Medulloblastomas

Also known as: Medulloblastoma

DrugDrug NameDrug Description
DB00262CarmustineA cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
DB00515CisplatinCisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
DrugDrug NameTargetType
DB00262CarmustineGlutathione reductase, mitochondrialtarget
DB00262CarmustineDNAtarget
DB00262CarmustineCytochrome P450 1A2enzyme
DB00262CarmustineRNAtarget
DB00515CisplatinDNAtarget
DB00515CisplatinCanalicular multispecific organic anion transporter 2transporter
DB00515CisplatinMultidrug resistance-associated protein 5transporter
DB00515CisplatinCanalicular multispecific organic anion transporter 1transporter
DB00515CisplatinSolute carrier family 22 member 2transporter
DB00515CisplatinHigh affinity copper uptake protein 1transporter
DB00515CisplatinProbable low affinity copper uptake protein 2transporter
DB00515CisplatinMultidrug resistance-associated protein 6transporter
DB00515CisplatinMultidrug resistance protein 1transporter
DB00515CisplatinCopper-transporting ATPase 2transporter
DB00515CisplatinCopper-transporting ATPase 1transporter
DB00515CisplatinProstaglandin G/H synthase 2enzyme
DB00515CisplatinMyeloperoxidaseenzyme
DB00515CisplatinXanthine dehydrogenase/oxidaseenzyme
DB00515CisplatinArylamine N-acetyltransferaseenzyme
DB00515CisplatinCytochrome P450 2C9enzyme
DB00515CisplatinCytochrome P450 2B6enzyme
DB00515CisplatinCholinesteraseenzyme
DB00515CisplatinCytochrome P450 4A11enzyme
DB00515CisplatinATP-binding cassette sub-family G member 2transporter
DB00515CisplatinGlutathione S-transferase theta-1enzyme
DB00515CisplatinMetallothionein-1Aenzyme
DB00515CisplatinMetallothionein-2enzyme
DB00515CisplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00515CisplatinGlutathione S-transferase Penzyme
DB00515CisplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00515CisplatinGlutathione S-transferase Mu 1enzyme
DB00515CisplatinDNA-3-methyladenine glycosylasetarget
DB00515CisplatinAlpha-2-macroglobulintarget
DB00515CisplatinSerum albumincarrier
DB00515CisplatinSerotransferrintarget
DB00515CisplatinCopper transport protein ATOX1target
DrugDrug NamePhaseStatusCount
DB00958Carboplatin1Completed1
DB00531Cyclophosphamide1Recruiting1
DB00260Cycloserine1Completed1
DB00773Etoposide1Recruiting1
DB00099Filgrastim1Recruiting1
DB00441Gemcitabine1Recruiting1
DB00724Imiquimod1Completed1
DB12827Indoximod1Recruiting1
DB00762Irinotecan1Not Yet Recruiting1
DB06549Labradimil1Completed1
DB00643Mebendazole1Recruiting1
DB00526Oxaliplatin1Recruiting1
DB09073Palbociclib1Not Yet Recruiting1
DB00019Pegfilgrastim1Recruiting1
DB11730Ribociclib1Recruiting1
DB00877Sirolimus1Active Not Recruiting1
DB09143Sonidegib1Completed2
DB09143Sonidegib1Recruiting1
DB00853Temozolomide1Completed1
DB00853Temozolomide1Not Yet Recruiting1
DB00853Temozolomide1Recruiting1
DB00323Tolcapone1Recruiting1
DB08911Trametinib1Recruiting1
DB00313Valproic Acid1Withdrawn1
DB07232Veliparib1Completed1
DB00515Cisplatin1 / 2Active Not Recruiting1
DB01262Decitabine1 / 2Terminated1
DB01206Lomustine1 / 2Active Not Recruiting1
DB09143Sonidegib1 / 2Completed1
DB00541Vincristine1 / 2Active Not Recruiting1
DB06361rsPSMA Vaccine1 / 2Terminated1
DB09393Amino acids2Recruiting1
DB09393Amino acids2Withdrawn1
DB00112Bevacizumab2Recruiting1
DB00958Carboplatin2Unknown Status1
DB00493Cefotaxime2Recruiting1
DB00482Celecoxib2Recruiting1
DB00515Cisplatin2Recruiting2
DB00515Cisplatin2Terminated1
DB00515Cisplatin2Unknown Status1
DB09110Coenzyme M2Terminated1
DB00531Cyclophosphamide2Recruiting4
DB00531Cyclophosphamide2Terminated1
DB00987Cytarabine2Recruiting1
DB08912Dabrafenib2Recruiting1
DB00530Erlotinib2Recruiting1
DB00773Etoposide2Recruiting2
DB00773Etoposide2Terminated1
DB00773Etoposide2Unknown Status1
DB01039Fenofibrate2Recruiting1
DB00441Gemcitabine2Recruiting1
DB01645Genistein2Recruiting1
DB00142Glutamic Acid2Active Not Recruiting1
DB00145Glycine2Active Not Recruiting1
DB00117Histidine2Active Not Recruiting1
DB00762Irinotecan2Completed1
DB00160L-Alanine2Active Not Recruiting1
DB00125L-Arginine2Active Not Recruiting1
DB00125L-Arginine2Recruiting2
DB00125L-Arginine2Withdrawn1
DB00128L-Aspartic Acid2Active Not Recruiting1
DB00167L-Isoleucine2Active Not Recruiting1
DB00149L-Leucine2Active Not Recruiting1
DB00123L-Lysine2Active Not Recruiting1
DB00123L-Lysine2Recruiting1
DB00123L-Lysine2Withdrawn1
DB00120L-Phenylalanine2Active Not Recruiting1
DB00172L-Proline2Active Not Recruiting1
DB00156L-Threonine2Active Not Recruiting1
DB00150L-Tryptophan2Active Not Recruiting1
DB00161L-Valine2Active Not Recruiting1
DB01206Lomustine2Recruiting1
DB01206Lomustine2Terminated1
DB01042Melphalan2Unknown Status1
DB00134Methionine2Active Not Recruiting1
DB00134Methionine2Recruiting1
DB12117Mitometh2Recruiting1
DB11102N-acetyltyrosine2Active Not Recruiting1
DB11820Nifurtimox2Recruiting1
DB00642Pemetrexed2Completed1
DB00642Pemetrexed2Recruiting1
DB08910Pomalidomide2Recruiting1
DB00133Serine2Active Not Recruiting1
DB09143Sonidegib2Completed1
DB00853Temozolomide2Completed2
DB00853Temozolomide2Recruiting2
DB01041Thalidomide2Recruiting1
DB04572Thiotepa2Unknown Status1
DB01030Topotecan2Recruiting1
DB08911Trametinib2Recruiting1
DB00541Vincristine2Recruiting2
DB00541Vincristine2Terminated1
DB00361Vinorelbine2Unknown Status1
DB08828Vismodegib2Recruiting1
DB00958Carboplatin2 / 3Completed1
DB00773Etoposide2 / 3Completed1
DB00853Temozolomide2 / 3Completed1
DB04572Thiotepa2 / 3Completed1
DB12902Trofosfamide2 / 3Completed1
DB00958Carboplatin3Suspended1
DB00493Cefotaxime3Suspended1
DB00515Cisplatin3Suspended1
DB00531Cyclophosphamide3Suspended1
DB00099Filgrastim3Suspended1
DB00982Isotretinoin3Suspended1
DB12257Platinum3Suspended1
DB00755Tretinoin3Suspended1
DB00541Vincristine3Suspended1
DB00958Carboplatin4Recruiting1
DB00773Etoposide4Recruiting1
DB04572Thiotepa4Recruiting1
DB01008BusulfanNot AvailableRecruiting1
DB00958CarboplatinNot AvailableActive Not Recruiting1
DB00958CarboplatinNot AvailableRecruiting1
DB00493CefotaximeNot AvailableActive Not Recruiting1
DB00515CisplatinNot AvailableActive Not Recruiting1
DB00515CisplatinNot AvailableRecruiting1
DB09110Coenzyme MNot AvailableRecruiting2
DB00531CyclophosphamideNot AvailableActive Not Recruiting1
DB00531CyclophosphamideNot AvailableRecruiting1
DB00773EtoposideNot AvailableActive Not Recruiting1
DB00773EtoposideNot AvailableRecruiting1
DB01181IfosfamideNot AvailableRecruiting1
DB00982IsotretinoinNot AvailableActive Not Recruiting1
DB01206LomustineNot AvailableRecruiting1
DB01042MelphalanNot AvailableRecruiting1
DB12117MitomethNot AvailableActive Not Recruiting1
DB01229PaclitaxelNot AvailableRecruiting1
DB04572ThiotepaNot AvailableActive Not Recruiting1
DB04572ThiotepaNot AvailableRecruiting1
DB00755TretinoinNot AvailableActive Not Recruiting1
DB01586Ursodeoxycholic acidNot AvailableRecruiting1
DB00541VincristineNot AvailableActive Not Recruiting1
DB00541VincristineNot AvailableRecruiting1
DB02546VorinostatNot AvailableActive Not Recruiting1