Chronic Myelomonocytic Leukemia

Also known as: Chronic myelomonocytic leukaemia / Chronic myelomonocytic leukemia with failed remission / Leukemia, Myelomonocytic, Chronic

DrugDrug NameDrug Description
DB00928AzacitidineA pyrimidine nucleoside analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent. [PubChem]
DB01262DecitabineDecitabine is indicated for treatment of patients with myelodysplastic syndrome (MDS). It is a chemical analogue of cytidine, a nucleoside present in DNA and RNA. Cells in the presence of Decitabine incorporate it into DNA during replication and RNA during transcription. The incorporation of Decitabine into DNA or RNA inhibits methyltransferase thereby causing demethylation in that sequence. This adversely affects the way that cell regulatory proteins are able to bind to the DNA/RNA substrate.
DrugDrug NamePhaseStatusCount
DB00928Azacitidine1Active Not Recruiting3
DB00928Azacitidine1Completed1
DB00928Azacitidine1Recruiting1
DB00928Azacitidine1Terminated1
DB05015Belinostat1Completed1
DB11752Bryostatin 11Completed1
DB00958Carboplatin1Active Not Recruiting1
DB11059Carboxymethylcellulose1Completed1
DB01413Cefepime1Completed1
DB00493Cefotaxime1Active Not Recruiting1
DB00631Clofarabine1Completed1
DB00631Clofarabine1Terminated1
DB06189Clofarabine1Terminated1
DB00631Clofarabine1Unknown Status1
DB00531Cyclophosphamide1Active Not Recruiting1
DB00531Cyclophosphamide1Unknown Status1
DB00091Cyclosporine1Active Not Recruiting2
DB00091Cyclosporine1Completed1
DB00987Cytarabine1Completed2
DB01262Decitabine1Active Not Recruiting1
DB01262Decitabine1Completed2
DB01262Decitabine1Not Yet Recruiting1
DB11841Entinostat1Active Not Recruiting1
DB00773Etoposide1Completed1
DB01073Fludarabine1Active Not Recruiting3
DB01073Fludarabine1Completed1
DB09053Ibrutinib1Recruiting1
DB00619Imatinib1Completed1
DB06186Ipilimumab1Active Not Recruiting1
DB00480Lenalidomide1Completed1
DB00688Mycophenolate mofetil1Active Not Recruiting3
DB00688Mycophenolate mofetil1Completed1
DB11697Pacritinib1Not Yet Recruiting1
DB06603Panobinostat1Active Not Recruiting1
DB00020Sargramostim1Completed1
DB09143Sonidegib1Active Not Recruiting1
DB01268Sunitinib1Completed1
DB00864Tacrolimus1Active Not Recruiting1
DB06398Tanespimycin1Completed1
DB00853Temozolomide1Active Not Recruiting1
DB04960Tipifarnib1Completed1
DB01030Topotecan1Active Not Recruiting1
DB07232Veliparib1Active Not Recruiting2
DB02546Vorinostat1Completed2
DB11684APR-2461 / 2Not Yet Recruiting1
DB00041Aldesleukin1 / 2Completed1
DB11595Atezolizumab1 / 2Recruiting1
DB00928Azacitidine1 / 2Active Not Recruiting1
DB00928Azacitidine1 / 2Not Yet Recruiting1
DB00928Azacitidine1 / 2Recruiting1
DB00631Clofarabine1 / 2Completed1
DB00091Cyclosporine1 / 2Active Not Recruiting3
DB00091Cyclosporine1 / 2Recruiting1
DB00987Cytarabine1 / 2Completed1
DB00694Daunorubicin1 / 2Completed1
DB01262Decitabine1 / 2Completed1
DB01073Fludarabine1 / 2Active Not Recruiting3
DB01073Fludarabine1 / 2Recruiting1
DB01177Idarubicin1 / 2Completed1
DB00480Lenalidomide1 / 2Active Not Recruiting1
DB00688Mycophenolate mofetil1 / 2Active Not Recruiting3
DB00688Mycophenolate mofetil1 / 2Recruiting1
DB11697Pacritinib1 / 2Completed1
DB12146Rigosertib1 / 2Recruiting1
DB06436Semaxanib1 / 2Completed1
DB00877Sirolimus1 / 2Recruiting1
DB04960Tipifarnib1 / 2Completed2
DB02546Vorinostat1 / 2Active Not Recruiting1
DB08885Aflibercept2Terminated1
DB00087Alemtuzumab2Active Not Recruiting1
DB09312Antilymphocyte immunoglobulin (horse)2Completed1
DB00098Antithymocyte immunoglobulin (rabbit)2Completed1
DB01169Arsenic trioxide2Recruiting1
DB00928Azacitidine2Active Not Recruiting1
DB00928Azacitidine2Completed4
DB00928Azacitidine2Recruiting2
DB00394Beclomethasone dipropionate2Completed1
DB01008Busulfan2Completed2
DB01008Busulfan2Recruiting3
DB01197Captopril2Recruiting1
DB00958Carboplatin2Not Yet Recruiting1
DB00958Carboplatin2Recruiting1
DB00493Cefotaxime2Completed2
DB00493Cefotaxime2Recruiting1
DB00631Clofarabine2Active Not Recruiting1
DB06189Clofarabine2Active Not Recruiting1
DB00631Clofarabine2Completed1
DB06189Clofarabine2Completed1
DB00631Clofarabine2Recruiting1
DB06189Clofarabine2Recruiting1
DB00531Cyclophosphamide2Completed2
DB00531Cyclophosphamide2Recruiting5
DB00091Cyclosporine2Active Not Recruiting3
DB00091Cyclosporine2Completed3
DB00987Cytarabine2Active Not Recruiting1
DB00987Cytarabine2Recruiting1
DB01254Dasatinib2Recruiting1
DB01262Decitabine2Active Not Recruiting1
DB01262Decitabine2Completed2
DB01262Decitabine2Recruiting3
DB01262Decitabine2Terminated1
DB01262Decitabine2Unknown Status1
DB06210Eltrombopag2Recruiting1
DB11841Entinostat2Completed2
DB00099Filgrastim2Active Not Recruiting1
DB00099Filgrastim2Recruiting1
DB01073Fludarabine2Active Not Recruiting5
DB01073Fludarabine2Completed3
DB01073Fludarabine2Recruiting6
DB04901Galiximab2Recruiting1
DB00619Imatinib2Completed4
DB00480Lenalidomide2Active Not Recruiting2
DB00480Lenalidomide2Recruiting1
DB11740MK-17752Recruiting1
DB01042Melphalan2Active Not Recruiting1
DB01042Melphalan2Recruiting1
DB00563Methotrexate2Active Not Recruiting1
DB00563Methotrexate2Completed3
DB00563Methotrexate2Recruiting1
DB00959Methylprednisolone2Completed1
DB00688Mycophenolate mofetil2Active Not Recruiting4
DB00688Mycophenolate mofetil2Completed1
DB00688Mycophenolate mofetil2Recruiting5
DB01024Mycophenolic acid2Recruiting2
DB04868Nilotinib2Recruiting1
DB00904Ondansetron2Completed1
DB08901Ponatinib2Recruiting1
DB00020Sargramostim2Completed1
DB00877Sirolimus2Recruiting2
DB00398Sorafenib2Recruiting1
DB12118Sotatercept2Active Not Recruiting1
DB01268Sunitinib2Completed1
DB01268Sunitinib2Recruiting1
DB01268Sunitinib2Terminated1
DB00864Tacrolimus2Active Not Recruiting1
DB00864Tacrolimus2Completed3
DB00864Tacrolimus2Recruiting6
DB06287Temsirolimus2Completed1
DB01041Thalidomide2Completed1
DB04572Thiotepa2Recruiting1
DB01030Topotecan2Not Yet Recruiting1
DB11678Treosulfan2Active Not Recruiting1
DB11678Treosulfan2Completed1
DB11940Triapine2Completed1
DB07232Veliparib2Not Yet Recruiting1
DB02546Vorinostat2Active Not Recruiting1
DB02546Vorinostat2Completed1
DB00041Aldesleukin3Completed1
DB00023Asparaginase3Completed1
DB01008Busulfan3Completed1
DB00493Cefotaxime3Completed1
DB00531Cyclophosphamide3Completed1
DB00531Cyclophosphamide3Terminated1
DB00987Cytarabine3Completed1
DB00694Daunorubicin3Completed1
DB01262Decitabine3Not Yet Recruiting1
DB01234Dexamethasone3Completed1
DB00514Dextromethorphan3Completed1
DB00016Erythropoietin3Active Not Recruiting1
DB00773Etoposide3Completed1
DB00099Filgrastim3Completed1
DB01073Fludarabine3Completed1
DB00741Hydrocortisone3Completed1
DB01177Idarubicin3Completed1
DB00128L-Aspartic Acid3Completed1
DB00480Lenalidomide3Active Not Recruiting1
DB00563Methotrexate3Completed1
DB00563Methotrexate3Terminated1
DB12146Rigosertib3Active Not Recruiting2
DB00352Tioguanine3Completed1
DB09312Antilymphocyte immunoglobulin (horse)Not AvailableActive Not Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)Not AvailableActive Not Recruiting1
DB00091CyclosporineNot AvailableActive Not Recruiting1
DB00091CyclosporineNot AvailableCompleted1
DB00987CytarabineNot AvailableCompleted1
DB01609DeferasiroxNot AvailableTerminated1
DB01073FludarabineNot AvailableActive Not Recruiting2
DB01073FludarabineNot AvailableCompleted1
DB00529FoscarnetNot AvailableCompleted1
DB01004GanciclovirNot AvailableCompleted1
DB01177IdarubicinNot AvailableCompleted1
DB00619ImatinibNot AvailableCompleted1
DB01356LithiumNot AvailableCompleted1
DB01042MelphalanNot AvailableActive Not Recruiting1
DB00688Mycophenolate mofetilNot AvailableActive Not Recruiting1
DB00688Mycophenolate mofetilNot AvailableCompleted1
DB00039PaliferminNot AvailableCompleted1
DB00175PravastatinNot AvailableCompleted1
DB01610ValganciclovirNot AvailableCompleted1