Hypertension,Essential

Also known as: Primary Hypertension / Hypertension, Essential / Essential Hypertension / Essential hypertension, unspecified / Essential (primary) hypertension / Unspecified essential hypertension

DrugDrug NameDrug Description
DB01275HydralazineA direct-acting vasodilator that is used as an antihypertensive agent.
DB00999HydrochlorothiazideA thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It has been used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
DB00790PerindoprilPerindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Perindopril may be used to treat mild to moderate essential hypertension, mild to moderate congestive heart failure, and to reduce the cardiovascular risk of individuals with hypertension or post-myocardial infarction and stable coronary disease.
DrugDrug NamePhaseStatusCount
DB00381Amlodipine1Completed1
DB11842Angiotensin II1Recruiting1
DB01076Atorvastatin1Completed4
DB00796Candesartan cilexetil1Completed2
DB11086Cocoa butter1Recruiting1
DB00390Digoxin1Completed1
DB09279Fimasartan1Completed10
DB00999Hydrochlorothiazide1Completed2
DB01026Ketoconazole1Completed1
DB09237Levamlodipine1Completed1
DB01115Nifedipine1Completed1
DB00388Phenylephrine1Recruiting1
DB13107QGC-0011Completed2
DB01045Rifampicin1Completed1
DB11088Shark liver oil1Recruiting1
DB09153Sodium Chloride1Completed1
DB00966Telmisartan1Completed2
DB01116Trimethaphan1Recruiting1
DB00682Warfarin1Completed1
DB05739CYT006-AngQb1 / 2Completed1
DB00999Hydrochlorothiazide1 / 2Recruiting1
DB00437Allopurinol2Completed1
DB00381Amlodipine2Completed3
DB00381Amlodipine2Recruiting1
DB00381Amlodipine2Unknown Status1
DB08822Azilsartan medoxomil2Completed1
DB00796Candesartan cilexetil2Completed3
DB00796Candesartan cilexetil2Recruiting1
DB00796Candesartan cilexetil2Unknown Status1
DB00584Enalapril2Completed1
DB00700Eplerenone2Completed2
DB00898Ethanol2Not Yet Recruiting1
DB09279Fimasartan2Completed2
DB00999Hydrochlorothiazide2Completed1
DB02325Isopropyl alcohol2Not Yet Recruiting1
DB00528Lercanidipine2Completed2
DB00722Lisinopril2Completed1
DB00678Losartan2Unknown Status1
DB04861Nebivolol2Completed1
DB01115Nifedipine2Completed1
DB11837Osilodrostat2Completed1
DB13107QGC-0012Completed1
DB12350Rostafuroxin2Completed1
DB12350Rostafuroxin2Unknown Status1
DB09292Sacubitril2Completed1
DB00421Spironolactone2Completed1
DB00820Tadalafil2Completed1
DB00177Valsartan2Completed3
DB00381Amlodipine2 / 3Completed1
DB00381Amlodipine2 / 3Unknown Status2
DB12236Bexagliflozin2 / 3Completed1
DB11121Chloroxylenol2 / 3Unknown Status2
DB00125L-Arginine2 / 3Completed1
DB00177Valsartan2 / 3Completed1
DB09026Aliskiren3Completed4
DB00381Amlodipine3Completed12
DB00381Amlodipine3Recruiting1
DB00381Amlodipine3Unknown Status2
DB00335Atenolol3Completed1
DB01076Atorvastatin3Completed1
DB05358Azilsartan medoxomil3Completed4
DB08822Azilsartan medoxomil3Completed6
DB08822Azilsartan medoxomil3Unknown Status1
DB00796Candesartan cilexetil3Unknown Status2
DB01136Carvedilol3Unknown Status1
DB00310Chlorthalidone3Completed5
DB00700Eplerenone3Completed2
DB00876Eprosartan3Completed1
DB09279Fimasartan3Completed3
DB09279Fimasartan3Recruiting1
DB00695Furosemide3Completed1
DB00999Hydrochlorothiazide3Completed12
DB11783Imidapril3Unknown Status1
DB00678Losartan3Completed4
DB00678Losartan3Unknown Status1
DB00275Olmesartan3Completed16
DB00275Olmesartan3Unknown Status1
DB00790Perindopril3Completed2
DB01098Rosuvastatin3Recruiting1
DB09292Sacubitril3Completed4
DB00641Simvastatin3Completed1
DB00421Spironolactone3Completed1
DB00966Telmisartan3Completed1
DB00177Valsartan3Completed4
DB00945Acetylsalicylic acid4Completed1
DB09026Aliskiren4Completed2
DB00594Amiloride4Unknown Status1
DB00381Amlodipine4Completed7
DB00381Amlodipine4Unknown Status1
DB09204Arotinolol4Recruiting1
DB00335Atenolol4Completed1
DB00335Atenolol4Terminated1
DB08822Azilsartan medoxomil4Completed1
DB00796Candesartan cilexetil4Completed1
DB00796Candesartan cilexetil4Unknown Status1
DB01136Carvedilol4Completed1
DB00310Chlorthalidone4Recruiting1
DB00590Doxazosin4Completed1
DB00584Enalapril4Completed2
DB00584Enalapril4Not Yet Recruiting1
DB00876Eprosartan4Completed1
DB00999Hydrochlorothiazide4Completed1
DB00999Hydrochlorothiazide4Not Yet Recruiting1
DB00999Hydrochlorothiazide4Unknown Status1
DB01088Iloprost4Completed1
DB01029Irbesartan4Completed1
DB09236Lacidipine4Completed1
DB00528Lercanidipine4Completed2
DB09237Levamlodipine4Recruiting1
DB00722Lisinopril4Completed2
DB00678Losartan4Completed1
DB00678Losartan4Unknown Status2
DB09238Manidipine4Completed1
DB00264Metoprolol4Recruiting1
DB01115Nifedipine4Completed1
DB01115Nifedipine4Unknown Status1
DB00275Olmesartan4Completed1
DB00275Olmesartan4Terminated1
DB00881Quinapril4Completed1
DB00178Ramipril4Completed3
DB00178Ramipril4Unknown Status1
DB00641Simvastatin4Unknown Status1
DB00966Telmisartan4Completed1
DB00966Telmisartan4Recruiting1
DB00966Telmisartan4Unknown Status1
DB00177Valsartan4Completed4
DB00177Valsartan4Unknown Status1
DB00594AmilorideNot AvailableCompleted1
DB00381AmlodipineNot AvailableCompleted1
DB00381AmlodipineNot AvailableRecruiting1
DB00612BisoprololNot AvailableRecruiting1
DB00310ChlorthalidoneNot AvailableCompleted1
DB00492FosinoprilNot AvailableCompleted1
DB00999HydrochlorothiazideNot AvailableCompleted2
DB00999HydrochlorothiazideNot AvailableRecruiting1
DB00125L-ArginineNot AvailableRecruiting1
DB00722LisinoprilNot AvailableCompleted1
DB00331MetforminNot AvailableCompleted1
DB00727NitroglycerinNot AvailableRecruiting1
DB00275OlmesartanNot AvailableCompleted1
DB00275OlmesartanNot AvailableRecruiting1
DB00790PerindoprilNot AvailableCompleted2
DB00790PerindoprilNot AvailableRecruiting1
DB01001SalbutamolNot AvailableRecruiting1
DB00421SpironolactoneNot AvailableCompleted1
DB00966TelmisartanNot AvailableCompleted1
DB11815TilarginineNot AvailableUnknown Status1