Urinary Tract Infections (UTIs)

Also known as: Urinary Tract Infections / Infections, Urinary Tract / Urinary Tract Infection(UTI) / Urinary Infections / Urinary tract infection / Urinary Tract Infection (UTI) / Urinary Infection / Urinary infection NOS / UTI / Urinary tract infection, site not specified / Urinary tract infection NOS / Infection urinary tract

DrugDrug NameDrug Description
DB01060AmoxicillinA broad-spectrum semisynthetic antibiotic similar to ampicillin except that its resistance to gastric acid permits higher serum levels with oral administration. Amoxicillin is commonly prescribed with clauvanic acid (a beta lactamase inhibitor) as it is susceptible to beta-lacatamase degradation.
DB00415AmpicillinAmpicillin is a semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
DB00572AtropineAn alkaloid, originally from Atropa belladonna, but found in other plants, mainly solanaceae.
DB00355AztreonamA monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
DB01140CefadroxilLong-acting, broad-spectrum, water-soluble, cephalexin derivative.
DB01150CefprozilCefprozil is a cephalosporin antibiotic. It can be used to treat bronchitis, ear infections, skin infections, and other bacterial infections.
DB00438CeftazidimeSemisynthetic, broad-spectrum antibacterial derived from cephaloridine and used especially for Pseudomonas and other gram-negative infections in debilitated patients.
DB01112CefuroximeBroad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus.
DB00618DemeclocyclineA tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
DB00254DoxycyclineDoxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline [FDA label]. This drug is a second-generation tetracycline, exhibiting lesser toxicity than first-generation tetracyclines [A174034]. Doxycycline may be used to treat a wide range of bacterial infections, depending on the results of antibiotic susceptibility testing.
DB01148FlavoxateA drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist. [PubChem]
DB06799MethenamineMethenamine is a heterocyclic organic compound with a cage-like structure similar to adamantane. In salt form it is used for the treatment of urinary tract infection (Example: methenamine hippurate which is the hippuric acid salt of methenamine).
DB01017MinocyclineA tetracycline analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant staphylococcus infections.
DB00698NitrofurantoinA bacteriostatic or bactericidal agent depending on the concentration and susceptibility of the infecting organism. Nitrofurantoin is active against some gram positive organisms such as S. aureus, S. epidermidis, S. saprophyticus, Enterococcus faecalis, S. agalactiae, group D streptococci, viridians streptococci and Corynebacterium. Its spectrum of activity against gram negative organisms includes E. coli, Enterobacter, Neisseria, Salmonella and Shigella. It may be used as an alternative to trimethoprim/sulfamethoxazole for treating urinary tract infections though it may be less effective at eradicating vaginal bacteria. May also be used in females as prophylaxis against recurrent cystitis related to coitus. Nitrofurantoin is highly stable to the development of bacterial resistance, a property thought to be due to its multiplicity of mechanisms of action.
DB01438PhenazopyridineA local anesthetic that has been used in urinary tract disorders. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity.
DB00781Polymyxin BPolymyxin B was discovered in the 1940s[A176429]. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes[A176426]. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic[A176426,FDA Label]. All gram-positive bacteria, fungi, and the gram-negative cocci, are resistant[A176426]. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of _Pseudomonas aeruginosa_[FDA Label]. Polymyxin B has a narrow therapeutic index and so its use is limited and unlikely to be used first line[A176429].
DB01082StreptomycinStreptomycin is an aminoglycoside antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by binding to the 30S ribosomal subunit of susceptible organisms and disrupting the initiation and elongation steps in protein synthesis. It is bactericidal due to effects that are not fully understood.
DB00359SulfadiazineOne of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.
DB00759TetracyclineTetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane causing intracellular components to leak from bacterial cells.
DB00440TrimethoprimTrimethoprim is a pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to pyrimethamine. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by sulfonamides and the trimethoprim-sulfamethoxazole combination is the form most often used. It is sometimes used alone as an antimalarial. Trimethoprim resistance has been reported.
DrugDrug NameTargetType
DB01060AmoxicillinPenicillin-binding protein 1Atarget
DB01060AmoxicillinCytochrome P450 2C19enzyme
DB01060AmoxicillinSolute carrier family 15 member 1transporter
DB01060AmoxicillinSolute carrier family 15 member 2transporter
DB01060AmoxicillinSolute carrier family 22 member 6transporter
DB00415AmpicillinSerum albumincarrier
DB00415AmpicillinSolute carrier family 22 member 5transporter
DB00415AmpicillinSolute carrier family 15 member 1transporter
DB00415AmpicillinSolute carrier family 15 member 2transporter
DB00415AmpicillinPenicillin-binding protein 2atarget
DB00415AmpicillinPenicillin-binding protein 1btarget
DB00415AmpicillinPenicillin-binding protein 3target
DB00415AmpicillinPenicillin-binding protein 1Atarget
DB00415AmpicillinPenicillin-binding protein 2Btarget
DB00415AmpicillinMonocarboxylate transporter 1transporter
DB00415AmpicillinSolute carrier family 15 member 1target
DB00415AmpicillinSolute carrier family 15 member 2target
DB00415AmpicillinAngiopoietin-1 receptortarget
DB00572AtropineMuscarinic acetylcholine receptor M2target
DB00572AtropineMuscarinic acetylcholine receptor M1target
DB00572AtropineMuscarinic acetylcholine receptor M4target
DB00572AtropineMuscarinic acetylcholine receptor M5target
DB00572AtropineMuscarinic acetylcholine receptor M3target
DB00572AtropineGlycine receptor subunit alpha-1target
DB00572AtropineNeuronal acetylcholine receptor subunit alpha-4target
DB00572AtropineNeuronal acetylcholine receptor subunit beta-2target
DB00572AtropineBile salt export pumptransporter
DB00355AztreonamPenicillin-binding protein 3target
DB00355AztreonamBeta-lactamasetarget
DB01140CefadroxilSolute carrier family 22 member 5transporter
DB01140CefadroxilSolute carrier family 15 member 1transporter
DB01140CefadroxilSolute carrier family 15 member 2transporter
DB01140CefadroxilSolute carrier family 22 member 6transporter
DB01140CefadroxilSolute carrier family 22 member 8transporter
DB01140CefadroxilPenicillin-binding protein 3target
DB01140CefadroxilPenicillin-binding protein 1Atarget
DB01140CefadroxilPenicillin-binding protein 1btarget
DB01140CefadroxilPenicillin-binding protein 2Btarget
DB01150CefprozilPenicillin-binding protein 1Atarget
DB01150CefprozilPenicillin-binding protein 2xtarget
DB01150CefprozilPenicillin-binding protein 2Btarget
DB00438CeftazidimeSolute carrier family 22 member 5transporter
DB00438CeftazidimeSolute carrier family 15 member 1transporter
DB00438CeftazidimeSolute carrier family 15 member 2transporter
DB00438CeftazidimeSolute carrier family 22 member 6transporter
DB00438CeftazidimePeptidoglycan synthase FtsItarget
DB00438CeftazidimePenicillin-binding protein 3target
DB00438CeftazidimePenicillin-binding protein 1Atarget
DB00438CeftazidimePenicillin-binding protein 1Atarget
DB00438CeftazidimePenicillin-binding protein 1Btarget
DB00438CeftazidimePenicillin-binding protein 1Btarget
DB00438CeftazidimePenicillin-binding protein 2target
DB00438CeftazidimePenicillin-binding protein 2target
DB00438CeftazidimeD-alanyl-D-alanine endopeptidasetarget
DB01112CefuroximePenicillin-binding protein 1Atarget
DB01112CefuroximeSolute carrier family 15 member 1transporter
DB01112CefuroximeSolute carrier family 15 member 2transporter
DB00618Demeclocycline30S ribosomal protein S4target
DB00618Demeclocycline30S ribosomal protein S9target
DB00254Doxycycline16S rRNAtarget
DB00254DoxycyclineSolute carrier family 22 member 6transporter
DB00254DoxycyclineCytochrome P450 3A4enzyme
DB00254DoxycyclineATP-binding cassette sub-family B member 5transporter
DB01148FlavoxateMuscarinic acetylcholine receptor M1target
DB01148FlavoxateMuscarinic acetylcholine receptor M2target
DB01017Minocycline30S ribosomal protein S4target
DB01017Minocycline30S ribosomal protein S9target
DB01017Minocycline16S rRNAtarget
DB01017MinocyclineInterleukin-1 betatarget
DB01017MinocyclineArachidonate 5-lipoxygenasetarget
DB01017MinocyclineMatrix metalloproteinase-9target
DB01017MinocyclineVascular endothelial growth factor Atarget
DB01017MinocyclineCaspase-1target
DB01017MinocyclineCaspase-3target
DB01017MinocyclineCytochrome ctarget
DB01017MinocyclineSolute carrier family 22 member 6transporter
DB01017MinocyclineSolute carrier family 22 member 8transporter
DB01017MinocyclineSolute carrier family 22 member 11transporter
DB01017MinocyclineSolute carrier family 22 member 7transporter
DB00698Nitrofurantoin30S ribosomal protein S10target
DB00698NitrofurantoinOxygen-insensitive NADPH nitroreductasetarget
DB00698NitrofurantoinProbable pyruvate-flavodoxin oxidoreductasetarget
DB00698NitrofurantoinATP-binding cassette sub-family G member 2transporter
DB00698NitrofurantoinNADPH--cytochrome P450 reductaseenzyme
DB00698NitrofurantoinBile salt export pumptransporter
DB00698NitrofurantoinThyroxine-binding globulincarrier
DB01438PhenazopyridineSodium channel protein type 1 subunit alphatarget
DB00781Polymyxin BBacterial outer membranetarget
DB00781Polymyxin BSolute carrier family 15 member 2transporter
DB01082Streptomycin30S ribosomal protein S12target
DB01082Streptomycin16S rRNAtarget
DB01082StreptomycinSolute carrier family 22 member 6transporter
DB01082StreptomycinProtein-arginine deiminase type-4target
DB00359SulfadiazineCytochrome P450 2C9enzyme
DB00359SulfadiazineDihydropteroate synthetasetarget
DB00359SulfadiazineCytochrome P450 2C8enzyme
DB00359SulfadiazineCytochrome P450 2E1enzyme
DB00359SulfadiazineCytochrome P450 3A4enzyme
DB00759Tetracycline16S rRNAtarget
DB00759TetracyclineMajor prion proteintarget
DB00759TetracyclineSerum albumincarrier
DB00759TetracyclineCytochrome P450 3A4enzyme
DB00759TetracyclineSolute carrier family 22 member 6transporter
DB00759TetracyclineSolute carrier family 22 member 8transporter
DB00759TetracyclineSolute carrier family 22 member 11transporter
DB00759TetracyclineSolute carrier family 22 member 7transporter
DB00759Tetracycline30S ribosomal protein S3target
DB00759Tetracycline30S ribosomal protein S8target
DB00759Tetracycline30S ribosomal protein S19target
DB00759Tetracycline30S ribosomal protein S14target
DB00759Tetracycline30S ribosomal protein S7target
DB00759TetracyclineMultidrug translocase MdfAtarget
DB00759TetracyclineProtein-arginine deiminase type-4target
DB00759TetracyclineSolute carrier organic anion transporter family member 2B1transporter
DB00440TrimethoprimThymidylate synthasetarget
DB00440TrimethoprimDihydrofolate reductasetarget
DB00440TrimethoprimCytochrome P450 2C8enzyme
DB00440TrimethoprimCytochrome P450 3A4enzyme
DB00440TrimethoprimMultidrug resistance protein 1transporter
DB00440TrimethoprimCytochrome P450 2C9enzyme
DB00440TrimethoprimSolute carrier family 22 member 2transporter
DrugDrug NamePhaseStatusCount
DB14322Coconut oil0Terminated1
DB09047Finafloxacin1Completed1
DB00760Meropenem1Completed1
DB09060Avibactam2Completed1
DB00671Cefixime2Recruiting1
DB01329Cefoperazone2Unknown Status1
DB06590Ceftaroline fosamil2Completed1
DB00567Cephalexin2Recruiting1
DB01597Cilastatin2Completed2
DB01597Cilastatin2Terminated1
DB00537Ciprofloxacin2Completed2
DB10631Cranberry2Completed1
DB06211Doripenem2Completed1
DB11744Epetraborole2Terminated1
DB09047Finafloxacin2Completed1
DB00828Fosfomycin2Active Not Recruiting1
DB00828Fosfomycin2Not Yet Recruiting1
DB01598Imipenem2Completed2
DB01598Imipenem2Terminated1
DB00281Lidocaine2Completed1
DB06799Methenamine2Not Yet Recruiting1
DB00698Nitrofurantoin2Completed1
DB11892Prulifloxacin2Unknown Status1
DB12377Relebactam2Completed1
DB09153Sodium chloride2Completed1
DB09324Sulbactam2Unknown Status1
DB01015Sulfamethoxazole2Completed1
DB01015Sulfamethoxazole2Recruiting1
DB11104Sulfur hexafluoride2Completed1
DB00440Trimethoprim2Completed1
DB00440Trimethoprim2Recruiting1
DB00303Ertapenem2 / 3Active Not Recruiting1
DB00798Gentamicin2 / 3Active Not Recruiting1
DB12907Mannose2 / 3Recruiting1
DB13261Sitafloxacin2 / 3Active Not Recruiting1
DB09153Sodium chloride2 / 3Active Not Recruiting1
DB01060Amoxicillin3Recruiting1
DB01066Cefditoren3Completed1
DB01413Cefepime3Not Yet Recruiting1
DB01413Cefepime3Terminated1
DB01212Ceftriaxone3Completed1
DB00537Ciprofloxacin3Completed2
DB00537Ciprofloxacin3Recruiting2
DB00766Clavulanic acid3Recruiting1
DB10631Cranberry3Completed1
DB01234Dexamethasone3Completed1
DB06211Doripenem3Completed1
DB00303Ertapenem3Completed2
DB00303Ertapenem3Recruiting2
DB00303Ertapenem3Terminated1
DB00783Estradiol3Terminated1
DB00898Ethanol3Withdrawn1
DB11935Flomoxef3Terminated1
DB01137Levofloxacin3Completed3
DB00760Meropenem3Not Yet Recruiting1
DB00760Meropenem3Terminated1
DB00959Methylprednisolone3Unknown Status1
DB01438Phenazopyridine3Completed1
DB00319Piperacillin3Recruiting1
DB00860Prednisolone3Completed1
DB01032Probenecid3Recruiting2
DB01015Sulfamethoxazole3Completed1
DB00706Tamsulosin3Completed1
DB01606Tazobactam3Recruiting1
DB12343Temocillin3Recruiting1
DB08604Triclosan3Withdrawn1
DB00440Trimethoprim3Completed1
DB00415Ampicillin4Active Not Recruiting1
DB00126Ascorbic acid4Terminated1
DB00493Cefotaxime4Recruiting1
DB01331Cefoxitin4Terminated1
DB01212Ceftriaxone4Active Not Recruiting1
DB00878Chlorhexidine4Unknown Status1
DB00537Ciprofloxacin4Completed8
DB10631Cranberry4Withdrawn1
DB00586Diclofenac4Terminated1
DB06211Doripenem4Completed3
DB00303Ertapenem4Not Yet Recruiting1
DB00828Fosfomycin4Active Not Recruiting1
DB00828Fosfomycin4Completed2
DB00828Fosfomycin4Recruiting2
DB00798Gentamicin4Active Not Recruiting1
DB00798Gentamicin4Recruiting2
DB08818Hyaluronic acid4Withdrawn1
DB01050Ibuprofen4Completed1
DB01598Imipenem4Terminated1
DB04465Lactose4Recruiting1
DB01137Levofloxacin4Completed1
DB01137Levofloxacin4Recruiting2
DB01137Levofloxacin4Unknown Status1
DB12907Mannose4Recruiting1
DB00760Meropenem4Not Yet Recruiting1
DB06799Methenamine4Recruiting1
DB08167Methylthioninium4Recruiting1
DB00698Nitrofurantoin4Active Not Recruiting2
DB00698Nitrofurantoin4Completed2
DB00698Nitrofurantoin4Recruiting1
DB01059Norfloxacin4Not Yet Recruiting1
DB01059Norfloxacin4Terminated1
DB01165Ofloxacin4Completed1
DB00319Piperacillin4Completed1
DB00319Piperacillin4Unknown Status1
DB01605Pivmecillinam4Recruiting1
DB06812Povidone-iodine4Terminated1
DB06812Povidone-iodine4Unknown Status1
DB01591Solifenacin4Unknown Status1
DB09324Sulbactam4Unknown Status1
DB01015Sulfamethoxazole4Completed1
DB01015Sulfamethoxazole4Recruiting1
DB01606Tazobactam4Completed1
DB12343Temocillin4Active Not Recruiting1
DB12343Temocillin4Recruiting2
DB12343Temocillin4Withdrawn1
DB00440Trimethoprim4Completed1
DB00440Trimethoprim4Recruiting1
DB00512Vancomycin4Active Not Recruiting1
DB00802AlfentanilNot AvailableRecruiting1
DB00479AmikacinNot AvailableRecruiting1
DB00513Aminocaproic AcidNot AvailableRecruiting1
DB01060AmoxicillinNot AvailableCompleted1
DB00415AmpicillinNot AvailableRecruiting1
DB00415AmpicillinNot AvailableUnknown Status1
DB00207AzithromycinNot AvailableCompleted1
DB00559BosentanNot AvailableRecruiting1
DB01413CefepimeNot AvailableRecruiting1
DB01416CefpodoximeNot AvailableCompleted1
DB00369CidofovirNot AvailableRecruiting1
DB00537CiprofloxacinNot AvailableActive Not Recruiting1
DB00537CiprofloxacinNot AvailableCompleted1
DB00537CiprofloxacinNot AvailableRecruiting1
DB00537CiprofloxacinNot AvailableTerminated1
DB00363ClozapineNot AvailableRecruiting1
DB00286Conjugated estrogensNot AvailableUnknown Status1
DB10631CranberryNot AvailableRecruiting1
DB00303ErtapenemNot AvailableUnknown Status1
DB00828FosfomycinNot AvailableActive Not Recruiting1
DB00828FosfomycinNot AvailableRecruiting2
DB00798GentamicinNot AvailableRecruiting1
DB00502HaloperidolNot AvailableRecruiting1
DB00598LabetalolNot AvailableRecruiting1
DB14224Lactobacillus reuteriNot AvailableCompleted1
DB01137LevofloxacinNot AvailableUnknown Status1
DB08815LurasidoneNot AvailableRecruiting1
DB06799MethenamineNot AvailableActive Not Recruiting1
DB00959MethylprednisoloneNot AvailableRecruiting1
DB01618MolindoneNot AvailableRecruiting1
DB00607NafcillinNot AvailableRecruiting1
DB00994NeomycinNot AvailableUnknown Status1
DB01115NifedipineNot AvailableRecruiting1
DB00698NitrofurantoinNot AvailableRecruiting1
DB00698NitrofurantoinNot AvailableTerminated1
DB00497OxycodoneNot AvailableRecruiting1
DB00312PentobarbitalNot AvailableRecruiting1
DB00728RocuroniumNot AvailableRecruiting1
DB00658SevelamerNot AvailableRecruiting1
DB00421SpironolactoneNot AvailableRecruiting1
DB01015SulfamethoxazoleNot AvailableActive Not Recruiting1
DB01015SulfamethoxazoleNot AvailableUnknown Status1
DB00684TobramycinNot AvailableRecruiting1
DB00302Tranexamic acidNot AvailableRecruiting1
DB00440TrimethoprimNot AvailableActive Not Recruiting2
DB00440TrimethoprimNot AvailableUnknown Status1
DB00512VancomycinNot AvailableRecruiting1
DB01339VecuroniumNot AvailableRecruiting1
DB00682WarfarinNot AvailableRecruiting1
DB00246ZiprasidoneNot AvailableRecruiting1
DB00425ZolpidemNot AvailableRecruiting1