Showing BioInteractions for Pirlindole (DB09244)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

Target Mediated Interactions 3
Enzyme Mediated Interactions 1

	Interacting Group	Interacting Drugs
	Pirlindole is a Amine oxidase [flavin-containing] A antagonist
1	Amine oxidase [flavin-containing] A inhibitors	4-Methoxyamphetamine, Brofaromine, Capsaicin, Ephedra sinica root, Furazolidone, Iproniazid, Isocarboxazid, Linezolid, Metamfetamine, Minaprine, MMDA, Moclobemide, Nandrolone decanoate, Nicotine, Pargyline, Phenylpropanolamine, Pirlindole, Propranolol, Pseudoephedrine, Safinamide, Selegiline, Tedizolid, Tedizolid phosphate, Toloxatone, Tranylcypromine, Ubrogepant, Zimelidine, Zonisamide
2	Amine oxidase [flavin-containing] A antagonists	Moclobemide, Phenelzine, Phentermine, Toloxatone
3	Amine oxidase [flavin-containing] A substrates	Almotriptan, Bicifadine, Bufotenine, Dopamine, Eravacycline, Naratriptan, Phenelzine, Phenylephrine, Rizatriptan, Sertraline, Sumatriptan, Zolmitriptan
4	Amine oxidase [flavin-containing] A cofactors	Riboflavin
5	Amine oxidase [flavin-containing] A inducers	Oxymetholone, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate
6	Amine oxidase [flavin-containing] A binders	Flortaucipir F-18

	Interacting Group	Interacting Drugs
	Pirlindole is a 5-hydroxytryptamine receptor 1A antagonist
1	5-hydroxytryptamine receptor 1A partial agonists	Aripiprazole, Aripiprazole lauroxil, Brexpiprazole, Buspirone, Cariprazine, Perospirone, Quetiapine, Trazodone, Yohimbine
2	5-hydroxytryptamine receptor 1A agonists	5-methoxy-N,N-dimethyltryptamine, Apomorphine, Brexpiprazole, Bromocriptine, Cabergoline, Cannabidiol, Cariprazine, Cinitapride, Eletriptan, Ergotamine, Fenfluramine, Flibanserin, Lisuride, Lofexidine, Methysergide, Naluzotan, Naratriptan, Pergolide, Pramipexole, Rotigotine, SEP-363856, Sumatriptan, Tetrahydrocannabivarin, Vilazodone, Vortioxetine, Ziprasidone, Zolmitriptan
3	5-hydroxytryptamine receptor 1A antagonists	Acepromazine, Alprenolol, Alverine, Amoxapine, Asenapine, Chlorpromazine, Clozapine, Dosulepin, Doxepin, Iloperidone, Lurasidone, Molindone, Nefazodone, Nortriptyline, Paliperidone, Penbutolol, Pindolol, Pipotiazine, Pizotifen, Quetiapine, Risperidone, Thioproperazine, Trazodone, Trimipramine
4	5-hydroxytryptamine receptor 1A inhibitors	Amitriptyline, Escitalopram, Tianeptine
5	5-hydroxytryptamine receptor 1A inducers	Amitriptyline
6	5-hydroxytryptamine receptor 1A binders	Desipramine, Dopamine, Loxapine
7	5-hydroxytryptamine receptor 1A activators	Imipramine
8	5-hydroxytryptamine receptor 1A blockers	Mianserin

	Interacting Group	Interacting Drugs
	Pirlindole is a Alpha-2A adrenergic receptor antagonist
1	Alpha-2A adrenergic receptor agonists	4-Methoxyamphetamine, Amitriptyline, Apomorphine, Apraclonidine, Benzphetamine, Brimonidine, Bromocriptine, Clonidine, Dexmedetomidine, Dihydroergotamine, Dipivefrin, DL-Methylephedrine, Droxidopa, Ephedra sinica root, Epinephrine, Guanabenz, Guanfacine, Lofexidine, Metamfetamine, Moxonidine, Naphazoline, Norepinephrine, Oxymetazoline, Pramipexole, Pseudoephedrine, Racepinephrine, Xylometazoline
2	Alpha-2A adrenergic receptor antagonists	Amitriptyline, Amoxapine, Aripiprazole, Asenapine, Cabergoline, Carvedilol, Celiprolol, Clozapine, Dronedarone, Fenoldopam, Methotrimeprazine, Mianserin, Mirtazapine, Nefazodone, Paliperidone, Periciazine, Phenoxybenzamine, Phentolamine, Pipamperone, Pizotifen, Quetiapine, Tolazoline, Trazodone, Yohimbine, Ziprasidone, Zuclopenthixol
3	Alpha-2A adrenergic receptor partial agonists	Ergotamine, Oxymetazoline
4	Alpha-2A adrenergic receptor binders	Loxapine, Prazosin
5	Alpha-2A adrenergic receptor inhibitors	Lamotrigine

	Interacting Group	Interacting Drugs
	Pirlindole is a Amine oxidase [flavin-containing] A inhibitor
1	Amine oxidase [flavin-containing] A inhibitors	4-Methoxyamphetamine, Brofaromine, Capsaicin, Ephedra sinica root, Furazolidone, Iproniazid, Isocarboxazid, Linezolid, Metamfetamine, Minaprine, MMDA, Moclobemide, Nandrolone decanoate, Nicotine, Pargyline, Phenylpropanolamine, Propranolol, Pseudoephedrine, Safinamide, Selegiline, Tedizolid, Tedizolid phosphate, Toloxatone, Tranylcypromine, Ubrogepant, Zimelidine, Zonisamide
2	Amine oxidase [flavin-containing] A antagonists	Moclobemide, Phenelzine, Phentermine, Pirlindole, Toloxatone
3	Amine oxidase [flavin-containing] A substrates	Almotriptan, Bicifadine, Bufotenine, Dopamine, Eravacycline, Naratriptan, Phenelzine, Phenylephrine, Rizatriptan, Sertraline, Sumatriptan, Zolmitriptan
4	Amine oxidase [flavin-containing] A cofactors	Riboflavin
5	Amine oxidase [flavin-containing] A inducers	Oxymetholone, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate
6	Amine oxidase [flavin-containing] A binders	Flortaucipir F-18