Endometriosis

Also known as: Endometriosis, site unspecified

DrugDrug NameDrug Description
DB06719BuserelinBuserelin is a synthetic peptide analog of the luteinizing hormone-releasing hormone (LHRH) agonist, which stimulates the pituitary gland's gonadotrophin-releasing hormone receptor (GnRHR). It is used in prostate cancer treatment.
DB01406DanazolA synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.
DB09123DienogestDienogest is an orally-active semisynthetic progestogen which also possesses the properties of 17α-hydroxyprogesterone. It is a derivative of 19-nortestosterone and has antiandrogenic properties. It is primarily used as a contraceptive in combination with ethinylestradiol, or in other combination form pills approved in United States and Europe however it is not available in the US by itself. In Europe, Australia, Malaysia, Singapore and Japan, dienogest single therapy is an approved treatment for endometriosis to alleviate painful symptoms of endometriosis and reduce endometriotic lesions [A20330]. Dienogest is commonly marketed as Visanne, Natazia and Qlaira.
DB01395DrospirenoneDrospirenone is a synthetic progestin that is an analog to spironolactone. It is found in a number of birth control formulations. Drospirenone differs from other synthetic progestins in that its pharmacological profile in preclinical studies shows it to be closer to the natural progesterone. As such it has anti-mineralocorticoid properties, counteracts the estrogen-stimulated activity of the renin-angiotensin-aldosterone system, and is not androgenic. It was shown in animal studies that drospirenone exhibits antiandrogenic activity judging from accessory sex gland growth in castrated, androgen-treated, juvenile rats.
DB00823Ethynodiol diacetateA synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive. Although etynodiol or ethynodiol are sometimes used as a synonym for ethynodiol diacetate, what is usually being referred to is actually ethynodiol diacetate and not ethynodiol (which is a separate drug that has never been marketed, see [DB13866]).
DB00014GoserelinGoserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medication is stopped, hormone levels return to normal.
DB00007LeuprolideLeuprolide belongs to the general class of drugs known as hormones or hormone antagonists. It is a synthetic 9 residue peptide analog of gonadotropin releasing hormone. Leuprolide is used to treat advanced prostate cancer. It is also used to treat uterine fibroids and endometriosis. Leuprolide is also under investigation for possible use in the treatment of mild to moderate Alzheimer's disease.
DB00603Medroxyprogesterone acetateMedroxyprogesterone acetate (INN, USAN, BAN), also known as 17α-hydroxy-6α-methylprogesterone acetate, and commonly abbreviated as MPA, is a steroidal progestin, a synthetic variant of the human hormone progesterone. It is used as a contraceptive, in hormone replacement therapy and for the treatment of endometriosis as well as several other indications. MPA is a more potent derivative of its parent compound medroxyprogesterone (MP). While medroxyprogesterone is sometimes used as a synonym for medroxyprogesterone acetate, what is normally being administered is MPA and not MP.
DB01357MestranolThe 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives.
DB00666NafarelinA potent synthetic agonist of gonadotropin-releasing hormone with 3-(2-naphthyl)-D-alanine substitution at residue 6. Nafarelin has been used in the treatments of central precocious puberty and endometriosis. [PubChem]
DB00717NorethisteroneNorethisterone (INN, BAN), also known as Norethindrone (USAN), is a synthetic progestational hormone with actions similar to those of progesterone but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.
DB09389NorgestrelNorgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active.
DrugDrug NameTargetType
DB06719BuserelinLutropin-choriogonadotropic hormone receptortarget
DB06719BuserelinGonadotropin-releasing hormone receptortarget
DB06719BuserelinCytochrome P450 19A1enzyme
DB01406DanazolEstrogen receptor alphatarget
DB01406DanazolGonadotropin-releasing hormone receptortarget
DB01406DanazolPutative gonadotropin-releasing hormone II receptortarget
DB01406DanazolSex hormone-binding globulincarrier
DB01406DanazolC-C motif chemokine 2target
DB01406DanazolCytochrome P450 19A1enzyme
DB01406DanazolAndrogen receptortarget
DB01406DanazolProgesterone receptortarget
DB01406DanazolCytochrome P450 3A4enzyme
DB09123DienogestCytochrome P450 3A4enzyme
DB09123DienogestProgesterone receptortarget
DB09123DienogestAndrogen receptortarget
DB01395DrospirenoneProgesterone receptortarget
DB01395DrospirenoneMineralocorticoid receptortarget
DB01395DrospirenoneAndrogen receptortarget
DB01395DrospirenoneProstaglandin G/H synthase 2enzyme
DB01395DrospirenoneCholinesteraseenzyme
DB01395DrospirenoneCytochrome P450 3A4enzyme
DB00823Ethynodiol diacetateEstrogen receptor alphatarget
DB00823Ethynodiol diacetateProgesterone receptortarget
DB00823Ethynodiol diacetateCytochrome P450 3A4enzyme
DB00014GoserelinLutropin-choriogonadotropic hormone receptortarget
DB00014GoserelinGonadotropin-releasing hormone receptortarget
DB00007LeuprolideGonadotropin-releasing hormone receptortarget
DB00007LeuprolideCytochrome P450 3A4enzyme
DB00603Medroxyprogesterone acetateProgesterone receptortarget
DB00603Medroxyprogesterone acetateEstrogen receptor alphatarget
DB00603Medroxyprogesterone acetateCytochrome P450 3A4enzyme
DB00603Medroxyprogesterone acetateCytochrome P450 2C8enzyme
DB00603Medroxyprogesterone acetate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
DB00603Medroxyprogesterone acetateCytochrome P450 2C9enzyme
DB01357MestranolEstrogen receptor alphatarget
DB01357MestranolCytochrome P450 2C9enzyme
DB01357MestranolCytochrome P450 3A4enzyme
DB01357MestranolCytochrome P450 2C8enzyme
DB00666NafarelinGonadotropin-releasing hormone receptortarget
DB00666NafarelinPutative gonadotropin-releasing hormone II receptortarget
DB00717NorethisteroneProgesterone receptortarget
DB00717NorethisteroneCytochrome P450 3A4enzyme
DB00717NorethisteroneMultidrug resistance protein 1transporter
DB00717NorethisteroneCytochrome P450 2C19enzyme
DB00717NorethisteroneCytochrome P450 3A5enzyme
DB00717NorethisteroneCytochrome P450 3A7enzyme
DB00717NorethisteroneSerum albumincarrier
DB00717NorethisteroneSex hormone-binding globulincarrier
DB09389NorgestrelProgesterone receptortarget
DB09389Norgestrel3-oxo-5-alpha-steroid 4-dehydrogenase 1target
DB09389NorgestrelAndrogen receptortarget
DB09389NorgestrelCytochrome P450 3A4enzyme
DB09389NorgestrelCytochrome P450 19A1enzyme
DrugDrug NamePhaseStatusCount
DB09374Indocyanine green acid form0Recruiting1
DB01217Anastrozole1Completed1
DB01076Atorvastatin1Completed1
DB01008Busulfan1Completed1
DB00196Fluconazole1Completed1
DB00367Levonorgestrel1Completed1
DB01110Miconazole1Completed1
DB00683Midazolam1Completed1
DB11853Relugolix1Completed1
DB01045Rifampicin1Completed1
DB01041Thalidomide1Terminated1
DB11971Vilaprisan1Completed1
DB00603Medroxyprogesterone acetate1 / 2Completed1
DB00666Nafarelin1 / 2Completed1
DB01217Anastrozole2Completed1
DB06680Asoprisnil2Completed3
DB00248Cabergoline2Completed1
DB00248Cabergoline2Not Yet Recruiting1
DB01164Calcium Chloride2Completed1
DB00050Cetrorelix2Completed1
DB00286Conjugated estrogens2Completed1
DB09123Dienogest2Completed1
DB09123Dienogest2Withdrawn1
DB11074Dimethicone2Not Yet Recruiting1
DB05694Elagolix2Completed1
DB11979Elagolix2Completed3
DB00668Epinephrine2Completed1
DB06597Estradiol sulfamate2Completed1
DB00099Filgrastim2Not Yet Recruiting1
DB14307Green tea leaf2Recruiting1
DB00007Leuprolide2Active Not Recruiting1
DB00007Leuprolide2Completed5
DB00367Levonorgestrel2Completed1
DB00281Lidocaine2Completed1
DB00603Medroxyprogesterone acetate2Completed1
DB01065Melatonin2Not Yet Recruiting1
DB00717Norethisterone2Completed2
DB00540Nortriptyline2Not Yet Recruiting1
DB11058Petrolatum2Not Yet Recruiting1
DB00761Potassium chloride2Completed1
DB09097Quinagolide2Not Yet Recruiting1
DB00481Raloxifene2Completed1
DB11853Relugolix2Completed2
DB00412Rosiglitazone2Terminated1
DB11127Selenious acid2Completed1
DB11135Selenium2Completed1
DB09153Sodium chloride2Completed1
DB12335Tanezumab2Terminated1
DB05253Telapristone acetate2Completed1
DB05253Telapristone acetate2Terminated2
DB05253Telapristone acetate2Withdrawn1
DB11971Vilaprisan2Active Not Recruiting1
DB09123Dienogest2 / 3Suspended1
DB00367Levonorgestrel2 / 3Suspended1
DB00834Mifepristone2 / 3Completed1
DB01132Pioglitazone2 / 3Withdrawn1
DB00412Rosiglitazone2 / 3Withdrawn1
DB06699Degarelix3Completed1
DB09123Dienogest3Completed4
DB01395Drospirenone3Completed1
DB11979Elagolix3Active Not Recruiting1
DB11979Elagolix3Completed4
DB11979Elagolix3Terminated1
DB00783Estradiol3Active Not Recruiting1
DB00783Estradiol3Terminated1
DB00014Goserelin3Completed1
DB00007Leuprolide3Not Yet Recruiting1
DB00007Leuprolide3Unknown Status1
DB00717Norethisterone3Active Not Recruiting1
DB00717Norethisterone3Completed1
DB00717Norethisterone3Terminated1
DB00717Norethisterone3Unknown Status1
DB00396Progesterone3Recruiting1
DB11853Relugolix3Enrolling by Invitation1
DB11853Relugolix3Not Yet Recruiting1
DB06825Triptorelin3Active Not Recruiting1
DB06825Triptorelin3Completed1
DB06825Triptorelin3Unknown Status1
DB11121Chloroxylenol4Completed1
DB11121Chloroxylenol4Unknown Status1
DB01406Danazol4Completed1
DB09123Dienogest4Recruiting1
DB00898Ethanol4Completed1
DB00977Ethinylestradiol4Recruiting1
DB00294Etonogestrel4Completed1
DB00014Goserelin4Completed1
DB00014Goserelin4Unknown Status1
DB00007Leuprolide4Completed2
DB00007Leuprolide4Not Yet Recruiting1
DB00367Levonorgestrel4Completed2
DB00603Medroxyprogesterone acetate4Completed1
DB00717Norethisterone4Recruiting1
DB02709Resveratrol4Completed1
DB00728Rocuronium4Enrolling by Invitation1
DB09070Tibolone4Not Yet Recruiting1
DB06825Triptorelin4Completed2
DB08867Ulipristal4Active Not Recruiting1
DB11768Zytron4Completed1
DB01076AtorvastatinNot AvailableUnknown Status1
DB00169CholecalciferolNot AvailableCompleted1
DB00882ClomifeneNot AvailableWithdrawn1
DB00304DesogestrelNot AvailableCompleted1
DB00304DesogestrelNot AvailableUnknown Status1
DB09123DienogestNot AvailableActive Not Recruiting1
DB09123DienogestNot AvailableCompleted4
DB09123DienogestNot AvailableRecruiting1
DB01075DiphenhydramineNot AvailableCompleted1
DB00378DydrogesteroneNot AvailableCompleted1
DB00378DydrogesteroneNot AvailableRecruiting1
DB00898EthanolNot AvailableEnrolling by Invitation1
DB00977EthinylestradiolNot AvailableActive Not Recruiting1
DB00977EthinylestradiolNot AvailableUnknown Status1
DB06785GanirelixNot AvailableNot Yet Recruiting1
DB01006LetrozoleNot AvailableCompleted1
DB00007LeuprolideNot AvailableCompleted2
DB00281LidocaineNot AvailableCompleted1
DB00175PravastatinNot AvailableNot Yet Recruiting1
DB00175PravastatinNot AvailableWithdrawn1
DB06825TriptorelinNot AvailableActive Not Recruiting1
DB06825TriptorelinNot AvailableRecruiting1