Sjögren's Syndrome

Also known as: Sjögren Syndrome / Sjogren's Disease / Sjogren's Syndrome / Sjogren Syndrome / Sicca syndrome [Sjögren] / Gougerot-Mulock-Houwer syndrome / Sjogren's / Syndrome Sjogren's / Sjoegren's syndrome / Sicca syndrome

DrugDrug NameDrug Description
DB00185CevimelineA muscarinic agonist with parasympathomimetic activities that is used for the symptomatic treatment of dry mouth in patients with Sjögren's Syndrome.
DB01611HydroxychloroquineAn antimalarial medication used to treat uncomplicated cases of malaria and for chemoprophylaxis in specific regions. Also a disease modifying anti-rheumatic drug (DMARD) indicated for treatment of rheumatoid arthritis and lupus erythematosus.
DB01085PilocarpineA muscarinic cholinergic agonist used on the eye to treat elevated intraocular pressure, various types of glaucoma, and to induce miosis. Also available orally to treat symptoms of dry mouth associated with Sjogren's syndrome and radiotherapy.
DB00860PrednisoloneA glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.
DB00635PrednisoneA corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases.
DrugDrug NameTargetType
DB00185CevimelineMuscarinic acetylcholine receptor M1target
DB00185CevimelineMuscarinic acetylcholine receptor M3target
DB00185CevimelineCytochrome P450 3A4enzyme
DB00185CevimelineCytochrome P450 2D6enzyme
DB00185CevimelineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB01611HydroxychloroquineDNAtarget
DB01611HydroxychloroquineToll-like receptor 7target
DB01611HydroxychloroquineToll-like receptor 9target
DB01611HydroxychloroquineCytochrome P450 2D6enzyme
DB01611HydroxychloroquineP-glycoprotein 1transporter
DB01611HydroxychloroquineSerum albumincarrier
DB01611Hydroxychloroquinealpha1-acid glycoproteincarrier
DB01611HydroxychloroquineCytochrome P450 3A4enzyme
DB01611HydroxychloroquineSolute carrier organic anion transporter family member 1A2transporter
DB01611HydroxychloroquineAngiotensin-converting enzyme 2target
DB01611HydroxychloroquineCytochrome P450 2C8enzyme
DB01085PilocarpineMuscarinic acetylcholine receptor M1target
DB01085PilocarpineMuscarinic acetylcholine receptor M2target
DB01085PilocarpineCytochrome P450 2A6enzyme
DB01085PilocarpineMuscarinic acetylcholine receptor M3target
DB01085PilocarpineCytochrome P450 3A4enzyme
DB01085PilocarpineMuscarinic acetylcholine receptor M4target
DB00860PrednisoloneCorticosteroid-binding globulincarrier
DB00860PrednisoloneCytochrome P450 3A4enzyme
DB00860PrednisoloneGlucocorticoid receptortarget
DB00860PrednisoloneSolute carrier organic anion transporter family member 1A2transporter
DB00860PrednisoloneP-glycoprotein 1transporter
DB00860PrednisoloneSerum albumincarrier
DB00635PrednisoneGlucocorticoid receptortarget
DB00635PrednisoneCytochrome P450 3A4enzyme
DB00635PrednisoneP-glycoprotein 1transporter
DB00635PrednisoneSolute carrier organic anion transporter family member 1A2transporter
DB00635PrednisoneCytochrome P450 2C19enzyme
DB00635PrednisoneSerum albumincarrier
DB00635PrednisoneCytochrome P450 3A5enzyme
DB00635PrednisoneCorticosteroid-binding globulincarrier
DB00635PrednisoneCytochrome P450 3A Subfamilyenzyme
DB00635PrednisoneCytochrome P450 2A6enzyme
DB00635PrednisoneCytochrome P450 1B1enzyme
DB00635PrednisoneCytochrome P450 2B6enzyme
DB00635PrednisoneCytochrome P450 2C8enzyme
DB00635PrednisoneCytochrome P450 2C9enzyme
DB00635PrednisoneCorticosteroid 11-beta-dehydrogenase isozyme 1enzyme
DrugDrug NamePhaseStatusCount
DB00787Acyclovir1Completed1
DB01076Atorvastatin1Completed1
DB00169Cholecalciferol1Completed1
DB00003Dornase alfa1Withdrawn1
DB00005Etanercept1Completed1
DB00563Methotrexate1Completed1
DB09035Nivolumab1Recruiting1
DB00043Omalizumab1Completed1
DB00073Rituximab1Completed1
DB00759Tetracycline1Completed1
DB14848Tibulizumab1Completed1
DB12233Iguratimod1 / 2Recruiting1
DB00073Rituximab1 / 2Completed1
DB08895Tofacitinib1 / 2Not Yet Recruiting1
DB09145Water1 / 2Completed1
DB01281Abatacept2Recruiting1
DB15291BMS-9861422Terminated1
DB08879Belimumab2Completed3
DB00091Cyclosporine2Completed1
DB01234Dexamethasone2Terminated1
DB00095Efalizumab2Terminated1
DB00005Etanercept2Completed1
DB14845Filgotinib2Completed1
DB15260Iscalimab2Recruiting1
DB14770Lanraplenib2Completed1
DB00583Levocarnitine2Not Yet Recruiting1
DB15441Lulizumab pegol2Terminated1
DB00688Mycophenolate mofetil2Enrolling by Invitation1
DB05152NGX2672Completed1
DB01708Prasterone2Completed2
DB11656Rebamipide2Completed1
DB00073Rituximab2Completed1
DB01041Thalidomide2Completed1
DB12003Thymosin beta-42Completed1
DB15227Tirabrutinib2Completed1
DB00073Rituximab2 / 3Completed1
DB01281Abatacept3Completed1
DB00091Cyclosporine3Completed1
DB08818Hyaluronic acid3Unknown Status1
DB01611Hydroxychloroquine3Completed1
DB00864Tacrolimus3Completed1
DB06724Calcium carbonate4Recruiting1
DB04272Citric acid4Completed1
DB00091Cyclosporine4Recruiting1
DB01234Dexamethasone4Completed1
DB09567Olive oil4Completed1
DB01708Prasterone4Unknown Status1
DB00635Prednisone4Recruiting1
DB11656Rebamipide4Completed1
DB00864Tacrolimus4Completed1
DB15649CarbomerNot AvailableRecruiting2
DB09255DextranNot AvailableRecruiting2
DB09462GlycerinNot AvailableRecruiting2
DB00741HydrocortisoneNot AvailableActive Not Recruiting1
DB01611HydroxychloroquineNot AvailableCompleted1
DB11075HypromelloseNot AvailableRecruiting2
DB14596Loteprednol etabonateNot AvailableCompleted1
DB10805Yellow Fever VaccineNot AvailableCompleted1