Sjögren's Syndrome

Also known as: Sjogren's Syndrome / Sjogren Syndrome / Sjogren's Disease / Sjögren Syndrome / Syndrome, Sjogren's / Sicca syndrome [Sjögren] / Gougerot-Mulock-Houwer syndrome / Sjogren's / Syndrome Sjogren's / Sjoegren's syndrome / Sicca syndrome

DrugDrug NameDrug Description
DB00185CevimelineCevimeline is a parasympathomimetic agent that act as an agonist at the muscarinic acetylcholine receptors M1 and M3. It is indicated by the Food and Drug Administration for the treatment of dry mouth associated with Sjögren's syndrome.
DB01611HydroxychloroquineHydroxychloroquine is a racemic mixture consisting of an R and S enantiomer.[A183047] Hydroxychloroquine is an aminoquinoline like [chloroquine].[L8072] It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus.[L8072] Hydroxychloroquine is also used for the prophylaxis of malaria in regions where chloroquine resistance is unlikely.[L8072] Hydroxychloroquine was developed during World War II as a derivative of [quinacrine] with less severe side effects.[A183092] Hydroxychloroquine was granted FDA approval on 18 April 1955.[L8072]
DB01085PilocarpineA slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
DB00860PrednisoloneA glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
DB00635PrednisoneA synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver.
DrugDrug NameTargetType
DB00185CevimelineMuscarinic acetylcholine receptor M1target
DB00185CevimelineMuscarinic acetylcholine receptor M3target
DB00185CevimelineCytochrome P450 3A4enzyme
DB00185CevimelineCytochrome P450 2D6enzyme
DB00185CevimelineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB01611HydroxychloroquineDNAtarget
DB01611HydroxychloroquineToll-like receptor 7target
DB01611HydroxychloroquineToll-like receptor 9target
DB01611HydroxychloroquineCytochrome P450 2D6enzyme
DB01611HydroxychloroquineP-glycoprotein 1transporter
DB01611HydroxychloroquineSerum albumincarrier
DB01611Hydroxychloroquinealpha1-acid glycoproteincarrier
DB01611HydroxychloroquineCytochrome P450 3A4enzyme
DB01611HydroxychloroquineSolute carrier organic anion transporter family member 1A2transporter
DB01085PilocarpineMuscarinic acetylcholine receptor M1target
DB01085PilocarpineMuscarinic acetylcholine receptor M2target
DB01085PilocarpineCytochrome P450 2A6enzyme
DB01085PilocarpineMuscarinic acetylcholine receptor M3target
DB01085PilocarpineCytochrome P450 3A4enzyme
DB01085PilocarpineMuscarinic acetylcholine receptor M4target
DB00860PrednisoloneCorticosteroid-binding globulincarrier
DB00860PrednisoloneCytochrome P450 3A4enzyme
DB00860PrednisoloneGlucocorticoid receptortarget
DB00860PrednisoloneSolute carrier organic anion transporter family member 1A2transporter
DB00860PrednisoloneP-glycoprotein 1transporter
DB00635PrednisoneGlucocorticoid receptortarget
DB00635PrednisoneCytochrome P450 3A4enzyme
DB00635PrednisoneP-glycoprotein 1transporter
DB00635PrednisoneSolute carrier organic anion transporter family member 1A2transporter
DB00635PrednisoneCytochrome P450 2C19enzyme
DB00635PrednisoneSerum albumincarrier
DB00635PrednisoneCorticosteroid 11-beta-dehydrogenase isozyme 1target
DB00635PrednisoneCytochrome P450 3A5enzyme
DrugDrug NamePhaseStatusCount
DB00787Acyclovir1Completed1
DB01076Atorvastatin1Completed1
DB00169Cholecalciferol1Completed1
DB00003Dornase alfa1Withdrawn1
DB00005Etanercept1Completed1
DB00563Methotrexate1Completed1
DB09035Nivolumab1Recruiting1
DB00043Omalizumab1Completed1
DB00073Rituximab1Completed1
DB00759Tetracycline1Completed1
DB14848Tibulizumab1Completed1
DB12233Iguratimod1 / 2Recruiting1
DB00073Rituximab1 / 2Completed1
DB09145Water1 / 2Completed1
DB01281Abatacept2Recruiting1
DB15291BMS-9861422Terminated1
DB08879Belimumab2Active Not Recruiting1
DB08879Belimumab2Completed2
DB00091Cyclosporine2Completed1
DB01234Dexamethasone2Terminated1
DB00095Efalizumab2Terminated1
DB00005Etanercept2Completed1
DB14845Filgotinib2Active Not Recruiting1
DB15260Iscalimab2Recruiting1
DB14770Lanraplenib2Active Not Recruiting1
DB00583Levocarnitine2Not Yet Recruiting1
DB15441Lulizumab pegol2Terminated1
DB00688Mycophenolate mofetil2Enrolling by Invitation1
DB05152NGX2672Completed1
DB01708Prasterone2Completed2
DB11656Rebamipide2Completed1
DB00073Rituximab2Active Not Recruiting1
DB01041Thalidomide2Completed1
DB12003Thymosin beta-42Completed1
DB15227Tirabrutinib2Active Not Recruiting1
DB00073Rituximab2 / 3Completed1
DB01281Abatacept3Completed1
DB00091Cyclosporine3Completed1
DB08818Hyaluronic acid3Unknown Status1
DB01611Hydroxychloroquine3Completed1
DB00864Tacrolimus3Completed1
DB06724Calcium carbonate4Not Yet Recruiting1
DB04272Citric acid4Completed1
DB00091Cyclosporine4Not Yet Recruiting1
DB01234Dexamethasone4Completed1
DB09567Olive oil4Completed1
DB01708Prasterone4Unknown Status1
DB00635Prednisone4Not Yet Recruiting1
DB11656Rebamipide4Completed1
DB00864Tacrolimus4Completed1
DB09255DextranNot AvailableRecruiting2
DB09462GlycerinNot AvailableRecruiting2
DB00741HydrocortisoneNot AvailableActive Not Recruiting1
DB01611HydroxychloroquineNot AvailableCompleted1
DB11075HypromelloseNot AvailableRecruiting2
DB14596Loteprednol etabonateNot AvailableCompleted1
DB10805Yellow Fever VaccineNot AvailableCompleted1