Hyperuricemia

Also known as: Hyperuricaemia / Blood urate / Hyperuricaemic / Uric acid retention

DrugDrug NameDrug Description
DB00437AllopurinolA xanthine oxidase inhibitor used to reduce urinary and serum uric acid concentrations in patients with gout, recurrent calcium oxalate calculi, and various malignancies.
DB11560LesinuradA uric acid 1 transporter inhibitor typically used in combination with a xanthine oxidase inhibitor to treat hyperuricemia associated with gout in patients with inadequate control of uric acid levels with xanthine oxidase inhibitor monotherapy.
DB01032ProbenecidA medication used to treat gouty arthritis, tophaceous gout, and hyperuricemia.
DB00049RasburicaseA recombinant form of urate-oxidase enzyme used to treat hyperuricemia following chemotherapy for leukemias and non-Hodgkin's lymphoma.
DB01138SulfinpyrazoneA platelet inhibitory and uricosuric agent used to inhibit thrombotic and embolic processes and to manage the chronic phases of gout .
DrugDrug NameTargetType
DB00437AllopurinolXanthine dehydrogenase/oxidasetarget
DB00437AllopurinolSolute carrier family 22 member 8transporter
DB00437AllopurinolSolute carrier family 22 member 7transporter
DB00437AllopurinolAldehyde oxidaseenzyme
DB00437AllopurinolXanthine dehydrogenase/oxidaseenzyme
DB00437AllopurinolATP-binding cassette sub-family G member 2transporter
DB00437AllopurinolSolute carrier family 22 member 2transporter
DB11560LesinuradSolute carrier family 22 member 12target
DB11560LesinuradSolute carrier family 22 member 11target
DB11560LesinuradCytochrome P450 2C9enzyme
DB11560LesinuradCytochrome P450 3A4enzyme
DB01032ProbenecidSolute carrier family 22 member 8target
DB01032ProbenecidSolute carrier family 22 member 11target
DB01032ProbenecidSerum albumincarrier
DB01032ProbenecidSolute carrier family 22 member 2transporter
DB01032ProbenecidSolute carrier family 22 member 1transporter
DB01032ProbenecidCanalicular multispecific organic anion transporter 2transporter
DB01032ProbenecidMultidrug resistance-associated protein 4transporter
DB01032ProbenecidMultidrug resistance-associated protein 5transporter
DB01032ProbenecidMonocarboxylate transporter 2transporter
DB01032ProbenecidSolute carrier family 22 member 5transporter
DB01032ProbenecidMultidrug resistance-associated protein 6transporter
DB01032ProbenecidMultidrug resistance-associated protein 1transporter
DB01032ProbenecidSolute carrier organic anion transporter family member 1A2transporter
DB01032ProbenecidMonocarboxylate transporter 1transporter
DB01032ProbenecidSodium/bile acid cotransportertransporter
DB01032ProbenecidSolute carrier family 22 member 6transporter
DB01032ProbenecidSolute carrier family 22 member 10transporter
DB01032ProbenecidSolute carrier family 22 member 8transporter
DB01032ProbenecidCanalicular multispecific organic anion transporter 1transporter
DB01032ProbenecidATP-binding cassette sub-family C member 11transporter
DB01032ProbenecidSolute carrier family 22 member 11transporter
DB01032ProbenecidSolute carrier organic anion transporter family member 1C1transporter
DB01032ProbenecidSolute carrier family 22 member 7transporter
DB01032ProbenecidSolute carrier family 22 member 6target
DB01032ProbenecidPannexin-1target
DB01032ProbenecidCytochrome P450 2C8enzyme
DB01032ProbenecidCytochrome P450 3A4enzyme
DB01032ProbenecidSolute carrier family 22 member 12transporter
DB01032ProbenecidSolute carrier family 2, facilitated glucose transporter member 9transporter
DB01032ProbenecidTaste receptor type 2 member 16target
DB01032ProbenecidUDP-glucuronosyltransferase 1-1enzyme
DB01032ProbenecidCytochrome P450 2C9enzyme
DB00049RasburicaseUric acidtarget
DB01138SulfinpyrazoneMultidrug resistance-associated protein 1target
DB01138SulfinpyrazoneCanalicular multispecific organic anion transporter 1target
DB01138SulfinpyrazoneFatty acid-binding protein, intestinalcarrier
DB01138SulfinpyrazoneCytochrome P450 2C9enzyme
DB01138SulfinpyrazoneCanalicular multispecific organic anion transporter 2transporter
DB01138SulfinpyrazoneMultidrug resistance-associated protein 4transporter
DB01138SulfinpyrazoneMultidrug resistance-associated protein 5transporter
DB01138SulfinpyrazoneMultidrug resistance-associated protein 6transporter
DB01138SulfinpyrazoneMultidrug resistance-associated protein 1transporter
DB01138SulfinpyrazoneCanalicular multispecific organic anion transporter 1transporter
DB01138SulfinpyrazoneCytochrome P450 3A4enzyme
DB01138SulfinpyrazoneCytochrome P450 2B6enzyme
DB01138SulfinpyrazoneCytochrome P450 2C8enzyme
DB01138SulfinpyrazoneSolute carrier family 22 member 12target
DB01138SulfinpyrazoneNuclear receptor subfamily 1 group I member 2target
DB01138SulfinpyrazoneBile salt export pumptransporter
DrugDrug NamePhaseStatusCount
DB00437Allopurinol0Withdrawn1
DB04854Febuxostat1Recruiting1
DB00788Naproxen1Not Yet Recruiting1
DB15129Pegadricase1Unknown Status2
DB02134Xanthine1Not Yet Recruiting1
DB00437Allopurinol2Completed3
DB00437Allopurinol2Recruiting2
DB06158Arhalofenate2Completed2
DB11811Arhalofenate2Completed3
DB12319Benzbromarone2Recruiting1
DB01394Colchicine2Completed3
DB04854Febuxostat2Completed4
DB04854Febuxostat2Not Yet Recruiting2
DB11560Lesinurad2Completed1
DB09208Pegloticase2Not Yet Recruiting1
DB01032Probenecid2Completed1
DB05228RDEA8062Completed1
DB00049Rasburicase2Completed2
DB00049Rasburicase2Terminated1
DB00877Sirolimus2Completed1
DB08811Tofisopam2Unknown Status1
DB01685Topiroxostat2Completed1
DB07615Tranilast2Completed2
DB12353Ulodesine2Completed2
DB11873Verinurad2Completed1
DB02134Xanthine2Not Yet Recruiting1
DB00635Prednisone2 / 3Recruiting1
DB00437Allopurinol3Completed1
DB00437Allopurinol3Not Yet Recruiting1
DB00437Allopurinol3Terminated1
DB00049Rasburicase3Completed1
DB00049Rasburicase3Terminated1
DB08844Uric acid3Completed1
DB00437Allopurinol4Active Not Recruiting1
DB00437Allopurinol4Completed3
DB00126Ascorbic acid4Recruiting1
DB12319Benzbromarone4Active Not Recruiting1
DB12319Benzbromarone4Completed1
DB00121Biotin4Recruiting1
DB01373Calcium4Recruiting1
DB08907Canagliflozin4Active Not Recruiting1
DB00169Cholecalciferol4Recruiting1
DB11136Chromium4Recruiting1
DB00115Cyanocobalamin4Recruiting1
DB00783Estradiol4Completed1
DB04854Febuxostat4Active Not Recruiting1
DB04854Febuxostat4Completed1
DB04854Febuxostat4Recruiting2
DB14491Ferrous fumarate4Recruiting1
DB00158Folic acid4Recruiting1
DB00999Hydrochlorothiazide4Completed1
DB14513Magnesium4Recruiting1
DB11137Molybdenum4Recruiting1
DB02701Nicotinamide4Recruiting1
DB00717Norethisterone4Completed1
DB01783Pantothenic acid4Recruiting1
DB00790Perindopril4Completed1
DB14500Potassium4Recruiting1
DB00635Prednisone4Completed1
DB00165Pyridoxine4Recruiting1
DB00049Rasburicase4Completed3
DB00140Riboflavin4Recruiting1
DB11135Selenium4Recruiting1
DB00152Thiamine4Recruiting1
DB00162Vitamin A4Recruiting1
DB01593Zinc4Recruiting1
DB14003alpha-Tocopherol acetate4Recruiting1
DB00945Acetylsalicylic acidNot AvailableNot Yet Recruiting1
DB00437AllopurinolNot AvailableCompleted1
DB00437AllopurinolNot AvailableUnknown Status1
DB12319BenzbromaroneNot AvailableCompleted1
DB12319BenzbromaroneNot AvailableNot Yet Recruiting1
DB00758ClopidogrelNot AvailableNot Yet Recruiting1
DB04854FebuxostatNot AvailableActive Not Recruiting1
DB04854FebuxostatNot AvailableCompleted2
DB04854FebuxostatNot AvailableNot Yet Recruiting1
DB11560LesinuradNot AvailableNot Yet Recruiting1
DB00049RasburicaseNot AvailableCompleted2
DB08844Uric acidNot AvailableCompleted1
DB08844Uric acidNot AvailableUnknown Status1
DB02134XanthineNot AvailableNot Yet Recruiting1