Retinopathy, Diabetic

Also known as: Diabetic Retinopathy / Retinal abnormality - diabetes-related / Retinopathy diabetic

DrugDrug NameDrug Description
DB08885AfliberceptAflibercept is a recombinant fusion protein that comprises of two main components: the vascular endothelial growth factor (VEGF) binding portions from the extracellular domains of human VEGF receptors 1 and 2 which is then fused to the Fc portion of human IgG1. Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 kilo Daltons (kDa). It contains approximately 15% glycosylation to give a total molecular weight of 115 kDa. All five putative N-glycosylation sites on each polypeptide chain predicted by the primary sequence can be occupied with carbohydrate and exhibit some degree of chain heterogeneity, including heterogeneity in terminal sialic acid residues, except at the single unsialylated site associated with the Fc domain. Aflibercept, as an ophthalmic agent, is used in the treatment of macular edema following Central Retinal Vein Occlusion (CRVO) and neovascular Age-Related Macular Degeneration (AMD). Ziv-aflibercept, under the brand name Zaltrap, was developed as an injection for treatment of metastatic colorectal cancer. FDA approved in November 18, 2011 and EMA approved in November 2012.
DB01270RanibizumabRanibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment designed for intraocular use. Ranibizumab binds to and inhibits the biologic activity of human vascular endothelial growth factor A (VEGF-A). Ranibizumab has a molecular weight of approximately 48 kilodaltons and is produced by an E. coli expression system in a nutrient medium containing the antibiotic tetracycline (tetracycline is not detectable in the final product). Ranibizumab is marketed under the name Lucentis®. It is indicated for the treatment of macular edema after retinal vein occlusion, age-related macular degeneration (wet), and diabetic macular edema.
DrugDrug NamePhaseStatusCount
DB00284Acarbose0Recruiting1
DB00047Insulin Glargine0Recruiting1
DB00331Metformin0Recruiting1
DB00620Triamcinolone0Completed1
DB00051Adalimumab1Unknown Status1
DB00112Bevacizumab1Unknown Status1
DB02533Pimagedine1Recruiting1
DB00877Sirolimus1Completed1
DB05075TG-1008011Completed1
DB00620Triamcinolone1Completed1
DB00620Triamcinolone1Unknown Status1
DB08885Aflibercept1 / 2Recruiting1
DB00112Bevacizumab1 / 2Completed1
DB01270Ranibizumab1 / 2Completed1
DB00877Sirolimus1 / 2Completed1
DB00620Triamcinolone1 / 2Unknown Status2
DB00819Acetazolamide2Completed2
DB00945Acetylsalicylic acid2Completed1
DB08885Aflibercept2Recruiting2
DB00112Bevacizumab2Completed4
DB00112Bevacizumab2Recruiting1
DB00112Bevacizumab2Unknown Status1
DB00484Brimonidine2Completed2
DB00758Clopidogrel2Completed1
DB01234Dexamethasone2Completed1
DB01234Dexamethasone2Recruiting1
DB00254Doxycycline2Completed2
DB00070Hyaluronidase2Completed1
DB11075Hypromellose2Completed1
DB00465Ketorolac2Completed1
DB06802Nepafenac2Completed1
DB08888Ocriplasmin2Recruiting1
DB11077Polyethylene glycol 4002Completed1
DB11078Propylene glycol2Completed1
DB01270Ranibizumab2Completed5
DB01270Ranibizumab2Unknown Status2
DB12332Rucaparib2Withdrawn1
DB06271Sulodexide2Completed1
DB00620Triamcinolone2Unknown Status1
DB00112Bevacizumab2 / 3Unknown Status1
DB00484Brimonidine2 / 3Completed1
DB00421Spironolactone2 / 3Recruiting1
DB00945Acetylsalicylic acid3Completed1
DB08885Aflibercept3Recruiting1
DB00112Bevacizumab3Completed2
DB00112Bevacizumab3Unknown Status1
DB01039Fenofibrate3Completed1
DB00070Hyaluronidase3Completed2
DB00065Infliximab3Terminated1
DB06802Nepafenac3Terminated1
DB04895Pegaptanib3Completed1
DB01270Ranibizumab3Completed3
DB11829Ruboxistaurin3Completed3
DB00641Simvastatin3Completed1
DB02712Sorbinil3Completed1
DB00620Triamcinolone3Completed2
DB08885Aflibercept4Recruiting2
DB00112Bevacizumab4Completed2
DB01432Cholestyramine4Recruiting1
DB13071Creatinolfosfate4Unknown Status1
DB01039Fenofibrate4Unknown Status1
DB05259Glatiramer Acetate4Unknown Status1
DB00654Latanoprost4Completed1
DB00742Mannitol4Unknown Status1
DB01270Ranibizumab4Completed4
DB01270Ranibizumab4Unknown Status1
DB08869Tesamorelin4Recruiting1
DB08885AfliberceptNot AvailableActive Not Recruiting1
DB00381AmlodipineNot AvailableCompleted1
DB00112BevacizumabNot AvailableCompleted2
DB00112BevacizumabNot AvailableUnknown Status1
DB00586DiclofenacNot AvailableCompleted2
DB00869DorzolamideNot AvailableCompleted1
DB00869DorzolamideNot AvailableRecruiting1
DB00654LatanoprostNot AvailableCompleted1
DB00722LisinoprilNot AvailableCompleted1
DB06812Povidone-iodineNot AvailableUnknown Status1
DB06824TriethylenetetramineNot AvailableTerminated1