Pulmonary Hypertension (PH)

Also known as: Hypertension, Pulmonary / Pulmonary; Hypertension / Pulmonary hypertension / Hypertension Pulmonary / Pulmonary hypertensions / Pulmonary hypertension NOS

DrugDrug NameDrug Description
DB01115NifedipineNifedipine has been formulated as both a long- and short-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nifedipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drug’s vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Nifedipine is used to treat hypertension and chronic stable angina.
DB00435Nitric OxideNitric oxide or Nitrogen monoxide is a chemical compound with chemical formula NO. This gas is an important signaling molecule in the body of mammals including humans and is an extremely important intermediate in the chemical industry. It is also a toxic air pollutant produced by automobile engines and power plants. Nitric oxide (NO) should not be confused with nitrous oxide (N2O), a general anaesthetic, or with nitrogen dioxide (NO2) which is another poisonous air pollutant. The nitric oxide molecule is a free radical, which is relevant to understanding its high reactivity. It reacts with the ozone in air to form nitrogen dioxide, signalled by the appearance of the reddish-brown color.
DrugDrug NameTargetType
DB01115NifedipineVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB01115NifedipineCytochrome P450 3A4enzyme
DB01115NifedipineCytochrome P450 2E1enzyme
DB01115NifedipineCytochrome P450 2D6enzyme
DB01115NifedipineCalmodulintarget
DB01115NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB01115NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB01115NifedipineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB01115NifedipineVoltage-dependent L-type calcium channel subunit beta-2target
DB01115NifedipinePotassium voltage-gated channel subfamily A member 1target
DB01115NifedipineVoltage-dependent T-type calcium channel subunit alpha-1Htarget
DB01115NifedipineCytochrome P450 1A2enzyme
DB01115NifedipineCytochrome P450 2A6enzyme
DB01115NifedipineCytochrome P450 2C8enzyme
DB01115NifedipineCytochrome P450 3A5enzyme
DB01115NifedipineCytochrome P450 3A7enzyme
DB01115NifedipineCanalicular multispecific organic anion transporter 2transporter
DB01115NifedipineMultidrug resistance protein 1transporter
DB01115NifedipineCanalicular multispecific organic anion transporter 1transporter
DB01115NifedipineCytochrome P450 1A1enzyme
DB01115NifedipineCytochrome P450 2B6enzyme
DB01115NifedipineCytochrome P450 2C9enzyme
DB01115NifedipineNuclear receptor subfamily 1 group I member 2target
DB00435Nitric OxideGuanylate cyclase soluble subunit alpha-2target
DB00435Nitric OxideAldehyde dehydrogenase, mitochondrialenzyme
DB00435Nitric OxideCytochrome P450 1A2enzyme
DB00435Nitric OxideCytochrome P450 2B6enzyme
DB00435Nitric OxideCytochrome P450 3A4enzyme
DB00435Nitric OxideMetallothionein-1Atarget
DB00435Nitric OxideIndoleamine 2,3-dioxygenase 1target
DrugDrug NamePhaseStatusCount
DB01005Hydroxyurea0Withdrawn1
DB04335Inosine0Terminated1
DB00556Perflutren0Not Yet Recruiting1
DB11104Sulfur hexafluoride0Not Yet Recruiting1
DB00559Bosentan1Completed1
DB01136Carvedilol1Withdrawn1
DB08908Dimethyl fumarate1Recruiting1
DB00016Erythropoietin1Completed1
DB00736Esomeprazole1Completed1
DB01005Hydroxyurea1Completed1
DB01088Iloprost1Completed1
DB00619Imatinib1Withdrawn1
DB04335Inosine1Active Not Recruiting1
DB08932Macitentan1Recruiting1
DB00435Nitric Oxide1Completed2
DB08931Riociguat1Completed2
DB00203Sildenafil1Completed1
DB00641Simvastatin1Unknown Status1
DB09112Sodium Nitrite1Completed1
DB00374Treprostinil1Completed3
DB09315Xenon-1331Recruiting1
DB00026Anakinra1 / 2Terminated1
DB11588Carbon monoxide1 / 2Withdrawn1
DB09150Fludeoxyglucose F-181 / 2Not Yet Recruiting1
DB01005Hydroxyurea1 / 2Terminated1
DB01088Iloprost1 / 2Withdrawn1
DB00235Milrinone1 / 2Completed1
DB00203Sildenafil1 / 2Completed1
DB00641Simvastatin1 / 2Completed1
DB00819Acetazolamide2Completed1
DB00945Acetylsalicylic acid2Completed1
DB00945Acetylsalicylic acid2Terminated1
DB00770Alprostadil2Withdrawn1
DB06403Ambrisentan2Completed4
DB06403Ambrisentan2Recruiting1
DB06403Ambrisentan2Suspended1
DB06403Ambrisentan2Unknown Status1
DB01076Atorvastatin2Completed1
DB12054BQ-1232Unknown Status1
DB00559Bosentan2Terminated2
DB06774Capsaicin2Completed2
DB01136Carvedilol2Completed1
DB00758Clopidogrel2Completed1
DB01240Epoprostenol2Terminated1
DB09150Fludeoxyglucose F-182Active Not Recruiting1
DB01088Iloprost2Completed4
DB01088Iloprost2Terminated2
DB00619Imatinib2Terminated1
DB04335Inosine2Not Yet Recruiting1
DB09146Iron saccharate2Suspended1
DB00130L-Glutamine2Completed1
DB08932Macitentan2Completed1
DB08932Macitentan2Recruiting1
DB00235Milrinone2Completed2
DB08893Mirabegron2Not Yet Recruiting1
DB00435Nitric Oxide2Completed1
DB00435Nitric Oxide2Recruiting1
DB00435Nitric Oxide2Terminated1
DB00435Nitric Oxide2Withdrawn1
DB12529Nitrite2Completed1
DB11736PF-004897912Terminated1
DB01708Prasterone2Unknown Status1
DB08931Riociguat2Active Not Recruiting2
DB08931Riociguat2Completed2
DB08931Riociguat2Recruiting1
DB08931Riociguat2Terminated2
DB00203Sildenafil2Completed5
DB00203Sildenafil2Terminated3
DB00641Simvastatin2Terminated1
DB09112Sodium Nitrite2Recruiting1
DB11104Sulfur hexafluoride2Completed1
DB00820Tadalafil2Completed1
DB00820Tadalafil2Withdrawn1
DB12204Terbogrel2Completed1
DB12204Terbogrel2Terminated1
DB00374Treprostinil2Not Yet Recruiting1
DB00374Treprostinil2Terminated1
DB00374Treprostinil2Withdrawn1
DB00067Vasopressin2Terminated1
DB00682Warfarin2Terminated1
DB00819Acetazolamide2 / 3Recruiting2
DB06403Ambrisentan2 / 3Completed1
DB06403Ambrisentan2 / 3Unknown Status1
DB00559Bosentan2 / 3Completed1
DB00633Dexmedetomidine2 / 3Completed1
DB00203Sildenafil2 / 3Active Not Recruiting1
DB00203Sildenafil2 / 3Completed2
DB00203Sildenafil2 / 3Unknown Status1
DB06268Sitaxentan2 / 3Unknown Status1
DB00820Tadalafil2 / 3Completed1
DB00374Treprostinil2 / 3Enrolling by Invitation1
DB00374Treprostinil2 / 3Recruiting1
DB06403Ambrisentan3Active Not Recruiting1
DB06403Ambrisentan3Completed4
DB06403Ambrisentan3Terminated1
DB00559Bosentan3Completed5
DB00559Bosentan3Terminated4
DB00559Bosentan3Unknown Status1
DB01175Escitalopram3Completed1
DB01088Iloprost3Completed4
DB01088Iloprost3Terminated1
DB00155L-Citrulline3Completed1
DB00678Losartan3Completed1
DB00235Milrinone3Completed1
DB01115Nifedipine3Completed1
DB09140Oxygen3Terminated1
DB01708Prasterone3Unknown Status1
DB08931Riociguat3Active Not Recruiting2
DB08931Riociguat3Completed3
DB08931Riociguat3Recruiting1
DB00203Sildenafil3Completed6
DB00203Sildenafil3Recruiting3
DB00203Sildenafil3Terminated3
DB00203Sildenafil3Unknown Status1
DB00203Sildenafil3Withdrawn1
DB06268Sitaxentan3Completed1
DB06268Sitaxentan3Terminated5
DB00820Tadalafil3Completed3
DB00820Tadalafil3Recruiting1
DB00820Tadalafil3Terminated1
DB00820Tadalafil3Withdrawn1
DB00374Treprostinil3Completed2
DB00374Treprostinil3Not Yet Recruiting1
DB00374Treprostinil3Recruiting1
DB06267Udenafil3Completed1
DB00862Vardenafil3Completed1
DB00819Acetazolamide4Completed1
DB06403Ambrisentan4Not Yet Recruiting1
DB06403Ambrisentan4Terminated1
DB06403Ambrisentan4Unknown Status2
DB00559Bosentan4Completed2
DB00559Bosentan4Terminated2
DB00559Bosentan4Unknown Status1
DB04920Clevidipine4Completed1
DB01240Epoprostenol4Completed3
DB01240Epoprostenol4Terminated1
DB09341Glucose4Completed1
DB00062Human Serum Albumin4Completed1
DB00096Human Serum Albumin4Completed1
DB01088Iloprost4Not Yet Recruiting1
DB01088Iloprost4Terminated2
DB00753Isoflurane4Completed1
DB00125L-Arginine4Completed1
DB00703Methazolamide4Completed1
DB04861Nebivolol4Recruiting1
DB04899Nesiritide4Completed1
DB04899Nesiritide4Terminated1
DB00435Nitric Oxide4Not Yet Recruiting1
DB01132Pioglitazone4Terminated1
DB00818Propofol4Completed1
DB00243Ranolazine4Completed1
DB08931Riociguat4Completed2
DB08931Riociguat4Recruiting1
DB00203Sildenafil4Completed3
DB00203Sildenafil4Recruiting1
DB00203Sildenafil4Terminated1
DB00203Sildenafil4Unknown Status1
DB00203Sildenafil4Withdrawn1
DB00421Spironolactone4Recruiting1
DB00820Tadalafil4Not Yet Recruiting1
DB00820Tadalafil4Unknown Status2
DB00374Treprostinil4Completed2
DB00374Treprostinil4Terminated2
DB00374Treprostinil4Unknown Status1
DB00770AlprostadilNot AvailableCompleted1
DB06403AmbrisentanNot AvailableActive Not Recruiting1
DB06403AmbrisentanNot AvailableCompleted1
DB06403AmbrisentanNot AvailableUnknown Status1
DB00559BosentanNot AvailableCompleted1
DB00559BosentanNot AvailableUnknown Status1
DB01136CarvedilolNot AvailableCompleted1
DB00872ConivaptanNot AvailableWithdrawn1
DB01262DecitabineNot AvailableCompleted1
DB08826DeferiproneNot AvailableCompleted1
DB00746DeferoxamineNot AvailableCompleted1
DB00390DigoxinNot AvailableRecruiting1
DB01240EpoprostenolNot AvailableCompleted1
DB01088IloprostNot AvailableActive Not Recruiting2
DB01088IloprostNot AvailableCompleted5
DB01088IloprostNot AvailableNot Yet Recruiting1
DB01088IloprostNot AvailableRecruiting1
DB04335InosineNot AvailableCompleted1
DB09146Iron saccharateNot AvailableCompleted1
DB00125L-ArginineNot AvailableCompleted1
DB00243RanolazineNot AvailableActive Not Recruiting1
DB00243RanolazineNot AvailableRecruiting1
DB06213RegadenosonNot AvailableTerminated1
DB08931RiociguatNot AvailableActive Not Recruiting1
DB08931RiociguatNot AvailableCompleted1
DB08931RiociguatNot AvailableNo Longer Available1
DB08931RiociguatNot AvailableRecruiting2
DB00203SildenafilNot AvailableCompleted5
DB00203SildenafilNot AvailableRecruiting1
DB06268SitaxentanNot AvailableUnknown Status1
DB00421SpironolactoneNot AvailableWithdrawn1
DB00820TadalafilNot AvailableRecruiting1
DB00374TreprostinilNot AvailableCompleted1