Waldenstrom's Macroglobulinemia (WM)

Also known as: Waldenström macroglobulinemia / Waldenstrom's Macroglobulinaemia / Waldenstrom's macroglobulinaemias / Waldenstrom's Macroglobulinemia / Waldenström Macroglobulinemia (WM) / Waldenström's Macroglobulinemia / Waldenstrom Macroglobulinemia / Waldenstrom Macroglobulinaemia / Waldenström Macroglobulinaemia / Lymphoplasmacytic lymphoma with IgM-production / Macroglobulinemia, Waldenstrom / Macroglobulinemia / Waldenstrom's macroglobulinemia NOS / Waldenstrom's macroglobulinaemia NOS / Von Waldenstrom macroglobulinaemia / Von Waldenstrom macroglobulinemia / Macroglobulinaemia NOS / Macroglobulinaemia

DrugDrug NameDrug Description
DB06769BendamustineBendamustine is a nitrogen mustard drug indicated for use in the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Bendamustine is a bifunctional mechlorethamine derivative capable of forming electrophilic alkyl groups that covalently bond to other molecules. Through this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
DB08889CarfilzomibCarfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved on July 20, 2012.
DB00291ChlorambucilA nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
DB00531CyclophosphamidePrecursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer. [PubChem]
DB00997DoxorubicinDoxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius. Doxorubicin binds to nucleic acids, presumably by specific intercalation of the planar anthracycline nucleus with the DNA double helix.
DB09053IbrutinibIbrutinib is a small molecule anti-cancer drug that targets B-cell malignancies. In November 2013 ibrutinib was approved by the FDA for the treatment of mantle cell lymphoma, and later in February 2014 for the treatment of chronic lymphocytic leukemia. Ibrutinib is also indicated for the treatment of patients with Waldenström's Macroglobulinemia (WM). Ibrutinib is marketed under the brand Imbruvica® by Janssen Biotech, Inc., but was first designed and synthesized at Celera Genomics in 2007. Ibrutinib was approved for use in chronic graft versus host disease in August 2017 [L937].
DB01041ThalidomideA piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppresive and anti-angiogenic activity. It inhibits release of tumor necrosis factor-alpha from monocytes, and modulates other cytokine action. [PubChem]
DrugDrug NameTargetType
DB06769BendamustineCytochrome P450 1A2enzyme
DB08889CarfilzomibProteasome subunit beta type-5target
DB08889CarfilzomibProteasome subunit beta type-8target
DB08889CarfilzomibProteasome subunit beta type-1target
DB08889CarfilzomibProteasome subunit beta type-9target
DB08889CarfilzomibProteasome subunit beta type-2target
DB08889CarfilzomibProteasome subunit beta type-10target
DB08889CarfilzomibMultidrug resistance protein 1transporter
DB00291ChlorambucilDNAtarget
DB00291ChlorambucilGlutathione S-transferase Penzyme
DB00291ChlorambucilSolute carrier organic anion transporter family member 1A2transporter
DB00531CyclophosphamideCytochrome P450 2B6enzyme
DB00531CyclophosphamideCytochrome P450 2C9enzyme
DB00531CyclophosphamideCytochrome P450 3A4enzyme
DB00531CyclophosphamideCytochrome P450 2C19enzyme
DB00531CyclophosphamideCytochrome P450 2A6enzyme
DB00531CyclophosphamideCytochrome P450 2C18enzyme
DB00531CyclophosphamideCytochrome P450 2C8enzyme
DB00531CyclophosphamideCytochrome P450 2D6enzyme
DB00531CyclophosphamideCytochrome P450 3A7enzyme
DB00531CyclophosphamideCytochrome P450 3A5enzyme
DB00531CyclophosphamideDNAtarget
DB00531CyclophosphamideNuclear receptor subfamily 1 group I member 2target
DB00531CyclophosphamideMultidrug resistance protein 1transporter
DB00997DoxorubicinDNA topoisomerase 2-alphatarget
DB00997DoxorubicinDNAtarget
DB00997DoxorubicinCytochrome P450 3A4enzyme
DB00997DoxorubicinCytochrome P450 2D6enzyme
DB00997DoxorubicinCytochrome P450 2B6enzyme
DB00997DoxorubicinMultidrug resistance protein 1transporter
DB00997DoxorubicinCanalicular multispecific organic anion transporter 2transporter
DB00997DoxorubicinMultidrug resistance-associated protein 6transporter
DB00997DoxorubicinMultidrug resistance-associated protein 1transporter
DB00997DoxorubicinMultidrug resistance-associated protein 7transporter
DB00997DoxorubicinATP-binding cassette sub-family G member 2transporter
DB00997DoxorubicinBile salt export pumptransporter
DB00997DoxorubicinSolute carrier family 22 member 16transporter
DB00997DoxorubicinATP-binding cassette sub-family B member 8, mitochondrialtransporter
DB00997DoxorubicinCytochrome P450 1B1enzyme
DB00997DoxorubicinCarbonyl reductase [NADPH] 1enzyme
DB00997DoxorubicinCarbonyl reductase [NADPH] 3enzyme
DB00997DoxorubicinAlcohol dehydrogenase [NADP(+)]enzyme
DB00997DoxorubicinAldo-keto reductase family 1 member C3enzyme
DB00997DoxorubicinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00997DoxorubicinXanthine dehydrogenase/oxidaseenzyme
DB00997DoxorubicinNitric oxide synthase, endothelialenzyme
DB00997DoxorubicinNitric oxide synthase, inducibleenzyme
DB00997DoxorubicinNitric oxide synthase, brainenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialenzyme
DB00997DoxorubicinNADPH--cytochrome P450 reductaseenzyme
DB00997DoxorubicinRalA-binding protein 1transporter
DB00997DoxorubicinCanalicular multispecific organic anion transporter 1transporter
DB00997DoxorubicinSerum albumincarrier
DB00997DoxorubicinNucleolar and coiled-body phosphoprotein 1target
DB09053IbrutinibTyrosine-protein kinase BTKtarget
DB09053IbrutinibCytochrome P450 3A4enzyme
DB09053IbrutinibCytochrome P450 3A5enzyme
DB09053IbrutinibCytochrome P450 2D6enzyme
DB01041ThalidomideTumor necrosis factortarget
DB01041ThalidomideNuclear factor NF-kappa-B p105 subunittarget
DB01041ThalidomideProstaglandin G/H synthase 2target
DB01041ThalidomideCytochrome P450 2C19enzyme
DB01041ThalidomideCytochrome P450 1A2enzyme
DB01041ThalidomideCytochrome P450 1A1enzyme
DB01041ThalidomideCytochrome P450 2E1enzyme
DB01041ThalidomideCytochrome P450 2C9enzyme
DB01041ThalidomideProstaglandin G/H synthase 1enzyme
DB01041ThalidomideProstaglandin G/H synthase 2enzyme
DB01041ThalidomideCytochrome P450 3A5enzyme
DB01041ThalidomideFibroblast growth factor receptor 2target
DB01041ThalidomideDNAtarget
DB01041ThalidomideProtein cereblontarget
DB01041ThalidomideNuclear factor kappa-light-chain-enhancer of activated B cellstarget
DB01041Thalidomidealpha1-acid glycoproteintarget
DrugDrug NamePhaseStatusCount
DB01008Busulfan0Completed1
DB00493Cefotaxime0Completed2
DB00531Cyclophosphamide0Completed2
DB00773Etoposide0Completed1
DB00099Filgrastim0Completed1
DB00073Rituximab0Completed1
DB130302'-fluoro-5-ethylarabinosyluracil1Completed1
DB12707AR-421Active Not Recruiting1
DB00041Aldesleukin1Completed1
DB05220Alisertib1Active Not Recruiting1
DB05220Alisertib1Completed1
DB12442Alvespimycin1Completed1
DB03496Alvocidib1Completed2
DB00098Antithymocyte immunoglobulin (rabbit)1Recruiting1
DB05015Belinostat1Completed1
DB05015Belinostat1Terminated1
DB06769Bendamustine1Active Not Recruiting1
DB06769Bendamustine1Recruiting1
DB06769Bendamustine1Terminated1
DB00112Bevacizumab1Completed1
DB00188Bortezomib1Completed4
DB00188Bortezomib1Terminated2
DB01008Busulfan1Recruiting1
DB12109CPI-6131Terminated1
DB09061Cannabidiol1Completed1
DB01101Capecitabine1Completed1
DB00958Carboplatin1Completed1
DB08889Carfilzomib1Completed1
DB04849Cediranib1Completed1
DB00493Cefotaxime1Completed1
DB00531Cyclophosphamide1Completed1
DB01254Dasatinib1Completed1
DB01234Dexamethasone1Completed1
DB01234Dexamethasone1Terminated1
DB11841Entinostat1Completed1
DB01073Fludarabine1Completed4
DB01073Fludarabine1Recruiting1
DB00441Gemcitabine1Completed1
DB09053Ibrutinib1Active Not Recruiting2
DB09053Ibrutinib1Terminated1
DB00619Imatinib1Completed1
DB00982Isotretinoin1Completed1
DB00480Lenalidomide1Active Not Recruiting1
DB00480Lenalidomide1Completed1
DB00480Lenalidomide1Terminated2
DB00563Methotrexate1Recruiting1
DB01229Paclitaxel1Completed1
DB08910Pomalidomide1Completed1
DB08910Pomalidomide1Terminated1
DB11870RG-47331Completed1
DB00073Rituximab1Active Not Recruiting2
DB00073Rituximab1Completed3
DB00073Rituximab1Recruiting1
DB00073Rituximab1Terminated3
DB11836Sapanisertib1Completed1
DB00398Sorafenib1Completed1
DB11764Spebrutinib1Completed1
DB01268Sunitinib1Completed1
DB12756TAK-9011Completed1
DB06398Tanespimycin1Terminated3
DB00755Tretinoin1Completed1
DB11940Triapine1Completed1
DB00541Vincristine1Recruiting1
DB02546Vorinostat1Active Not Recruiting1
DB02546Vorinostat1Completed1
DB02546Vorinostat1Terminated1
DB11703Acalabrutinib1 / 2Recruiting1
DB03496Alvocidib1 / 2Completed1
DB03496Alvocidib1 / 2Terminated1
DB06769Bendamustine1 / 2Completed1
DB00188Bortezomib1 / 2Active Not Recruiting2
DB08870Brentuximab vedotin1 / 2Recruiting1
DB00958Carboplatin1 / 2Completed1
DB00262Carmustine1 / 2Active Not Recruiting1
DB00262Carmustine1 / 2Unknown Status1
DB00493Cefotaxime1 / 2Active Not Recruiting1
DB00493Cefotaxime1 / 2Recruiting1
DB00531Cyclophosphamide1 / 2Active Not Recruiting1
DB00531Cyclophosphamide1 / 2Recruiting1
DB00091Cyclosporine1 / 2Active Not Recruiting2
DB00987Cytarabine1 / 2Active Not Recruiting1
DB00987Cytarabine1 / 2Unknown Status1
DB01234Dexamethasone1 / 2Active Not Recruiting1
DB00997Doxorubicin1 / 2Recruiting1
DB00773Etoposide1 / 2Active Not Recruiting1
DB00773Etoposide1 / 2Completed1
DB00773Etoposide1 / 2Recruiting1
DB00773Etoposide1 / 2Unknown Status1
DB01590Everolimus1 / 2Active Not Recruiting3
DB05076Fenretinide1 / 2Terminated1
DB00099Filgrastim1 / 2Terminated1
DB01073Fludarabine1 / 2Active Not Recruiting3
DB00441Gemcitabine1 / 2Completed1
DB00078Ibritumomab tiuxetan1 / 2Terminated1
DB09053Ibrutinib1 / 2Not Yet Recruiting1
DB01181Ifosfamide1 / 2Completed1
DB06186Ipilimumab1 / 2Suspended1
DB06186Ipilimumab1 / 2Terminated1
DB00480Lenalidomide1 / 2Active Not Recruiting2
DB00480Lenalidomide1 / 2Completed2
DB00480Lenalidomide1 / 2Recruiting1
DB00480Lenalidomide1 / 2Unknown Status1
DB00480Lenalidomide1 / 2Withdrawn1
DB01042Melphalan1 / 2Active Not Recruiting1
DB01042Melphalan1 / 2Unknown Status1
DB00688Mycophenolate mofetil1 / 2Active Not Recruiting3
DB00038Oprelvekin1 / 2Terminated1
DB11991Oprozomib1 / 2Active Not Recruiting1
DB06603Panobinostat1 / 2Active Not Recruiting1
DB09037Pembrolizumab1 / 2Recruiting1
DB05527Pralatrexate1 / 2Completed1
DB06813Pralatrexate1 / 2Completed1
DB00635Prednisone1 / 2Recruiting1
DB00073Rituximab1 / 2Active Not Recruiting2
DB00073Rituximab1 / 2Completed4
DB00073Rituximab1 / 2Recruiting2
DB00073Rituximab1 / 2Terminated2
DB00073Rituximab1 / 2Unknown Status1
DB00073Rituximab1 / 2Withdrawn1
DB06176Romidepsin1 / 2Withdrawn1
DB00864Tacrolimus1 / 2Active Not Recruiting1
DB06287Temsirolimus1 / 2Active Not Recruiting2
DB11850Ublituximab1 / 2Active Not Recruiting1
DB11850Ublituximab1 / 2Completed1
DB12018Ulocuplumab1 / 2Not Yet Recruiting1
DB07232Veliparib1 / 2Completed1
DB00541Vincristine1 / 2Recruiting1
DB02546Vorinostat1 / 2Completed1
DB11703Acalabrutinib2Active Not Recruiting1
DB00087Alemtuzumab2Active Not Recruiting2
DB05220Alisertib2Active Not Recruiting1
DB09312Antilymphocyte immunoglobulin (horse)2Active Not Recruiting1
DB09312Antilymphocyte immunoglobulin (horse)2Completed1
DB00098Antithymocyte immunoglobulin (rabbit)2Active Not Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)2Completed1
DB01076Atorvastatin2Recruiting1
DB06769Bendamustine2Completed1
DB00188Bortezomib2Active Not Recruiting4
DB00188Bortezomib2Completed3
DB00188Bortezomib2Terminated1
DB00188Bortezomib2Unknown Status1
DB01008Busulfan2Active Not Recruiting1
DB01008Busulfan2Completed3
DB01008Busulfan2Recruiting1
DB00958Carboplatin2Completed1
DB08889Carfilzomib2Completed1
DB08889Carfilzomib2Not Yet Recruiting1
DB00262Carmustine2Recruiting1
DB00493Cefotaxime2Active Not Recruiting1
DB00493Cefotaxime2Completed5
DB00493Cefotaxime2Recruiting2
DB00493Cefotaxime2Terminated1
DB00493Cefotaxime2Withdrawn1
DB00531Cyclophosphamide2Active Not Recruiting3
DB00531Cyclophosphamide2Completed5
DB00531Cyclophosphamide2Recruiting4
DB00531Cyclophosphamide2Terminated1
DB00531Cyclophosphamide2Withdrawn1
DB00091Cyclosporine2Active Not Recruiting4
DB00091Cyclosporine2Completed4
DB00091Cyclosporine2Recruiting2
DB00987Cytarabine2Recruiting1
DB09331Daratumumab2Not Yet Recruiting1
DB01234Dexamethasone2Active Not Recruiting3
DB01234Dexamethasone2Completed5
DB01234Dexamethasone2Unknown Status1
DB00514Dextromethorphan2Active Not Recruiting1
DB00514Dextromethorphan2Completed3
DB00997Doxorubicin2Terminated1
DB00254Doxycycline2Terminated1
DB04958Epratuzumab2Terminated1
DB00773Etoposide2Completed2
DB00773Etoposide2Recruiting1
DB01590Everolimus2Active Not Recruiting1
DB00099Filgrastim2Completed1
DB01073Fludarabine2Active Not Recruiting8
DB01073Fludarabine2Completed2
DB01073Fludarabine2Recruiting6
DB01073Fludarabine2Withdrawn1
DB00441Gemcitabine2Completed1
DB09053Ibrutinib2Active Not Recruiting2
DB09053Ibrutinib2Enrolling by Invitation1
DB09053Ibrutinib2Recruiting1
DB09054Idelalisib2Not Yet Recruiting1
DB09054Idelalisib2Recruiting2
DB09054Idelalisib2Terminated1
DB09570Ixazomib2Active Not Recruiting1
DB09570Ixazomib2Recruiting1
DB00480Lenalidomide2Active Not Recruiting1
DB00480Lenalidomide2Terminated3
DB01042Melphalan2Active Not Recruiting1
DB01042Melphalan2Recruiting2
DB00563Methotrexate2Active Not Recruiting1
DB00563Methotrexate2Completed2
DB00959Methylprednisolone2Completed2
DB00688Mycophenolate mofetil2Active Not Recruiting8
DB00688Mycophenolate mofetil2Completed2
DB00688Mycophenolate mofetil2Recruiting6
DB00688Mycophenolate mofetil2Withdrawn1
DB01024Mycophenolic acid2Recruiting1
DB01280Nelarabine2Terminated1
DB08935Obinutuzumab2Recruiting1
DB06650Ofatumumab2Completed1
DB06650Ofatumumab2Terminated1
DB00526Oxaliplatin2Completed1
DB06603Panobinostat2Active Not Recruiting2
DB09037Pembrolizumab2Recruiting1
DB00552Pentostatin2Active Not Recruiting1
DB00635Prednisone2Terminated1
DB00073Rituximab2Active Not Recruiting10
DB00073Rituximab2Completed6
DB00073Rituximab2Not Yet Recruiting1
DB00073Rituximab2Recruiting1
DB00073Rituximab2Terminated4
DB00073Rituximab2Unknown Status1
DB00203Sildenafil2Completed1
DB00641Simvastatin2Terminated1
DB00877Sirolimus2Active Not Recruiting1
DB00877Sirolimus2Recruiting1
DB00864Tacrolimus2Active Not Recruiting4
DB00864Tacrolimus2Completed2
DB00864Tacrolimus2Recruiting4
DB00864Tacrolimus2Withdrawn1
DB06287Temsirolimus2Completed1
DB01041Thalidomide2Completed2
DB01041Thalidomide2Terminated1
DB04572Thiotepa2Recruiting1
DB00577Valaciclovir2Active Not Recruiting1
DB11581Venetoclax2Recruiting1
DB00541Vincristine2Terminated1
DB02546Vorinostat2Completed1
DB00188Bortezomib3Recruiting1
DB00291Chlorambucil3Completed1
DB00531Cyclophosphamide3Recruiting1
DB00091Cyclosporine3Active Not Recruiting2
DB01234Dexamethasone3Recruiting1
DB01073Fludarabine3Active Not Recruiting2
DB01073Fludarabine3Completed1
DB09053Ibrutinib3Active Not Recruiting1
DB09053Ibrutinib3Recruiting2
DB00688Mycophenolate mofetil3Active Not Recruiting2
DB00073Rituximab3Active Not Recruiting1
DB00073Rituximab3Recruiting1
DB00877Sirolimus3Active Not Recruiting1
DB00188Bortezomib4Recruiting1
DB00073Rituximab4Recruiting1
DB01041Thalidomide4Recruiting1
DB119196-O-benzylguanineNot AvailableWithdrawn1
DB09312Antilymphocyte immunoglobulin (horse)Not AvailableActive Not Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)Not AvailableActive Not Recruiting1
DB01169Arsenic trioxideNot AvailableTerminated1
DB00188BortezomibNot AvailableActive Not Recruiting1
DB08870Brentuximab vedotinNot AvailableActive Not Recruiting1
DB01008BusulfanNot AvailableActive Not Recruiting1
DB00958CarboplatinNot AvailableActive Not Recruiting1
DB00262CarmustineNot AvailableActive Not Recruiting1
DB00262CarmustineNot AvailableWithdrawn1
DB00493CefotaximeNot AvailableActive Not Recruiting1
DB00531CyclophosphamideNot AvailableActive Not Recruiting1
DB00091CyclosporineNot AvailableActive Not Recruiting3
DB00091CyclosporineNot AvailableCompleted1
DB00987CytarabineNot AvailableWithdrawn1
DB01609DeferasiroxNot AvailableCompleted1
DB00773EtoposideNot AvailableActive Not Recruiting1
DB00773EtoposideNot AvailableTerminated1
DB00773EtoposideNot AvailableWithdrawn1
DB00099FilgrastimNot AvailableActive Not Recruiting1
DB00099FilgrastimNot AvailableTerminated1
DB01073FludarabineNot AvailableActive Not Recruiting3
DB01073FludarabineNot AvailableCompleted1
DB00529FoscarnetNot AvailableCompleted1
DB01004GanciclovirNot AvailableCompleted1
DB01042MelphalanNot AvailableActive Not Recruiting2
DB01042MelphalanNot AvailableWithdrawn1
DB00688Mycophenolate mofetilNot AvailableActive Not Recruiting3
DB00688Mycophenolate mofetilNot AvailableCompleted1
DB06809PlerixaforNot AvailableTerminated1
DB00073RituximabNot AvailableCompleted1
DB04572ThiotepaNot AvailableActive Not Recruiting1
DB01610ValganciclovirNot AvailableCompleted1