Hyperuricemia

Also known as: Hyperuricaemia / Blood urate / Hyperuricaemic / Uric acid retention

DrugDrug NameDrug Description
DB00437AllopurinolA xanthine oxidase inhibitor that decreases uric acid production. It also acts as an antimetabolite on some simpler organisms. Allopurinol is considered a standard treatment of hyperuricemia associated with gout. In August 2017, an oral combination agent Duzallo was approved by FDA as a dual-mechanism treatment of hyperuricemia in patients with uncontrolled gout. Duzallo contains allopurinol and [Lesinurad], a recently FDA-approved URAT1 inhibitor indicated for the treatment of hyperuricemia associated with gout.
DB11560LesinuradLesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter associated with diuretic-induced hyperuricemia. Marketed as the product Zurampic, it is indicated for use in combination with a xanthine oxidase inhibitor for the treatment of hyperuricemia associated with gout in patients who have not achieved target serum uric acid levels with a xanthine oxidase inhibitor alone. In August 2017, a combination oral therapy consisting of lesinurad and [DB00437] was FDA-approved under the brand name Duzallo indicated for the treatment of gout-related hyperuricemia in patients with uncontrolled gout.
DB01032ProbenecidThe prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
DB00049RasburicaseRasburicase is a recombinant urate-oxidase enzyme produced by a genetically modified Saccharomyces cerevisiae strain. The cDNA coding for rasburicase was cloned from a strain of _Aspergillus flavus_.
DB01138SulfinpyrazoneA uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.
DrugDrug NameTargetType
DB00437AllopurinolXanthine dehydrogenase/oxidasetarget
DB00437AllopurinolSolute carrier family 22 member 8transporter
DB00437AllopurinolSolute carrier family 22 member 7transporter
DB00437AllopurinolAldehyde oxidaseenzyme
DB00437AllopurinolXanthine dehydrogenase/oxidaseenzyme
DB11560LesinuradSolute carrier family 22 member 12target
DB11560LesinuradSolute carrier family 22 member 11target
DB11560LesinuradCytochrome P450 2C9enzyme
DB01032ProbenecidSolute carrier family 22 member 8target
DB01032ProbenecidSolute carrier family 22 member 11target
DB01032ProbenecidSerum albumincarrier
DB01032ProbenecidCytochrome P450 2C19enzyme
DB01032ProbenecidSolute carrier family 22 member 2transporter
DB01032ProbenecidSolute carrier family 22 member 1transporter
DB01032ProbenecidCanalicular multispecific organic anion transporter 2transporter
DB01032ProbenecidMultidrug resistance-associated protein 4transporter
DB01032ProbenecidMultidrug resistance-associated protein 5transporter
DB01032ProbenecidMonocarboxylate transporter 2transporter
DB01032ProbenecidSolute carrier family 22 member 5transporter
DB01032ProbenecidMultidrug resistance-associated protein 6transporter
DB01032ProbenecidMultidrug resistance-associated protein 1transporter
DB01032ProbenecidSolute carrier organic anion transporter family member 1A2transporter
DB01032ProbenecidMonocarboxylate transporter 1transporter
DB01032ProbenecidSodium/bile acid cotransportertransporter
DB01032ProbenecidSolute carrier family 22 member 6transporter
DB01032ProbenecidSolute carrier family 22 member 10transporter
DB01032ProbenecidSolute carrier family 22 member 8transporter
DB01032ProbenecidCanalicular multispecific organic anion transporter 1transporter
DB01032ProbenecidATP-binding cassette sub-family C member 11transporter
DB01032ProbenecidSolute carrier family 22 member 11transporter
DB01032ProbenecidSolute carrier organic anion transporter family member 1C1transporter
DB01032ProbenecidSolute carrier family 22 member 7transporter
DB01032ProbenecidSolute carrier family 22 member 6target
DB01032ProbenecidPannexin-1target
DB01032ProbenecidCytochrome P450 2C8enzyme
DB01032ProbenecidCytochrome P450 3A4enzyme
DB01032ProbenecidSolute carrier family 22 member 12transporter
DB01032ProbenecidSolute carrier family 2, facilitated glucose transporter member 9transporter
DB01032ProbenecidTaste receptor type 2 member 16target
DB01032ProbenecidUDP-glucuronosyltransferase 1-1enzyme
DB00049RasburicaseUric acidtarget
DB01138SulfinpyrazoneMultidrug resistance-associated protein 1target
DB01138SulfinpyrazoneCanalicular multispecific organic anion transporter 1target
DB01138SulfinpyrazoneFatty acid-binding protein, intestinalcarrier
DB01138SulfinpyrazoneCytochrome P450 2C9enzyme
DB01138SulfinpyrazoneCanalicular multispecific organic anion transporter 2transporter
DB01138SulfinpyrazoneMultidrug resistance-associated protein 4transporter
DB01138SulfinpyrazoneMultidrug resistance-associated protein 5transporter
DB01138SulfinpyrazoneMultidrug resistance-associated protein 6transporter
DB01138SulfinpyrazoneMultidrug resistance-associated protein 1transporter
DB01138SulfinpyrazoneCanalicular multispecific organic anion transporter 1transporter
DB01138SulfinpyrazoneCytochrome P450 3A4enzyme
DB01138SulfinpyrazoneCytochrome P450 2B6enzyme
DB01138SulfinpyrazoneCytochrome P450 2C8enzyme
DB01138SulfinpyrazoneSolute carrier family 22 member 12target
DB01138SulfinpyrazoneNuclear receptor subfamily 1 group I member 2target
DB01138SulfinpyrazoneBile salt export pumptransporter
DrugDrug NamePhaseStatusCount
DB00437Allopurinol0Recruiting1
DB00437Allopurinol2Completed3
DB00437Allopurinol2Recruiting1
DB06158Arhalofenate2Completed2
DB11811Arhalofenate2Completed3
DB12319Benzbromarone2Recruiting1
DB01394Colchicine2Completed3
DB04854Febuxostat2Completed3
DB11560Lesinurad2Completed1
DB01032Probenecid2Completed1
DB05228RDEA8062Completed1
DB00049Rasburicase2Completed2
DB00049Rasburicase2Terminated1
DB01685Topiroxostat2Completed1
DB07615Tranilast2Completed2
DB12353Ulodesine2Completed2
DB00635Prednisone2 / 3Recruiting1
DB00437Allopurinol3Completed1
DB00437Allopurinol3Terminated1
DB00049Rasburicase3Completed1
DB00049Rasburicase3Terminated1
DB00437Allopurinol4Active Not Recruiting1
DB00437Allopurinol4Completed3
DB12319Benzbromarone4Active Not Recruiting1
DB12319Benzbromarone4Completed1
DB08907Canagliflozin4Enrolling by Invitation1
DB04854Febuxostat4Active Not Recruiting1
DB04854Febuxostat4Completed1
DB04854Febuxostat4Recruiting2
DB00635Prednisone4Completed1
DB00049Rasburicase4Completed3
DB00945Acetylsalicylic acidNot AvailableNot Yet Recruiting1
DB00437AllopurinolNot AvailableCompleted1
DB12319BenzbromaroneNot AvailableNot Yet Recruiting1
DB12319BenzbromaroneNot AvailableRecruiting1
DB00758ClopidogrelNot AvailableNot Yet Recruiting1
DB04854FebuxostatNot AvailableActive Not Recruiting1
DB04854FebuxostatNot AvailableNot Yet Recruiting1
DB04854FebuxostatNot AvailableRecruiting1
DB00049RasburicaseNot AvailableCompleted2