Schizoaffective Disorders

Also known as: Schizoaffective disorder / Schizophrenia schizoaffective / Schizoaffective psychosis / Schizo-affective type schizophrenia

DrugDrug NameDrug Description
DB00363ClozapineA tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent. [PubChem]
DB01267PaliperidonePaliperidone is the primary active metabolite of the older antipsychotic risperidone. While its specific mechanism of action is unknown, it is believed that paliperidone and risperidone act via similar if not the same pathways. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism. Paliperidone is also active as an antagonist at alpha 1 and alpha 2 adrenergic receptors and H1 histaminergic receptors, which may explain some of the other effects of the drug. Paliperidone was approved by the FDA for treatment of schizophrenia on December 20, 2006.
DrugDrug NameTargetType
DB00363ClozapineD(4) dopamine receptortarget
DB00363ClozapineHistamine H1 receptortarget
DB00363ClozapineD(2) dopamine receptortarget
DB00363ClozapineNeuron-specific vesicular protein calcyontarget
DB00363ClozapineHistamine H4 receptortarget
DB00363Clozapine5-hydroxytryptamine receptor 2Atarget
DB00363Clozapine5-hydroxytryptamine receptor 1Atarget
DB00363Clozapine5-hydroxytryptamine receptor 2Ctarget
DB00363ClozapineD(1A) dopamine receptortarget
DB00363ClozapineCytochrome P450 1A2enzyme
DB00363ClozapineCytochrome P450 2D6enzyme
DB00363ClozapineD(3) dopamine receptortarget
DB00363ClozapineMuscarinic acetylcholine receptor M1target
DB00363ClozapineMuscarinic acetylcholine receptor M2target
DB00363ClozapineMuscarinic acetylcholine receptor M3target
DB00363ClozapineMuscarinic acetylcholine receptor M4target
DB00363ClozapineMuscarinic acetylcholine receptor M5target
DB00363Clozapine5-hydroxytryptamine receptor 1Btarget
DB00363Clozapine5-hydroxytryptamine receptor 1Dtarget
DB00363Clozapine5-hydroxytryptamine receptor 1Etarget
DB00363Clozapine5-hydroxytryptamine receptor 3Atarget
DB00363Clozapine5-hydroxytryptamine receptor 6target
DB00363Clozapine5-hydroxytryptamine receptor 7target
DB00363ClozapineAlpha-1A adrenergic receptortarget
DB00363ClozapineAlpha-1B adrenergic receptortarget
DB00363ClozapineAlpha-2A adrenergic receptortarget
DB00363ClozapineAlpha-2B adrenergic receptortarget
DB00363ClozapineAlpha-2C adrenergic receptortarget
DB00363ClozapineCytochrome P450 2C9enzyme
DB00363ClozapineMultidrug resistance protein 1transporter
DB00363ClozapineCytochrome P450 3A4enzyme
DB00363ClozapineCytochrome P450 2C19enzyme
DB00363ClozapineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00363ClozapineUDP-glucuronosyltransferase 1-4enzyme
DB00363ClozapineCytochrome P450 1A1enzyme
DB00363ClozapineCytochrome P450 1B1enzyme
DB00363ClozapineCytochrome P450 2A6enzyme
DB00363ClozapineCytochrome P450 2C8enzyme
DB00363ClozapineCytochrome P450 2E1enzyme
DB00363ClozapineGlutathione S-transferase Ptarget
DB01267PaliperidoneD(2) dopamine receptortarget
DB01267Paliperidone5-hydroxytryptamine receptor 2Atarget
DB01267PaliperidoneHistamine H1 receptortarget
DB01267PaliperidoneAlpha-1A adrenergic receptortarget
DB01267PaliperidoneAlpha-1B adrenergic receptortarget
DB01267PaliperidoneD(3) dopamine receptortarget
DB01267PaliperidoneD(4) dopamine receptortarget
DB01267PaliperidoneD(1A) dopamine receptortarget
DB01267PaliperidoneAlpha-2A adrenergic receptortarget
DB01267PaliperidoneAlpha-2B adrenergic receptortarget
DB01267PaliperidoneAlpha-2C adrenergic receptortarget
DB01267Paliperidone5-hydroxytryptamine receptor 1Atarget
DB01267Paliperidone5-hydroxytryptamine receptor 1Dtarget
DB01267Paliperidone5-hydroxytryptamine receptor 2Ctarget
DB01267PaliperidoneCytochrome P450 3A4target
DB01267PaliperidoneCytochrome P450 2D6target
DB01267PaliperidoneCytochrome P450 3A5target
DB01267Paliperidone5-hydroxytryptamine receptor 7target
DrugDrug NamePhaseStatusCount
DB00915Amantadine1Completed1
DB01238Aripiprazole1Completed1
DB09128Brexpiprazole1Completed1
DB00470Dronabinol1Completed1
DB11726Encenicline1Completed1
DB00563Methotrexate1Completed1
DB01017Minocycline1Recruiting1
DB00745Modafinil1Completed1
DB00218Moxifloxacin1Completed1
DB00334Olanzapine1Completed2
DB00904Ondansetron1Unknown Status1
DB01267Paliperidone1Completed2
DB01224Quetiapine1Recruiting1
DB00734Risperidone1Completed4
DB00641Simvastatin1Unknown Status1
DB01212Ceftriaxone1 / 2Unknown Status1
DB00169Cholecalciferol1 / 2Suspended1
DB00115Cyanocobalamin1 / 2Suspended1
DB00158Folic Acid1 / 2Suspended1
DB01404Ginseng1 / 2Completed1
DB02701Nicotinamide1 / 2Suspended1
DB00165Pyridoxine1 / 2Suspended1
DB00140Riboflavin1 / 2Suspended1
DB00360Sapropterin1 / 2Suspended1
DB00152Thiamine1 / 2Suspended1
DB00162Vitamin A1 / 2Suspended1
DB00126Vitamin C1 / 2Suspended1
DB01238Aripiprazole2Completed1
DB01238Aripiprazole2Terminated1
DB05687BL-10202Completed1
DB06698Betahistine2Completed1
DB04888Bifeprunox2Completed3
DB09061Cannabidiol2Completed1
DB09061Cannabidiol2Recruiting1
DB00169Cholecalciferol2Withdrawn1
DB03929D-Serine2Completed1
DB03929D-Serine2Unknown Status2
DB00783Estradiol2Completed3
DB05708GTS-212Completed1
DB00674Galantamine2Terminated1
DB10989Hepatitis A Vaccine2Completed1
DB00159Icosapent2Completed1
DB00186Lorazepam2Completed1
DB08815Lurasidone2Completed1
DB00939Meclofenamic acid2Enrolling by Invitation1
DB01043Memantine2Terminated1
DB00334Olanzapine2Terminated2
DB11133Omega-3 fatty acids2Completed1
DB00904Ondansetron2Completed1
DB01267Paliperidone2Completed1
DB01267Paliperidone2Terminated1
DB00652Pentazocine2Completed1
DB00686Pentosan Polysulfate2Enrolling by Invitation1
DB09286Pipamperone2Completed1
DB00396Progesterone2Completed1
DB01224Quetiapine2Terminated1
DB09226RP50632Completed1
DB00481Raloxifene2Completed1
DB06155Rimonabant2Terminated1
DB00734Risperidone2Completed1
DB00734Risperidone2Terminated1
DB00641Simvastatin2Completed1
DB00675Tamoxifen2Completed1
DB00577Valaciclovir2Unknown Status1
DB01273Varenicline2Completed1
DB00246Ziprasidone2Completed1
DB00260Cycloserine2 / 3Completed1
DB00145Glycine2 / 3Completed1
DB00159Icosapent2 / 3Completed1
DB08887Icosapent ethyl2 / 3Completed1
DB01224Quetiapine2 / 3Completed1
DB00246Ziprasidone2 / 3Completed1
DB00945Acetylsalicylic acid3Unknown Status1
DB00915Amantadine3Completed1
DB01238Aripiprazole3Completed3
DB01238Aripiprazole3Terminated2
DB06216Asenapine3Completed2
DB00307Bexarotene3Withdrawn1
DB03929D-Serine3Completed1
DB03929D-Serine3Unknown Status1
DB05076Fenretinide3Withdrawn1
DB00674Galantamine3Completed1
DB00502Haloperidol3Completed1
DB00186Lorazepam3Completed1
DB08815Lurasidone3Completed1
DB00331Metformin3Completed1
DB01017Minocycline3Unknown Status1
DB00334Olanzapine3Completed5
DB00334Olanzapine3Withdrawn1
DB01267Paliperidone3Completed3
DB00413Pramipexole3Unknown Status1
DB01224Quetiapine3Completed1
DB01224Quetiapine3Terminated1
DB00481Raloxifene3Recruiting1
DB00481Raloxifene3Unknown Status1
DB00734Risperidone3Completed5
DB00734Risperidone3Terminated1
DB00734Risperidone3Unknown Status2
DB00641Simvastatin3Recruiting1
DB00246Ziprasidone3Completed1
DB00246Ziprasidone3Terminated2
DB00909Zonisamide3Completed1
DB00659Acamprosate4Completed1
DB00437Allopurinol4Completed1
DB00915Amantadine4Terminated1
DB06288Amisulpride4Active Not Recruiting1
DB06288Amisulpride4Recruiting1
DB01238Aripiprazole4Completed10
DB01238Aripiprazole4Unknown Status1
DB06413Armodafinil4Completed1
DB00289Atomoxetine4Completed1
DB12401Bromperidol4Active Not Recruiting1
DB01156Bupropion4Completed1
DB00477Chlorpromazine4Recruiting1
DB01068Clonazepam4Withdrawn1
DB00363Clozapine4Completed4
DB00363Clozapine4Recruiting1
DB00260Cycloserine4Recruiting1
DB00843Donepezil4Unknown Status1
DB01175Escitalopram4Completed1
DB01276Exenatide4Recruiting1
DB00623Fluphenazine4Active Not Recruiting1
DB04842Fluspirilene4Active Not Recruiting1
DB00674Galantamine4Completed2
DB01018Guanfacine4Unknown Status1
DB00502Haloperidol4Active Not Recruiting1
DB00502Haloperidol4Completed4
DB04946Iloperidone4Terminated1
DB04465Lactose4Recruiting2
DB01356Lithium4Recruiting1
DB04871Lorcaserin4Recruiting1
DB00678Losartan4Recruiting1
DB08815Lurasidone4Completed1
DB01065Melatonin4Completed1
DB00331Metformin4Completed1
DB00331Metformin4Recruiting1
DB00331Metformin4Withdrawn1
DB01017Minocycline4Completed1
DB00745Modafinil4Completed1
DB00745Modafinil4Unknown Status1
DB00704Naltrexone4Completed1
DB00184Nicotine4Completed2
DB00334Olanzapine4Active Not Recruiting1
DB00334Olanzapine4Completed13
DB00334Olanzapine4Recruiting2
DB00334Olanzapine4Withdrawn1
DB11133Omega-3 fatty acids4Completed1
DB09539Omega-3-acid ethyl esters4Completed1
DB01267Paliperidone4Active Not Recruiting1
DB01267Paliperidone4Completed3
DB01267Paliperidone4Recruiting1
DB00850Perphenazine4Active Not Recruiting1
DB00850Perphenazine4Completed1
DB01100Pimozide4Active Not Recruiting1
DB01278Pramlintide4Completed1
DB00175Pravastatin4Completed2
DB00860Prednisolone4Recruiting1
DB01224Quetiapine4Active Not Recruiting1
DB01224Quetiapine4Completed8
DB01224Quetiapine4Terminated1
DB00481Raloxifene4Completed1
DB00481Raloxifene4Recruiting2
DB00980Ramelteon4Completed1
DB00734Risperidone4Active Not Recruiting1
DB00734Risperidone4Completed13
DB00734Risperidone4Unknown Status1
DB01399Salsalate4Completed1
DB06144Sertindole4Active Not Recruiting1
DB00641Simvastatin4Recruiting1
DB00641Simvastatin4Withdrawn1
DB00391Sulpiride4Active Not Recruiting1
DB00966Telmisartan4Completed1
DB00679Thioridazine4Active Not Recruiting1
DB06273Tocilizumab4Completed1
DB00313Valproic Acid4Completed1
DB01273Varenicline4Completed1
DB01273Varenicline4Terminated1
DB01273Varenicline4Unknown Status1
DB00246Ziprasidone4Active Not Recruiting1
DB00246Ziprasidone4Completed8
DB01624Zuclopenthixol4Active Not Recruiting1
DB06288AmisulprideNot AvailableCompleted1
DB01238AripiprazoleNot AvailableCompleted2
DB01238AripiprazoleNot AvailableTerminated2
DB00245BenzatropineNot AvailableTerminated1
DB12537BenzodiazepineNot AvailableActive Not Recruiting1
DB11695CarnosineNot AvailableCompleted1
DB01178ChlormezanoneNot AvailableCompleted1
DB00477ChlorpromazineNot AvailableCompleted1
DB01239ChlorprothixeneNot AvailableCompleted1
DB00363ClozapineNot AvailableCompleted1
DB00363ClozapineNot AvailableUnknown Status1
DB00975DipyridamoleNot AvailableCompleted1
DB00153ErgocalciferolNot AvailableCompleted1
DB00402EszopicloneNot AvailableCompleted1
DB00875FlupentixolNot AvailableCompleted1
DB00623FluphenazineNot AvailableCompleted1
DB04842FluspirileneNot AvailableCompleted1
DB00502HaloperidolNot AvailableCompleted2
DB00270IsradipineNot AvailableRecruiting1
DB00408LoxapineNot AvailableCompleted1
DB01065MelatoninNot AvailableActive Not Recruiting1
DB00933MesoridazineNot AvailableCompleted1
DB01403MethotrimeprazineNot AvailableCompleted1
DB00704NaltrexoneNot AvailableActive Not Recruiting1
DB00704NaltrexoneNot AvailableCompleted1
DB00184NicotineNot AvailableCompleted1
DB00334OlanzapineNot AvailableActive Not Recruiting1
DB00334OlanzapineNot AvailableCompleted3
DB00334OlanzapineNot AvailableUnknown Status1
DB11133Omega-3 fatty acidsNot AvailableCompleted1
DB00107OxytocinNot AvailableCompleted1
DB01267PaliperidoneNot AvailableCompleted1
DB00850PerphenazineNot AvailableCompleted1
DB01100PimozideNot AvailableCompleted1
DB01621PipotiazineNot AvailableCompleted1
DB01224QuetiapineNot AvailableCompleted3
DB00734RisperidoneNot AvailableCompleted4
DB00734RisperidoneNot AvailableRecruiting2
DB00734RisperidoneNot AvailableSuspended1
DB00734RisperidoneNot AvailableTerminated3
DB00444TeniposideNot AvailableActive Not Recruiting1
DB04844TetrabenazineNot AvailableCompleted2
DB01622ThioproperazineNot AvailableCompleted1
DB00679ThioridazineNot AvailableCompleted1
DB01623ThiothixeneNot AvailableCompleted1
DB00831TrifluoperazineNot AvailableCompleted1
DB00246ZiprasidoneNot AvailableCompleted2
DB01624ZuclopenthixolNot AvailableCompleted1