Waldenström's Macroglobulinemia (WM)

Also known as: Waldenstroms Macroglobulinemia / Waldenstrom's macroglobulinaemias / Waldenstrom's Macroglobulinaemia / Waldenstrom's Macroglobulinemia (WM) / Waldenstrom's Macroglobulinemia / Waldenström Macroglobulinemia (WM) / Waldenström's Macroglobulinemia / Waldenström Macroglobulinemia / Waldenstrom Macroglobulinemia / Waldenström Macroglobulinaemia / Waldenstrom Macroglobulinaemia / Lymphoplasmacytic lymphoma with IgM-production / Macroglobulinemia, Waldenstrom / Macroglobulinemia / Waldenstrom's macroglobulinemia NOS / Waldenstrom's macroglobulinaemia NOS / Von Waldenstrom macroglobulinaemia / Von Waldenstrom macroglobulinemia / Macroglobulinaemia NOS / Macroglobulinaemia

DrugDrug NameDrug Description
DB06769BendamustineAn antineoplastic agent used for the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed following rituximab therapy.
DB08889CarfilzomibA proteasome inhibitor used either alone or in conjunction with a chemotherapy regimen to treat patients with relapsed or refractory multiple myeloma.
DB00291ChlorambucilA chemotherapy agent used in the management of chronic lymphocytic leukemia and malignant lymphomas.
DB00531CyclophosphamideA nitrogen mustard used to treat lymphomas, myelomas, leukemia, mycosis fungoides, neuroblastoma, ovarian adenocarcinoma, retinoblastoma, and breast carcinoma.
DB00997DoxorubicinA medication used to treat various cancers and Kaposi's Sarcoma.
DB09053IbrutinibAn antineoplastic agent used to treat chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom's Macroglobulinemia.
DB01041ThalidomideA medication used to treat newly diagnosed multiple myeloma and erythema nodosum leprosum.
DrugDrug NameTargetType
DB06769BendamustineCytochrome P450 1A2enzyme
DB08889CarfilzomibP-glycoprotein 1transporter
DB08889CarfilzomibProteasome subunit beta type-5target
DB08889CarfilzomibProteasome subunit beta type-9target
DB08889CarfilzomibProteasome subunit beta type-10target
DB08889CarfilzomibProteasome subunit beta type-8target
DB08889CarfilzomibProteasome subunit beta type-1target
DB08889CarfilzomibProteasome subunit beta type-2target
DB00291ChlorambucilDNAtarget
DB00291ChlorambucilGlutathione S-transferase Penzyme
DB00291ChlorambucilSolute carrier organic anion transporter family member 1A2transporter
DB00531CyclophosphamideDNAtarget
DB00531CyclophosphamideCytochrome P450 2B6enzyme
DB00531CyclophosphamideCytochrome P450 2C9enzyme
DB00531CyclophosphamideCytochrome P450 3A4enzyme
DB00531CyclophosphamideCytochrome P450 2C19enzyme
DB00531CyclophosphamideCytochrome P450 2A6enzyme
DB00531CyclophosphamideCytochrome P450 2C18enzyme
DB00531CyclophosphamideCytochrome P450 2C8enzyme
DB00531CyclophosphamideCytochrome P450 3A5enzyme
DB00531CyclophosphamideNuclear receptor subfamily 1 group I member 2target
DB00997DoxorubicinDNA topoisomerase 2-alphatarget
DB00997DoxorubicinDNAtarget
DB00997DoxorubicinCytochrome P450 3A4enzyme
DB00997DoxorubicinCytochrome P450 2D6enzyme
DB00997DoxorubicinCytochrome P450 2B6enzyme
DB00997DoxorubicinP-glycoprotein 1transporter
DB00997DoxorubicinCanalicular multispecific organic anion transporter 2transporter
DB00997DoxorubicinMultidrug resistance-associated protein 6transporter
DB00997DoxorubicinMultidrug resistance-associated protein 1transporter
DB00997DoxorubicinMultidrug resistance-associated protein 7transporter
DB00997DoxorubicinATP-binding cassette sub-family G member 2transporter
DB00997DoxorubicinBile salt export pumptransporter
DB00997DoxorubicinSolute carrier family 22 member 16transporter
DB00997DoxorubicinATP-binding cassette sub-family B member 8, mitochondrialtransporter
DB00997DoxorubicinCytochrome P450 1B1enzyme
DB00997DoxorubicinCarbonyl reductase [NADPH] 1enzyme
DB00997DoxorubicinCarbonyl reductase [NADPH] 3enzyme
DB00997DoxorubicinAlcohol dehydrogenase [NADP(+)]enzyme
DB00997DoxorubicinAldo-keto reductase family 1 member C3enzyme
DB00997DoxorubicinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00997DoxorubicinXanthine dehydrogenase/oxidaseenzyme
DB00997DoxorubicinNitric oxide synthase, endothelialenzyme
DB00997DoxorubicinNitric oxide synthase, inducibleenzyme
DB00997DoxorubicinNitric oxide synthase, brainenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialenzyme
DB00997DoxorubicinNADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialenzyme
DB00997DoxorubicinNADPH--cytochrome P450 reductaseenzyme
DB00997DoxorubicinRalA-binding protein 1transporter
DB00997DoxorubicinCanalicular multispecific organic anion transporter 1transporter
DB00997DoxorubicinSerum albumincarrier
DB00997DoxorubicinNucleolar and coiled-body phosphoprotein 1target
DB09053IbrutinibTyrosine-protein kinase BTKtarget
DB09053IbrutinibCytochrome P450 3A4enzyme
DB09053IbrutinibCytochrome P450 3A5enzyme
DB09053IbrutinibSerum albumincarrier
DB09053Ibrutinibalpha1-acid glycoproteincarrier
DB09053IbrutinibCytochrome P450 2D6enzyme
DB01041ThalidomideTumor necrosis factortarget
DB01041ThalidomideNuclear factor NF-kappa-B p105 subunittarget
DB01041ThalidomideProstaglandin G/H synthase 2target
DB01041ThalidomideCytochrome P450 2C19enzyme
DB01041ThalidomideCytochrome P450 1A1enzyme
DB01041ThalidomideCytochrome P450 2E1enzyme
DB01041ThalidomideCytochrome P450 2C9enzyme
DB01041ThalidomideProstaglandin G/H synthase 1enzyme
DB01041ThalidomideProstaglandin G/H synthase 2enzyme
DB01041ThalidomideCytochrome P450 3A5enzyme
DB01041ThalidomideFibroblast growth factor receptor 2target
DB01041ThalidomideDNAtarget
DB01041ThalidomideProtein cereblontarget
DB01041Thalidomidealpha1-acid glycoproteintarget
DrugDrug NamePhaseStatusCount
DB01008Busulfan0Completed1
DB00531Cyclophosphamide0Completed2
DB00773Etoposide0Completed1
DB00099Filgrastim0Completed1
DB00073Rituximab0Completed1
DB12707AR-421Completed1
DB05500AVN-9441Completed1
DB00041Aldesleukin1Completed1
DB05220Alisertib1Completed2
DB12442Alvespimycin1Completed1
DB03496Alvocidib1Completed2
DB00098Antithymocyte immunoglobulin (rabbit)1Recruiting1
DB05015Belinostat1Completed1
DB05015Belinostat1Terminated1
DB06769Bendamustine1Active Not Recruiting1
DB06769Bendamustine1Recruiting1
DB06769Bendamustine1Terminated1
DB00112Bevacizumab1Completed1
DB00188Bortezomib1Completed4
DB00188Bortezomib1Terminated2
DB11666Buparlisib1Active Not Recruiting1
DB01008Busulfan1Recruiting1
DB12109CPI-6131Terminated1
DB01101Capecitabine1Completed1
DB00958Carboplatin1Completed1
DB08889Carfilzomib1Completed1
DB04849Cediranib1Completed1
DB00531Cyclophosphamide1Completed1
DB01254Dasatinib1Completed1
DB01254Dasatinib1Not Yet Recruiting1
DB01234Dexamethasone1Completed2
DB01234Dexamethasone1Terminated1
DB11841Entinostat1Completed1
DB01073Fludarabine1Completed4
DB01073Fludarabine1Recruiting1
DB00441Gemcitabine1Completed1
DB14865Human interleukin-21Completed1
DB09053Ibrutinib1Active Not Recruiting2
DB09053Ibrutinib1Not Yet Recruiting1
DB09053Ibrutinib1Terminated1
DB00619Imatinib1Completed1
DB11659Indium1Active Not Recruiting1
DB05707Isosorbide1Completed1
DB00982Isotretinoin1Completed1
DB06188Ispinesib1Terminated1
DB00480Lenalidomide1Active Not Recruiting1
DB00480Lenalidomide1Completed1
DB00480Lenalidomide1Terminated2
DB00166Lipoic acid1Terminated1
DB00563Methotrexate1Recruiting1
DB06328Methoxyamine1Completed1
DB01229Paclitaxel1Completed1
DB11697Pacritinib1Recruiting1
DB08910Pomalidomide1Completed1
DB08910Pomalidomide1Terminated1
DB11870RG-47331Completed1
DB01220Rifaximin1Recruiting1
DB12146Rigosertib1Completed1
DB00073Rituximab1Active Not Recruiting2
DB00073Rituximab1Completed3
DB00073Rituximab1Recruiting1
DB00073Rituximab1Terminated3
DB11836Sapanisertib1Completed1
DB00398Sorafenib1Completed1
DB11764Spebrutinib1Completed1
DB01268Sunitinib1Completed1
DB12756TAK-9011Completed1
DB06398Tanespimycin1Terminated3
DB15232Telaglenastat1Completed1
DB00755Tretinoin1Completed1
DB11940Triapine1Completed1
DB00135Tyrosine1Active Not Recruiting1
DB00541Vincristine1Recruiting1
DB02546Vorinostat1Completed2
DB02546Vorinostat1Terminated1
DB13076Yttrium Y-901Active Not Recruiting1
DB11703Acalabrutinib1 / 2Active Not Recruiting1
DB03496Alvocidib1 / 2Completed1
DB03496Alvocidib1 / 2Terminated1
DB14990Bazlitoran1 / 2Completed2
DB06769Bendamustine1 / 2Completed1
DB02379Beta-D-Glucose1 / 2Active Not Recruiting1
DB02379Beta-D-Glucose1 / 2Completed1
DB00188Bortezomib1 / 2Active Not Recruiting2
DB08870Brentuximab vedotin1 / 2Recruiting1
DB00958Carboplatin1 / 2Completed1
DB00262Carmustine1 / 2Active Not Recruiting1
DB00262Carmustine1 / 2Completed1
DB00531Cyclophosphamide1 / 2Active Not Recruiting1
DB00531Cyclophosphamide1 / 2Recruiting1
DB00091Cyclosporine1 / 2Active Not Recruiting2
DB00987Cytarabine1 / 2Active Not Recruiting1
DB00987Cytarabine1 / 2Completed1
DB01234Dexamethasone1 / 2Active Not Recruiting1
DB00997Doxorubicin1 / 2Recruiting1
DB00773Etoposide1 / 2Active Not Recruiting1
DB00773Etoposide1 / 2Completed2
DB00773Etoposide1 / 2Recruiting1
DB01590Everolimus1 / 2Active Not Recruiting3
DB05076Fenretinide1 / 2Terminated1
DB00099Filgrastim1 / 2Terminated1
DB01073Fludarabine1 / 2Active Not Recruiting3
DB00441Gemcitabine1 / 2Completed1
DB00078Ibritumomab tiuxetan1 / 2Completed1
DB00078Ibritumomab tiuxetan1 / 2Terminated1
DB09053Ibrutinib1 / 2Recruiting1
DB01181Ifosfamide1 / 2Completed1
DB06186Ipilimumab1 / 2Suspended1
DB06186Ipilimumab1 / 2Terminated1
DB00160L-Alanine1 / 2Active Not Recruiting1
DB00160L-Alanine1 / 2Completed1
DB00480Lenalidomide1 / 2Active Not Recruiting1
DB00480Lenalidomide1 / 2Completed4
DB00480Lenalidomide1 / 2Recruiting1
DB00480Lenalidomide1 / 2Withdrawn1
DB00888Mechlorethamine1 / 2Active Not Recruiting1
DB00888Mechlorethamine1 / 2Completed1
DB01042Melphalan1 / 2Active Not Recruiting1
DB01042Melphalan1 / 2Completed1
DB00688Mycophenolate mofetil1 / 2Active Not Recruiting3
DB00038Oprelvekin1 / 2Terminated1
DB11991Oprozomib1 / 2Completed1
DB06603Panobinostat1 / 2Active Not Recruiting1
DB09037Pembrolizumab1 / 2Active Not Recruiting1
DB05527Pralatrexate1 / 2Completed1
DB06813Pralatrexate1 / 2Completed1
DB00635Prednisone1 / 2Recruiting1
DB00073Rituximab1 / 2Active Not Recruiting2
DB00073Rituximab1 / 2Completed5
DB00073Rituximab1 / 2Recruiting3
DB00073Rituximab1 / 2Terminated2
DB00073Rituximab1 / 2Withdrawn1
DB06176Romidepsin1 / 2Withdrawn1
DB00877Sirolimus1 / 2Active Not Recruiting3
DB00877Sirolimus1 / 2Completed1
DB14546Sulfate ion1 / 2Recruiting1
DB00864Tacrolimus1 / 2Active Not Recruiting1
DB06287Temsirolimus1 / 2Active Not Recruiting1
DB06287Temsirolimus1 / 2Completed1
DB11850Ublituximab1 / 2Completed2
DB12018Ulocuplumab1 / 2Recruiting1
DB07232Veliparib1 / 2Completed1
DB00541Vincristine1 / 2Recruiting1
DB02546Vorinostat1 / 2Completed1
DB11703Acalabrutinib2Active Not Recruiting1
DB00087Alemtuzumab2Active Not Recruiting2
DB00087Alemtuzumab2Completed1
DB05220Alisertib2Terminated1
DB09312Antilymphocyte immunoglobulin (horse)2Completed1
DB09312Antilymphocyte immunoglobulin (horse)2Terminated1
DB00098Antithymocyte immunoglobulin (rabbit)2Completed1
DB00098Antithymocyte immunoglobulin (rabbit)2Terminated1
DB01076Atorvastatin2Active Not Recruiting1
DB06769Bendamustine2Active Not Recruiting1
DB06769Bendamustine2Completed1
DB02379Beta-D-Glucose2Completed1
DB00188Bortezomib2Active Not Recruiting3
DB00188Bortezomib2Completed6
DB00188Bortezomib2Recruiting3
DB00188Bortezomib2Terminated1
DB00188Bortezomib2Unknown Status1
DB08870Brentuximab vedotin2Recruiting1
DB01008Busulfan2Completed3
DB01008Busulfan2Recruiting1
DB01008Busulfan2Terminated1
DB00958Carboplatin2Completed1
DB08889Carfilzomib2Completed2
DB00262Carmustine2Completed1
DB00531Cyclophosphamide2Active Not Recruiting1
DB00531Cyclophosphamide2Completed7
DB00531Cyclophosphamide2Recruiting4
DB00531Cyclophosphamide2Terminated2
DB00531Cyclophosphamide2Withdrawn1
DB00091Cyclosporine2Active Not Recruiting4
DB00091Cyclosporine2Completed6
DB00987Cytarabine2Completed1
DB09331Daratumumab2Recruiting2
DB01609Deferasirox2Completed1
DB01234Dexamethasone2Active Not Recruiting2
DB01234Dexamethasone2Completed7
DB01234Dexamethasone2Recruiting2
DB01234Dexamethasone2Unknown Status1
DB00997Doxorubicin2Terminated1
DB00254Doxycycline2Terminated1
DB06486Enzastaurin2Completed1
DB04958Epratuzumab2Terminated1
DB00773Etoposide2Completed3
DB01590Everolimus2Completed1
DB00099Filgrastim2Completed1
DB01073Fludarabine2Active Not Recruiting5
DB01073Fludarabine2Completed7
DB01073Fludarabine2Recruiting4
DB01073Fludarabine2Terminated1
DB01073Fludarabine2Withdrawn1
DB00441Gemcitabine2Completed1
DB09053Ibrutinib2Active Not Recruiting1
DB09053Ibrutinib2Completed2
DB09053Ibrutinib2Recruiting4
DB09054Idelalisib2Active Not Recruiting1
DB09054Idelalisib2Recruiting2
DB09054Idelalisib2Terminated1
DB10791Influenza A virus A/California/7/2009 X-179A (H1N1) antigen (formaldehyde inactivated)2Completed1
DB14445Influenza A virus A/Victoria/210/2009 X-187 (H3N2) antigen (formaldehyde inactivated)2Completed1
DB10794Influenza B virus B/Brisbane/60/2008 antigen (formaldehyde inactivated)2Completed1
DB09570Ixazomib2Active Not Recruiting1
DB09570Ixazomib2Recruiting1
DB00160L-Alanine2Completed1
DB00480Lenalidomide2Active Not Recruiting1
DB00480Lenalidomide2Recruiting1
DB00480Lenalidomide2Terminated3
DB00888Mechlorethamine2Completed1
DB01042Melphalan2Completed2
DB01042Melphalan2Recruiting1
DB00563Methotrexate2Completed3
DB00959Methylprednisolone2Completed2
DB14644Methylprednisolone hemisuccinate2Completed2
DB00688Mycophenolate mofetil2Active Not Recruiting5
DB00688Mycophenolate mofetil2Completed7
DB00688Mycophenolate mofetil2Recruiting3
DB00688Mycophenolate mofetil2Terminated1
DB00688Mycophenolate mofetil2Withdrawn1
DB01024Mycophenolic acid2Recruiting1
DB01280Nelarabine2Terminated1
DB09035Nivolumab2Recruiting1
DB08935Obinutuzumab2Active Not Recruiting1
DB08935Obinutuzumab2Recruiting1
DB06650Ofatumumab2Completed1
DB06650Ofatumumab2Terminated1
DB00526Oxaliplatin2Completed1
DB06603Panobinostat2Active Not Recruiting2
DB09037Pembrolizumab2Not Yet Recruiting1
DB09037Pembrolizumab2Recruiting2
DB00552Pentostatin2Active Not Recruiting1
DB06641Perifosine2Completed2
DB00635Prednisone2Terminated1
DB00073Rituximab2Active Not Recruiting5
DB00073Rituximab2Completed12
DB00073Rituximab2Not Yet Recruiting1
DB00073Rituximab2Recruiting4
DB00073Rituximab2Terminated7
DB00073Rituximab2Unknown Status1
DB00203Sildenafil2Completed1
DB00641Simvastatin2Terminated1
DB00877Sirolimus2Completed2
DB00877Sirolimus2Recruiting1
DB14546Sulfate ion2Terminated1
DB00864Tacrolimus2Active Not Recruiting1
DB00864Tacrolimus2Completed5
DB00864Tacrolimus2Recruiting2
DB00864Tacrolimus2Terminated1
DB00864Tacrolimus2Withdrawn1
DB06287Temsirolimus2Completed1
DB01041Thalidomide2Completed2
DB01041Thalidomide2Recruiting1
DB01041Thalidomide2Terminated1
DB04572Thiotepa2Recruiting1
DB14989Umbralisib2Recruiting1
DB00577Valaciclovir2Active Not Recruiting1
DB11581Venetoclax2Active Not Recruiting1
DB00541Vincristine2Terminated1
DB02546Vorinostat2Completed1
DB15035Zanubrutinib2Recruiting1
DB00531Cyclophosphamide2 / 3Not Yet Recruiting1
DB01234Dexamethasone2 / 3Not Yet Recruiting1
DB09053Ibrutinib2 / 3Not Yet Recruiting1
DB00073Rituximab2 / 3Not Yet Recruiting1
DB00188Bortezomib3Active Not Recruiting1
DB00291Chlorambucil3Completed1
DB00531Cyclophosphamide3Active Not Recruiting1
DB00091Cyclosporine3Active Not Recruiting1
DB00091Cyclosporine3Completed1
DB01234Dexamethasone3Active Not Recruiting1
DB01073Fludarabine3Active Not Recruiting1
DB01073Fludarabine3Completed2
DB09053Ibrutinib3Active Not Recruiting2
DB09053Ibrutinib3Recruiting1
DB00688Mycophenolate mofetil3Active Not Recruiting1
DB00688Mycophenolate mofetil3Completed1
DB00073Rituximab3Active Not Recruiting2
DB00877Sirolimus3Completed1
DB15035Zanubrutinib3Active Not Recruiting1
DB00188Bortezomib4Recruiting1
DB09053Ibrutinib4Not Yet Recruiting1
DB00073Rituximab4Recruiting1
DB01041Thalidomide4Recruiting1
DB119196-O-benzylguanineNot AvailableWithdrawn1
DB09312Antilymphocyte immunoglobulin (horse)Not AvailableActive Not Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)Not AvailableActive Not Recruiting1
DB01169Arsenic trioxideNot AvailableTerminated1
DB04456Arsenous acidNot AvailableTerminated1
DB00188BortezomibNot AvailableActive Not Recruiting1
DB01008BusulfanNot AvailableCompleted1
DB00958CarboplatinNot AvailableCompleted1
DB00262CarmustineNot AvailableCompleted1
DB00262CarmustineNot AvailableWithdrawn1
DB00531CyclophosphamideNot AvailableCompleted1
DB00091CyclosporineNot AvailableActive Not Recruiting2
DB00091CyclosporineNot AvailableCompleted2
DB00987CytarabineNot AvailableWithdrawn1
DB00773EtoposideNot AvailableCompleted1
DB00773EtoposideNot AvailableTerminated1
DB00773EtoposideNot AvailableWithdrawn1
DB00099FilgrastimNot AvailableActive Not Recruiting1
DB00099FilgrastimNot AvailableTerminated1
DB01073FludarabineNot AvailableActive Not Recruiting2
DB01073FludarabineNot AvailableCompleted2
DB00529FoscarnetNot AvailableCompleted1
DB01004GanciclovirNot AvailableCompleted1
DB01042MelphalanNot AvailableActive Not Recruiting1
DB01042MelphalanNot AvailableCompleted1
DB01042MelphalanNot AvailableWithdrawn1
DB00688Mycophenolate mofetilNot AvailableActive Not Recruiting2
DB00688Mycophenolate mofetilNot AvailableCompleted2
DB06809PlerixaforNot AvailableTerminated1
DB00073RituximabNot AvailableCompleted1
DB04572ThiotepaNot AvailableCompleted1
DB01610ValganciclovirNot AvailableCompleted1
DB15035ZanubrutinibNot AvailableAvailable1