Plasmodium Infections

Also known as: Malaria / Plasmodia infections / Malaria NOS / Plasmodium infection / Malaria, unspecified / Paludism / Unspecified malaria

DrugDrug NameDrug Description
DB14033Acetyl sulfisoxazoleSulfisoxazole acetyl is an ester of _sulfisoxazole_, a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial activity. Sulfisoxazole acetyl competes with PABA for the bacterial enzyme, _dihydropteroate synthase_, preventing the incorporation of PABA into dihydrofolic acid, which is the precursor of folic acid. This process causes an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, resulting in cell growth arrest and cell death [L2788]. It is often combined with erythromycin to treat acute otitis media caused by the bacteria, haemophilus influenzae [L2790].
DB00608ChloroquineThe prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
DB01190ClindamycinClindamycin is a semisynthetic lincosamide antibiotic that has largely replaced lincomycin due to an improved side effect profile. Clindamycin inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits. It may be bacteriostatic or bactericidal depending on the organism and drug concentration.
DB00254DoxycyclineA synthetic tetracycline derivative with similar antimicrobial activity. Animal studies suggest that it may cause less tooth staining than other tetracyclines. It is used in some areas for the treatment of chloroquine-resistant falciparum malaria (malaria, falciparum).
DB00358MefloquineA phospholipid-interacting antimalarial drug (antimalarials). It is very effective against plasmodium falciparum with very few side effects. [PubChem]
DB01087PrimaquineAn aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
DB00205PyrimethamineOne of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.
DB00359SulfadiazineOne of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections. [PubChem]
DrugDrug NameTargetType
DB14033Acetyl sulfisoxazoleDihydropteroate synthasetarget
DB14033Acetyl sulfisoxazoleCytochrome P450 2C9enzyme
DB14033Acetyl sulfisoxazoleCytochrome P450 3A4enzyme
DB00608ChloroquineTumor necrosis factortarget
DB00608ChloroquineToll-like receptor 9target
DB00608ChloroquineGlutathione S-transferase A2target
DB00608ChloroquineCytochrome P450 2D6enzyme
DB00608ChloroquineCytochrome P450 3A4enzyme
DB00608ChloroquineCytochrome P450 1A1enzyme
DB00608ChloroquineCytochrome P450 2C8enzyme
DB00608ChloroquineCytochrome P450 3A5enzyme
DB00608ChloroquineFe(II)-protoporphyrin IXtarget
DB00608ChloroquineGlutathione S-transferasetarget
DB00608ChloroquineMultidrug resistance protein 1transporter
DB01190Clindamycin50S ribosomal protein L10target
DB01190ClindamycinCytochrome P450 3A4enzyme
DB01190Clindamycin23S rRNAtarget
DB00254Doxycycline30S ribosomal protein S4target
DB00254Doxycycline30S ribosomal protein S9target
DB00254Doxycycline16S rRNAtarget
DB00254DoxycyclineSolute carrier family 22 member 6transporter
DB00254DoxycyclineSolute carrier family 22 member 8transporter
DB00254DoxycyclineSolute carrier family 22 member 11transporter
DB00254DoxycyclineCytochrome P450 3A4enzyme
DB00254DoxycyclineProtein-arginine deiminase type-4target
DB00254DoxycyclineBeta-2-microglobulintarget
DB00358MefloquineHemoglobin subunit alphatarget
DB00358MefloquineCholinesteraseenzyme
DB00358MefloquineCytochrome P450 3A4enzyme
DB00358MefloquineAdenosine receptor A2atarget
DB00358MefloquineFe(II)-protoporphyrin IXtarget
DB00358MefloquineMultidrug resistance protein 1transporter
DB00358MefloquineCytochrome P450 19A1enzyme
DB00358MefloquineCytochrome P450 2D6enzyme
DB00358MefloquineAcetylcholinesteraseenzyme
DB01087PrimaquineCytochrome P450 1A1enzyme
DB01087PrimaquineCytochrome P450 1A2enzyme
DB01087PrimaquineCytochrome P450 3A4enzyme
DB01087PrimaquineKeratin, type II cytoskeletal 7target
DB01087PrimaquineCytochrome P450 1B1enzyme
DB01087PrimaquineCytochrome P450 2D6enzyme
DB01087PrimaquineRibosyldihydronicotinamide dehydrogenase [quinone]target
DB01087PrimaquineFe(II)-protoporphyrin IXtarget
DB01087PrimaquineMultidrug resistance protein 1transporter
DB00205PyrimethamineBifunctional dihydrofolate reductase-thymidylate synthasetarget
DB00205PyrimethamineDihydrofolate reductasetarget
DB00205PyrimethamineCytochrome P450 2D6enzyme
DB00205PyrimethamineCytochrome P450 2C9enzyme
DB00205PyrimethamineCytochrome P450 2C8enzyme
DB00205PyrimethamineBeta-hexosaminidase subunit betatarget
DB00359SulfadiazineCytochrome P450 2C9enzyme
DB00359SulfadiazineDihydropteroate synthetasetarget
DB00359SulfadiazineCytochrome P450 2C8enzyme
DB00359SulfadiazineCytochrome P450 2E1enzyme
DB00359SulfadiazineCytochrome P450 3A4enzyme
DrugDrug NamePhaseStatusCount
DB00125L-Arginine0Completed1
DB00709Lamivudine0Completed1
DB01601Lopinavir0Completed1
DB00238Nevirapine0Completed1
DB00503Ritonavir0Completed1
DB00495Zidovudine0Completed1
DB00613Amodiaquine1Completed1
DB11809Artefenomel1Completed4
DB11809Artefenomel1Terminated1
DB06697Artemether1Completed2
DB06697Artemether1Enrolling by Invitation1
DB06697Artemether1Recruiting1
DB09274Artesunate1Completed5
DB01117Atovaquone1Active Not Recruiting1
DB01117Atovaquone1Completed1
DB00207Azithromycin1Completed2
DB00608Chloroquine1Completed6
DB00608Chloroquine1Recruiting1
DB09065Cobicistat1Recruiting1
DB00625Efavirenz1Completed1
DB10989Hepatitis A Vaccine1Completed1
DB11627Hepatitis B Vaccine (Recombinant)1Unknown Status2
DB00602Ivermectin1Completed1
DB01601Lopinavir1Completed1
DB06708Lumefantrine1Completed1
DB06708Lumefantrine1Enrolling by Invitation1
DB06708Lumefantrine1Recruiting1
DB00563Methotrexate1Completed1
DB00264Metoprolol1Completed1
DB10798Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigen1Completed1
DB05144PEV3A1Unknown Status1
DB01087Primaquine1Completed3
DB01131Proguanil1Active Not Recruiting1
DB00205Pyrimethamine1Completed1
DB00205Pyrimethamine1Recruiting1
DB12975Pyronaridine1Completed2
DB10283Rabies virus inactivated antigen, A1Completed1
DB10283Rabies virus inactivated antigen, A1Unknown Status1
DB13085Riamet1Completed1
DB00503Ritonavir1Completed2
DB00412Rosiglitazone1Terminated1
DB01098Rosuvastatin1Terminated1
DB12659SJ-7331Recruiting1
DB09153Sodium Chloride1Completed3
DB09449Sodium phosphate, monobasic1Completed1
DB11084Sodium phosphate, monobasic1Completed1
DB06608Tafenoquine1Completed1
DB12794p-Quaterphenyl1Completed2
DB06361rsPSMA Vaccine1Enrolling by Invitation1
DB00613Amodiaquine1 / 2Completed1
DB11809Artefenomel1 / 2Completed2
DB11809Artefenomel1 / 2Terminated1
DB01117Atovaquone1 / 2Completed1
DB00602Ivermectin1 / 2Completed1
DB05144PEV3A1 / 2Completed1
DB13941Piperaquine1 / 2Completed1
DB01087Primaquine1 / 2Completed2
DB01131Proguanil1 / 2Completed2
DB10283Rabies virus inactivated antigen, A1 / 2Completed1
DB00316Acetaminophen2Recruiting1
DB09278Activated charcoal2Completed1
DB00613Amodiaquine2Completed5
DB11809Artefenomel2Completed1
DB06697Artemether2Active Not Recruiting1
DB06697Artemether2Not Yet Recruiting1
DB06697Artemether2Recruiting1
DB09274Artesunate2Completed5
DB01117Atovaquone2Completed1
DB01117Atovaquone2Not Yet Recruiting1
DB00207Azithromycin2Unknown Status1
DB12768BCG vaccine2Completed1
DB00608Chloroquine2Not Yet Recruiting1
DB00608Chloroquine2Terminated1
DB12306Cipargamin2Completed2
DB12306Cipargamin2Recruiting1
DB01190Clindamycin2Unknown Status1
DB00927Famotidine2Not Yet Recruiting1
DB02948Fosmidomycin2Completed1
DB02948Fosmidomycin2Unknown Status2
DB02948Fosmidomycin2Withdrawn1
DB11627Hepatitis B Vaccine (Recombinant)2Completed2
DB01050Ibuprofen2Recruiting1
DB00602Ivermectin2Completed1
DB06708Lumefantrine2Active Not Recruiting1
DB06708Lumefantrine2Not Yet Recruiting1
DB06708Lumefantrine2Recruiting1
DB06708Lumefantrine2Terminated1
DB00358Mefloquine2Completed1
DB09241Methylene blue2Completed2
DB01087Primaquine2Completed2
DB01087Primaquine2Terminated1
DB01131Proguanil2Completed1
DB01131Proguanil2Not Yet Recruiting1
DB00468Quinine2Completed1
DB10283Rabies virus inactivated antigen, A2Completed2
DB10283Rabies virus inactivated antigen, A2Recruiting1
DB10286Streptococcus pneumoniae type 4 capsular polysaccharide diphtheria crm197 protein conjugate antigen2Completed1
DB06608Tafenoquine2Completed2
DB06608Tafenoquine2Terminated1
DB10805Yellow Fever Vaccine2Completed1
DB00518Albendazole2 / 3Completed1
DB00613Amodiaquine2 / 3Completed4
DB09274Artesunate2 / 3Completed1
DB00608Chloroquine2 / 3Completed1
DB00602Ivermectin2 / 3Completed1
DB00358Mefloquine2 / 3Completed1
DB00205Pyrimethamine2 / 3Completed2
DB01299Sulfadoxine2 / 3Completed2
DB00316Acetaminophen3Recruiting1
DB01370Aluminium3Completed2
DB00613Amodiaquine3Completed12
DB06697Artemether3Completed11
DB06697Artemether3Unknown Status1
DB09274Artesunate3Completed12
DB00207Azithromycin3Completed3
DB12768BCG vaccine3Completed1
DB00608Chloroquine3Completed5
DB00608Chloroquine3Suspended1
DB00608Chloroquine3Withdrawn1
DB11121Chloroxylenol3Completed1
DB12314Chlorproguanil3Terminated1
DB01190Clindamycin3Completed2
DB00250Dapsone3Terminated1
DB12496Dihydroxyacetone phosphate3Completed1
DB00625Efavirenz3Completed1
DB00158Folic Acid3Completed1
DB02948Fosmidomycin3Completed1
DB01005Hydroxyurea3Completed1
DB01005Hydroxyurea3Recruiting1
DB00602Ivermectin3Enrolling by Invitation1
DB00602Ivermectin3Not Yet Recruiting1
DB00709Lamivudine3Completed1
DB01601Lopinavir3Completed1
DB06708Lumefantrine3Completed11
DB06708Lumefantrine3Unknown Status1
DB00358Mefloquine3Completed3
DB05804Prasterone sulfate3Suspended1
DB00635Prednisone3Withdrawn1
DB01087Primaquine3Completed4
DB00205Pyrimethamine3Completed2
DB00205Pyrimethamine3Recruiting1
DB00205Pyrimethamine3Terminated1
DB00468Quinine3Completed2
DB13085Riamet3Completed1
DB00503Ritonavir3Completed1
DB01299Sulfadoxine3Completed2
DB01299Sulfadoxine3Recruiting1
DB01299Sulfadoxine3Terminated1
DB01015Sulfamethoxazole3Completed1
DB10805Yellow Fever Vaccine3Active Not Recruiting1
DB00495Zidovudine3Completed1
DB00316Acetaminophen4Unknown Status1
DB00173Adenine4Completed1
DB01370Aluminium4Completed1
DB01370Aluminium4Terminated1
DB00613Amodiaquine4Completed2
DB00613Amodiaquine4Suspended1
DB06697Artemether4Completed15
DB06697Artemether4Terminated2
DB06697Artemether4Unknown Status2
DB11638Artenimol4Unknown Status1
DB09274Artesunate4Active Not Recruiting1
DB09274Artesunate4Completed6
DB09274Artesunate4Recruiting1
DB09274Artesunate4Suspended1
DB09274Artesunate4Unknown Status1
DB01117Atovaquone4Completed4
DB00207Azithromycin4Recruiting1
DB12768BCG vaccine4Terminated1
DB00608Chloroquine4Completed4
DB03756Doconexent4Completed1
DB00125L-Arginine4Unknown Status1
DB00128L-Aspartic Acid4Completed1
DB06708Lumefantrine4Completed16
DB06708Lumefantrine4Terminated2
DB06708Lumefantrine4Unknown Status2
DB00358Mefloquine4Completed4
DB00358Mefloquine4Recruiting1
DB04930Permethrin4Recruiting1
DB01087Primaquine4Completed4
DB01087Primaquine4Not Yet Recruiting1
DB01087Primaquine4Recruiting1
DB01131Proguanil4Completed4
DB00205Pyrimethamine4Completed2
DB00468Quinine4Completed2
DB00468Quinine4Unknown Status1
DB13085Riamet4Completed2
DB01299Sulfadoxine4Completed2
DB00316AcetaminophenNot AvailableCompleted2
DB00518AlbendazoleNot AvailableCompleted2
DB00613AmodiaquineNot AvailableCompleted2
DB01060AmoxicillinNot AvailableCompleted2
DB06697ArtemetherNot AvailableCompleted6
DB09274ArtesunateNot AvailableCompleted5
DB01117AtovaquoneNot AvailableCompleted3
DB00207AzithromycinNot AvailableCompleted1
DB00608ChloroquineNot AvailableCompleted4
DB00608ChloroquineNot AvailableTerminated1
DB12496Dihydroxyacetone phosphateNot AvailableRecruiting1
DB00927FamotidineNot AvailableCompleted2
DB01592IronNot AvailableCompleted1
DB01592IronNot AvailableTerminated1
DB06708LumefantrineNot AvailableCompleted6
DB00358MefloquineNot AvailableCompleted3
DB01058PraziquantelNot AvailableCompleted2
DB01087PrimaquineNot AvailableCompleted1
DB01087PrimaquineNot AvailableUnknown Status1
DB01131ProguanilNot AvailableCompleted3
DB00412RosiglitazoneNot AvailableRecruiting1