Depression, Bipolar

Also known as: Bipolar I depression / Bipolar depression / Bipolar affective disorder, depressed / Manic-depressive - now depressed / Bipolar disorder / Manic depressive reaction / Bipolar affective disorder, unspecified / Manic depressive / Reaction manic-depressive / Psychosis manic-depressive / Manic depressive illness / Manic depression / Manic depressive psychosis / Bipolar affective disorder / Bipolar disorders

DrugDrug NameDrug Description
DB01156BupropionA unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to block dopamine uptake. The hydrochloride is available as an aid to smoking cessation treatment.
DB00472FluoxetineFluoxetine hydrochloride is the first agent of the class of antidepressants known as selective serotonin-reuptake inhibitors (SSRIs). Fluoxetine is a racemic mixture of the R- and S- enantiomers and are of equivalent pharmacologic activity. Despite distinct structural differences between compounds in this class, SSRIs possess similar pharmacological activity. As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. SSRIs are potent inhibitors of neuronal serotonin reuptake. They have little to no effect on norepinephrine or dopamine reuptake and do not antagonize α- or β-adrenergic, dopamine D2 or histamine H1 receptors. During acute use, SSRIs block serotonin reuptake and increase serotonin stimulation of somatodendritic 5-HT1A and terminal autoreceptors. Chronic use leads to desensitization of somatodendritic 5-HT1A and terminal autoreceptors. The overall clinical effect of increased mood and decreased anxiety is thought to be due to adaptive changes in neuronal function that leads to enhanced serotonergic neurotransmission. Side effects include dry mouth, nausea, dizziness, drowsiness, sexual dysfunction and headache. Side effects generally occur within the first two weeks of therapy and are usually less severe and frequent than those observed with tricyclic antidepressants. Fluoxetine may be used to treat major depressive disorder (MDD), moderate to severe bulimia nervosa, obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), panic disorder with or without agoraphobia, and in combination with olanzapine for treatment-resistant or bipolar I depression. Fluoxetine is the most anorexic and stimulating SSRI.
DB01356Lithium cationLithium was used during the 19th century to treat gout. Lithium salts such as lithium carbonate (Li2CO3), lithium citrate, and lithium orotate are mood stabilizers. They are used in the treatment of bipolar disorder, since unlike most other mood altering drugs, they counteract both mania and depression. Lithium can also be used to augment other antidepressant drugs. It is also sometimes prescribed as a preventive treatment for migraine disease and cluster headaches. The active principle in these salts is the lithium ion Li+, which having a smaller diameter, can easily displace K+ and Na+ and even Ca+2, in spite of its greater charge, occupying their sites in several critical neuronal enzymes and neurotransmitter receptors.
DrugDrug NameTargetType
DB01156BupropionSodium-dependent dopamine transportertarget
DB01156BupropionSodium-dependent noradrenaline transportertarget
DB01156BupropionCytochrome P450 2B6enzyme
DB01156BupropionCytochrome P450 2D6enzyme
DB01156BupropionAlpha-1-acid glycoprotein 1carrier
DB01156BupropionNeuronal acetylcholine receptor subunit alpha-3target
DB01156BupropionCytochrome P450 2A6enzyme
DB01156BupropionCytochrome P450 2C8enzyme
DB01156BupropionCytochrome P450 2C9enzyme
DB01156BupropionCytochrome P450 2E1enzyme
DB01156BupropionCytochrome P450 3A4enzyme
DB01156BupropionSolute carrier family 22 member 2transporter
DB00472FluoxetineSodium-dependent serotonin transportertarget
DB00472FluoxetineCytochrome P450 2C9enzyme
DB00472FluoxetineCytochrome P450 2D6enzyme
DB00472FluoxetineCYP2B proteinenzyme
DB00472FluoxetineCytochrome P450 1A2enzyme
DB00472FluoxetineCytochrome P450 3A4enzyme
DB00472FluoxetineCytochrome P450 2C19enzyme
DB00472FluoxetineMultidrug resistance protein 1transporter
DB00472FluoxetineCytochrome P450 2B6enzyme
DB00472FluoxetineCytochrome P450 3A5enzyme
DB00472FluoxetineSerum albumincarrier
DB00472FluoxetineAlpha-1-acid glycoprotein 1carrier
DB00472FluoxetinePotassium voltage-gated channel subfamily H member 2target
DB00472Fluoxetine5-hydroxytryptamine receptor 2Ctarget
DB00472FluoxetineCyclin-dependent kinases regulatory subunit 1target
DB00472FluoxetineNeuronal acetylcholine receptor subunit alpha-2target
DB00472FluoxetineNeuronal acetylcholine receptor subunit alpha-3target
DB00472FluoxetineNeuronal acetylcholine receptor subunit beta-4target
DB01356Lithium cationInositol monophosphatase 2target
DB01356Lithium cationInositol monophosphatase 1target
DB01356Lithium cationGlycogen synthase kinase-3 betatarget
DB01356Lithium cationGlutamate receptor 3target
DrugDrug NamePhaseStatusCount
DB01221Ketamine0Completed1
DB00683Midazolam0Completed1
DB09315Xenon-1330Not Yet Recruiting1
DB01175Escitalopram1Terminated1
DB01221Ketamine1Recruiting1
DB00683Midazolam1Recruiting1
DB11706Raxatrigine1Completed1
DB12704Spiradoline1Completed1
DB01221Ketamine1 / 2Completed1
DB00555Lamotrigine1 / 2Completed1
DB06413Armodafinil2Completed1
DB06216Asenapine2Recruiting1
DB06016Cariprazine2Completed2
DB00016Erythropoietin2Recruiting1
DB00065Infliximab2Active Not Recruiting1
DB01221Ketamine2Completed1
DB01221Ketamine2Withdrawn1
DB01356Lithium cation2Withdrawn1
DB08815Lurasidone2Completed1
DB00834Mifepristone2Withdrawn1
DB00413Pramipexole2Completed1
DB01224Quetiapine2Completed1
DB05055RG24172Completed1
DB00740Riluzole2Terminated1
DB00747Scopolamine2Terminated1
DB09153Sodium chloride2Completed1
DB09153Sodium chloride2Recruiting1
DB01956Taurine2Completed1
DB11103Taurine2Completed1
DB02745Uridine2Completed2
DB00313Valproic Acid2Withdrawn2
DB00246Ziprasidone2Completed1
DB09061Cannabidiol2 / 3Recruiting1
DB00215Citalopram2 / 3Completed1
DB08815Lurasidone2 / 3Not Yet Recruiting1
DB01238Aripiprazole3Recruiting1
DB00482Celecoxib3Recruiting1
DB00674Galantamine3Completed1
DB01221Ketamine3Not Yet Recruiting1
DB01221Ketamine3Recruiting1
DB00555Lamotrigine3Completed3
DB01255Lisdexamfetamine3Terminated1
DB06077Lumateperone3Active Not Recruiting2
DB06077Lumateperone3Recruiting1
DB08815Lurasidone3Active Not Recruiting1
DB08815Lurasidone3Completed6
DB03323Maltose3Recruiting1
DB01017Minocycline3Completed1
DB01017Minocycline3Recruiting1
DB00334Olanzapine3Completed1
DB00715Paroxetine3Completed1
DB01224Quetiapine3Completed6
DB01104Sertraline3Completed1
DB09153Sodium chloride3Not Yet Recruiting1
DB12310Trehalose3Recruiting1
DB00246Ziprasidone3Completed1
DB01238Aripiprazole4Completed2
DB09128Brexpiprazole4Completed1
DB00564Carbamazepine4Completed1
DB04657Carboxin4Completed1
DB00472Fluoxetine4Completed2
DB01221Ketamine4Completed1
DB00555Lamotrigine4Completed1
DB01255Lisdexamfetamine4Terminated1
DB01356Lithium cation4Completed2
DB01043Memantine4Completed1
DB00474Methohexital4Completed1
DB01017Minocycline4Completed1
DB01017Minocycline4Recruiting1
DB00334Olanzapine4Completed4
DB01132Pioglitazone4Completed1
DB01224Quetiapine4Completed1
DB01224Quetiapine4Unknown Status1
DB01224Quetiapine4Withdrawn1
DB00734Risperidone4Completed1
DB01037Selegiline4Terminated1
DB00313Valproic Acid4Completed2
DB00313Valproic Acid4Withdrawn1
DB00246Ziprasidone4Completed1
DB00118AdemetionineNot AvailableCompleted1
DB01212CeftriaxoneNot AvailableTerminated1
DB00169CholecalciferolNot AvailableCompleted1
DB01221KetamineNot AvailableTerminated1
DB00555LamotrigineNot AvailableCompleted1
DB00555LamotrigineNot AvailableRecruiting1
DB01202LevetiracetamNot AvailableCompleted1
DB01356Lithium cationNot AvailableRecruiting2
DB08815LurasidoneNot AvailableCompleted1
DB00474MethohexitalNot AvailableTerminated1
DB00740RiluzoleNot AvailableCompleted1
DB09153Sodium chlorideNot AvailableTerminated1
DB09270UbidecarenoneNot AvailableCompleted2
DB02745UridineNot AvailableCompleted1