Bile salt export pump
Details
- Name
- Bile salt export pump
- Synonyms
- ATP-binding cassette sub-family B member 11
- BSEP
- Gene Name
- ABCB11
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010492|Bile salt export pump MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQLFRFSSSTDIW LMFVGSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQIPGKACVNNTIVWTNSSLN QNMTNGTRCGLLNIESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFR RIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWK LTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKRE VERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLV QIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEI EFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVT VDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNF IMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEV LSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQG NQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKST YEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQIL GTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAML GQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKL SLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFI EALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRV ISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDF VDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMID GHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDF VMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVA LDKAREGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTTGSPI S
- Number of residues
- 1321
- Molecular Weight
- 146405.83
- Theoretical pI
- 6.52
- GO Classification
- FunctionsATP binding / bile acid-exporting ATPase activity / canalicular bile acid transmembrane transporter activity / sodium-exporting ATPase activity, phosphorylative mechanism / transporter activityProcessesbile acid and bile salt transport / bile acid biosynthetic process / bile acid metabolic process / canalicular bile acid transport / small molecule metabolic process / sodium ion transmembrane transport / transportComponentsapical part of cell / extracellular exosome / integral component of plasma membrane / intercellular canaliculus / membrane / plasma membrane
- General Function
- Transporter activity
- Specific Function
- Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
- Pfam Domain Function
- Transmembrane Regions
- 63-83 148-168 216-236 241-261 320-340 354-374 756-776 795-815 870-890 891-911 980-1000 1012-1032
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0010493|Bile salt export pump (ABCB11) ATGTCTGACTCAGTAATTCTTCGAAGTATAAAGAAATTTGGAGAGGAGAATGATGGTTTT GAGTCAGATAAATCATATAATAATGATAAGAAATCAAGGTTACAAGATGAGAAGAAAGGT GATGGCGTTAGAGTTGGCTTCTTTCAATTGTTTCGGTTTTCTTCATCAACTGACATTTGG CTGATGTTTGTGGGAAGTTTGTGTGCATTTCTCCATGGAATAGCCCAGCCAGGCGTGCTA CTCATTTTTGGCACAATGACAGATGTTTTTATTGACTACGACGTTGAGTTACAAGAACTC CAGATTCCAGGAAAAGCATGTGTGAATAACACCATTGTATGGACTAACAGTTCCCTCAAC CAGAACATGACAAATGGAACACGTTGTGGGTTGCTGAACATCGAGAGCGAAATGATCAAA TTTGCCAGTTACTATGCTGGAATTGCTGTCGCAGTACTTATCACAGGATATATTCAAATA TGCTTTTGGGTCATTGCCGCAGCTCGTCAGATACAGAAAATGAGAAAATTTTACTTTAGG AGAATAATGAGAATGGAAATAGGGTGGTTTGACTGCAATTCAGTGGGGGAGCTGAATACA AGATTCTCTGATGATATTAATAAAATCAATGATGCCATAGCTGACCAAATGGCCCTTTTC ATTCAGCGCATGACCTCGACCATCTGTGGTTTCCTGTTGGGATTTTTCAGGGGTTGGAAA CTGACCTTGGTTATTATTTCTGTCAGCCCTCTCATTGGGATTGGAGCAGCCACCATTGGT CTGAGTGTGTCCAAGTTTACGGACTATGAGCTGAAGGCCTATGCCAAAGCAGGGGTGGTG GCTGATGAAGTCATTTCATCAATGAGAACAGTGGCTGCTTTTGGTGGTGAGAAAAGAGAG GTTGAAAGGTATGAGAAAAATCTTGTGTTCGCCCAGCGTTGGGGAATTAGAAAAGGAATA GTGATGGGATTCTTTACTGGATTCGTGTGGTGTCTCATCTTTTTGTGTTATGCACTGGCC TTCTGGTACGGCTCCACACTTGTCCTGGATGAAGGAGAATATACACCAGGAACCCTTGTC CAGATTTTCCTCAGTGTCATAGTAGGAGCTTTAAATCTTGGCAATGCCTCTCCTTGTTTG GAAGCCTTTGCAACTGGACGTGCAGCAGCCACCAGCATTTTTGAGACAATAGACAGGAAA CCCATCATTGACTGCATGTCAGAAGATGGTTACAAGTTGGATCGAATCAAGGGTGAAATT GAATTCCATAATGTGACCTTCCATTATCCTTCCAGACCAGAGGTGAAGATTCTAAATGAC CTCAACATGGTCATTAAACCAGGGGAAATGACAGCTCTGGTAGGACCCAGTGGAGCTGGA AAAAGTACAGCACTGCAACTCATTCAGCGATTCTATGACCCCTGTGAAGGAATGGTGACC GTGGATGGCCATGACATTCGCTCTCTTAACATTCAGTGGCTTAGAGATCAGATTGGGATA GTGGAGCAAGAGCCAGTTCTGTTCTCTACCACCATTGCAGAAAATATTCGCTATGGCAGA GAAGATGCAACAATGGAAGACATAGTCCAAGCTGCCAAGGAGGCCAATGCCTACAACTTC ATCATGGACCTGCCACAGCAATTTGACACCCTTGTTGGAGAAGGAGGAGGCCAGATGAGT GGTGGCCAGAAACAAAGGGTAGCTATCGCCAGAGCCCTCATCCGAAATCCCAAGATTCTG CTTTTGGACATGGCCACCTCAGCTCTGGACAATGAGAGTGAAGCCATGGTGCAAGAAGTG CTGAGTAAGATTCAGCATGGGCACACAATCATTTCAGTTGCTCATCGCTTGTCTACGGTC AGAGCTGCAGATACCATCATTGGTTTTGAACATGGCACTGCAGTGGAAAGAGGGACCCAT GAAGAATTACTGGAAAGGAAAGGTGTTTACTTCACTCTAGTGACTTTGCAAAGCCAGGGA AATCAAGCTCTTAATGAAGAGGACATAAAGGATGCAACTGAAGATGACATGCTTGCGAGG ACCTTTAGCAGAGGGAGCTACCAGGATAGTTTAAGGGCTTCCATCCGGCAACGCTCCAAG TCTCAGCTTTCTTACCTGGTGCACGAACCTCCATTAGCTGTTGTAGATCATAAGTCTACC TATGAAGAAGATAGAAAGGACAAGGACATTCCTGTGCAGGAAGAAGTTGAACCTGCCCCA GTTAGGAGGATTCTGAAATTCAGTGCTCCAGAATGGCCCTACATGCTGGTAGGGTCTGTG GGTGCAGCTGTGAACGGGACAGTCACACCCTTGTATGCCTTTTTATTCAGCCAGATTCTT GGGACTTTTTCAATTCCTGATAAAGAGGAACAAAGGTCACAGATCAATGGTGTGTGCCTA CTTTTTGTAGCAATGGGCTGTGTATCTCTTTTCACCCAATTTCTACAGGGATATGCCTTT GCTAAATCTGGGGAGCTCCTAACAAAAAGGCTACGTAAATTTGGTTTCAGGGCAATGCTG GGGCAAGATATTGCCTGGTTTGATGACCTCAGAAATAGCCCTGGAGCATTGACAACAAGA CTTGCTACAGATGCTTCCCAAGTTCAAGGGGCTGCCGGCTCTCAGATCGGGATGATAGTC AATTCCTTCACTAACGTCACTGTGGCCATGATCATTGCCTTCTCCTTTAGCTGGAAGCTG AGCCTGGTCATCTTGTGCTTCTTCCCCTTCTTGGCTTTATCAGGAGCCACACAGACCAGG ATGTTGACAGGATTTGCCTCTCGAGATAAGCAGGCCCTGGAGATGGTGGGACAGATTACA AATGAAGCCCTCAGTAACATCCGCACTGTTGCTGGAATTGGAAAGGAGAGGCGGTTCATT GAAGCACTTGAGACTGAGCTGGAGAAGCCCTTCAAGACAGCCATTCAGAAAGCCAATATT TACGGATTCTGCTTTGCCTTTGCCCAGTGCATCATGTTTATTGCGAATTCTGCTTCCTAC AGATATGGAGGTTACTTAATCTCCAATGAGGGGCTCCATTTCAGCTATGTGTTCAGGGTG ATCTCTGCAGTTGTACTGAGTGCAACAGCTCTTGGAAGAGCCTTCTCTTACACCCCAAGT TATGCAAAAGCTAAAATATCAGCTGCACGCTTTTTTCAACTGCTGGACCGACAACCCCCA ATCAGTGTATACAATACTGCAGGTGAAAAATGGGACAACTTCCAGGGGAAGATTGATTTT GTTGATTGTAAATTTACATATCCTTCTCGACCTGACTCGCAAGTTCTGAATGGTCTCTCA GTGTCGATTAGTCCAGGGCAGACACTGGCGTTTGTTGGGAGCAGTGGATGTGGCAAAAGC ACTAGCATTCAGCTGTTGGAACGTTTCTATGATCCTGATCAAGGGAAGGTGATGATAGAT GGTCATGACAGCAAAAAAGTAAATGTCCAGTTCCTCCGCTCAAACATTGGAATTGTTTCC CAGGAACCAGTGTTGTTTGCCTGTAGCATAATGGACAATATCAAGTATGGAGACAACACC AAAGAAATTCCCATGGAAAGAGTCATAGCAGCTGCAAAACAGGCTCAGCTGCATGATTTT GTCATGTCACTCCCAGAGAAATATGAAACTAACGTTGGGTCCCAGGGGTCTCAACTCTCT AGAGGGGAGAAACAACGCATTGCTATTGCTCGGGCCATTGTACGAGATCCTAAAATCTTG CTACTAGATGAAGCCACTTCTGCCTTAGACACAGAAAGTGAAAAGACGGTGCAGGTTGCT CTAGACAAAGCCAGAGAGGGTCGGACCTGCATTGTCATTGCCCATCGCTTGTCCACCATC CAGAACGCGGATATCATTGCTGTCATGGCACAGGGGGTGGTGATTGAAAAGGGGACCCAT GAAGAACTGATGGCCCAAAAAGGAGCCTACTACAAACTAGTCACCACTGGATCCCCCATC AGTTGA
- Chromosome Location
- 2
- Locus
- 2q24
- External Identifiers
Resource Link UniProtKB ID O95342 UniProtKB Entry Name ABCBB_HUMAN GenBank Protein ID 3873243 GenBank Gene ID AF091582 GenAtlas ID ABCB11 HGNC ID HGNC:42 - General References
- Strautnieks SS, Bull LN, Knisely AS, Kocoshis SA, Dahl N, Arnell H, Sokal E, Dahan K, Childs S, Ling V, Tanner MS, Kagalwalla AF, Nemeth A, Pawlowska J, Baker A, Mieli-Vergani G, Freimer NB, Gardiner RM, Thompson RJ: A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis. Nat Genet. 1998 Nov;20(3):233-8. [Article]
- Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [Article]
- Mochizuki K, Kagawa T, Numari A, Harris MJ, Itoh J, Watanabe N, Mine T, Arias IM: Two N-linked glycans are required to maintain the transport activity of the bile salt export pump (ABCB11) in MDCK II cells. Am J Physiol Gastrointest Liver Physiol. 2007 Mar;292(3):G818-28. Epub 2006 Nov 2. [Article]
- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
- Jansen PL, Strautnieks SS, Jacquemin E, Hadchouel M, Sokal EM, Hooiveld GJ, Koning JH, De Jager-Krikken A, Kuipers F, Stellaard F, Bijleveld CM, Gouw A, Van Goor H, Thompson RJ, Muller M: Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis. Gastroenterology. 1999 Dec;117(6):1370-9. [Article]
- Saito S, Iida A, Sekine A, Miura Y, Ogawa C, Kawauchi S, Higuchi S, Nakamura Y: Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population. J Hum Genet. 2002;47(1):38-50. [Article]
- Chen HL, Chang PS, Hsu HC, Ni YH, Hsu HY, Lee JH, Jeng YM, Shau WY, Chang MH: FIC1 and BSEP defects in Taiwanese patients with chronic intrahepatic cholestasis with low gamma-glutamyltranspeptidase levels. J Pediatr. 2002 Jan;140(1):119-24. [Article]
- van Mil SW, van der Woerd WL, van der Brugge G, Sturm E, Jansen PL, Bull LN, van den Berg IE, Berger R, Houwen RH, Klomp LW: Benign recurrent intrahepatic cholestasis type 2 is caused by mutations in ABCB11. Gastroenterology. 2004 Aug;127(2):379-84. [Article]
- Pauli-Magnus C, Lang T, Meier Y, Zodan-Marin T, Jung D, Breymann C, Zimmermann R, Kenngott S, Beuers U, Reichel C, Kerb R, Penger A, Meier PJ, Kullak-Ublick GA: Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy. Pharmacogenetics. 2004 Feb;14(2):91-102. [Article]
- Noe J, Kullak-Ublick GA, Jochum W, Stieger B, Kerb R, Haberl M, Mullhaupt B, Meier PJ, Pauli-Magnus C: Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis. J Hepatol. 2005 Sep;43(3):536-43. [Article]
- Lang T, Haberl M, Jung D, Drescher A, Schlagenhaufer R, Keil A, Mornhinweg E, Stieger B, Kullak-Ublick GA, Kerb R: Genetic variability, haplotype structures, and ethnic diversity of hepatic transporters MDR3 (ABCB4) and bile salt export pump (ABCB11). Drug Metab Dispos. 2006 Sep;34(9):1582-99. Epub 2006 Jun 8. [Article]
- Meier Y, Pauli-Magnus C, Zanger UM, Klein K, Schaeffeler E, Nussler AK, Nussler N, Eichelbaum M, Meier PJ, Stieger B: Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver. Hepatology. 2006 Jul;44(1):62-74. [Article]
- Lang C, Meier Y, Stieger B, Beuers U, Lang T, Kerb R, Kullak-Ublick GA, Meier PJ, Pauli-Magnus C: Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury. Pharmacogenet Genomics. 2007 Jan;17(1):47-60. [Article]
- Hu G, He P, Liu Z, Chen Q, Zheng B, Zhang Q: Diagnosis of ABCB11 gene mutations in children with intrahepatic cholestasis using high resolution melting analysis and direct sequencing. Mol Med Rep. 2014 Sep;10(3):1264-74. doi: 10.3892/mmr.2014.2349. Epub 2014 Jun 20. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00171 ATP investigational, nutraceutical unknown Details DB01016 Glyburide approved unknown inhibitor Details DB01586 Ursodeoxycholic acid approved, investigational unknown substrateinhibitorinducer Details DB03619 Deoxycholic acid approved unknown inducer Details DB04348 Taurocholic acid approved, experimental unknown substrateinducer Details DB02659 Cholic Acid approved unknown substrateinhibitorinducer Details DB01234 Dexamethasone approved, investigational, vet_approved unknown inducer Details DB01174 Phenobarbital approved, investigational unknown inducer Details DB00977 Ethinylestradiol approved unknown inhibitor Details DB01045 Rifampicin approved unknown inhibitor Details DB02123 Glycochenodeoxycholic Acid experimental unknown substrateinhibitor Details DB01016 Glyburide approved unknown substrateinhibitor Details DB00091 Cyclosporine approved, investigational, vet_approved unknown substrateinhibitor Details DB00206 Reserpine approved, investigational, withdrawn unknown inhibitor Details DB00570 Vinblastine approved no substrateinhibitor Details DB00396 Progesterone approved, vet_approved unknown inhibitor Details DB01026 Ketoconazole approved, investigational unknown inhibitor Details DB00197 Troglitazone approved, investigational, withdrawn unknown inhibitor Details DB01229 Paclitaxel approved, vet_approved no substrateinhibitor Details DB02703 Fusidic acid approved, investigational unknown inhibitor Details DB00559 Bosentan approved, investigational unknown inhibitor Details DB00997 Doxorubicin approved, investigational unknown substrate Details DB00693 Fluorescein approved unknown substrate Details DB00541 Vincristine approved, investigational unknown substrate Details DB00390 Digoxin approved unknown substrate Details DB00175 Pravastatin approved no substrate Details DB01098 Rosuvastatin approved unknown substrate Details DB06290 Simeprevir approved unknown inhibitor Details DB12070 Letermovir approved, investigational unknown inhibitor Details DB00932 Tipranavir approved, investigational unknown substrateinhibitor Details DB00257 Clotrimazole approved, vet_approved unknown substrateinhibitor Details DB09078 Lenvatinib approved, investigational unknown inhibitor Details DB00966 Telmisartan approved, investigational no substrate Details DB09374 Indocyanine green acid form approved, investigational no substrate Details DB01149 Nefazodone approved, withdrawn no substrate Details DB01232 Saquinavir approved, investigational no substrate Details DB01601 Lopinavir approved no inhibitor Details DB00503 Ritonavir approved, investigational no inhibitor Details DB00834 Mifepristone approved, investigational no substrate Details DB00455 Loratadine approved, investigational unknown substrate Details DB13345 Dihydroergocristine approved, experimental no substrate Details DB12319 Benzbromarone investigational, withdrawn no substrate Details DB00622 Nicardipine approved, investigational no substrate Details DB00227 Lovastatin approved, investigational no substrate Details DB01023 Felodipine approved, investigational no substrate Details DB00255 Diethylstilbestrol approved, investigational, withdrawn no substrate Details DB00678 Losartan approved no substrate Details DB00222 Glimepiride approved no substrate Details DB00822 Disulfiram approved no substrate Details DB00641 Simvastatin approved no substrate Details DB00421 Spironolactone approved no substrate Details DB01076 Atorvastatin approved no substrate Details DB00439 Cerivastatin approved, withdrawn no substrate Details DB00270 Isradipine approved, investigational no substrate Details DB00973 Ezetimibe approved no substrate Details DB00975 Dipyridamole approved no substrate Details DB08860 Pitavastatin approved no substrate Details DB01039 Fenofibrate approved no substrate Details DB01072 Atazanavir approved, investigational no substrate Details DB00912 Repaglinide approved, investigational no substrate Details DB01138 Sulfinpyrazone approved no substrate Details DB00243 Ranolazine approved, investigational no substrate Details DB00412 Rosiglitazone approved, investigational no substrate Details DB00220 Nelfinavir approved no substrate Details DB01222 Budesonide approved no substrate Details DB00224 Indinavir approved no substrate Details DB00482 Celecoxib approved, investigational no inhibitor Details DB00833 Cefaclor approved no substrate Details DB05804 Prasterone sulfate investigational no substrate Details DB00637 Astemizole approved, withdrawn no substrate Details DB01118 Amiodarone approved, investigational no substrateinhibitor Details DB00911 Tinidazole approved, investigational no substrate Details DB12712 Pilsicainide investigational no substrate Details DB00698 Nitrofurantoin approved, vet_approved no substrate Details DB00619 Imatinib approved no substrate Details DB00328 Indomethacin approved, investigational no substrate Details DB00176 Fluvoxamine approved, investigational no substrate Details DB01165 Ofloxacin approved no substrate Details DB01067 Glipizide approved, investigational no substrate Details DB00275 Olmesartan approved, investigational no inhibitor Details DB00335 Atenolol approved no substrate Details DB00625 Efavirenz approved, investigational no substrate Details DB00342 Terfenadine approved, withdrawn no substrate Details DB01211 Clarithromycin approved no substrate Details DB13751 Glycyrrhizic acid approved, experimental no substrate Details DB00572 Atropine approved, vet_approved no substrate Details DB00301 Flucloxacillin approved, investigational no substrate Details DB01054 Nitrendipine approved, investigational no substrate Details DB00199 Erythromycin approved, investigational, vet_approved no substrateinhibitor Details DB00586 Diclofenac approved, vet_approved no substrate Details DB01115 Nifedipine approved no inhibitor Details DB01015 Sulfamethoxazole approved no inhibitor Details DB00788 Naproxen approved, vet_approved no substrate Details DB00477 Chlorpromazine approved, investigational, vet_approved no inhibitor Details DB00501 Cimetidine approved, investigational unknown inhibitor Details DB00908 Quinidine approved, investigational no inhibitor Details DB00675 Tamoxifen approved no inhibitor Details DB14057 Valinomycin experimental no inhibitor Details DB05990 Obeticholic acid approved unknown inhibitorinducer Details DB14761 Remdesivir approved, investigational unknown inhibitor Details DB14649 Dexamethasone acetate approved, investigational, vet_approved unknown inducer Details DB15719 Belantamab mafodotin approved unknown substrate Details DB15822 Pralsetinib approved, investigational no inhibitor Details DB11886 Infigratinib approved, investigational no inhibitor Details DB12151 Brincidofovir approved, investigational no inhibitor Details DB15233 Avapritinib approved, investigational unknown inhibitor Details DB06176 Romidepsin approved, investigational no inhibitor Details DB08834 Tauroursodeoxycholic acid approved, investigational unknown regulator Details DB15133 Tepotinib approved, investigational no inhibitor Details DB05467 Palovarotene approved, investigational no inhibitor Details DB15059 Aprocitentan approved, investigational no inhibitor Details DB12914 Resmetirom approved, investigational unknown inhibitor Details DB14733 Ceftobiprole medocaril approved, experimental, investigational no inhibitor Details DB04918 Ceftobiprole approved, investigational no inhibitor Details