Congestive Heart Failure (CHF)

Also known as: Heart Failure Congestive / Heart Failureļ¼ŒCongestive / CHF / Congestive Cardiac Failure / Heart Failure, Congestive / Congestive Heart Failure / Failure heart congestive / Cardiac failure congestive / Biventricular (heart) failure NOS / Cardiac failure, congestive / CCF

DrugDrug NameDrug Description
DB00819AcetazolamideA cardiac anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma.
DB00594AmilorideA pyrizine compound used to treat hypertension and congestive heart failure.
DB01076AtorvastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.
DB01197CaptoprilAn ACE inhibitor used for the management of essential or renovascular hypertension, congestive heart failure, left ventricular dysfunction following myocardial infarction, and nephropathy.
DB01340CilazaprilAn ACE inhibitor used for the management of hypertension and heart failure.
DB00876EprosartanAn ARB used to treat hypertension, diabetic nephropathy, and congestive heart failure.
DB00903Etacrynic acidA diuretic used to treat ascites and edema in congestive heart failure, liver cirrhosis, and renal disease.
DB00695FurosemideA loop diuretic used to treat hypertension and edema in congestive heart failure, liver cirrhosis, renal disease, and hypertension.
DB00999HydrochlorothiazideA thiazide diuretic used to treat edema associated with a number of conditions, and hypertension.
DB01064IsoprenalineA non-selective beta-adrenergic agonist typically used to treat bradycardia and heart block; it is structurally related to epinephrine.
DB00722LisinoprilAn ACE inhibitor used to treat hypertension, heart failure, and acute myocardial infarction.
DB00232MethyclothiazideA diuretic drug used to treat hypertension and edema caused by heart failure, renal conditions, treatment with corticosteroids, and estrogen therapy.
DB00524MetolazoneA thiazide-like diuretic used to treat hypertension.
DB00235MilrinoneAn inotropic vasodilator agent used to treat acute, decompensated heart failure.
DB00727NitroglycerinA nitrate vasodilator used to treat or prevent angina, treat hypertension, control heart failure in myocardial infarction, and to induce hypotension intraoperatively.
DB00325NitroprussideA direct acting vasodilator used to treat hypertension, to induce controlled hypotension to reduce postoperative bleeding, and to manage acute heart failure.
DB00881QuinaprilAn ACE inhibitor prodrug used to treat hypertension, congestive heart failure, and slow rate of progression of renal disease.
DB00015ReteplaseA purified form of human tissue plasminogen activator used in the emergency treatment of myocardial infarction, ischemic stroke, and pulmonary emboli.
DB00421SpironolactoneAn aldosterone receptor antagonist used for the treatment of hypertension, hyperaldosteronism, edema due to various conditions, hirsutism (off-label) and hypokalemia.
DB00214TorasemideA diuretic used to treat hypertension and edema associated with heart failure, renal failure, or liver disease.
DB00384TriamtereneA potassium-sparing diuretic used in the treatment of edema and in the management of hypertension.
DrugDrug NameTargetType
DB00819AcetazolamideCarbonic anhydrase 1target
DB00819AcetazolamideAquaporin-1target
DB00819AcetazolamideCarbonic anhydrase 14target
DB00819AcetazolamideSolute carrier family 22 member 6transporter
DB00819AcetazolamideCarbonic anhydrase 2target
DB00819AcetazolamideCarbonic anhydrase 3target
DB00819AcetazolamideCarbonic anhydrase 4target
DB00819AcetazolamideCytochrome P450 3A4enzyme
DB00819AcetazolamideCarbonic anhydrase 7target
DB00819AcetazolamideCarbonic anhydrase 12target
DB00594AmilorideAmiloride-sensitive sodium channel subunit betatarget
DB00594AmilorideAcid-sensing ion channel 1target
DB00594AmilorideAmiloride-sensitive amine oxidase [copper-containing]target
DB00594AmilorideAmiloride-sensitive sodium channel subunit alphatarget
DB00594AmilorideAmiloride-sensitive sodium channel subunit gammatarget
DB00594AmilorideSodium/hydrogen exchanger 1target
DB00594AmilorideAcid-sensing ion channel 2target
DB00594AmilorideAmiloride-sensitive sodium channel subunit deltatarget
DB00594AmilorideUrokinase-type plasminogen activatortarget
DB00594AmilorideSolute carrier family 22 member 2transporter
DB00594AmilorideSolute carrier family 22 member 4transporter
DB00594AmilorideAmiloride-sensitive amine oxidase [copper-containing]enzyme
DB00594AmilorideAmiloride-sensitive amine oxidase [copper-containing]enzyme
DB01076Atorvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB01076AtorvastatinCytochrome P450 3A4enzyme
DB01076AtorvastatinDipeptidyl peptidase 4target
DB01076AtorvastatinCytochrome P450 2D6enzyme
DB01076AtorvastatinCytochrome P450 2C9enzyme
DB01076AtorvastatinCytochrome P450 2C19enzyme
DB01076AtorvastatinCytochrome P450 3A5enzyme
DB01076AtorvastatinCytochrome P450 3A7enzyme
DB01076AtorvastatinP-glycoprotein 1transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1A2transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1B1transporter
DB01076AtorvastatinMultidrug resistance-associated protein 4transporter
DB01076AtorvastatinMultidrug resistance-associated protein 5transporter
DB01076AtorvastatinMultidrug resistance-associated protein 1transporter
DB01076AtorvastatinCytochrome P450 2B6enzyme
DB01076AtorvastatinCytochrome P450 2C8enzyme
DB01076AtorvastatinAryl hydrocarbon receptortarget
DB01076AtorvastatinSolute carrier organic anion transporter family member 2B1transporter
DB01076AtorvastatinSolute carrier organic anion transporter family member 1B3transporter
DB01076AtorvastatinUDP-glucuronosyltransferase 1-1enzyme
DB01076AtorvastatinUDP-glucuronosyltransferase 1-3enzyme
DB01076AtorvastatinCanalicular multispecific organic anion transporter 1transporter
DB01076AtorvastatinBile salt export pumptransporter
DB01076AtorvastatinSerum albumincarrier
DB01076AtorvastatinHistone deacetylase 2target
DB01076AtorvastatinNuclear receptor subfamily 1 group I member 3target
DB01197CaptoprilAngiotensin-converting enzymetarget
DB01197CaptoprilSerum albumincarrier
DB01197Captopril72 kDa type IV collagenasetarget
DB01197CaptoprilMatrix metalloproteinase-9target
DB01197CaptoprilP-glycoprotein 1transporter
DB01197CaptoprilSolute carrier family 15 member 1transporter
DB01197CaptoprilSolute carrier family 22 member 6transporter
DB01197CaptoprilLeukotriene A-4 hydrolasetarget
DB01197CaptoprilB1 bradykinin receptortarget
DB01340CilazaprilAngiotensin-converting enzymetarget
DB01340CilazaprilP-glycoprotein 1transporter
DB01340CilazaprilSolute carrier family 15 member 1transporter
DB01340CilazaprilSolute carrier family 15 member 2transporter
DB00876EprosartanType-1 angiotensin II receptortarget
DB00876EprosartanCanalicular multispecific organic anion transporter 1transporter
DB00903Etacrynic acidSolute carrier family 12 member 1target
DB00903Etacrynic acidSodium/potassium-transporting ATPase subunit alpha-1target
DB00903Etacrynic acidGlutathione S-transferase A2enzyme
DB00903Etacrynic acidSerum albumincarrier
DB00903Etacrynic acidSolute carrier family 22 member 6transporter
DB00903Etacrynic acidLymphoid enhancer-binding factor 1target
DB00903Etacrynic acidGlutathione S-transferase Ptarget
DB00695FurosemideSolute carrier family 12 member 1target
DB00695FurosemideSerum albumincarrier
DB00695FurosemideSolute carrier family 22 member 6transporter
DB00695FurosemideSolute carrier family 22 member 5transporter
DB00695FurosemideSolute carrier family 22 member 8transporter
DB00695FurosemideCanalicular multispecific organic anion transporter 1transporter
DB00695FurosemideSolute carrier organic anion transporter family member 2A1transporter
DB00695FurosemideSolute carrier family 22 member 11transporter
DB00695Furosemide6-phosphogluconate dehydrogenase, decarboxylatingenzyme
DB00695FurosemideCarbonic anhydrase 2target
DB00695FurosemideUDP-glucuronosyltransferase 1-1enzyme
DB00695FurosemideThyroxine-binding globulincarrier
DB00999HydrochlorothiazideSolute carrier family 12 member 3target
DB00999HydrochlorothiazideSolute carrier family 22 member 6transporter
DB00999HydrochlorothiazideCalcium-activated potassium channel subunit alpha-1target
DB00999HydrochlorothiazideSerum albumincarrier
DB00999HydrochlorothiazideSolute carrier family 22 member 11transporter
DB00999HydrochlorothiazideMultidrug resistance-associated protein 4transporter
DB00999HydrochlorothiazideSolute carrier family 22 member 8transporter
DB01064IsoprenalineBeta-1 adrenergic receptortarget
DB01064IsoprenalineBeta-2 adrenergic receptortarget
DB01064IsoprenalinePhosphatidylinositol 3-kinase regulatory subunit alphatarget
DB01064IsoprenalineBeta-3 adrenergic receptortarget
DB01064IsoprenalineMitogen-activated protein kinase 1target
DB01064IsoprenalinePhosphatidylinositol 3-kinase regulatory subunit betatarget
DB01064IsoprenalinePhosphatidylinositol 3-kinase regulatory subunit gammatarget
DB01064IsoprenalineCytochrome P450 1A1enzyme
DB01064IsoprenalineCAMP phosphodiesterasetarget
DB01064IsoprenalineSuperoxide dismutase [Cu-Zn]target
DB00722LisinoprilAngiotensin-converting enzymetarget
DB00722LisinoprilSolute carrier family 15 member 1transporter
DB00722LisinoprilSolute carrier family 15 member 2transporter
DB00722LisinoprilRenintarget
DB00232MethyclothiazideSolute carrier family 12 member 1target
DB00232MethyclothiazideCarbonic anhydrase 4target
DB00232MethyclothiazideCarbonic anhydrase 2target
DB00232MethyclothiazideCarbonic anhydrase 1target
DB00524MetolazoneSolute carrier family 12 member 3target
DB00235MilrinonecGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
DB00727NitroglycerinAtrial natriuretic peptide receptor 1target
DB00727NitroglycerinAldehyde dehydrogenase, mitochondrialenzyme
DB00325NitroprussideAtrial natriuretic peptide receptor 1target
DB00325NitroprussideCytochrome P450 1A1enzyme
DB00881QuinaprilAngiotensin-converting enzymetarget
DB00881QuinaprilSolute carrier family 15 member 1transporter
DB00881QuinaprilSolute carrier family 15 member 2transporter
DB00881QuinaprilSolute carrier family 22 member 8transporter
DB00881QuinaprilLiver carboxylesterase 1enzyme
DB00881QuinaprilSerum albumincarrier
DB00015ReteplaseUrokinase plasminogen activator surface receptortarget
DB00015ReteplaseFibrinogen alpha chaintarget
DB00015ReteplasePlasminogentarget
DB00015ReteplasePlasminogen activator inhibitor 1target
DB00421SpironolactoneMineralocorticoid receptortarget
DB00421SpironolactoneCytochrome P450 2C8enzyme
DB00421SpironolactoneCanalicular multispecific organic anion transporter 1transporter
DB00421SpironolactoneP-glycoprotein 1transporter
DB00421SpironolactoneSolute carrier organic anion transporter family member 1A2transporter
DB00421SpironolactoneCytochrome P450 11B1, mitochondrialenzyme
DB00421SpironolactoneAndrogen receptortarget
DB00421SpironolactoneProgesterone receptortarget
DB00421SpironolactoneGlucocorticoid receptortarget
DB00421SpironolactoneCytochrome P450 11B2, mitochondrialtarget
DB00421SpironolactoneSteroid 17-alpha-hydroxylase/17,20 lyasetarget
DB00421Spironolactone3-oxo-5-alpha-steroid 4-dehydrogenasetarget
DB00421SpironolactoneSex hormone-binding globulintarget
DB00421SpironolactoneVoltage-dependent calcium channeltarget
DB00421SpironolactoneNuclear receptor subfamily 1 group I member 2target
DB00421SpironolactoneBile salt export pumptransporter
DB00421SpironolactoneSerum albumincarrier
DB00421Spironolactonealpha1-acid glycoproteincarrier
DB00214TorasemideSolute carrier family 12 member 1target
DB00214TorasemideCytochrome P450 2C8enzyme
DB00214TorasemideCytochrome P450 2C9enzyme
DB00214TorasemideSolute carrier organic anion transporter family member 1B1transporter
DB00214TorasemideSolute carrier family 12 member 2target
DB00214TorasemideSerum albumincarrier
DB00384TriamtereneAmiloride-sensitive sodium channel subunit gammatarget
DB00384TriamtereneAmiloride-sensitive sodium channel subunit alphatarget
DB00384TriamtereneAmiloride-sensitive sodium channel subunit betatarget
DB00384TriamtereneAmiloride-sensitive sodium channel subunit deltatarget
DB00384TriamtereneCytochrome P450 1A2enzyme
DrugDrug NamePhaseStatusCount
DB06157Istaroxime0Withdrawn1
DB01261Sitagliptin0Completed1
DB01136Carvedilol1Completed1
DB11777Cenderitide1Completed3
DB14983Cimlanod1Completed2
DB01234Dexamethasone1Suspended1
DB11981Elamipretide1Completed1
DB15288Etamicastat1Completed2
DB01288Fenoterol1Completed1
DB00695Furosemide1Completed1
DB06704Iobenguane1Terminated1
DB00524Metolazone1Completed1
DB00218Moxifloxacin1Completed1
DB04899Nesiritide1Terminated1
DB05392Perflubutane1Completed1
DB00203Sildenafil1Terminated1
DB00815Sodium lauryl sulfate1Completed1
DB11815Tilarginine1Completed1
DB06212Tolvaptan1Completed1
DB00214Torasemide1Completed1
DB05034Ularitide1Withdrawn1
DB00437Allopurinol1 / 2Withdrawn1
DB00559Bosentan1 / 2Unknown Status1
DB00012Darbepoetin alfa1 / 2Completed1
DB00841Dobutamine1 / 2Withdrawn1
DB00695Furosemide1 / 2Not Yet Recruiting1
DB00583Levocarnitine1 / 2Not Yet Recruiting1
DB04899Nesiritide1 / 2Completed3
DB02772Sucrose1 / 2Completed1
DB00820Tadalafil1 / 2Completed1
DB11677Triheptanoin1 / 2Withdrawn1
DB11195Xylitol1 / 2Not Yet Recruiting1
DB126293,5-diiodothyropropionic acid2Terminated2
DB05162Albiglutide2Completed1
DB00437Allopurinol2Completed1
DB04957Azimilide2Completed1
DB01164Calcium Chloride2Terminated1
DB06231Caldaret2Completed1
DB00169Cholecalciferol2Completed1
DB14983Cimlanod2Recruiting1
DB01914D-glucose2Completed1
DB00012Darbepoetin alfa2Completed1
DB12446Derenofylline2Completed1
DB00841Dobutamine2Terminated1
DB09038Empagliflozin2Completed1
DB00813Fentanyl2Completed1
DB00695Furosemide2Recruiting1
DB00222Glimepiride2Completed1
DB01275Hydralazine2Active Not Recruiting1
DB00702Icodextrin2Terminated1
DB12439Ioforminol2Completed1
DB00883Isosorbide dinitrate2Active Not Recruiting1
DB09083Ivabradine2Completed1
DB04398Lactic acid2Terminated1
DB06655Liraglutide2Completed1
DB06666Lixivaptan2Completed1
DB09407Magnesium chloride2Terminated1
DB00331Metformin2Completed1
DB00235Milrinone2Terminated1
DB04899Nesiritide2Completed4
DB04899Nesiritide2Terminated1
DB00435Nitric Oxide2Completed1
DB09152Nitrogen2Completed1
DB04873Piboserod2Completed1
DB15073Ribose2Withdrawn1
DB12670Rolofylline2Completed1
DB00412Rosiglitazone2Completed1
DB05794Serelaxin2Terminated1
DB09153Sodium chloride2Terminated2
DB06212Tolvaptan2Completed4
DB01586Ursodeoxycholic acid2Unknown Status1
DB06151Acetylcysteine2 / 3Unknown Status1
DB00381Amlodipine2 / 3Completed1
DB00695Furosemide2 / 3Completed1
DB01275Hydralazine2 / 3Completed1
DB05262Oxypurinol2 / 3Completed1
DB00635Prednisone2 / 3Suspended1
DB01001Salbutamol2 / 3Withdrawn1
DB01104Sertraline2 / 3Completed1
DB05640Tonapofylline2 / 3Completed1
DB12569Tonapofylline2 / 3Completed1
DB04630Aldosterone3Completed1
DB09026Aliskiren3Completed1
DB00594Amiloride3Suspended1
DB01118Amiodarone3Completed1
DB11842Angiotensin II3Completed3
DB01164Calcium Chloride3Terminated1
DB00796Candesartan cilexetil3Completed3
DB01136Carvedilol3Completed3
DB13152Coagulation Factor IX Human3Recruiting1
DB13150Coagulation factor VII human3Recruiting1
DB13148Coagulation factor X human3Recruiting1
DB00012Darbepoetin alfa3Completed1
DB00012Darbepoetin alfa3Terminated1
DB04855Dronedarone3Terminated1
DB00584Enalapril3Completed2
DB00584Enalapril3Terminated1
DB04880Enoximone3Terminated2
DB00016Erythropoietin3Completed1
DB11330Factor IX Complex (Human)3Recruiting1
DB00695Furosemide3Completed1
DB00695Furosemide3Suspended1
DB00702Icodextrin3Terminated1
DB06704Iobenguane3Completed2
DB01029Irbesartan3Completed1
DB01592Iron3Completed1
DB12208Iron isomaltoside 10003Completed1
DB04398Lactic acid3Terminated1
DB00922Levosimendan3Completed1
DB09407Magnesium chloride3Terminated1
DB00331Metformin3Terminated1
DB00264Metoprolol3Completed1
DB00264Metoprolol3Terminated1
DB04899Nesiritide3Completed7
DB04899Nesiritide3Withdrawn1
DB09140Oxygen3Terminated1
DB00213Pantoprazole3Withdrawn1
DB14500Potassium3Completed1
DB11312Protein C3Recruiting1
DB13149Protein S human3Recruiting1
DB11311Prothrombin3Recruiting1
DB12670Rolofylline3Completed3
DB01098Rosuvastatin3Completed1
DB01001Salbutamol3Completed1
DB00203Sildenafil3Completed2
DB09153Sodium chloride3Terminated1
DB00421Spironolactone3Completed2
DB06212Tolvaptan3Completed1
DB06212Tolvaptan3Recruiting1
DB09026Aliskiren4Unknown Status1
DB11842Angiotensin II4Terminated1
DB01076Atorvastatin4Completed1
DB08961Azosemide4Completed1
DB00612Bisoprolol4Completed1
DB00887Bumetanide4Recruiting1
DB00796Candesartan cilexetil4Completed1
DB01136Carvedilol4Completed2
DB01136Carvedilol4Terminated1
DB00700Eplerenone4Completed2
DB01276Exenatide4Completed1
DB00695Furosemide4Completed4
DB01275Hydralazine4Completed1
DB00999Hydrochlorothiazide4Unknown Status1
DB00047Insulin glargine4Completed1
DB00883Isosorbide dinitrate4Completed1
DB00678Losartan4Completed1
DB00331Metformin4Completed1
DB00524Metolazone4Unknown Status1
DB00264Metoprolol4Terminated1
DB04899Nesiritide4Completed2
DB04899Nesiritide4Terminated4
DB04899Nesiritide4Withdrawn1
DB09263Patiromer4Not Yet Recruiting1
DB09292Sacubitril4Terminated1
DB09292Sacubitril4Withdrawn1
DB00421Spironolactone4Withdrawn1
DB00966Telmisartan4Completed1
DB01041Thalidomide4Unknown Status1
DB06212Tolvaptan4Active Not Recruiting1
DB00214Torasemide4Completed1
DB00177Valsartan4Completed2
DB00177Valsartan4Terminated1
DB00177Valsartan4Unknown Status1
DB00177Valsartan4Withdrawn1
DB04876Vildagliptin4Completed1
DB11094Vitamin D4Completed1
DB01076AtorvastatinNot AvailableUnknown Status1
DB00012Darbepoetin alfaNot AvailableCompleted1
DB12446DerenofyllineNot AvailableTerminated1
DB00153ErgocalciferolNot AvailableCompleted1
DB00695FurosemideNot AvailableWithdrawn2
DB10773Influenza A virus A/California/7/2009 (H1N1) recombinant hemagglutinin antigenNot AvailableRecruiting1
DB14417Influenza A virus A/Hong Kong/4801/2014 (H3N2) recombinant hemagglutinin antigenNot AvailableRecruiting1
DB14423Influenza A virus A/Michigan/45/2015 (H1N1) recombinant hemagglutinin antigenNot AvailableRecruiting1
DB10774Influenza A virus A/Victoria/361/2011 (H3N2) recombinant hemagglutinin antigenNot AvailableRecruiting1
DB14418Influenza B virus B/Brisbane/60/2008 recombinant hemagglutinin antigenNot AvailableRecruiting1
DB10779Influenza B virus B/Phuket/3073/2013 recombinant hemagglutinin antigenNot AvailableRecruiting1
DB10775Influenza B virus B/Wisconsin/1/2010 recombinant hemagglutinin antigenNot AvailableRecruiting1
DB06704IobenguaneNot AvailableCompleted1
DB09420Iodide I-123Not AvailableCompleted1
DB09083IvabradineNot AvailableRecruiting1
DB00524MetolazoneNot AvailableWithdrawn2
DB00264MetoprololNot AvailableRecruiting1
DB04899NesiritideNot AvailableCompleted1
DB09220NicorandilNot AvailableCompleted1
DB00806PentoxifyllineNot AvailableUnknown Status1
DB00692PhentolamineNot AvailableUnknown Status1
DB15073RiboseNot AvailableTerminated1
DB00421SpironolactoneNot AvailableCompleted1
DB00421SpironolactoneNot AvailableTerminated1
DB00421SpironolactoneNot AvailableWithdrawn2
DB00624TestosteroneNot AvailableTerminated1
DB00152ThiamineNot AvailableCompleted1
DB06212TolvaptanNot AvailableActive Not Recruiting1
DB09270UbidecarenoneNot AvailableUnknown Status1