BMI >27 kg/m2

Also known as: Overweight

DrugDrug NameDrug Description
DB00704NaltrexoneDerivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
DB00191PhenterminePhentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine.[A174370] Phentermine has not been reported an addictive potential which allows this agent to be classified under the Schedule IV drugs (low abuse potential).[A174367] Phentermine was FDA approved for short-term weight management in 1959 and it became widely used in 1960. This initial product, formed by the combination of phentermine with [fenfluramine] and [dexfenfluramine] was discontinued after finding several reports of abnormal valves in nearly 30% of the consumers.[A174376, T403] Later on, phentermine was approved alone and in combination with topiramate in 2012 as a new alternative that required lower doses of phentermine to obtain the desired effect.[A174373]
DrugDrug NamePhaseStatusCount
DB14949AZD-76871Completed1
DB00316Acetaminophen1Not Yet Recruiting1
DB06698Betahistine1Completed1
DB00331Metformin1Recruiting1
DB01083Orlistat1Completed1
DB14887PF-046201101Completed2
DB01132Pioglitazone1Completed1
DB13928Semaglutide1Active Not Recruiting2
DB13928Semaglutide1Recruiting1
DB11700Setmelanotide1Completed1
DB01586Ursodeoxycholic acid1Recruiting1
DB05098Leptin1 / 2Completed1
DB09046Metreleptin1 / 2Completed1
DB11700Setmelanotide1 / 2Completed1
DB01156Bupropion2Completed1
DB00608Chloroquine2Active Not Recruiting1
DB14956Davalintide2Completed1
DB11994Diacerein2Completed1
DB01276Exenatide2Completed1
DB01039Fenofibrate2Terminated1
DB05098Leptin2Completed1
DB15048Licogliflozin2Completed1
DB06655Liraglutide2Recruiting1
DB09046Metreleptin2Completed2
DB00704Naltrexone2Completed1
DB14016Ox bile extract2Completed1
DB00191Phentermine2Completed1
DB01278Pramlintide2Completed4
DB11700Setmelanotide2Completed1
DB01105Sibutramine2Completed2
DB12414Usistapide2Completed2
DB00159Icosapent2 / 3Active Not Recruiting1
DB11133Omega-3 fatty acids2 / 3Active Not Recruiting1
DB14151Phosphorus2 / 3Completed1
DB01399Salsalate2 / 3Completed1
DB09026Aliskiren3Completed1
DB06413Armodafinil3Completed1
DB01156Bupropion3Completed4
DB01156Bupropion3Terminated1
DB13961Fish oil3Terminated1
DB06655Liraglutide3Recruiting1
DB04871Lorcaserin3Completed1
DB00678Losartan3Completed1
DB00331Metformin3Completed1
DB00704Naltrexone3Completed4
DB00704Naltrexone3Terminated1
DB13928Semaglutide3Active Not Recruiting4
DB13928Semaglutide3Recruiting2
DB01238Aripiprazole4Completed1
DB01373Calcium4Completed1
DB06724Calcium carbonate4Completed1
DB08907Canagliflozin4Completed1
DB00758Clopidogrel4Completed1
DB01276Exenatide4Recruiting1
DB06655Liraglutide4Active Not Recruiting1
DB06655Liraglutide4Completed2
DB06655Liraglutide4Not Yet Recruiting1
DB06655Liraglutide4Recruiting2
DB06655Liraglutide4Terminated1
DB04871Lorcaserin4Completed1
DB04871Lorcaserin4Recruiting1
DB00331Metformin4Active Not Recruiting1
DB00331Metformin4Completed1
DB00331Metformin4Recruiting2
DB01141Micafungin4Completed1
DB01252Mitiglinide4Active Not Recruiting1
DB09242Moxonidine4Unknown Status1
DB00275Olmesartan4Completed1
DB01083Orlistat4Completed1
DB11094Vitamin D4Completed1
DB00437AllopurinolNot AvailableCompleted1
DB01156BupropionNot AvailableCompleted1
DB00608ChloroquineNot AvailableActive Not Recruiting1
DB00586DiclofenacNot AvailableCompleted1
DB00153ErgocalciferolNot AvailableCompleted1
DB06655LiraglutideNot AvailableCompleted1
DB06655LiraglutideNot AvailableEnrolling by Invitation1
DB06655LiraglutideNot AvailableRecruiting2
DB04871LorcaserinNot AvailableActive Not Recruiting1
DB00704NaltrexoneNot AvailableCompleted1
DB00184NicotineNot AvailableCompleted1
DB01083OrlistatNot AvailableCompleted4
DB01083OrlistatNot AvailableNot Yet Recruiting1
DB01083OrlistatNot AvailableWithdrawn1
DB00191PhentermineNot AvailableCompleted1
DB00191PhentermineNot AvailableNot Yet Recruiting1
DB09528PhylloquinoneNot AvailableUnknown Status1
DB01032ProbenecidNot AvailableCompleted1
DB11094Vitamin DNot AvailableCompleted1