Also known as: Arthritis NOS / Arthrosis NOS

DrugDrug NameDrug Description
DB11344(+)-mentholNot Available
DB11345(S)-camphor(S)-camphor, or L(-)-Camphor, is a stereoisomer of [DB01744], a bicyclic monoterpene known to potentiate both heat and cold sensations [A33087]. (S)-camphor is not the naturally-occurring stereoisomer but displays similar TRPV channel affinity and current inhibition [A33086]. [DB01744] is isolated from the wood of the camphor laurel tree, _Cinnamomum camphora_, and had a long history of medicinal use. It has been used as a nasal decongestant and cough suppressant, and has been topically applied due to its antipruritic, analgesic, and counterirritant properties [A33086]. Camphor is a major active ingredient in over-the-counter balms and liniments supplied as topical analgesics by causing sensitization to heat and coolness to relieve minor muscle and joint pain [A33086].
DB111742-(l-menthoxy)ethanolNot Available
DB00945Acetylsalicylic acidAlso known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial infarction (MI) [FDA label]. Interestingly, the results of various studies have demonstrated that long-term use of acetylsalicylic acid may decrease the risk of various cancers, including colorectal, esophageal, breast, lung, prostate, liver and skin cancer [A177325]. Aspirin is classified as a _non-selective cyclooxygenase (COX) inhibitor_ [A32682, A177268] and is available in many doses and forms, including chewable tablets, suppositories, extended release formulations, and others [L5968]. Acetylsalicylic acid is a very common cause of accidental poisoning in young children. It should be kept out of reach from young children, toddlers, and infants [FDA label].
DB01744CamphorA bicyclic monoterpene ketone found widely in plants, especially cinnamomum camphora. It is used topically as a skin antipruritic and as an anti-infective agent.
DB06774CapsaicinCapsaicin is most often used as a topical analgesic and exists in many formulations of cream, liquid, and patch preparations of various strengths; however, it may also be found in some dietary supplements. Capsaicin is a naturally-occurring botanical irritant in chili peppers, synthetically derived for pharmaceutical formulations. The most recent capsaicin FDA approval was Qutenza, an 8% capsaicin patch dermal-delivery system, indicated for neuropathic pain associated with post-herpetic neuralgia.
DB01401Choline magnesium trisalicylateCholine magnesium trisalicylate is a non-acetylated salicylate used widely as a nonsteroidal anti-inflammatory drug. Trisalicylate significantly reduces methotrexate renal clearance, displacing methotrexate from protein, increasing the fraction unbound by 28% [A19653, A19654].
DB09301Chondroitin sulfateChondroitin sulfate is a glycosaminoglycan considered as a symptomatic slow-acting drug for osteoarthritis (SYSADOA).[A7906] The SYSADOA status suggested a pain relief and increased joint mobility after a relative long regular administration, as well as a long-lasting effect after the end of the treatment. Chondroitin sulfate is composed of alternating 1,3-N-acetyl-β-d-galactosamine and 1,4-β-d-glucuronic acid units which bear 4-O- and/or 6-O-sulfations at the N-acetylgalactosamine units disposed of in specific patterns. Depending on the predominating disaccharide unit, it will present different biological activities.[A32063] Chondroitin sulfate is sold as an OTC dietary supplement in North America and it is a prescription drug under the EMA in Europe.[A32066]
DB11201Menthyl salicylateMenthyl salicylate is an ester of menthol and salicylic acid [L2808]. This product is used to treat minor aches and pains of the muscles/joints (e.g., arthritis, backache, sprains) [L2810].
DB00788NaproxenNaproxen is classified as a nonsteroidal anti-inflammatory dug (NSAID) and was initially approved for prescription use in 1976 and then for over-the-counter (OTC) use in 1994.[A178975]
DB13747TrolamineTrolamine, which is also referred to as triethanolamine (TEA), is a tertiary amine and a triol. It is a bifunctional compound that exhibits both properties of alcohols and amines. Trolamine contains small amounts of diethanolamine and ethanolamine and may also act as an antioxidant against the auto-oxidation of animal and vegetable fats [A27174]. It is commonly used as a pH adjuster and surfactant in industrial and cosmetic products such as skin and hair conditioning products.
DB11120TurpentineTurpentine, also known as spirit of turpentine, oil of turpentine, and wood turpentine, is a liquid extracted from live trees, mainly pine, through distillation of resin. It is used as a solvent and base material in organic synthesis reactions. Turpentine is composed of terpenes, mainly the monoterpenes alpha-pinene and beta-pinene with lesser amounts of carene, camphene, dipentene, and terpinolene.
DrugDrug NameTargetType
DB11345(S)-camphorTransient receptor potential cation channel subfamily V member 1target
DB11345(S)-camphorTransient receptor potential cation channel subfamily V member 3target
DB11345(S)-camphorTransient receptor potential cation channel subfamily A member 1target
DB11345(S)-camphorTransient receptor potential cation channel subfamily M member 8target
DB00945Acetylsalicylic acidProstaglandin G/H synthase 1target
DB00945Acetylsalicylic acidProstaglandin G/H synthase 2target
DB00945Acetylsalicylic acidAldo-keto reductase family 1 member C1target
DB00945Acetylsalicylic acidSolute carrier family 22 member 6transporter
DB00945Acetylsalicylic acidMultidrug resistance protein 1transporter
DB00945Acetylsalicylic acidCytochrome P450 2C19enzyme
DB00945Acetylsalicylic acidCytochrome P450 2C9enzyme
DB00945Acetylsalicylic acid5'-AMP-activated protein kinasetarget
DB00945Acetylsalicylic acidEndothelin-1 receptortarget
DB00945Acetylsalicylic acidNuclear factor kappa b beta subunittarget
DB00945Acetylsalicylic acidCellular tumor antigen p53target
DB00945Acetylsalicylic acid78 kDa glucose-regulated proteintarget
DB00945Acetylsalicylic acidRibosomal protein S6 kinase alpha-3target
DB00945Acetylsalicylic acidNF-kappa-B inhibitor alphatarget
DB00945Acetylsalicylic acidTumor necrosis factor-inducible gene 6 proteintarget
DB00945Acetylsalicylic acidCaspase-1target
DB00945Acetylsalicylic acidCaspase-3target
DB00945Acetylsalicylic acidInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB00945Acetylsalicylic acidExtracellular signal-regulated kinase (ERK)target
DB00945Acetylsalicylic acidG1/S-specific cyclin-D1target
DB00945Acetylsalicylic acidMyc proto-oncogene proteintarget
DB00945Acetylsalicylic acidProliferating cell nuclear antigentarget
DB00945Acetylsalicylic acidCyclin Atarget
DB00945Acetylsalicylic acidUDP-glucuronosyltransferase 1-6enzyme
DB00945Acetylsalicylic acidArylamine N-acetyltransferase 2enzyme
DB00945Acetylsalicylic acidSolute carrier family 22 member 8transporter
DB01744CamphorCamphor 5-monooxygenasetarget
DB01744CamphorTransient receptor potential cation channel subfamily V member 1target
DB01744CamphorTransient receptor potential cation channel subfamily V member 3target
DB01744CamphorTransient receptor potential cation channel subfamily A member 1target
DB01744CamphorTransient receptor potential cation channel subfamily M member 8target
DB06774CapsaicinCytochrome P450 3A4enzyme
DB06774CapsaicinProstaglandin G/H synthase 2enzyme
DB06774CapsaicinCytochrome P450 1A2enzyme
DB06774CapsaicinCytochrome P450 2E1enzyme
DB06774CapsaicinAmine oxidase [flavin-containing] Aenzyme
DB06774CapsaicinDopamine beta-hydroxylaseenzyme
DB06774CapsaicinGlutamine synthetaseenzyme
DB06774CapsaicinTransient receptor potential cation channel subfamily V member 1target
DB01401Choline magnesium trisalicylateProstaglandin G/H synthase 1target
DB01401Choline magnesium trisalicylateProstaglandin G/H synthase 2target
DB09301Chondroitin sulfateBrain-derived neurotrophic factortarget
DB09301Chondroitin sulfateGlial cell line-derived neurotrophic factortarget
DB09301Chondroitin sulfateVascular endothelial growth factor Atarget
DB09301Chondroitin sulfateC-C motif chemokine 2target
DB09301Chondroitin sulfateBeta-glucuronidaseenzyme
DB09301Chondroitin sulfateBeta-hexosaminidase subunit betaenzyme
DB09301Chondroitin sulfateN-acetylgalactosamine-6-sulfataseenzyme
DB09301Chondroitin sulfateIduronate 2-sulfataseenzyme
DB09301Chondroitin sulfateAlpha-L-iduronidaseenzyme
DB09301Chondroitin sulfateArylsulfatase Benzyme
DB09301Chondroitin sulfateGlucuronate-2-sulfataseenzyme
DB11201Menthyl salicylateBlood vesselstarget
DB11201Menthyl salicylateProstaglandin G/H synthase 1target
DB11201Menthyl salicylateProstaglandin G/H synthase 2target
DB00788NaproxenProstaglandin G/H synthase 1target
DB00788NaproxenProstaglandin G/H synthase 2target
DB00788NaproxenSerum albumincarrier
DB00788NaproxenCytochrome P450 2C9enzyme
DB00788NaproxenCytochrome P450 1A2enzyme
DB00788NaproxenSolute carrier organic anion transporter family member 1A2transporter
DB00788NaproxenSolute carrier family 22 member 6transporter
DB00788NaproxenCytochrome P450 2C8enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-1enzyme
DB00788NaproxenUDP-glucuronosyltransferase 2B7enzyme
DB00788NaproxenPeptostreptococcal albumin-binding proteintarget
DB00788NaproxenBile salt export pumptransporter
DB00788NaproxenMultidrug resistance protein 1transporter
DB11120TurpentineMitogen-activated protein kinase 1target
DrugDrug NamePhaseStatusCount
DB04272Citric Acid1Withdrawn1
DB09154Sodium Citrate1Withdrawn1
DB00443Betamethasone1 / 2Completed1
DB02300Calcipotriol1 / 2Completed1
DB00482Celecoxib1 / 2Not Yet Recruiting1
DB00161L-Valine1 / 2Not Yet Recruiting1
DB00331Metformin1 / 2Not Yet Recruiting1
DB13127Olokizumab1 / 2Completed1
DB00177Valsartan1 / 2Not Yet Recruiting1
DB00083Botulinum toxin type A2Unknown Status1
DB10318Varicella Zoster Vaccine (Live/Attenuated)2Active Not Recruiting2
DB00005Etanercept2 / 3Recruiting1
DB00065Infliximab2 / 3Withdrawn1
DB00945Acetylsalicylic acid4Completed1
DB00051Adalimumab4Unknown Status1
DB00297Bupivacaine4Active Not Recruiting1
DB01234Dexamethasone4Unknown Status1
DB01613Erythrityl tetranitrate4Unknown Status1
DB00005Etanercept4Unknown Status1
DB01628Etoricoxib4Active Not Recruiting1
DB00563Methotrexate4Unknown Status2
DB00302Tranexamic acid4Terminated1
DB09145Water4Unknown Status1
DB00181BaclofenNot AvailableCompleted1
DB00297BupivacaineNot AvailableCompleted1
DB06774CapsaicinNot AvailableCompleted1
DB00924CyclobenzaprineNot AvailableCompleted1
DB00586DiclofenacNot AvailableCompleted1
DB00668EpinephrineNot AvailableCompleted1
DB00712FlurbiprofenNot AvailableCompleted1
DB00996GabapentinNot AvailableCompleted1
DB01221KetamineNot AvailableCompleted1
DB00825LevomentholNot AvailableCompleted1
DB00825LevomentholNot AvailableRecruiting1
DB00281LidocaineNot AvailableCompleted1
DB00281LidocaineNot AvailableRecruiting1
DB00814MeloxicamNot AvailableCompleted1
DB00563MethotrexateNot AvailableCompleted1
DB00688Mycophenolate mofetilNot AvailableCompleted1
DB01024Mycophenolic acidNot AvailableCompleted1
DB00750PrilocaineNot AvailableCompleted1
DB00669SumatriptanNot AvailableCompleted1
DB00697TizanidineNot AvailableCompleted1
DB06273TocilizumabNot AvailableRecruiting1
DB00273TopiramateNot AvailableCompleted1