Hodgkins Disease (HD)
Also known as: Hodgkins Disease / Disease, Hodgkin / Hodgkin's Disease / Hodgkin Disease / Hodgkin's disease NEC / Disease, Hodgkins / Hodgkin's disease NOS / Hodgkin's granuloma / Hodgkin's paragranuloma / Hodgkin's sarcoma / Hodgkin's disease, unspecified type / Hodgins / Hodgkin lymphoma / Lymphomas Hodgkin's disease / Hodgkin's lymphoma / Lymphogranulomatosis
| Drug | Drug Name | Drug Description |
|---|---|---|
| DB00291 | Chlorambucil | A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed) |
| DB00888 | Mechlorethamine | A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. [PubChem] The FDA granted marketing approval for the orphan drug Valchlor (mechlorethamine) gel on August 23, 2013 for the topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma (CTCL) in patients who have received prior skin-directed therapy. Each tube of Valchlor contains 0.016% of mechlorethamine which is equivalent to 0.02% mechlorethamine HCL. |
| Drug | Drug Name | Target | Type |
|---|---|---|---|
| DB00291 | Chlorambucil | DNA | target |
| DB00291 | Chlorambucil | Glutathione S-transferase P | enzyme |
| DB00291 | Chlorambucil | Solute carrier organic anion transporter family member 1A2 | transporter |
| DB00888 | Mechlorethamine | DNA | target |
| DB00888 | Mechlorethamine | Cholinesterase | enzyme |