Huntington's Disease (HD)

Also known as: Huntington Disease / Huntington's chorea / Huntington's Disease

DrugDrug NameDrug Description
DB00915AmantadineA medication used to treat dyskinesia in Parkinson's patients receiving levodopa, as well as extrapyramidal side effects of medications.
DB12161DeutetrabenazineA vesicular monoamine transporter 2 inhibitor used for the symptomatic treatment of chorea in Huntington's disease and tardive dyskinesia.
DB00623FluphenazineA phenothiazine used to treat patients requiring long-term neuroleptic therapy.
DB00502HaloperidolAn antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium.
DB04844TetrabenazineA vesicular monoamine transporter 2 (VMAT) inhibitor used for the management of chorea associated with Huntington's Disease.
DrugDrug NameTargetType
DB00915AmantadineDopamine D2 receptortarget
DB00915AmantadineMatrix protein 2target
DB00915AmantadineAromatic-L-amino-acid decarboxylaseenzyme
DB00915AmantadineAmine oxidase [flavin-containing] Benzyme
DB00915AmantadineSolute carrier family 22 member 2transporter
DB00915AmantadineSolute carrier family 22 member 1transporter
DB00915AmantadineGlutamate receptor ionotropic, NMDA 3Atarget
DB00915AmantadineNeuronal acetylcholine receptor subunit alpha-7target
DB00915AmantadineNeuronal acetylcholine receptor subunit alpha-4target
DB00915AmantadineNeuronal acetylcholine receptor subunit alpha-3target
DB12161DeutetrabenazineSynaptic vesicular amine transportertarget
DB12161DeutetrabenazineCarbonyl reductase [NADPH] 1enzyme
DB12161DeutetrabenazineCarbonyl reductase [NADPH] 3enzyme
DB12161DeutetrabenazineCytochrome P450 2D6enzyme
DB12161DeutetrabenazineCytochrome P450 1A2enzyme
DB12161DeutetrabenazineCytochrome P450 3A5enzyme
DB12161DeutetrabenazineCytochrome P450 3A4enzyme
DB00623FluphenazineDopamine D2 receptortarget
DB00623FluphenazineCalmodulintarget
DB00623FluphenazineDopamine D1 receptortarget
DB00623FluphenazineCytochrome P450 2D6enzyme
DB00623FluphenazineP-glycoprotein 1transporter
DB00623FluphenazineCytochrome P450 2E1enzyme
DB00623FluphenazineAndrogen receptortarget
DB00623Fluphenazine5-hydroxytryptamine receptor 2Atarget
DB00623Fluphenazine5-hydroxytryptamine receptor 2Ctarget
DB00502HaloperidolDopamine D2 receptortarget
DB00502HaloperidolGlutamate receptor ionotropic, NMDA 2Btarget
DB00502HaloperidolDopamine D1 receptortarget
DB00502HaloperidolCytochrome P450 1A2enzyme
DB00502HaloperidolCytochrome P450 2D6enzyme
DB00502Haloperidol5-hydroxytryptamine receptor 2Atarget
DB00502HaloperidolDopamine D3 receptortarget
DB00502HaloperidolCytochrome P450 3A4enzyme
DB00502HaloperidolCytochrome P450 3A5enzyme
DB00502HaloperidolCytochrome P450 3A7enzyme
DB00502HaloperidolP-glycoprotein 1transporter
DB00502HaloperidolCarbonyl reductase [NADPH] 1enzyme
DB00502HaloperidolUDP-glucuronosyltransferase 1-9enzyme
DB00502HaloperidolCytochrome P450 2C19enzyme
DB00502HaloperidolCytochrome P450 2C9enzyme
DB00502HaloperidolMelanin-concentrating hormone receptor 1target
DB00502HaloperidolSynaptic vesicular amine transportertarget
DB00502Haloperidol5-hydroxytryptamine receptor 2Ctarget
DB00502HaloperidolSigma non-opioid intracellular receptor 1target
DB00502HaloperidolHistamine H1 receptortarget
DB00502HaloperidolMuscarinic acetylcholine receptor M3target
DB00502HaloperidolAlpha-1A adrenergic receptortarget
DB00502HaloperidolAlpha-2A adrenergic receptortarget
DB00502HaloperidolAlpha-2B adrenergic receptortarget
DB00502HaloperidolAlpha-2C adrenergic receptortarget
DB00502Haloperidol5-hydroxytryptamine receptor 1Atarget
DB00502Haloperidol5-hydroxytryptamine receptor 6target
DB00502Haloperidol5-hydroxytryptamine receptor 7target
DB00502HaloperidolCytochrome P450 1A1enzyme
DB04844TetrabenazineSynaptic vesicular amine transportertarget
DB04844TetrabenazineCytochrome P450 2D6enzyme
DB04844TetrabenazineDopamine D2 receptortarget
DB04844TetrabenazineCarbonyl reductase [NADPH] 1enzyme
DrugDrug NamePhaseStatusCount
DB00404Alprazolam1Completed1
DB00514Dextromethorphan1Completed1
DB00390Digoxin1Completed1
DB13134Fluorine F-181Completed1
DB12542GSK-3562781Completed2
DB00502Haloperidol1Recruiting1
DB01026Ketoconazole1Completed1
DB11725Latrepirdine1Completed9
DB04868Nilotinib1Recruiting1
DB00338Omeprazole1Completed1
DB00734Risperidone1Recruiting1
DB01954Rolipram1Completed1
DB01104Sertraline1Recruiting1
DB09270Ubidecarenone1Recruiting1
DB01586Ursodeoxycholic acid1Unknown Status1
DB00682Warfarin1Completed1
DB00148Creatine1 / 2Completed1
DB11725Latrepirdine1 / 2Completed1
DB01017Minocycline1 / 2Completed1
DB00915Amantadine2Completed1
DB00289Atomoxetine2Completed1
DB01156Bupropion2Completed1
DB09061Cannabidiol2Completed1
DB00215Citalopram2Completed1
DB00148Creatine2Completed3
DB00470Dronabinol2Completed1
DB01039Fenofibrate2Active Not Recruiting1
DB06685Laquinimod2Completed1
DB11725Latrepirdine2Completed1
DB14509Lithium carbonate2Completed1
DB08387Mardepodect2Completed2
DB08387Mardepodect2Terminated1
DB13004Mavoglurant2Terminated1
DB01043Memantine2Completed1
DB07138Neflamapimod2Recruiting1
DB15155Pepinemab2Active Not Recruiting1
DB06819Phenylbutyric acid2Completed1
DB11947Pridopidine2Completed2
DB11947Pridopidine2Terminated1
DB00734Risperidone2Not Yet Recruiting1
DB11677Triheptanoin2Active Not Recruiting1
DB11677Triheptanoin2Completed1
DB09270Ubidecarenone2Completed1
DB00313Valproic acid2Completed1
DB01017Minocycline2 / 3Completed1
DB11947Pridopidine2 / 3Completed1
DB00514Dextromethorphan3Recruiting1
DB09341Dextrose, unspecified form3Terminated1
DB08887Icosapent ethyl3Completed1
DB11725Latrepirdine3Completed1
DB11725Latrepirdine3Terminated1
DB00334Olanzapine3Completed1
DB11947Pridopidine3Completed1
DB00908Quinidine3Recruiting1
DB00740Riluzole3Completed1
DB04844Tetrabenazine3Completed1
DB13025Tiapride3Completed1
DB09270Ubidecarenone3Terminated1
DB01043Memantine4Unknown Status1
DB04844Tetrabenazine4Recruiting2
DB00915AmantadineNot AvailableRecruiting1
DB00190CarbidopaNot AvailableRecruiting1
DB00494EntacaponeNot AvailableRecruiting1
DB01235LevodopaNot AvailableRecruiting1
DB00413PramipexoleNot AvailableRecruiting1
DB00980RamelteonNot AvailableWithdrawn1
DB00268RopiniroleNot AvailableRecruiting1
DB00323TolcaponeNot AvailableRecruiting1