Urinary Bladder, Overactive

Also known as: Urinary Bladder Overactive / Overactive Bladder Syndrome / Overactive Urinary Bladder / Over Active Bladder / Overactive Bladder / Overactive Bladder (OAB) / Bladder, Overactive / Hypertonic bladder / Hyperactive bladder / Detrusor muscle hyperactivity / Hypertonicity of bladder

DrugDrug NameDrug Description
DB00083Botulinum toxin type APurified botulinum toxin from Clostridium botulinum, purified from culture via dialysis and acid precipitation.
DB00496DarifenacinDarifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin works by blocking the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions. It thereby decreases the urgency to urinate. It should not be used in people with urinary retention. It is not known whether this selectivity for the M3 receptor translates into any clinical advantage when treating symptoms of overactive bladder syndrome.
DB06702FesoterodineFesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome.
DB08893MirabegronMirabegron is a beta-3 adrenergic receptor agonist for the management of overactive bladder. It is an alternative to antimuscarinic drugs for this indication. FDA approved on June 28, 2012.
DB01062OxybutyninOxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties, including frequent urination and inability to control urination, by decreasing muscle spasms of the bladder. It competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor.
DB12278PropiverinePropiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB) [A32576]. Overactive bladder (OAB) is a chronic condition of the lower urinary tract characterized by urinary urgency, increased frequency of urination, and nocturia (frequent waking during the night to urinate). OAB has a negative impact on quality of life and may lead to leakage and inconvenient urinary accidents [L2327], [L2328]. Overactive bladder syndrome affects millions of elderly individuals in the United States and shows equal prevalence in men and women. The impact of OAB on quality of life is sometimes devastating, especially to elderly patients with other medical conditions [L2328]. Propiverine hydrochloride is a bladder detrusor muscle relaxant drug with dual antimuscarinic and calcium-modulating properties for the treatment of OAB [L2317].
DB01591SolifenacinSolifenacin (rINN), marketed as solifenacin succinate under the trade name Vesicare, is a urinary antispasmodic of the anticholinergic class. It is used in the treatment of overactive bladder with urge incontinence.
DB01036TolterodineTolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors.
DB00209TrospiumTrospium is a urinary antispasmodic. It is sold under the brand name Sanctura in the US, and as Trosec in Canada. [Wikipedia]
DrugDrug NameTargetType
DB00083Botulinum toxin type ASynaptosomal-associated protein 25target
DB00083Botulinum toxin type ARho-related GTP-binding protein RhoBtarget
DB00496DarifenacinMuscarinic acetylcholine receptor M3target
DB00496DarifenacinCytochrome P450 3A4enzyme
DB00496DarifenacinCytochrome P450 2D6enzyme
DB00496DarifenacinMuscarinic acetylcholine receptor M1target
DB00496DarifenacinMuscarinic acetylcholine receptor M2target
DB00496DarifenacinMuscarinic acetylcholine receptor M4target
DB00496DarifenacinMuscarinic acetylcholine receptor M5target
DB06702FesoterodineMuscarinic acetylcholine receptor M1target
DB06702FesoterodineMuscarinic acetylcholine receptor M3target
DB06702FesoterodineCytochrome P450 3A4enzyme
DB06702FesoterodineMuscarinic acetylcholine receptor M2target
DB06702FesoterodineMuscarinic acetylcholine receptor M4target
DB06702FesoterodineMuscarinic acetylcholine receptor M5target
DB06702FesoterodineCytochrome P450 2D6enzyme
DB06702FesoterodineMultidrug resistance protein 1transporter
DB08893MirabegronCytochrome P450 3A4enzyme
DB08893MirabegronCytochrome P450 2D6enzyme
DB08893MirabegronMultidrug resistance protein 1transporter
DB08893MirabegronSolute carrier organic anion transporter family member 1A2transporter
DB08893MirabegronSerum albumincarrier
DB08893MirabegronAlpha-1-acid glycoprotein 1carrier
DB08893MirabegronCholinesteraseenzyme
DB08893MirabegronBeta-3 adrenergic receptortarget
DB01062OxybutyninMuscarinic acetylcholine receptor M1target
DB01062OxybutyninMuscarinic acetylcholine receptor M2target
DB01062OxybutyninMuscarinic acetylcholine receptor M3target
DB01062OxybutyninCytochrome P450 3A4enzyme
DB01062OxybutyninCytochrome P450 2C8enzyme
DB01062OxybutyninCytochrome P450 2D6enzyme
DB01062OxybutyninCytochrome P450 3A5enzyme
DB12278PropiverineMuscarinic acetylcholine receptor M1target
DB12278PropiverineMuscarinic acetylcholine receptor M2target
DB12278PropiverineMuscarinic acetylcholine receptor M3target
DB12278PropiverineMuscarinic acetylcholine receptor M4target
DB12278PropiverineMuscarinic acetylcholine receptor M5target
DB12278PropiverineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB12278PropiverineAlpha-1A adrenergic receptortarget
DB12278PropiverineCytochrome P450 3A4enzyme
DB12278PropiverineDimethylaniline monooxygenase [N-oxide-forming] 1enzyme
DB12278PropiverineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB12278PropiverineCYP2B proteinenzyme
DB01591SolifenacinMuscarinic acetylcholine receptor M3target
DB01591SolifenacinMuscarinic acetylcholine receptor M1target
DB01591SolifenacinCytochrome P450 3A4enzyme
DB01591SolifenacinMuscarinic acetylcholine receptor M2target
DB01591SolifenacinMuscarinic acetylcholine receptor M4target
DB01591SolifenacinMuscarinic acetylcholine receptor M5target
DB01036TolterodineMuscarinic acetylcholine receptor M1target
DB01036TolterodineMuscarinic acetylcholine receptor M2target
DB01036TolterodineMuscarinic acetylcholine receptor M3target
DB01036TolterodineCytochrome P450 2D6enzyme
DB01036TolterodineCytochrome P450 3A4enzyme
DB01036TolterodineCytochrome P450 2C9enzyme
DB01036TolterodineCytochrome P450 2C19enzyme
DB01036TolterodineMuscarinic acetylcholine receptor M4target
DB01036TolterodineMuscarinic acetylcholine receptor M5target
DB00209TrospiumMuscarinic acetylcholine receptor M1target
DB00209TrospiumCytochrome P450 2D6enzyme
DrugDrug NamePhaseStatusCount
DB00083Botulinum toxin type A1Completed1
DB00567Cephalexin1Terminated1
DB10631Cranberry1Completed1
DB06702Fesoterodine1Completed2
DB01137Levofloxacin1Terminated1
DB08893Mirabegron1Completed3
DB01062Oxybutynin1Completed1
DB00203Sildenafil1Completed1
DB06190Solabegron1Completed2
DB01591Solifenacin1Completed4
DB00706Tamsulosin1Completed1
DB01036Tolterodine1Completed4
DB01036Tolterodine1Terminated1
DB00682Warfarin1Completed2
DB00083Botulinum toxin type A1 / 2Completed1
DB01093Dimethyl sulfoxide1 / 2Completed1
DB08893Mirabegron1 / 2Recruiting1
DB05072AV6082Terminated1
DB00174Asparagine2Completed1
DB00083Botulinum toxin type A2Completed4
DB00083Botulinum toxin type A2Terminated2
DB00083Botulinum toxin type A2Withdrawn1
DB06634Casopitant2Completed1
DB06634Casopitant2Terminated1
DB11807Dexmecamylamine2Completed1
DB00985Dimenhydrinate2Recruiting1
DB06702Fesoterodine2Completed2
DB06702Fesoterodine2Recruiting1
DB11902Gisadenafil2Completed1
DB09262Imidafenacin2Completed1
DB08893Mirabegron2Active Not Recruiting1
DB08893Mirabegron2Completed4
DB08893Mirabegron2Recruiting1
DB01062Oxybutynin2Recruiting1
DB00230Pregabalin2Completed1
DB12278Propiverine2Completed1
DB12080Ritobegron2Completed1
DB12626Senrebotase2Completed1
DB00133Serine2Completed1
DB06190Solabegron2Completed2
DB01591Solifenacin2Completed3
DB01591Solifenacin2Recruiting2
DB01036Tolterodine2Completed7
DB01036Tolterodine2Terminated1
DB00862Vardenafil2Completed1
DB00083Botulinum toxin type A2 / 3Unknown Status1
DB11121Chloroxylenol2 / 3Recruiting1
DB00994Neomycin2 / 3Completed1
DB00706Tamsulosin2 / 3Completed1
DB01036Tolterodine2 / 3Completed2
DB00083Botulinum toxin type A3Active Not Recruiting2
DB00083Botulinum toxin type A3Completed9
DB00083Botulinum toxin type A3Enrolling by Invitation1
DB00083Botulinum toxin type A3Recruiting2
DB00083Botulinum toxin type A3Terminated2
DB00496Darifenacin3Completed3
DB01093Dimethyl sulfoxide3Terminated1
DB06702Fesoterodine3Completed8
DB09262Imidafenacin3Completed2
DB00125L-Arginine3Completed1
DB00125L-Arginine3Recruiting1
DB08893Mirabegron3Completed14
DB08893Mirabegron3Recruiting1
DB01062Oxybutynin3Completed2
DB01062Oxybutynin3Recruiting1
DB12278Propiverine3Completed2
DB12080Ritobegron3Completed1
DB12080Ritobegron3Withdrawn1
DB01591Solifenacin3Completed15
DB01591Solifenacin3Recruiting1
DB01591Solifenacin3Terminated2
DB01036Tolterodine3Active Not Recruiting1
DB01036Tolterodine3Completed12
DB00209Trospium3Completed1
DB00207Azithromycin4Completed1
DB00181Baclofen4Terminated1
DB13913Belladonna4Completed1
DB13913Belladonna4Terminated1
DB00083Botulinum toxin type A4Completed5
DB00083Botulinum toxin type A4Recruiting1
DB11121Chloroxylenol4Completed1
DB00286Conjugated estrogens4Completed1
DB00286Conjugated estrogens4Recruiting1
DB00496Darifenacin4Completed3
DB00254Doxycycline4Completed1
DB01175Escitalopram4Completed1
DB00783Estradiol4Completed2
DB06702Fesoterodine4Completed9
DB06702Fesoterodine4Recruiting2
DB06702Fesoterodine4Terminated1
DB00588Fluticasone propionate4Unknown Status1
DB09262Imidafenacin4Completed2
DB00281Lidocaine4Recruiting1
DB08893Mirabegron4Completed10
DB08893Mirabegron4Not Yet Recruiting2
DB08893Mirabegron4Recruiting3
DB08893Mirabegron4Unknown Status1
DB08893Mirabegron4Withdrawn1
DB00295Morphine4Completed1
DB01062Oxybutynin4Completed2
DB01062Oxybutynin4Unknown Status1
DB00497Oxycodone4Completed1
DB12278Propiverine4Completed3
DB09153Sodium chloride4Completed1
DB09484Sodium fluorophosphate4Not Yet Recruiting1
DB01591Solifenacin4Completed21
DB01591Solifenacin4Not Yet Recruiting1
DB01591Solifenacin4Recruiting2
DB01591Solifenacin4Terminated1
DB01591Solifenacin4Unknown Status1
DB01591Solifenacin4Withdrawn1
DB01015Sulfamethoxazole4Recruiting1
DB00706Tamsulosin4Completed4
DB00706Tamsulosin4Not Yet Recruiting1
DB01036Tolterodine4Completed8
DB01036Tolterodine4Terminated1
DB01036Tolterodine4Unknown Status2
DB00440Trimethoprim4Recruiting1
DB00209Trospium4Completed5
DB00083Botulinum toxin type ANot AvailableActive Not Recruiting1
DB00083Botulinum toxin type ANot AvailableCompleted5
DB00286Conjugated estrogensNot AvailableCompleted1
DB00496DarifenacinNot AvailableActive Not Recruiting1
DB00496DarifenacinNot AvailableCompleted3
DB00496DarifenacinNot AvailableRecruiting1
DB00496DarifenacinNot AvailableTerminated1
DB00783EstradiolNot AvailableCompleted1
DB06702FesoterodineNot AvailableActive Not Recruiting1
DB06702FesoterodineNot AvailableCompleted7
DB06702FesoterodineNot AvailableRecruiting1
DB06702FesoterodineNot AvailableUnknown Status2
DB09262ImidafenacinNot AvailableActive Not Recruiting1
DB09262ImidafenacinNot AvailableRecruiting1
DB08893MirabegronNot AvailableActive Not Recruiting1
DB08893MirabegronNot AvailableCompleted6
DB08893MirabegronNot AvailableNot Yet Recruiting1
DB08893MirabegronNot AvailableRecruiting1
DB09567Olive oilNot AvailableTerminated1
DB01062OxybutyninNot AvailableActive Not Recruiting1
DB01062OxybutyninNot AvailableCompleted2
DB01062OxybutyninNot AvailableNot Yet Recruiting1
DB01062OxybutyninNot AvailableRecruiting1
DB12278PropiverineNot AvailableActive Not Recruiting1
DB01591SolifenacinNot AvailableActive Not Recruiting1
DB01591SolifenacinNot AvailableCompleted7
DB01591SolifenacinNot AvailableRecruiting1
DB01591SolifenacinNot AvailableUnknown Status3
DB01036TolterodineNot AvailableActive Not Recruiting1
DB01036TolterodineNot AvailableCompleted4
DB01036TolterodineNot AvailableNot Yet Recruiting1
DB01036TolterodineNot AvailableRecruiting1
DB00209TrospiumNot AvailableActive Not Recruiting1
DB00209TrospiumNot AvailableCompleted1
DB00209TrospiumNot AvailableRecruiting1
DB00209TrospiumNot AvailableUnknown Status1