In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib.

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Rolf MG, Curwen JO, Veldman-Jones M, Eberlein C, Wang J, Harmer A, Hellawell CJ, Braddock M

In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib.

Pharmacol Res Perspect. 2015 Oct;3(5):e00175. doi: 10.1002/prp2.175. Epub 2015 Sep 4.

PubMed ID

26516587 [ View in PubMed

]

Abstract

Off-target pharmacology may contribute to both adverse and beneficial effects of a new drug. In vitro pharmacological profiling is often applied early in drug discovery; there are fewer reports addressing the relevance of broad profiles to clinical adverse effects. Here, we have characterized the pharmacological profile of the active metabolite of fostamatinib, R406, linking an understanding of drug selectivity to the increase in blood pressure observed in clinical studies. R406 was profiled in a broad range of in vitro assays to generate a comprehensive pharmacological profile and key targets were further investigated using functional and cellular assay systems. A combination of traditional literature searches and text-mining approaches established potential mechanistic links between the profile of R406 and clinical side effects. R406 was selective outside the kinase domain, with only antagonist activity at the adenosine A3 receptor in the range relevant to clinical effects. R406 was less selective in the kinase domain, having activity at many protein kinases at therapeutically relevant concentrations when tested in multiple in vitro systems. Systematic literature analyses identified KDR as the probable target underlying the blood pressure increase observed in patients. While the in vitro pharmacological profile of R406 suggests a lack of selectivity among kinases, a combination of classical searching and text-mining approaches rationalized the complex profile establishing linkage between off-target pharmacology and clinically observed effects. These results demonstrate the utility of in vitro pharmacological profiling for a compound in late-stage clinical development.

DrugBank Data that Cites this Article

Drugs

Fostamatinib

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Fostamatinib	3-phosphoinositide-dependent protein kinase 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	5'-AMP-activated protein kinase (Protein Group)	Protein group	Humans	Unknown	Inhibitor	Details
Fostamatinib	5'-AMP-activated protein kinase catalytic subunit alpha-1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Activated CDC42 kinase 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Activin receptor type-1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Activin receptor type-1B	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Adenosine receptor A3	Protein	Humans	Unknown	Antagonist	Details
Fostamatinib	ALK tyrosine kinase receptor	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Angiopoietin-1 receptor	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Ankyrin repeat and protein kinase domain-containing protein 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	AP2-associated protein kinase 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Arachidonate 5-lipoxygenase	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Atypical kinase COQ8A, mitochondrial	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Atypical kinase COQ8B, mitochondrial	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Aurora kinase A	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Aurora kinase B	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Aurora kinase C	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	BDNF/NT-3 growth factors receptor	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	BMP-2-inducible protein kinase	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Bone morphogenetic protein receptor type-1B	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Bone morphogenetic protein receptor type-2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Calcium-dependent protein kinase 1	Protein	Plasmodium falciparum (isolate 3D7)	Unknown	Inhibitor	Details
Fostamatinib	Calcium/calmodulin-dependent protein kinase kinase 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Calcium/calmodulin-dependent protein kinase kinase 2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Calcium/calmodulin-dependent protein kinase type 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Calcium/calmodulin-dependent protein kinase type 1D	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Calcium/calmodulin-dependent protein kinase type 1G	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Calcium/calmodulin-dependent protein kinase type II subunit beta	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Calcium/calmodulin-dependent protein kinase type II subunit delta	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Calcium/calmodulin-dependent protein kinase type II subunit gamma	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	cAMP-dependent protein kinase catalytic subunit alpha	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	cAMP-dependent protein kinase catalytic subunit beta	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Casein kinase I isoform alpha	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Casein kinase II subunit alpha	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Casein kinase II subunit alpha'	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Cathepsin L1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Cathepsin S	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	cGMP-dependent protein kinase 2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	cGMP-specific 3',5'-cyclic phosphodiesterase	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Citron Rho-interacting kinase	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	CLIP-associating protein 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Cyclin-dependent kinase 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Cyclin-dependent kinase 15	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Cyclin-dependent kinase 16	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Cyclin-dependent kinase 17	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Cyclin-dependent kinase 4	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Cyclin-dependent kinase-like 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Cyclin-dependent kinase-like 2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Cyclin-G-associated kinase	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Cytoplasmic tyrosine-protein kinase BMX	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Death-associated protein kinase 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Death-associated protein kinase 2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Death-associated protein kinase 3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Discoidin domain-containing receptor 2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Dual specificity mitogen-activated protein kinase kinase 2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Dual specificity mitogen-activated protein kinase kinase 3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Dual specificity mitogen-activated protein kinase kinase 5	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Dual specificity mitogen-activated protein kinase kinase 6	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Dual specificity protein kinase CLK1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Dual specificity protein kinase CLK2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Dual specificity protein kinase CLK3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Dual specificity protein kinase CLK4	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Dual specificity protein kinase TTK	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Dual specificity testis-specific protein kinase 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	eIF-2-alpha kinase GCN2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Ephrin type-A receptor 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Ephrin type-A receptor 2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Ephrin type-A receptor 3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Ephrin type-A receptor 4	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Ephrin type-A receptor 5	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Ephrin type-A receptor 6	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Ephrin type-A receptor 7	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Ephrin type-A receptor 8	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Ephrin type-B receptor 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Ephrin type-B receptor 2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Ephrin type-B receptor 4	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Ephrin type-B receptor 6	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Epidermal growth factor receptor	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Epithelial discoidin domain-containing receptor 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Equilibrative nucleoside transporter 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Eukaryotic translation initiation factor 2-alpha kinase 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Fatty-acid amide hydrolase 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Fibroblast growth factor receptor 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Fibroblast growth factor receptor 2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Fibroblast growth factor receptor 3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Focal adhesion kinase 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Glycogen synthase kinase-3 alpha	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Glycogen synthase kinase-3 beta	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Hepatocyte growth factor receptor	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	High affinity nerve growth factor receptor	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Homeodomain-interacting protein kinase 2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Homeodomain-interacting protein kinase 3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Inhibitor of nuclear factor kappa-B kinase subunit beta	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Insulin receptor	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Insulin receptor-related protein	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Interferon-induced, double-stranded RNA-activated protein kinase	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Interleukin-1 receptor-associated kinase 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Interleukin-1 receptor-associated kinase 3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Interleukin-1 receptor-associated kinase 4	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Kappa-casein	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Leucine-rich repeat serine/threonine-protein kinase 2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Leukocyte tyrosine kinase receptor	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	LIM domain kinase 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	LIM domain kinase 2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Macrophage colony-stimulating factor 1 receptor	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Macrophage-stimulating protein receptor	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	MAP kinase-activated protein kinase 5	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	MAP kinase-interacting serine/threonine-protein kinase 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	MAP kinase-interacting serine/threonine-protein kinase 2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	MAP/microtubule affinity-regulating kinase 3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	MAP/microtubule affinity-regulating kinase 4	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mast/stem cell growth factor receptor Kit	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Maternal embryonic leucine zipper kinase	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Megakaryocyte-associated tyrosine-protein kinase	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Microtubule-associated serine/threonine-protein kinase 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Misshapen-like kinase 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase 10	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase 13	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase 14	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase 15	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase 4	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase 7	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase 9	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase kinase kinase 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase kinase kinase 10	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase kinase kinase 11	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase kinase kinase 12	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase kinase kinase 13	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase kinase kinase 15	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase kinase kinase 19	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase kinase kinase 2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase kinase kinase 3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase kinase kinase 4	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase kinase kinase 6	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase kinase kinase 9	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase kinase kinase kinase 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase kinase kinase kinase 2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase kinase kinase kinase 3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase kinase kinase kinase 4	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase kinase kinase kinase 5	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Mitogen-activated protein kinase kinase kinase MLT	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Muscle, skeletal receptor tyrosine-protein kinase	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Myosin light chain kinase 2, skeletal/cardiac muscle	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Myosin light chain kinase 3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Myosin light chain kinase family member 4	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Myosin light chain kinase, smooth muscle	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Myosin-IIIa	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Non-receptor tyrosine-protein kinase TNK1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Non-receptor tyrosine-protein kinase TYK2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	NT-3 growth factor receptor	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	NUAK family SNF1-like kinase 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	NUAK family SNF1-like kinase 2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Peripheral plasma membrane protein CASK	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Phosphatidylinositol 4-kinase beta	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Platelet-derived growth factor receptor alpha	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Platelet-derived growth factor receptor beta	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Protein kinase C delta type	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Protein kinase C epsilon type	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Protein kinase C gamma type (PRKCG)	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Protein kinase C iota type	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Protein kinase C theta type	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Protein-tyrosine kinase 2-beta	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Protein-tyrosine kinase 6	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Proto-oncogene tyrosine-protein kinase receptor Ret	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Proto-oncogene tyrosine-protein kinase ROS	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Proto-oncogene tyrosine-protein kinase Src	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	RAF proto-oncogene serine/threonine-protein kinase	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Receptor tyrosine-protein kinase erbB-2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Receptor tyrosine-protein kinase erbB-4	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Receptor-interacting serine/threonine-protein kinase 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Receptor-interacting serine/threonine-protein kinase 2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Receptor-interacting serine/threonine-protein kinase 4	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Receptor-type tyrosine-protein kinase FLT3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Rho-associated protein kinase 2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Ribosomal protein S6 kinase alpha-1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Ribosomal protein S6 kinase alpha-3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Ribosomal protein S6 kinase alpha-6	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase 10	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase 16	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase 17A	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase 17B	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase 24	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase 3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase 32A	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase 33	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase 35	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase 36	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase 38	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase 38-like	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase B-raf	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase Chk1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase Chk2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase D1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase DCLK1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase DCLK2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase DCLK3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase ICK	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase LATS1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase MARK1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase MARK2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase MRCK gamma	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase MST4	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase mTOR	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase N1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase N2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase Nek1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase Nek11	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase Nek2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase Nek3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase Nek4	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase Nek5	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase Nek9	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase NIM1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase OSR1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase PAK 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase PAK 2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase PAK 3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase PAK 4	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase PAK 5	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase PAK 6	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase pim-1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase pim-3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase PknB	Protein	Mycobacterium tuberculosis	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase PLK1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase PLK2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase PLK3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase PLK4	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase PRP4 homolog	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase RIO1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase RIO2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase RIO3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase SBK1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase Sgk3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase SIK1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase SIK2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase SIK3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase TAO1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase TAO2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase TAO3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase TBK1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase TNNI3K	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase tousled-like 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase tousled-like 2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase ULK1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase ULK2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase ULK3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Serine/threonine-protein kinase/endoribonuclease IRE1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	SNF-related serine/threonine-protein kinase	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	STE20-like serine/threonine-protein kinase	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	STE20/SPS1-related proline-alanine-rich protein kinase	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Synaptic vesicular amine transporter	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Testis-specific serine/threonine-protein kinase 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	TGF-beta receptor type-1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	TGF-beta receptor type-2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	TRAF2 and NCK-interacting protein kinase	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase ABL1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase ABL2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase Blk	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase BTK	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase CSK	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase Fer	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase Fes/Fps	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase Fgr	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase FRK	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase Fyn	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase HCK	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase ITK/TSK	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase JAK1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase JAK2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase JAK3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase Lck	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase Lyn	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase Mer	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase receptor Tie-1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase receptor TYRO3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase receptor UFO	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase Srms	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase SYK	Protein	Humans	Yes	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase Tec	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase TXK	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase Yes	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Tyrosine-protein kinase ZAP-70	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	UDP-glucuronosyltransferase 1-1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Uncharacterized serine/threonine-protein kinase SBK3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Vascular endothelial growth factor receptor 1	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Vascular endothelial growth factor receptor 2	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Vascular endothelial growth factor receptor 3	Protein	Humans	Unknown	Inhibitor	Details
Fostamatinib	Wee1-like protein kinase	Protein	Humans	Unknown	Inhibitor	Details