Depressive Disorders

Also known as: Depressive Disorder / Monopolar depression NOS / Depressive state / Depression psychic / [X]Depression NOS / Depression NOS / Depressed state / Depression / Depression mental / Depressive illness / Depressive neurosis

DrugDrug NameDrug Description
DB00472FluoxetineFluoxetine hydrochloride is the first agent of the class of antidepressants known as selective serotonin-reuptake inhibitors (SSRIs). Fluoxetine is a racemic mixture of the R- and S- enantiomers and are of equivalent pharmacologic activity. Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT1A and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Fluoxetine may be used to treat major depressive disorder (MDD), moderate to severe bulimia nervosa, obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), panic disorder with or without agoraphobia, and in combination with olanzapine for treatment-resistant or bipolar I depression. Fluoxetine is the most anorexic and stimulating SSRI.
DrugDrug NamePhaseStatusCount
DB00215Citalopram0Recruiting1
DB01238Aripiprazole1Completed2
DB01156Bupropion1Terminated1
DB12542GSK-3562781Completed1
DB00683Midazolam1Completed1
DB05805NS-23591Completed2
DB00184Nicotine1Completed1
DB00334Olanzapine1Completed1
DB12427Orvepitant1Completed2
DB01267Paliperidone1Completed1
DB00715Paroxetine1Completed2
DB01224Quetiapine1Completed1
DB00734Risperidone1Completed1
DB08839Serotonin1Completed1
DB00945Acetylsalicylic acid2Recruiting1
DB01156Bupropion2Completed2
DB00115Cyanocobalamin2Completed1
DB04953Ezogabine2Recruiting1
DB00158Folic Acid2Completed1
DB05087Ganaxolone2Recruiting2
DB01221Ketamine2Recruiting1
DB01221Ketamine2Terminated1
DB00657Mecamylamine2Completed1
DB01017Minocycline2Terminated1
DB05805NS-23592Completed2
DB12643Nelivaptan2Completed2
DB06690Nitrous oxide2Recruiting1
DB05423ORG-345172Completed2
DB12427Orvepitant2Terminated1
DB00107Oxytocin2Recruiting1
DB00715Paroxetine2Completed1
DB01708Prasterone2Completed1
DB00936Salicylic acid2Recruiting1
DB01104Sertraline2Completed1
DB00285Venlafaxine2Completed2
DB09068Vortioxetine2Completed1
DB01356Lithium cation2 / 3Active Not Recruiting1
DB00834Mifepristone2 / 3Terminated1
DB09128Brexpiprazole3Completed5
DB00921Buprenorphine3Completed1
DB01156Bupropion3Completed1
DB00215Citalopram3Completed1
DB01151Desipramine3Completed1
DB00476Duloxetine3Completed3
DB00476Duloxetine3Recruiting2
DB01175Escitalopram3Completed3
DB01175Escitalopram3Terminated1
DB00472Fluoxetine3Completed1
DB08887Icosapent ethyl3Completed1
DB00834Mifepristone3Terminated1
DB01183Naloxone3Completed1
DB00715Paroxetine3Completed2
DB01224Quetiapine3Completed1
DB00734Risperidone3Completed1
DB06660Saredutant3Completed3
DB01104Sertraline3Completed1
DB13196Valerian3Terminated1
DB00285Venlafaxine3Completed1
DB00289Atomoxetine4Completed1
DB01156Bupropion4Recruiting1
DB00215Citalopram4Recruiting1
DB00476Duloxetine4Completed1
DB00476Duloxetine4Recruiting1
DB01175Escitalopram4Completed1
DB01175Escitalopram4Recruiting1
DB00472Fluoxetine4Recruiting2
DB00176Fluvoxamine4Recruiting2
DB01221Ketamine4Enrolling by Invitation1
DB01221Ketamine4Unknown Status1
DB01356Lithium cation4Completed1
DB01356Lithium cation4Recruiting1
DB00186Lorazepam4Completed1
DB01043Memantine4Completed1
DB01011Metyrapone4Recruiting1
DB01017Minocycline4Completed1
DB00370Mirtazapine4Completed1
DB00370Mirtazapine4Recruiting1
DB00540Nortriptyline4Completed1
DB00334Olanzapine4Completed1
DB00715Paroxetine4Recruiting1
DB00715Paroxetine4Terminated1
DB01104Sertraline4Recruiting1
DB01236Sevoflurane4Unknown Status1
DB09153Sodium chloride4Unknown Status1
DB00285Venlafaxine4Completed2
DB00285Venlafaxine4Recruiting1
DB09068Vortioxetine4Recruiting1
DB06594AgomelatineNot AvailableCompleted1
DB06634CasopitantNot AvailableCompleted1
DB00215CitalopramNot AvailableTerminated1
DB00476DuloxetineNot AvailableCompleted1
DB01356Lithium cationNot AvailableTerminated1
DB06480PrucaloprideNot AvailableCompleted1
DB06480PrucaloprideNot AvailableNot Yet Recruiting1
DB01104SertralineNot AvailableCompleted2
DB00624TestosteroneNot AvailableCompleted1
DB01273VareniclineNot AvailableCompleted1
DB01273VareniclineNot AvailableWithdrawn1
DB00285VenlafaxineNot AvailableCompleted1