Solute carrier organic anion transporter family member 1B3

Details

Name
Solute carrier organic anion transporter family member 1B3
Synonyms
  • Liver-specific organic anion transporter 2
  • LST-2
  • LST2
  • OATP-8
  • OATP1B3
  • OATP8
  • Organic anion transporter 8
  • Organic anion-transporting polypeptide 8
  • SLC21A8
  • Solute carrier family 21 member 8
Gene Name
SLCO1B3
Organism
Humans
Amino acid sequence
>lcl|BSEQ0007032|Solute carrier organic anion transporter family member 1B3
MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKISITQIERRFD
ISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCLLMGTGSILTSLPHFFMGY
YRYSKETHINPSENSTSSLSTCLINQTLSFNGTSPEIVEKDCVKESGSHMWIYVFMGNML
RGIGETPIVPLGISYIDDFAKEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIGYV
DLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPFFFLPKNPNKPQKERKISLSLHVLK
TNDDRNQTANLTNQGKNVTKNVTGFFQSLKSILTNPLYVIFLLLTLLQVSSFIGSFTYVF
KYMEQQYGQSASHANFLLGIITIPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISFL
FQLLYFPLICESKSVAGLTLTYDGNNSVASHVDVPLSYCNSECNCDESQWEPVCGNNGIT
YLSPCLAGCKSSSGIKKHTVFYNCSCVEVTGLQNRNYSAHLGECPRDNTCTRKFFIYVAI
QVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAPIYFGALIDKTCM
KWSTNSCGAQGACRIYNSVFFGRVYLGLSIALRFPALVLYIVFIFAMKKKFQGKDTKASD
NERKVMDEANLEFLNNGEHFVPSAGTDSKTCNLDMQDNAAAN
Number of residues
702
Molecular Weight
77402.175
Theoretical pI
8.95
GO Classification
Functions
bile acid transmembrane transporter activity / organic anion transmembrane transporter activity / sodium-independent organic anion transmembrane transporter activity
Processes
anion transmembrane transport / bile acid and bile salt transport / bile acid metabolic process / organic anion transport / small molecule metabolic process / sodium-independent organic anion transport / transmembrane transport
Components
basolateral plasma membrane / integral component of plasma membrane / plasma membrane
General Function
Sodium-independent organic anion transmembrane transporter activity
Specific Function
Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.
Pfam Domain Function
Transmembrane Regions
29-48 68-88 95-119 169-197 217-237 256-280 332-353 374-397 402-425 538-560 570-595 630-647
Cellular Location
Basolateral cell membrane
Gene sequence
>lcl|BSEQ0012544|Solute carrier organic anion transporter family member 1B3 (SLCO1B3)
ATGGACCAACATCAACATTTGAATAAAACAGCAGAGTCAGCATCTTCAGAGAAAAAGAAA
ACAAGACGCTGCAATGGATTCAAGATGTTCTTGGCAGCCCTGTCATTCAGCTATATTGCT
AAAGCACTAGGTGGAATCATTATGAAAATTTCCATCACTCAAATAGAAAGGAGATTTGAC
ATATCCTCTTCTCTTGCTGGTTTAATTGATGGAAGCTTTGAAATTGGAAATTTGCTTGTG
ATTGTATTTGTAAGTTACTTTGGATCTAAACTACACAGACCGAAGTTAATTGGAATTGGT
TGTCTCCTTATGGGAACTGGAAGTATTTTGACATCTTTACCACATTTCTTCATGGGATAT
TATAGGTATTCTAAAGAAACCCATATTAATCCATCAGAAAATTCAACATCAAGTTTATCA
ACCTGTTTAATTAATCAAACCTTATCATTCAATGGAACATCACCTGAGATAGTAGAAAAA
GATTGTGTAAAGGAATCTGGGTCACACATGTGGATCTATGTCTTCATGGGGAATATGCTT
CGTGGCATAGGGGAAACCCCCATAGTACCATTGGGGATTTCATACATTGATGATTTTGCA
AAAGAAGGACATTCTTCCTTGTATTTAGGTAGTTTGAATGCAATAGGAATGATTGGTCCA
GTCATTGGCTTTGCACTGGGATCTCTGTTTGCTAAAATGTACGTGGATATTGGATATGTA
GATCTGAGCACTATCAGAATAACTCCTAAGGACTCTCGTTGGGTTGGAGCTTGGTGGCTT
GGTTTCCTTGTGTCTGGACTATTTTCCATTATTTCTTCCATACCATTTTTTTTCTTGCCG
AAAAATCCAAATAAACCACAAAAAGAAAGAAAAATTTCACTATCATTGCATGTGCTGAAA
ACAAATGATGATAGAAATCAAACAGCTAATTTGACCAACCAAGGAAAAAATGTTACCAAA
AATGTGACTGGTTTTTTCCAGTCTTTGAAAAGCATCCTTACCAATCCCCTGTATGTTATA
TTTCTGCTTTTGACATTGTTACAAGTAAGCAGCTTTATTGGTTCTTTTACTTACGTCTTT
AAATATATGGAGCAACAGTACGGTCAGTCTGCATCTCATGCTAACTTTTTGTTGGGAATC
ATAACCATTCCTACGGTTGCAACTGGAATGTTTTTAGGAGGATTTATCATTAAAAAATTC
AAATTGTCTTTAGTTGGAATTGCCAAATTTTCATTTCTTACTTCGATGATATCCTTCTTG
TTTCAACTTCTATATTTCCCTCTAATCTGCGAAAGCAAATCAGTTGCCGGCCTAACCTTG
ACCTATGATGGAAATAATTCAGTGGCATCTCATGTAGATGTACCACTTTCTTATTGCAAC
TCAGAGTGCAATTGTGATGAAAGTCAGTGGGAACCAGTCTGTGGGAACAATGGAATAACT
TACCTGTCACCTTGTCTAGCAGGATGCAAATCCTCAAGTGGTATTAAAAAGCATACAGTG
TTTTATAACTGTAGTTGTGTGGAAGTAACTGGTCTCCAGAACAGAAATTACTCAGCACAC
TTGGGTGAATGCCCAAGAGATAATACTTGTACAAGGAAATTTTTCATCTATGTTGCAATT
CAAGTCATAAACTCTTTGTTCTCTGCAACAGGAGGTACCACATTTATCTTGTTGACTGTG
AAGATTGTTCAACCTGAATTGAAAGCACTTGCAATGGGTTTCCAGTCAATGGTTATAAGA
ACACTAGGAGGAATTCTAGCTCCAATATATTTTGGGGCTCTGATTGATAAAACATGTATG
AAGTGGTCCACCAACAGCTGTGGAGCACAAGGAGCTTGTAGGATATATAATTCCGTATTT
TTTGGAAGGGTCTACTTGGGCTTATCTATAGCTTTAAGATTCCCAGCACTTGTTTTATAT
ATTGTTTTCATTTTTGCTATGAAGAAAAAATTTCAAGGAAAAGATACCAAGGCATCGGAC
AATGAAAGAAAAGTAATGGATGAAGCAAACTTAGAATTCTTAAATAATGGTGAACATTTT
GTACCTTCTGCTGGAACAGATAGTAAAACATGTAATTTGGACATGCAAGACAATGCTGCT
GCCAACTAA
Chromosome Location
12
Locus
12p12
External Identifiers
ResourceLink
UniProtKB IDQ9NPD5
UniProtKB Entry NameSO1B3_HUMAN
GenBank Protein ID9187497
GenBank Gene IDAJ251506
HGNC IDHGNC:10961
General References
  1. Konig J, Cui Y, Nies AT, Keppler D: Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. J Biol Chem. 2000 Jul 28;275(30):23161-8. [PubMed:10779507]
  2. Abe T, Unno M, Onogawa T, Tokui T, Kondo TN, Nakagomi R, Adachi H, Fujiwara K, Okabe M, Suzuki T, Nunoki K, Sato E, Kakyo M, Nishio T, Sugita J, Asano N, Tanemoto M, Seki M, Date F, Ono K, Kondo Y, Shiiba K, Suzuki M, Ohtani H, Shimosegawa T, Iinuma K, Nagura H, Ito S, Matsuno S: LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology. 2001 Jun;120(7):1689-99. [PubMed:11375950]
  3. Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G, Gibbs RA: The finished DNA sequence of human chromosome 12. Nature. 2006 Mar 16;440(7082):346-51. [PubMed:16541075]
  4. van de Steeg E, Stranecky V, Hartmannova H, Noskova L, Hrebicek M, Wagenaar E, van Esch A, de Waart DR, Oude Elferink RP, Kenworthy KE, Sticova E, al-Edreesi M, Knisely AS, Kmoch S, Jirsa M, Schinkel AH: Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. J Clin Invest. 2012 Feb;122(2):519-28. doi: 10.1172/JCI59526. Epub 2012 Jan 9. [PubMed:22232210]
  5. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [PubMed:24275569]
  6. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [PubMed:16959974]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01045RifampicinapprovedunknownsubstrateinhibitorDetails
DB01132Pioglitazoneapproved, investigationalunknowninhibitorDetails
DB04348Taurocholic acidapproved, experimentalunknownsubstrateDetails
DB00286Conjugated estrogensapprovedunknownsubstrateDetails
DB02659Cholic AcidapprovedunknownsubstrateDetails
DB00279Liothyronineapproved, vet_approvedunknownsubstrateDetails
DB01092OuabainapprovedunknownsubstrateDetails
DB00563MethotrexateapprovedunknownsubstrateDetails
DB00520CaspofunginapprovedunknownsubstrateDetails
DB00275Olmesartanapproved, investigationalunknownsubstrateDetails
DB00177Valsartanapproved, investigationalunknownsubstrateDetails
DB01583LiotrixapprovedunknownsubstrateDetails
DB06176Romidepsinapproved, investigationalunknownsubstrateDetails
DB08855Leukotriene C4experimental, investigationalunknownDetails
DB00783Estradiolapproved, investigational, vet_approvedunknownDetails
DB02691Glycocholic acidexperimental, investigationalunknownDetails
DB05804Prasterone sulfateinvestigationalunknownDetails
DB00451LevothyroxineapprovedunknowninhibitorDetails
DB08861DPDPEexperimentalunknownDetails
DB08862Cholecystokininapproved, investigationalunknownsubstrateDetails
DB00950Fexofenadineapproved, investigationalunknownDetails
DB01095FluvastatinapprovedunknownsubstrateDetails
DB08860PitavastatinapprovedunknownsubstrateDetails
DB01098RosuvastatinapprovedunknownDetails
DB06772CabazitaxelapprovedunknowninhibitorDetails
DB08864RilpivirineapprovedunknowninhibitorDetails
DB08884Gadoxetic acidapprovedunknownsubstrateDetails
DB08912Dabrafenibapproved, investigationalunknowninhibitorDetails
DB01076AtorvastatinapprovednosubstrateDetails
DB00688Mycophenolate mofetilapproved, investigationalunknownsubstrateDetails
DB00175PravastatinapprovednosubstrateDetails
DB01229Paclitaxelapproved, vet_approvedunknownsubstrateDetails
DB01248Docetaxelapproved, investigationalunknownsubstrateDetails
DB01211ClarithromycinapprovedunknownDetails
DB09054IdelalisibapprovednoinhibitorDetails
DB09292SacubitrilapprovedunknowninhibitorDetails
DB09102Daclatasvirapproved, investigationalunknowninhibitorDetails
DB05239Cobimetinibapproved, investigationalunknownsubstrateinhibitorDetails
DB11362SelexipagapprovednosubstrateDetails
DB06403Ambrisentanapproved, investigationalunknownsubstrateDetails
DB11575GrazoprevirapprovednosubstrateDetails
DB09137Technetium Tc-99m mebrofeninapprovedyessubstrateDetails
DB13154ParachlorophenolapprovedunknownsubstrateDetails
DB13139Levosalbutamolapproved, investigationalyessubstrateDetails
DB13153Levomenolapproved, experimentalunknownsubstrateDetails
DB11613Velpatasvirapproved, investigationalnoinhibitortransporterDetails
DB06290SimeprevirapprovedunknownsubstrateinhibitorDetails
DB06749Ginsenoside Rb1nutraceuticalunknowninhibitorDetails
DB06750Ginsenoside Rg1nutraceuticalunknownDetails
DB05016Atalurenapproved, investigationalnoinhibitorDetails
DB12026Voxilaprevirapproved, investigationalnosubstrateinhibitorDetails
DB13874Enasidenibapproved, investigationalunknowninhibitorDetails
DB13878Pibrentasvirapproved, investigationalunknowninhibitorDetails
DB13879Glecaprevirapproved, investigationalunknownsubstrateinhibitorDetails
DB12070Letermovirapproved, investigationalnosubstrateDetails
DB12332Rucaparibapproved, investigationalunknowninhibitorDetails
DB11817Baricitinibapproved, investigationalunknowninhibitorDetails
DB13952Estradiol acetateapproved, investigational, vet_approvedunknownDetails
DB13953Estradiol benzoateapproved, investigational, vet_approvedunknownDetails
DB13954Estradiol cypionateapproved, investigational, vet_approvedunknownDetails
DB13955Estradiol dienanthateapproved, investigational, vet_approvedunknownDetails
DB13956Estradiol valerateapproved, investigational, vet_approvedunknownDetails
DB09297Paritaprevirapproved, investigationalunknownsubstrateinhibitorDetails
DB00975DipyridamoleapprovedunknowninhibitorDetails
DB01072Atazanavirapproved, investigationalunknowninhibitorDetails
DB00541Vincristineapproved, investigationalunknowninhibitorDetails
DB09142SincalideapprovedunknownsubstrateDetails
DB00602Ivermectinapproved, investigational, vet_approvedunknowninhibitorDetails
DB01149Nefazodoneapproved, withdrawnunknowninhibitorDetails
DB00220NelfinavirapprovedunknowninhibitorDetails
DB01051Novobiocinapproved, investigational, vet_approvedunknowninhibitorDetails
DB00646Nystatinapproved, vet_approvedunknowninhibitorDetails
DB11869ValspodarinvestigationalunknowninhibitorDetails
DB09298Silibininexperimental, investigationalunknowninhibitorDetails
DB00795SulfasalazineapprovedunknowninhibitorDetails
DB00932Tipranavirapproved, investigationalunknowninhibitorDetails
DB09065CobicistatapprovedunknowninhibitorDetails
DB00199Erythromycinapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB01601LopinavirapprovedunknowninhibitorDetails
DB00976TelithromycinapprovedunknowninhibitorDetails
DB01590EverolimusapprovedunknowninhibitorDetails
DB11586Asunaprevirapproved, investigational, withdrawnunknowninhibitorDetails
DB05928DovitinibinvestigationalunknowninhibitorDetails
DB11753Rifamycinapproved, investigationalnoinhibitorDetails
DB11855Revefenacinapproved, investigationalnosubstrateDetails
DB00091Cyclosporineapproved, investigational, vet_approvednoinhibitorDetails
DB00834Mifepristoneapproved, investigationalnoinhibitorDetails
DB00257Clotrimazoleapproved, vet_approvedunknowninducerDetails
DB00396Progesteroneapproved, vet_approvedunknowninducerDetails
DB13946Testosterone undecanoateapproved, investigationalunknownDetails
DB09299Tenofovir alafenamideapprovednosubstrateDetails
DB00481Raloxifeneapproved, investigationalunknownsubstrateDetails
DB11942Selinexorapproved, investigationalunknowninhibitorDetails
DB00394Beclomethasone dipropionateapproved, investigationalunknowninhibitorDetails
DB00641SimvastatinapprovedunknownDetails
DB00227Lovastatinapproved, investigationalunknownDetails
DB12978Pexidartinibapproved, investigationalunknowninhibitorDetails
DB12500Fedratinibapproved, investigationalunknowninhibitorDetails
DB11757Istradefyllineapproved, investigationalunknowninhibitorDetails
DB01241GemfibrozilapprovedunknowninhibitorDetails
DB04855DronedaroneapprovednoinhibitorDetails
DB00624Testosteroneapproved, investigationalunknownsubstrateDetails
DB15444Elexacaftorapproved, investigationalunknowninhibitorDetails