Sickle Cell Anemia

Also known as: Sickle-Cell Anaemia / Anaemia, Sickle Cell / Sickle Cell Anaemia / Sickle-cell anemia / Anemia, Sickle Cell / Sickle-cell disease without crisis / Sickle cell disease / Sickle-cell anemia, unspecified / Sickle-cell anaemia, unspecified / Sickle-cell disorders / Sickle cell disorders / Anaemia sickle cell / Sickle cell disease NOS / Sickling disorder due to hemoglobin S (disorder) / Sickle cell-hemoglobin SS disease (disorder) / Anemia sickle cell

Drug	Drug Name	Drug Description
DB01005	Hydroxyurea	An antimetabolite used to treat sickle cell anemia crisis, resistant chronic myeloid leukemia, and Locally advanced squamous cell carcinomas of the head and neck (excluding the lip).

Drug	Drug Name	Target	Type
DB01005	Hydroxyurea	Ribonucleoside-diphosphate reductase large subunit	target
DB01005	Hydroxyurea	Solute carrier organic anion transporter family member 1A2	transporter
DB01005	Hydroxyurea	Solute carrier organic anion transporter family member 1B1	transporter
DB01005	Hydroxyurea	Solute carrier organic anion transporter family member 1B3	transporter
DB01005	Hydroxyurea	Urea transporter 2	transporter
DB01005	Hydroxyurea	Urea transporter 1	transporter
DB01005	Hydroxyurea	Solute carrier family 22 member 4	transporter
DB01005	Hydroxyurea	Solute carrier family 22 member 5	transporter
DB01005	Hydroxyurea	Serum albumin	carrier
DB01005	Hydroxyurea	Urease subunit alpha	enzyme

Drug	Drug Name	Phase	Status	Count
DB00121	Biotin	0	Completed	1
DB00331	Metformin	0	Completed	1
DB06403	Ambrisentan	1	Completed	1
DB00098	Antithymocyte immunoglobulin (rabbit)	1	Active Not Recruiting	1
DB00125	Arginine	1	Completed	1
DB16367	Autologous peripheral blood-derived CD34+ cells	1	Terminated	1
DB00531	Cyclophosphamide	1	Active Not Recruiting	1
DB01005	Hydroxyurea	1	Completed	3
DB17860	MP4CO	1	Completed	1
DB00688	Mycophenolate mofetil	1	Active Not Recruiting	1
DB01024	Mycophenolic acid	1	Active Not Recruiting	1
DB00435	Nitric Oxide	1	Completed	1
DB09112	Nitrous acid	1	Completed	2
DB00552	Pentostatin	1	Active Not Recruiting	1
DB03088	Pidolic acid	1	Completed	1
DB08910	Pomalidomide	1	Completed	1
DB06209	Prasugrel	1	Completed	1
DB00203	Sildenafil	1	Completed	1
DB01390	Sodium bicarbonate	1	Terminated	1
DB09153	Sodium chloride	1	Completed	1
DB00864	Tacrolimus	1	Active Not Recruiting	1
DB11815	Tilarginine	1	Completed	1
DB14975	Voxelotor	1	Completed	1
DB06151	Acetylcysteine	1 / 2	Completed	1
DB00087	Alemtuzumab	1 / 2	Active Not Recruiting	1
DB00087	Alemtuzumab	1 / 2	Recruiting	2
DB18136	Briquilimab	1 / 2	Recruiting	1
DB00257	Clotrimazole	1 / 2	Completed	1
DB09110	Coenzyme M	1 / 2	Recruiting	1
DB00531	Cyclophosphamide	1 / 2	Active Not Recruiting	1
DB00531	Cyclophosphamide	1 / 2	Recruiting	1
DB00091	Cyclosporine	1 / 2	Completed	1
DB00016	Erythropoietin	1 / 2	Recruiting	1
DB00099	Filgrastim	1 / 2	Recruiting	1
DB01073	Fludarabine	1 / 2	Completed	2
DB01073	Fludarabine	1 / 2	Recruiting	1
DB00158	Folic acid	1 / 2	Completed	1
DB01005	Hydroxyurea	1 / 2	Completed	1
DB01005	Hydroxyurea	1 / 2	Recruiting	3
DB00688	Mycophenolate mofetil	1 / 2	Completed	1
DB06809	Plerixafor	1 / 2	Recruiting	1
DB01131	Proguanil	1 / 2	Completed	1
DB04974	Rimiducid	1 / 2	Terminated	2
DB00073	Rituximab	1 / 2	Recruiting	2
DB06371	Siplizumab	1 / 2	Recruiting	1
DB00877	Sirolimus	1 / 2	Active Not Recruiting	1
DB00877	Sirolimus	1 / 2	Recruiting	2
DB04572	Thiotepa	1 / 2	Recruiting	1
DB17706	2,2-Dimethylbutyrate	2	Completed	1
DB17706	2,2-Dimethylbutyrate	2	Terminated	1
DB08842	Acetylcarnitine	2	Completed	1
DB03128	Acetylcholine	2	Completed	1
DB00087	Alemtuzumab	2	Completed	1
DB00087	Alemtuzumab	2	Terminated	2
DB00630	Alendronic acid	2	Not Yet Recruiting	1
DB00125	Arginine	2	Completed	3
DB01008	Busulfan	2	Completed	1
DB01008	Busulfan	2	Terminated	2
DB06168	Canakinumab	2	Completed	1
DB00169	Cholecalciferol	2	Active Not Recruiting	1
DB00531	Cyclophosphamide	2	Completed	1
DB00531	Cyclophosphamide	2	Terminated	1
DB00091	Cyclosporine	2	Completed	1
DB01609	Deferasirox	2	Completed	1
DB00746	Deferoxamine	2	Completed	1
DB00975	Dipyridamole	2	Withdrawn	1
DB00813	Fentanyl	2	Completed	1
DB00099	Filgrastim	2	Terminated	1
DB01073	Fludarabine	2	Terminated	2
DB01005	Hydroxyurea	2	Active Not Recruiting	1
DB01005	Hydroxyurea	2	Completed	4
DB01005	Hydroxyurea	2	Unknown Status	1
DB01005	Hydroxyurea	2	Withdrawn	1
DB00130	L-Glutamine	2	Completed	1
DB00130	L-Glutamine	2	Terminated	2
DB00166	Lipoic acid	2	Completed	1
DB00678	Losartan	2	Completed	1
DB00678	Losartan	2	Terminated	1
DB17860	MP4CO	2	Withdrawn	1
DB12583	Maltodextrin	2	Completed	1
DB00688	Mycophenolate mofetil	2	Completed	1
DB00435	Nitric Oxide	2	Completed	2
DB00727	Nitroglycerin	2	Completed	1
DB17720	Pegylated carboxyhemoglobin (bovine)	2	Completed	2
DB00252	Phenytoin	2	Terminated	1
DB06209	Prasugrel	2	Completed	1
DB00635	Prednisone	2	Terminated	1
DB06213	Regadenoson	2	Completed	1
DB06228	Rivaroxaban	2	Completed	1
DB06280	Senicapoc	2	Completed	1
DB09153	Sodium chloride	2	Withdrawn	1
DB14504	Sodium phosphate, dibasic, unspecified form	2	Completed	1
DB14503	Sodium phosphate, monobasic, unspecified form	2	Completed	1
DB00864	Tacrolimus	2	Terminated	2
DB00820	Tadalafil	2	Withdrawn	1
DB11815	Tilarginine	2	Completed	1
DB02546	Vorinostat	2	Terminated	1
DB00471	Montelukast	2 / 3	Recruiting	1
DB01053	Benzylpenicillin	3	Completed	1
DB00559	Bosentan	3	Terminated	1
DB01609	Deferasirox	3	Terminated	1
DB01234	Dexamethasone	3	Terminated	1
DB15572	Exagamglogene autotemcel	3	Enrolling by Invitation	1
DB15572	Exagamglogene autotemcel	3	Recruiting	1
DB01005	Hydroxyurea	3	Completed	5
DB01005	Hydroxyurea	3	Recruiting	1
DB01005	Hydroxyurea	3	Terminated	3
DB00130	L-Glutamine	3	Completed	1
DB00653	Magnesium sulfate	3	Completed	1
DB12583	Maltodextrin	3	Completed	1
DB11333	Poloxamer 188	3	Completed	1
DB00205	Pyrimethamine	3	Completed	1
DB12544	Rivipansel	3	Completed	1
DB12778	Rivipansel	3	Completed	1
DB12544	Rivipansel	3	Terminated	1
DB12778	Rivipansel	3	Terminated	1
DB06280	Senicapoc	3	Terminated	1
DB01299	Sulfadoxine	3	Completed	1
DB00035	Desmopressin	4	Terminated	1
DB00813	Fentanyl	4	Completed	1
DB01005	Hydroxyurea	4	Completed	1
DB01005	Hydroxyurea	4	Unknown Status	1
DB01050	Ibuprofen	4	Terminated	1
DB00465	Ketorolac	4	Terminated	1
DB00203	Sildenafil	4	Withdrawn	1
DB14975	Voxelotor	4	Completed	2
DB00188	Bortezomib	Not Available	Terminated	1
DB16741	Bortezomib D-mannitol	Not Available	Terminated	1
DB01008	Busulfan	Not Available	Completed	1
DB09157	Carbon dioxide	Not Available	Recruiting	1
DB00257	Clotrimazole	Not Available	Completed	1
DB00531	Cyclophosphamide	Not Available	Completed	1
DB00531	Cyclophosphamide	Not Available	Terminated	1
DB00987	Cytarabine	Not Available	Terminated	1
DB00035	Desmopressin	Not Available	Terminated	1
DB01073	Fludarabine	Not Available	Terminated	1
DB04173	Fructose	Not Available	Completed	1
DB01005	Hydroxyurea	Not Available	Active Not Recruiting	2
DB01005	Hydroxyurea	Not Available	Completed	6
DB01005	Hydroxyurea	Not Available	Recruiting	1
DB01270	Ranibizumab	Not Available	Withdrawn	1
DB06213	Regadenoson	Not Available	Unknown Status	1
DB00073	Rituximab	Not Available	Terminated	1