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Identification
NameMagnesium Sulfate
Accession NumberDB00653  (APRD01080)
TypeSmall Molecule
GroupsApproved, Vet Approved
Description

A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)

Structure
Thumb
Synonyms
Magnesium sulfate (1:1)
Magnesium sulfate anhydrous
Magnesium sulphate
Magnesium(ii) sulfate
Magnesiumsulfat
MgSO4
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Magnesium Sulfateinjection, solution500 mg/mLintramuscular; intravenousFresenius Kabi USA, LLC2016-01-29Not applicableUs
Magnesium Sulfateinjection, solution500 mg/mLintramuscular; intravenousCardinal Health2000-08-08Not applicableUs
Magnesium Sulfateinjection, solution500 mg/mLintramuscular; intravenousFresenius Kabi USA, LLC2000-08-08Not applicableUs
Magnesium Sulfateinjection, solution500 mg/mLintramuscular; intravenousGENERAL INJECTABLES AND VACCINES, INC.2015-09-16Not applicableUs
Magnesium Sulfateinjection, solution4 g/50mLintravenousHospira, Inc.1994-06-24Not applicableUs
Magnesium Sulfateinjection, solution4 g/100mLintravenousHospira, Inc.1994-06-24Not applicableUs
Magnesium Sulfate Dressingliquid45 %topicalDumex Medical Canada Inc.Not applicableNot applicableCanada
Magnesium Sulfate In Dextroseinjection, solution10 mg/mLintravenousHospira, Inc.1995-07-11Not applicableUs
Magnesium Sulfate In Dextroseinjection, solution20 mg/mLintravenousHospira, Inc.1995-07-11Not applicableUs
Magnesium Sulfate Inj 20% USPliquid200 mgintramuscular; intravenousSandoz Canada Incorporated1978-12-31Not applicableCanada
Magnesium Sulfate Inj 50%liquid500 mgintramuscularKripps Pharmacy Ltd.1980-12-31Not applicableCanada
Magnesium Sulfate Inj 50%liquid500 mgintramuscular; intravenousLyphomed, Division Of Fujisawa Canada Inc.1992-12-311996-09-10Canada
Magnesium Sulfate Inj 500mg/mlsolution500 mgintramuscular; intravenousAbbott Laboratories, Limited1981-12-311999-04-01Canada
Magnesium Sulfate Injectionsolution500 mgintramuscular; intravenousFresenius Kabi Canada Ltd1992-12-31Not applicableCanada
Magnesium Sulfate Injection 50% USPliquid500 mgintramuscular; intravenousSandoz Canada Incorporated1984-12-31Not applicableCanada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Magnesium Sulfateinjection, solution80 mg/mLintravenousFresenius Kabi USA, LLC2016-03-15Not applicableUs
Magnesium Sulfateinjection, solution500 mg/mLintramuscular; intravenousHospira, Inc.1987-07-22Not applicableUs
Magnesium Sulfateinjection, solution40 mg/mLintravenousFresenius Kabi USA, LLC2016-03-15Not applicableUs
Magnesium Sulfateinjection, solution500 mg/mLintramuscular; intravenousHospira, Inc.2000-04-25Not applicableUs
Magnesium Sulfateinjection1 g/100mLintravenousWG Critical Care, LLC2016-03-08Not applicableUs
Magnesium Sulfateinjection, solution500 mg/mLintramuscular; intravenousPhysicians Total Care, Inc.2006-12-12Not applicableUs
Magnesium Sulfateinjection, solution5 g/10mLintramuscular; intravenousGeneral Injectables & Vaccines, Inc2010-08-01Not applicableUs
Magnesium Sulfateinjection, solution500 mg/mLintramuscular; intravenousX Gen Pharmaceuticals, Inc.2014-02-23Not applicableUs
Magnesium Sulfate In 5% Dextroseinjection, solution1 g/100mLintravenousFresenius Kabi USA, LLC2016-03-07Not applicableUs
Approved Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Epsom Saltgranule, for solution1 g/goral; topicalMeijer Distribution, Inc2015-07-21Not applicableUs
Epsom Saltgranule, for solution1 g/goral; topicalTOPCO ASSOCIATES, LLC1999-07-15Not applicableUs
Epsom Saltgranule, for solution1 g/goral; topicalWalgreens2015-07-13Not applicableUs
Epsom Saltgranule, for solution1 g/goral; topicalDolgencorp, LLC1993-10-21Not applicableUs
Epsom Saltgranule, for solution1 g/goral; topicalKroger Co.1993-10-21Not applicableUs
Epsom Saltgranule, for solution1 g/goral; topicalGeiss, Destin and Dunn, Inc1992-07-15Not applicableUs
Epsom Saltgranule, for solution1 g/goral; topicalDZA Brands, LLC2008-02-27Not applicableUs
Epsom Saltgranule, for solution1 g/goral; topicalWinCo Foods, LLC2015-05-21Not applicableUs
Epsom Saltgranule, for solution1 g/goral; topicalFoodhold U.S.A., Llc2015-05-06Not applicableUs
Epsom Saltgranule100 kg/100kgoralWestern Family1998-06-05Not applicableUs
Epsom Saltgranule, for solution1 g/goral; topicalSAFEWAY INC2002-11-12Not applicableUs
Epsom Saltgranule, for solution1 g/goral; topicalMeijer Distribution, Inc2013-04-26Not applicableUs
Epsom Saltgranule, for solution100 g/100goral; topicalGood Neighbor Pharmacy2010-01-01Not applicableUs
Epsom Saltgranule, for solution1 g/goral; topicalValu Merchandisers, Co.2014-10-15Not applicableUs
Epsom Saltgranule, for solution1 g/goral; topicalYour Military Exchange2002-12-18Not applicableUs
Epsom Saltgranule, for solution1 g/goral; topicalWakefern Food Corp2014-05-01Not applicableUs
Epsom Saltgranule1.81 kg/100kgoral; topicalKinray, Inc.2012-06-14Not applicableUs
Epsom Saltgranule, for solution1 g/goral; topicalDiscount Drug Mart2002-12-02Not applicableUs
Epsom Saltgranule, for solution1 g/goral; topicalSUPERVALU INC.2005-03-21Not applicableUs
Epsom Saltgranule, for solution1 g/goral; topicalTarget Corporation1996-12-12Not applicableUs
Epsom Saltgranule1 g/goralPublix Super Markets, Inc.,2013-07-03Not applicableUs
Epsom Saltcrystal1.81 kg/100kgoral; topicalCardinal Health2012-03-26Not applicableUs
Epsom Saltgranule, for solution1 g/goral; topicalVi Jon1998-07-15Not applicableUs
Epsom Saltgranule, for solution1 g/goral; topicalPublix Super Markets, Inc2014-09-05Not applicableUs
Epsom Saltgranule, for solution1 g/goral; topicalFoodhold U.S.A., Llc2015-05-06Not applicableUs
Epsom Saltgranule, for solution1 g/goral; topicalShop Ko Stores Operating Co., Llc2009-06-05Not applicableUs
Epsom Salt Magnesium Sulfategranule1 g/goral; topicalCVS Pharmacy2014-12-31Not applicableUs
Epsom Salt Pws 100%powder for solution100 %oralJedmon Products Ltd.1990-12-312006-03-22Canada
Epsom Salt Soaking Solutiongranule2.72 kg/2.72kgtopicalAdvanced Beauty Systems, Inc.2012-06-13Not applicableUs
Epsom Saltspowder100 %oralLawton's Drug Stores Ltd.1987-12-311997-04-02Canada
Epsom Saltspowder100 %oralR.W. Packaging Ltd.1987-12-312004-07-21Canada
Epsom SaltspowderoralDawson Traders Ltd.1977-12-312006-03-22Canada
Epsom SaltspowderoralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1972-12-312000-07-27Canada
Epsom Salts Naturalcrystal100 g/100goral; topicalFirst Aid Research Corp.2015-05-15Not applicableUs
Epsom Salts Reliefgranule100 g/100goralBlue Cross Laboratories, Inc.2010-07-09Not applicableUs
Eucalyptus Scented Natural Epsom Saltpowder10 g/10gtopicalPoint Guard Marketing Inc.2016-01-26Not applicableUs
Eucalyptus Scented Natural Epsom Saltpowder10 g/10gtopicalAnhui Twowin Machinery Imp. & Exp. Co., Ltd.2016-01-26Not applicableUs
Green Tea Chamomile Natural Epsom Saltpowder10 g/10gtopicalAnhui Twowin Machinery Imp. & Exp. Co., Ltd.2016-01-26Not applicableUs
Green Tea Chamomile Natural Epsom Saltpowder10 g/10gtopicalPoint Guard Marketing Inc.2016-01-26Not applicableUs
Health Smart Natural Epsom Saltgranule, for solution1 g/goralInternational Wholesale, Inc.2013-08-01Not applicableUs
Health Smart Natural Epsom Saltgranule, for solution1 g/goralInternational Wholesale, Inc.2013-08-01Not applicableUs
Humco Epson Saltpowder, for solution1000 mg/goralHumco Holding Group, Inc.1998-03-25Not applicableUs
Morton Natural Epsom Saltgranule, for solution1 kg/kgoral; topicalMorton Salt, Inc.2012-09-01Not applicableUs
Natural Epsom Saltpowder10 g/10gtopicalPoint Guard Marketing Inc.2016-01-27Not applicableUs
Natural Epsom Saltpowder10 g/10gtopicalPoint Guard Marketing Inc.2016-01-26Not applicableUs
Natural Epsom Saltpowder10 g/10gtopicalAnhui Twowin Machinery Imp. & Exp. Co., Ltd.2014-10-09Not applicableUs
Natural Epsom Saltpowder10 g/10gtopicalMy Import USA Inc2014-10-09Not applicableUs
Natural Epsom Salt Lavenderpowder10 g/10gtopicalPoint Guard Marketing Inc.2016-01-26Not applicableUs
Natural Epsom Salt Lavenderpowder10 g/10gtopicalAnhui Twowin Machinery Imp. & Exp. Co., Ltd.2016-01-26Not applicableUs
Royal Epsom Saltgranule, for solution1 kg/kgoralFilo America2014-10-29Not applicableUs
Sel D EpsompowderoralProduits Marc O (1987) Inc., Division Of Technilab Inc.1989-12-152000-08-24Canada
Spearmint and Menthol Scented Natural Epsom Saltpowder10 g/10gtopicalAnhui Twowin Machinery Imp. & Exp. Co., Ltd.2016-01-27Not applicableUs
Spearmint and Menthol Scented Natural Epsom Saltpowder10 g/10gtopicalPoint Guard Marketing Inc.2016-01-27Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Magnesium Sulfateinjection, solution500 mg/mLintramuscular; intravenousAmerican Regent, Inc.1990-09-30Not applicableUs
Magnesium Sulfateinjection, solution500 mg/mLintramuscular; intravenousCardinal Health2000-08-08Not applicableUs
Magnesium Sulfateinjection, solution.5 g/mLintramuscular; intravenousGeneral Injectables & Vaccines, Inc2010-08-01Not applicableUs
Magnesium Sulfateinjection500 mg/mLintramuscular; intravenousGeneral Injectables & Vaccines, Inc2010-09-01Not applicableUs
Magnesium Sulfateinjection, solution20 g/250mLintravenousCantrell Drug Company2011-07-25Not applicableUs
Magnesium Sulfateinjection, solution20 g/500mLintravenousCantrell Drug Company2011-02-21Not applicableUs
Magnesium Sulfateinjection, solution500 mg/mLintramuscular; intravenousAmerican Regent, Inc.1990-09-30Not applicableUs
Magnesium Sulfateinjection, solution500 mg/mLintramuscular; intravenousAmerican Regent, Inc.1990-09-30Not applicableUs
International BrandsNot Available
Brand mixtures
NameLabellerIngredients
Concept DHAUs Pharmaceutical Corporation
Concept ObUs Pharmaceutical Corporation
Eau Purgative RigaGlendale Agencies
Magnesium CapAlsi Cie Ltee
Magnesium Sulfate In 5% Dextrose Inj(20mg/ml)Hospira Healthcare Corporation
Multiple Electrolyte Additive InjInternational Medication Systems Ltd.
Solution CardaLaboratoire Atlas Inc
Suprep Bowel PrepBraintree Laboratories, Inc.
Tandem ObUs Pharmaceutical Corporation
Tandem PlusUs Pharmaceutical Corporation
Vamin NFresenius Kabi Ab
Salts
Name/CASStructureProperties
Magnesium sulfate heptahydrate
ThumbNot applicableDBSALT001240
Categories
UNIIML30MJ2U7I
CAS number7487-88-9
WeightAverage: 120.368
Monoisotopic: 119.936771076
Chemical FormulaMgO4S
InChI KeyInChIKey=CSNNHWWHGAXBCP-UHFFFAOYSA-L
InChI
InChI=1S/Mg.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2
IUPAC Name
magnesium(2+) ion sulfate
SMILES
[Mg++].[O-]S([O-])(=O)=O
Taxonomy
DescriptionThis compound belongs to the class of inorganic compounds known as alkaline earth metal sulfates. These are inorganic compounds in which the largest oxoanion is sulfate, and in which the heaviest atom not in an oxoanion is an alkaline earth metal.
KingdomInorganic compounds
Super ClassMixed metal/non-metal compounds
ClassAlkaline earth metal oxoanionic compounds
Sub ClassAlkaline earth metal sulfates
Direct ParentAlkaline earth metal sulfates
Alternative Parents
Substituents
  • Alkaline earth metal sulfate
  • Inorganic oxide
  • Inorganic salt
  • Acyclic compound
Molecular FrameworkAcyclic compounds
External Descriptors
Pharmacology
IndicationUsed for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children. Also indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia. Also used in uterine tetany as a myometriat relaxant.
PharmacodynamicsMagnesium sulfate is a small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. Magnesium sulfate is gaining popularity as an initial treatment in the management of various dysrhythmias, particularly torsades de pointes, and dyrhythmias secondary to TCA overdose or digitalis toxicity.
Mechanism of actionMagnesium is the second most plentiful cation of the intracellular fluids. It is essential for the activity of many enzyme systems and plays an important role with regard to neurochemical transmission and muscular excitability. Magnesium sulfate reduces striated muscle contractions and blocks peripheral neuromuscular transmission by reducing acetylcholine release at the myoneural junction. Additionally, Magnesium inhibits Ca2+ influx through dihydropyridine-sensitive, voltage-dependent channels. This accounts for much of its relaxant action on vascular smooth muscle.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein binding25-30%
Metabolism

None

Route of eliminationMagnesium is excreted solely by the kidney at a rate proportional to the serum concentration and glomerular filtration.
Half life43.2 hours (for newborns)
ClearanceNot Available
ToxicityLD50 = 1200 mg/kg (rat, subcutaneous). May be harmful if swallowed. May act as an irritant. Adverse reactions include hypotension, ECG changes, diarrhea, urinary retention, CNS depression and respiratory depression.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.7487
Blood Brain Barrier+0.9646
Caco-2 permeable-0.6267
P-glycoprotein substrateNon-substrate0.9137
P-glycoprotein inhibitor INon-inhibitor0.9194
P-glycoprotein inhibitor IINon-inhibitor0.9904
Renal organic cation transporterNon-inhibitor0.9521
CYP450 2C9 substrateNon-substrate0.8775
CYP450 2D6 substrateNon-substrate0.8213
CYP450 3A4 substrateNon-substrate0.7007
CYP450 1A2 substrateNon-inhibitor0.7767
CYP450 2C9 inhibitorNon-inhibitor0.7602
CYP450 2D6 inhibitorNon-inhibitor0.9115
CYP450 2C19 inhibitorNon-inhibitor0.7547
CYP450 3A4 inhibitorNon-inhibitor0.9759
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9577
Ames testNon AMES toxic0.5773
CarcinogenicityCarcinogens 0.8111
BiodegradationReady biodegradable0.943
Rat acute toxicity2.4160 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.7988
hERG inhibition (predictor II)Non-inhibitor0.9446
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Abraxis pharmaceutical products
  • Hospira inc
Packagers
Dosage forms
FormRouteStrength
Capsule, liquid filledoral
Capsuleoral
Liquidoral
Crystaloral; topical1.81 kg/100kg
Granuleoral1 g/g
Granuleoral100 kg/100kg
Granuleoral; topical1.81 kg/100kg
Granule, for solutionoral; topical1 g/g
Granule, for solutionoral; topical100 g/100g
Granuleoral; topical1 g/g
Powder for solutionoral100 %
Granuletopical2.72 kg/2.72kg
Powderoral
Powderoral100 %
Crystaloral; topical100 g/100g
Granuleoral100 g/100g
Granule, for solutionoral1 g/g
Powder, for solutionoral1000 mg/g
Injectionintramuscular; intravenous500 mg/mL
Injectionintravenous1 g/100mL
Injection, solutionintramuscular; intravenous.5 g/mL
Injection, solutionintramuscular; intravenous5 g/10mL
Injection, solutionintramuscular; intravenous500 mg/mL
Injection, solutionintravenous20 g/250mL
Injection, solutionintravenous20 g/500mL
Injection, solutionintravenous4 g/50mL
Injection, solutionintravenous4 g/100mL
Injection, solutionintravenous40 mg/mL
Injection, solutionintravenous80 mg/mL
Liquidtopical45 %
Injection, solutionintravenous1 g/100mL
Solutionintravenous
Injection, solutionintravenous10 mg/mL
Injection, solutionintravenous20 mg/mL
Liquidintramuscular; intravenous200 mg
Liquidintramuscular500 mg
Solutionintramuscular; intravenous500 mg
Liquidintramuscular; intravenous500 mg
Granule, for solutionoral; topical1 kg/kg
Liquidintravenous
Powdertopical10 g/10g
Granule, for solutionoral1 kg/kg
Solution, concentrateoral
Prices
Unit descriptionCostUnit
Elliotts b solution ampule4.71USD ml
Magnesium Sulfate 50% Solution 2ml Vial0.92USD vial
Magnesium sulfate powder0.29USD g
Magnesium-ns 6 g/50 ml bag0.29USD ml
Magnesium-ns 4 g/50 ml bag0.27USD ml
Magnesium-ns 3 g/50 ml bag0.26USD ml
Magnesium sulfate-ns 2 gm bag0.25USD ml
Magnesium sulfate-ns 1 gm bag0.24USD ml
Magnesium-d5w 1 gm/100 ml soln0.07USD ml
Magnesium-lr 20 g/500 ml0.03USD ml
Magnesium-lr 40 g/500 ml bag0.03USD ml
Magnesium-lr 50 g/500 ml bag0.02USD ml
Epsom salt 100% powder0.01USD g
Magnesium sulf 4% iv soln0.01USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6946149 No2003-03-072023-03-07Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point1124 °C (decomposition)Not Available
water solubility710 mg/mLNot Available
logP-0.91Not Available
Predicted Properties
PropertyValueSource
logP-0.84ChemAxon
pKa (Strongest Acidic)-3ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area80.26 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity11.53 m3·mol-1ChemAxon
Polarizability5.81 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
References
Synthesis Reference

Shinichi Yamamoto, Akifumi Sekitani, “BASIC MAGNESIUM SULFATE GRANULE, AND PROCESS FOR PRODUCTION THEREOF.” U.S. Patent US20110042297, issued February 24, 2011.

US20110042297
General References
  1. Blitz M, Blitz S, Hughes R, Diner B, Beasley R, Knopp J, Rowe BH: Aerosolized magnesium sulfate for acute asthma: a systematic review. Chest. 2005 Jul;128(1):337-44. [PubMed:16002955 ]
  2. Yokoyama K, Takahashi N, Yada Y, Koike Y, Kawamata R, Uehara R, Kono Y, Honma Y, Momoi MY: Prolonged maternal magnesium administration and bone metabolism in neonates. Early Hum Dev. 2010 Mar;86(3):187-91. doi: 10.1016/j.earlhumdev.2010.02.007. Epub 2010 Mar 12. [PubMed:20226604 ]
  3. Wedig KE, Kogan J, Schorry EK, Whitsett JA: Skeletal demineralization and fractures caused by fetal magnesium toxicity. J Perinatol. 2006 Jun;26(6):371-4. [PubMed:16724078 ]
  4. Nassar AH, Sakhel K, Maarouf H, Naassan GR, Usta IM: Adverse maternal and neonatal outcome of prolonged course of magnesium sulfate tocolysis. Acta Obstet Gynecol Scand. 2006;85(9):1099-103. [PubMed:16929415 ]
  5. Malaeb SN, Rassi AI, Haddad MC, Seoud MA, Yunis KA: Bone mineralization in newborns whose mothers received magnesium sulphate for tocolysis of premature labour. Pediatr Radiol. 2004 May;34(5):384-6. Epub 2004 Feb 18. [PubMed:14985884 ]
  6. Matsuda Y, Maeda Y, Ito M, Sakamoto H, Masaoka N, Takada M, Sato K: Effect of magnesium sulfate treatment on neonatal bone abnormalities. Gynecol Obstet Invest. 1997;44(2):82-8. [PubMed:9286718 ]
  7. Schanler RJ, Smith LG Jr, Burns PA: Effects of long-term maternal intravenous magnesium sulfate therapy on neonatal calcium metabolism and bone mineral content. Gynecol Obstet Invest. 1997;43(4):236-41. [PubMed:9194621 ]
  8. Santi MD, Henry GW, Douglas GL: Magnesium sulfate treatment of preterm labor as a cause of abnormal neonatal bone mineralization. J Pediatr Orthop. 1994 Mar-Apr;14(2):249-53. [PubMed:8188843 ]
  9. Holcomb WL Jr, Shackelford GD, Petrie RH: Magnesium tocolysis and neonatal bone abnormalities: a controlled study. Obstet Gynecol. 1991 Oct;78(4):611-4. [PubMed:1923163 ]
  10. Cumming WA, Thomas VJ: Hypermagnesemia: a cause of abnormal metaphyses in the neonate. AJR Am J Roentgenol. 1989 May;152(5):1071-2. [PubMed:2705341 ]
  11. Lamm CI, Norton KI, Murphy RJ, Wilkins IA, Rabinowitz JG: Congenital rickets associated with magnesium sulfate infusion for tocolysis. J Pediatr. 1988 Dec;113(6):1078-82. [PubMed:3193315 ]
  12. McGuinness GA, Weinstein MM, Cruikshank DP, Pitkin RM: Effects of magnesium sulfate treatment on perinatal calcium metabolism. II. Neonatal responses. Obstet Gynecol. 1980 Nov;56(5):595-600. [PubMed:7432730 ]
  13. Riaz M, Porat R, Brodsky NL, Hurt H: The effects of maternal magnesium sulfate treatment on newborns: a prospective controlled study. J Perinatol. 1998 Nov-Dec;18(6 Pt 1):449-54. [PubMed:9848759 ]
External Links
ATC CodesA06AD04A12CC02B05XA05D11AX05V04CC02
AHFS Codes
  • 28:12.92
  • 40:12.00
  • 56:12.00
  • 84:92.00
  • 92:02.00*
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (72.1 KB)
Interactions
Drug Interactions
Drug
AcetaminophenThe metabolism of Magnesium Sulfate can be increased when combined with Acetaminophen.
Alendronic acidThe serum concentration of Alendronate can be decreased when it is combined with Magnesium Sulfate.
AlfacalcidolThe serum concentration of Magnesium Sulfate can be increased when it is combined with Alfacalcidol.
AlfentanilMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Alfentanil.
AlprazolamMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Alprazolam.
AmitriptylineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
AmlodipineThe risk or severity of adverse effects can be increased when Amlodipine is combined with Magnesium Sulfate.
AmobarbitalMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Amobarbital.
AmoxapineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.
AmrinoneThe risk or severity of adverse effects can be increased when Amrinone is combined with Magnesium Sulfate.
AripiprazoleMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Aripiprazole.
AsenapineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Asenapine.
Atracurium besylateMagnesium Sulfate may increase the neuromuscular blocking activities of Atracurium besylate.
AzelastineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
BaclofenMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Baclofen.
BepridilThe risk or severity of adverse effects can be increased when Bepridil is combined with Magnesium Sulfate.
BiotinMagnesium Sulfate can cause a decrease in the absorption of Biotin resulting in a reduced serum concentration and potentially a decrease in efficacy.
BrexpiprazoleMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Brexpiprazole.
BrimonidineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Brimonidine.
BromazepamMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Bromazepam.
BrompheniramineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Brompheniramine.
BuprenorphineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
BuspironeMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Buspirone.
ButabarbitalMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Butabarbital.
ButalbitalThe metabolism of Magnesium Sulfate can be increased when combined with Butalbital.
ButorphanolMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Butorphanol.
CaffeineThe metabolism of Magnesium Sulfate can be increased when combined with Caffeine.
CalcitriolThe serum concentration of Magnesium Sulfate can be increased when it is combined with Calcitriol.
Calcium AcetateThe therapeutic efficacy of Magnesium Sulfate can be decreased when used in combination with Calcium Acetate.
Calcium carbonateThe therapeutic efficacy of Magnesium Sulfate can be decreased when used in combination with Calcium carbonate.
Calcium ChlorideThe therapeutic efficacy of Magnesium Sulfate can be decreased when used in combination with Calcium Chloride.
Calcium citrateThe therapeutic efficacy of Magnesium Sulfate can be decreased when used in combination with Calcium citrate.
Calcium gluconateThe therapeutic efficacy of Magnesium Sulfate can be decreased when used in combination with Calcium gluconate.
CarbamazepineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Carbamazepine.
CarbinoxamineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Carbinoxamine.
CarisoprodolMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Carisoprodol.
CetirizineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Cetirizine.
ChlordiazepoxideMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Chlordiazepoxide.
ChlorphenamineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Chlorphenamine.
ChlorpromazineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Chlorpromazine.
ChlorzoxazoneMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Chlorzoxazone.
CimetidineThe serum concentration of Magnesium Sulfate can be increased when it is combined with Cimetidine.
CiprofloxacinThe serum concentration of Ciprofloxacin can be decreased when it is combined with Magnesium Sulfate.
Cisatracurium besylateMagnesium Sulfate may increase the neuromuscular blocking activities of Cisatracurium besylate.
ClarithromycinThe metabolism of Magnesium Sulfate can be decreased when combined with Clarithromycin.
ClemastineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Clemastine.
ClevidipineThe risk or severity of adverse effects can be increased when Clevidipine is combined with Magnesium Sulfate.
ClobazamMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Clobazam.
ClodronateThe serum concentration of Clodronate can be decreased when it is combined with Magnesium Sulfate.
ClomipramineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Clomipramine.
ClonazepamMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Clonazepam.
ClonidineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Clonidine.
ClopidogrelThe therapeutic efficacy of Clopidogrel can be decreased when used in combination with Magnesium Sulfate.
ClorazepateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Clorazepate.
ClozapineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Clozapine.
CyclizineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Cyclizine.
CyclobenzaprineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Cyclobenzaprine.
CyproheptadineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
DantroleneMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Dantrolene.
DeferiproneThe serum concentration of Deferiprone can be decreased when it is combined with Magnesium Sulfate.
DemeclocyclineMagnesium Sulfate can cause a decrease in the absorption of Demeclocycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
DesfluraneMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Desflurane.
DesipramineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
DesloratadineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Desloratadine.
Dexchlorpheniramine maleateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Dexchlorpheniramine maleate.
DiazepamMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Diazepam.
DiltiazemThe risk or severity of adverse effects can be increased when Diltiazem is combined with Magnesium Sulfate.
DimenhydrinateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Dimenhydrinate.
DiphenhydramineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Diphenhydramine.
DolutegravirThe serum concentration of Dolutegravir can be decreased when it is combined with Magnesium Sulfate.
DoxazosinDoxazosin may increase the hypotensive activities of Magnesium Sulfate.
DoxepinMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
DoxycyclineMagnesium Sulfate can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
DoxylamineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Doxylamine.
DroperidolMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Droperidol.
EfavirenzMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Efavirenz.
EltrombopagThe serum concentration of Eltrombopag can be decreased when it is combined with Magnesium Sulfate.
EntacaponeMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Entacapone.
ErythromycinThe metabolism of Magnesium Sulfate can be decreased when combined with Erythromycin.
EstazolamMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Estazolam.
EszopicloneMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Eszopiclone.
EthosuximideMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Ethosuximide.
EthotoinMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Ethotoin.
EzogabineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Ezogabine.
FelbamateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Felbamate.
FelodipineThe risk or severity of adverse effects can be increased when Felodipine is combined with Magnesium Sulfate.
FentanylMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Fentanyl.
FexofenadineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Fexofenadine.
FlibanserinMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Flibanserin.
FluconazoleThe serum concentration of Magnesium Sulfate can be increased when it is combined with Fluconazole.
FlunarizineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Flunarizine.
FlupentixolMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Flupentixol.
FluphenazineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Fluphenazine.
FlurazepamMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Flurazepam.
FosphenytoinMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Fosphenytoin.
GabapentinMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Gabapentin.
gabapentin enacarbilMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of gabapentin enacarbil.
Gamma Hydroxybutyric AcidMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Gamma Hydroxybutyric Acid.
GemifloxacinThe serum concentration of Gemifloxacin can be decreased when it is combined with Magnesium Sulfate.
GuanfacineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Guanfacine.
HaloperidolMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Haloperidol.
HydrocodoneMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
HydromorphoneMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Hydromorphone.
HydroxyzineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Hydroxyzine.
IbandronateThe serum concentration of Ibandronate can be decreased when it is combined with Magnesium Sulfate.
IloperidoneMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Iloperidone.
ImipramineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Imipramine.
IsofluraneMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Isoflurane.
IsradipineThe risk or severity of adverse effects can be increased when Isradipine is combined with Magnesium Sulfate.
ItraconazoleThe risk or severity of adverse effects can be increased when Itraconazole is combined with Magnesium Sulfate.
KetamineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Ketamine.
KetoconazoleThe risk or severity of adverse effects can be increased when Ketoconazole is combined with Magnesium Sulfate.
LamotrigineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Lamotrigine.
LercanidipineThe risk or severity of adverse effects can be increased when Lercanidipine is combined with Magnesium Sulfate.
LevetiracetamMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Levetiracetam.
LevocabastineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Levocabastine.
LevocetirizineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Levocetirizine.
LevofloxacinThe serum concentration of Levofloxacin can be decreased when it is combined with Magnesium Sulfate.
LevorphanolMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Levorphanol.
LevothyroxineThe serum concentration of Levothyroxine can be decreased when it is combined with Magnesium Sulfate.
Lipoic AcidMagnesium Sulfate can cause a decrease in the absorption of Lipoic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
LoratadineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Loratadine.
LorazepamMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Lorazepam.
LoxapineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Loxapine.
LurasidoneMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Lurasidone.
Magnesium chlorideThe risk or severity of adverse effects can be increased when Magnesium Sulfate is combined with Magnesium chloride.
Magnesium citrateThe risk or severity of adverse effects can be increased when Magnesium Sulfate is combined with Magnesium citrate.
Magnesium hydroxideThe risk or severity of adverse effects can be increased when Magnesium Sulfate is combined with Magnesium hydroxide.
Magnesium oxideThe risk or severity of adverse effects can be increased when Magnesium Sulfate is combined with Magnesium oxide.
Magnesium salicylateThe risk or severity of adverse effects can be increased when Magnesium Sulfate is combined with Magnesium salicylate.
MaprotilineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.
MeclizineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Meclizine.
MefloquineThe therapeutic efficacy of Magnesium Sulfate can be decreased when used in combination with Mefloquine.
MeprobamateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Meprobamate.
MetaxaloneMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.
MethadoneMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Methadone.
MethocarbamolMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Methocarbamol.
MethohexitalMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Methohexital.
MethotrimeprazineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
MethsuximideMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Methsuximide.
MidazolamMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Midazolam.
MinocyclineMagnesium Sulfate can cause a decrease in the absorption of Minocycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
MirtazapineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
MorphineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Morphine.
MoxifloxacinThe serum concentration of Moxifloxacin can be decreased when it is combined with Magnesium Sulfate.
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be decreased when it is combined with Magnesium Sulfate.
Mycophenolic acidThe serum concentration of Mycophenolic acid can be decreased when it is combined with Magnesium Sulfate.
NafcillinThe metabolism of Magnesium Sulfate can be increased when combined with Nafcillin.
NalbuphineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Nalbuphine.
NicardipineThe risk or severity of adverse effects can be increased when Nicardipine is combined with Magnesium Sulfate.
NifedipineThe risk or severity of adverse effects can be increased when Nifedipine is combined with Magnesium Sulfate.
NimodipineThe risk or severity of adverse effects can be increased when Nimodipine is combined with Magnesium Sulfate.
NisoldipineThe risk or severity of adverse effects can be increased when Nisoldipine is combined with Magnesium Sulfate.
NitrazepamMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Nitrazepam.
NitrendipineThe risk or severity of adverse effects can be increased when Nitrendipine is combined with Magnesium Sulfate.
NitroprussideMagnesium Sulfate may increase the hypotensive activities of Nitroprusside.
Nitrous oxideMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Nitrous oxide.
NorfloxacinThe serum concentration of Norfloxacin can be decreased when it is combined with Magnesium Sulfate.
NortriptylineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Nortriptyline.
OfloxacinThe serum concentration of Ofloxacin can be decreased when it is combined with Magnesium Sulfate.
OlanzapineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Olanzapine.
OlopatadineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Olopatadine.
OrlistatThe serum concentration of Magnesium Sulfate can be decreased when it is combined with Orlistat.
OrphenadrineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
OxazepamMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Oxazepam.
OxycodoneMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Oxycodone.
OxymorphoneMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Oxymorphone.
OxytetracyclineMagnesium Sulfate can cause a decrease in the absorption of Oxytetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
PaliperidoneMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Paliperidone.
PancuroniumMagnesium Sulfate may increase the neuromuscular blocking activities of Pancuronium.
ParaldehydeMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
PentazocineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Pentazocine.
PentobarbitalMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Pentobarbital.
PerampanelMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Perampanel.
PerhexilineThe risk or severity of adverse effects can be increased when Perhexiline is combined with Magnesium Sulfate.
PerphenazineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Perphenazine.
PethidineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Pethidine.
PhenobarbitalMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Phenobarbital.
PhenoxybenzaminePhenoxybenzamine may increase the hypotensive activities of Magnesium Sulfate.
PhentolaminePhentolamine may increase the hypotensive activities of Magnesium Sulfate.
PhenytoinMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Phenytoin.
PimozideMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Pimozide.
PipotiazineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Pipotiazine.
PizotifenMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Pizotifen.
Polystyrene sulfonateThe risk or severity of adverse effects can be increased when Magnesium Sulfate is combined with Polystyrene sulfonate.
PomalidomideMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Pomalidomide.
PosaconazoleThe risk or severity of adverse effects can be increased when Posaconazole is combined with Magnesium Sulfate.
PrazosinPrazosin may increase the hypotensive activities of Magnesium Sulfate.
PregabalinMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Pregabalin.
PrenylamineThe risk or severity of adverse effects can be increased when Prenylamine is combined with Magnesium Sulfate.
PrimidoneMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Primidone.
ProchlorperazineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Prochlorperazine.
PromazineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Promazine.
PromethazineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Promethazine.
PropofolMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Propofol.
ProtriptylineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Protriptyline.
QuazepamMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Quazepam.
QuetiapineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
RaltegravirThe serum concentration of Raltegravir can be decreased when it is combined with Magnesium Sulfate.
RamelteonMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Ramelteon.
RemifentanilMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Remifentanil.
ReserpineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Reserpine.
RifabutinThe serum concentration of Magnesium Sulfate can be decreased when it is combined with Rifabutin.
RifampicinThe serum concentration of Magnesium Sulfate can be decreased when it is combined with Rifampicin.
RifapentineThe serum concentration of Magnesium Sulfate can be decreased when it is combined with Rifapentine.
RisedronateThe risk or severity of adverse effects can be increased when Risedronate is combined with Magnesium Sulfate.
RisperidoneMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Risperidone.
RocuroniumMagnesium Sulfate may increase the neuromuscular blocking activities of Rocuronium.
ScopolamineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Scopolamine.
Scopolamine butylbromideMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Scopolamine butylbromide.
SecobarbitalMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Secobarbital.
SevofluraneMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Sevoflurane.
SilodosinSilodosin may increase the hypotensive activities of Magnesium Sulfate.
Sodium oxybateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
SparfloxacinThe serum concentration of Sparfloxacin can be decreased when it is combined with Magnesium Sulfate.
StiripentolMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Stiripentol.
SuccinylcholineMagnesium Sulfate may increase the neuromuscular blocking activities of Succinylcholine.
SufentanilMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Sufentanil.
SulfisoxazoleThe metabolism of Magnesium Sulfate can be decreased when combined with Sulfisoxazole.
SuvorexantMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
TamsulosinTamsulosin may increase the hypotensive activities of Magnesium Sulfate.
TapentadolMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Tapentadol.
TasimelteonMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Tasimelteon.
TelithromycinThe metabolism of Magnesium Sulfate can be decreased when combined with Telithromycin.
TemazepamMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Temazepam.
TerazosinTerazosin may increase the hypotensive activities of Magnesium Sulfate.
TetrabenazineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Tetrabenazine.
TetracyclineMagnesium Sulfate can cause a decrease in the absorption of Tetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
ThalidomideMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
ThioridazineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Thioridazine.
ThiothixeneMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Thiothixene.
TiagabineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Tiagabine.
TiludronateThe serum concentration of Tiludronate can be decreased when it is combined with Magnesium Sulfate.
TizanidineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Tizanidine.
TolcaponeMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Tolcapone.
TopiramateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Topiramate.
TramadolMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Tramadol.
TriazolamMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Triazolam.
TriethylenetetramineThe serum concentration of Magnesium Sulfate can be decreased when it is combined with Triethylenetetramine.
TrifluoperazineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Trifluoperazine.
TrimipramineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Trimipramine.
TriprolidineMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Triprolidine.
VecuroniumMagnesium Sulfate may increase the neuromuscular blocking activities of Vecuronium.
VerapamilThe risk or severity of adverse effects can be increased when Verapamil is combined with Magnesium Sulfate.
VigabatrinMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Vigabatrin.
VoriconazoleThe risk or severity of adverse effects can be increased when Voriconazole is combined with Magnesium Sulfate.
ZaleplonMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Zaleplon.
ZiconotideMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Ziconotide.
ZiprasidoneMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Ziprasidone.
ZolpidemMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
ZonisamideMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Zonisamide.
ZopicloneMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Zopiclone.
ZuclopenthixolMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Zuclopenthixol.
Food InteractionsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Voltage-gated calcium channel activity
Specific Function:
This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal muscle DHP-sensitive Ca(2+) channel may function only as a multiple subunit complex.
Gene Name:
CACNG1
Uniprot ID:
Q06432
Molecular Weight:
25028.105 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Voltage-gated calcium channel activity
Specific Function:
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity).
Gene Name:
CACNA2D1
Uniprot ID:
P54289
Molecular Weight:
124566.93 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Voltage-gated calcium channel activity
Specific Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belon...
Gene Name:
CACNA1C
Uniprot ID:
Q13936
Molecular Weight:
248974.1 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Voltage-gated calcium channel activity
Specific Function:
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Gene Name:
CACNB1
Uniprot ID:
Q02641
Molecular Weight:
65712.995 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Voltage-gated calcium channel activity
Specific Function:
The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Gene Name:
CACNB2
Uniprot ID:
Q08289
Molecular Weight:
73579.925 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Voltage-gated calcium channel activity
Specific Function:
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belon...
Gene Name:
CACNA1S
Uniprot ID:
Q13698
Molecular Weight:
212348.1 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
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Drug created on June 13, 2005 07:24 / Updated on June 27, 2016 01:53