeutic efficacy of Cupric sulfate can be decreased when used in combination with Almasilate.
AloglutamolThe therapeutic efficacy of Cupric sulfate can be decreased when used in combination with Aloglutamol.
AlphacetylmethadolThe therapeutic efficacy of Cupric sulfate can be decreased when used in combination with Alphacetylmethadol.
AlphaprodineThe therapeutic efficacy of Cupric sulfate can be decreased when used in combination with Alphaprodine.
AluminiumThe therapeutic efficacy of Cupric sulfate can be decreased when used in combination with Aluminium.
Food Interactions
Not Available

References

General References
  1. Faure A, Mathon L, Poupelin JC, Allaouchiche B, Chassard D: [Acute cupric sulfate intoxication: pathophysiology and therapy about a case report]. Ann Fr Anesth Reanim. 2003 Jun;22(6):557-9. [PubMed:12893385]
  2. Armstrong TA, Cook DR, Ward MM, Williams CM, Spears JW: Effect of dietary copper source (cupric citrate and cupric sulfate) and concentration on growth performance and fecal copper excretion in weanling pigs. J Anim Sci. 2004 Apr;82(4):1234-40. doi: 10.2527/2004.8241234x. [PubMed:15080347]
  3. Hebert CD, Elwell MR, Travlos GS, Fitz CJ, Bucher JR: Subchronic toxicity of cupric sulfate administered in drinking water and feed to rats and mice. Fundam Appl Toxicol. 1993 Nov;21(4):461-75. [PubMed:8253299]
  4. Lim J, Lawless HT: Oral sensations from iron and copper sulfate. Physiol Behav. 2005 Jun 30;85(3):308-13. doi: 10.1016/j.physbeh.2005.04.018. [PubMed:15935409]
  5. Barceloux DG: Copper. J Toxicol Clin Toxicol. 1999;37(2):217-30. [PubMed:10382557]
  6. Cupric Sulfate [Link]
  7. Copper Sulfate [Link]
  8. Cupric Sulfate ToxNet [Link]
  9. Cupric Sulfate, Britannica Online [Link]
  10. Cupric Sulfate [Link]
  11. Wilson Disease [Link]
  12. Complications and management of acute copper sulphate poisoning; a case discussion [Link]
  13. Using Copper to Improve the Well-Being of the Skin [Link]
  14. Veterinary Toxicology: Basic and Clinical Principals [Link]
  15. Abnormal Copper Homeostasis: Mechanisms and Roles in Neurodegeneration [Link]
  16. Copper [Link]
  17. Metallic Copper as an Antimicrobial Surface [Link]
  18. Bacterial Killing by Dry Metallic Copper Surfaces [Link]
External Links
KEGG Compound
C18713
PubChem Compound
24462
PubChem Substance
347827794
ChemSpider
22870
ChEBI
23414
ChEMBL
CHEMBL604
Wikipedia
Copper(II)_sulfate
ATC Codes
V03AB20 — Copper sulfate
MSDS
Download (51 KB)

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
Capsule, liquid filledOral
Injection, solutionIntravenous1.57 mg/1mL
LiquidTopical
Kit
TabletOral
Injection, solution, concentrateIntravenous
Injection, solutionIntravenous
Tablet, coatedOral
KitOral
LiquidOral
Capsule, gelatin coatedOral
CapsuleOral
Tablet, film coatedOral
Tablet, chewableOral
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)590MSDS
boiling point (°C)650MSDS
water solubilityVery soluble in hot water, soluble cold waterMSDS
Predicted Properties
PropertyValueSource
logP-0.84ChemAxon
pKa (Strongest Acidic)-3ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area80.26 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity11.53 m3·mol-1ChemAxon
Polarizability5.81 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as transition metal sulfates. These are inorganic compounds in which the largest oxoanion is sulfate, and in which the heaviest atom not in an oxoanion is a transition metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Transition metal oxoanionic compounds
Sub Class
Transition metal sulfates
Direct Parent
Transition metal sulfates
Alternative Parents
Inorganic oxides / Inorganic copper salts
Substituents
Transition metal sulfate / Inorganic copper salt / Inorganic oxide / Inorganic salt
Molecular Framework
Not Available
External Descriptors
metal sulfate (CHEBI:23414) / Copper fungicides (C18713)

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Phenylalanine 4-monooxygenase activity
Specific Function
Not Available
Gene Name
PAH
Uniprot ID
P00439
Uniprot Name
Phenylalanine-4-hydroxylase
Molecular Weight
51861.565 Da
References
  1. Copper [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Gene Name
SOD1
Uniprot ID
P00441
Uniprot Name
Superoxide dismutase [Cu-Zn]
Molecular Weight
15935.685 Da
References
  1. Copper [Link]
Kind
Protein group
Organism
Human
Pharmacological action
Unknown
General Function
Serotonin binding
Specific Function
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral...

Components:
References
  1. Copper [Link]
Kind
Protein
Organism
Homo sapiens
Pharmacological action
Unknown
Actions
Inducer
General Function
Protein-lysine 6-oxidase activity
Specific Function
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a rol...
Gene Name
LOX
Uniprot ID
P28300
Uniprot Name
Protein-lysine 6-oxidase
Molecular Weight
46943.67 Da
References
  1. Copper [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inducer
General Function
Iron ion binding
Specific Function
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic su...
Gene Name
MT-CO1
Uniprot ID
P00395
Uniprot Name
Cytochrome c oxidase subunit 1
Molecular Weight
57040.91 Da
References
  1. Copper [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Protein homodimerization activity
Specific Function
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA ...
Gene Name
TYR
Uniprot ID
P14679
Uniprot Name
Tyrosinase
Molecular Weight
60392.69 Da

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Toxic substance binding
Specific Function
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
Gene Name
ALB
Uniprot ID
P02768
Uniprot Name
Serum albumin
Molecular Weight
69365.94 Da
References
  1. Copper [Link]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Ferroxidase activity
Specific Function
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iro...
Gene Name
CP
Uniprot ID
P00450
Uniprot Name
Ceruloplasmin
Molecular Weight
122204.45 Da
References
  1. Copper [Link]

Drug created on September 14, 2010 10:21 / Updated on November 02, 2018 09:11