Post-Operative Nausea and Vomiting (PONV)

Also known as: Postoperative Nausea and Vomit / Postoperative Nausea / Postoperative Nausea and Vomiting / Vomiting Postoperative / Nausea, Postoperative / Post-Operative Nausea and Vomiting / Postoperative Vomiting / Procedural nausea / Vomiting, Postoperative / Post-op vomiting / Post procedural vomiting / Nausea postoperative / Procedural vomiting

DrugDrug NameDrug Description
DB00985DimenhydrinateA medication used to prevent and treat nausea, vomiting, vertigo, and motion sickness.
DB00757DolasetronAn antinauseant and antiemetic used in chemotherapy and postoperatively.
DB01364EphedrineAn alpha and beta-adrenergic agonist used for the management of respiratory conditions related to bronchial asthma, such as wheezing, shortness of breath, and tightness of chest.
DB01233MetoclopramideAn antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying.
DB00904OndansetronA serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively.
DB00377PalonosetronA serotonin antagonist used in the prophylaxis or management of vomiting that results from emetogenic chemotherapy, and for the management of postoperative nausea and vomiting.
DB00747ScopolamineAn anticholinergic used to treat excessive salivation, colicky abdominal pain, bradycardia, diverticulitis, IBS, and motion sickness.
DrugDrug NameTargetType
DB00985DimenhydrinateHistamine H1 receptortarget
DB00757Dolasetron5-hydroxytryptamine receptor 3Atarget
DB00757DolasetronCytochrome P450 3A4enzyme
DB00757DolasetronCytochrome P450 2D6enzyme
DB00757DolasetronCytochrome P450 2C9enzyme
DB01364EphedrineAcetylcholinesterasetarget
DB01364EphedrineAlpha-1A adrenergic receptortarget
DB01364EphedrineSodium-dependent noradrenaline transportertarget
DB01364EphedrineSynaptic vesicular amine transportertarget
DB01364EphedrineCholinesteraseenzyme
DB01233MetoclopramideMuscarinic acetylcholine receptor M1target
DB01233MetoclopramideDopamine D2 receptortarget
DB01233MetoclopramideCytochrome P450 2D6enzyme
DB01233Metoclopramide5-hydroxytryptamine receptor 4target
DB01233Metoclopramide5-hydroxytryptamine receptor 3Atarget
DB01233MetoclopramideCytochrome P450 3A4enzyme
DB01233MetoclopramideCytochrome P450 1A2enzyme
DB01233MetoclopramideP-glycoprotein 1transporter
DB01233MetoclopramideAlpha-1-acid glycoprotein 1carrier
DB00904Ondansetron5-hydroxytryptamine receptor 3Atarget
DB00904OndansetronCytochrome P450 3A4enzyme
DB00904OndansetronCytochrome P450 1A2enzyme
DB00904OndansetronCytochrome P450 2D6enzyme
DB00904OndansetronCytochrome P450 3A5enzyme
DB00904OndansetronCytochrome P450 3A7enzyme
DB00904Ondansetron5-hydroxytryptamine receptor 4target
DB00904Ondansetron5-hydroxytryptamine receptor 1Atarget
DB00904Ondansetron5-hydroxytryptamine receptor 1Btarget
DB00904OndansetronMu-type opioid receptortarget
DB00904OndansetronCytochrome P450 2C9enzyme
DB00904OndansetronCytochrome P450 2E1enzyme
DB00377Palonosetron5-hydroxytryptamine receptor 3Atarget
DB00377PalonosetronCytochrome P450 2D6enzyme
DB00377PalonosetronCytochrome P450 3A4enzyme
DB00377PalonosetronCytochrome P450 1A2enzyme
DB00747ScopolamineMuscarinic acetylcholine receptor M1target
DB00747ScopolamineSucrase-isomaltase, intestinaltarget
DB00747ScopolamineMuscarinic acetylcholine receptor M2target
DB00747ScopolamineMuscarinic acetylcholine receptor M3target
DB00747ScopolamineMuscarinic acetylcholine receptor M4target
DB00747ScopolamineMuscarinic acetylcholine receptor M5target
DB00747ScopolamineP-glycoprotein 1transporter
DB00747ScopolamineNeuronal acetylcholine receptor subunit alpha-4target
DB00747ScopolamineNeuronal acetylcholine receptor subunit beta-2target
DrugDrug NamePhaseStatusCount
DB00673Aprepitant1Completed2
DB06634Casopitant1Completed1
DB00757Dolasetron1Completed1
DB06717Fosaprepitant1Completed1
DB00889Granisetron1Completed1
DB00683Midazolam1Completed1
DB00904Ondansetron1Completed2
DB00412Rosiglitazone1Completed1
DB11949Vestipitant1Completed1
DB00904Ondansetron1 / 2Completed1
DB00316Acetaminophen2Completed1
DB00673Aprepitant2Unknown Status1
DB09020Bisacodyl2Completed1
DB06634Casopitant2Completed1
DB01189Desflurane2Completed1
DB01234Dexamethasone2Completed2
DB01234Dexamethasone2Terminated1
DB01234Dexamethasone2Unknown Status2
DB00985Dimenhydrinate2Completed1
DB00889Granisetron2Completed1
DB00486Nabilone2Completed1
DB00184Nicotine2Terminated1
DB00334Olanzapine2Completed1
DB00904Ondansetron2Completed5
DB00377Palonosetron2Completed1
DB00860Prednisolone2Completed1
DB00818Propofol2Completed1
DB09290Ramosetron2Completed1
DB09290Ramosetron2Unknown Status1
DB09291Rolapitant2Completed1
DB11949Vestipitant2Completed2
DB00316Acetaminophen2 / 3Recruiting1
DB00673Aprepitant2 / 3Completed1
DB00297Bupivacaine2 / 3Recruiting1
DB09061Cannabidiol2 / 3Recruiting1
DB01234Dexamethasone2 / 3Completed1
DB01234Dexamethasone2 / 3Not Yet Recruiting1
DB00633Dexmedetomidine2 / 3Recruiting1
DB00470Dronabinol2 / 3Recruiting1
DB00996Gabapentin2 / 3Completed1
DB00683Midazolam2 / 3Recruiting1
DB00334Olanzapine2 / 3Recruiting1
DB00673Aprepitant3Completed2
DB00443Betamethasone3Completed1
DB00297Bupivacaine3Withdrawn1
DB06634Casopitant3Completed2
DB01234Dexamethasone3Completed4
DB00633Dexmedetomidine3Withdrawn1
DB00450Droperidol3Completed1
DB01009Ketoprofen3Completed1
DB01400Neostigmine3Completed1
DB00904Ondansetron3Completed5
DB00497Oxycodone3Completed1
DB00377Palonosetron3Completed2
DB09290Ramosetron3Completed1
DB00296Ropivacaine3Recruiting1
DB00296Ropivacaine3Withdrawn1
DB06206Sugammadex3Completed1
DB00316Acetaminophen4Completed2
DB00316Acetaminophen4Not Yet Recruiting1
DB00316Acetaminophen4Recruiting1
DB00316Acetaminophen4Terminated1
DB00673Aprepitant4Completed6
DB00673Aprepitant4Recruiting2
DB00673Aprepitant4Terminated1
DB13295Atracurium4Completed1
DB00572Atropine4Completed1
DB00207Azithromycin4Not Yet Recruiting1
DB00083Botulinum toxin type A4Enrolling by Invitation1
DB00297Bupivacaine4Completed1
DB00297Bupivacaine4Recruiting1
DB01189Desflurane4Recruiting1
DB01234Dexamethasone4Completed11
DB01234Dexamethasone4Not Yet Recruiting2
DB01234Dexamethasone4Recruiting6
DB01234Dexamethasone4Terminated1
DB00633Dexmedetomidine4Recruiting1
DB00985Dimenhydrinate4Completed1
DB00450Droperidol4Completed1
DB00813Fentanyl4Recruiting1
DB06717Fosaprepitant4Recruiting1
DB00996Gabapentin4Completed1
DB00986Glycopyrronium4Completed1
DB00889Granisetron4Completed1
DB00889Granisetron4Recruiting1
DB00502Haloperidol4Completed1
DB00956Hydrocodone4Recruiting1
DB00327Hydromorphone4Recruiting1
DB01221Ketamine4Completed2
DB01221Ketamine4Recruiting1
DB01002Levobupivacaine4Completed1
DB00281Lidocaine4Completed3
DB00281Lidocaine4Recruiting1
DB00959Methylprednisolone4Completed2
DB01233Metoclopramide4Completed1
DB01233Metoclopramide4Not Yet Recruiting1
DB01233Metoclopramide4Recruiting1
DB00683Midazolam4Completed1
DB00295Morphine4Completed2
DB01400Neostigmine4Terminated1
DB00904Ondansetron4Completed13
DB00904Ondansetron4Not Yet Recruiting1
DB00904Ondansetron4Recruiting3
DB00497Oxycodone4Recruiting1
DB00377Palonosetron4Completed4
DB12492Piritramide4Completed1
DB00433Prochlorperazine4Recruiting1
DB01069Promethazine4Completed1
DB00818Propofol4Completed2
DB00818Propofol4Recruiting1
DB09290Ramosetron4Completed2
DB09290Ramosetron4Recruiting2
DB09290Ramosetron4Unknown Status1
DB00296Ropivacaine4Completed2
DB00747Scopolamine4Recruiting1
DB01236Sevoflurane4Completed2
DB01236Sevoflurane4Recruiting1
DB09153Sodium chloride4Completed2
DB00708Sufentanil4Completed1
DB06206Sugammadex4Recruiting1
DB06206Sugammadex4Terminated1
DB00193Tramadol4Completed1
DB13453Xenon4Completed1
DB00316AcetaminophenNot AvailableCompleted2
DB00316AcetaminophenNot AvailableRecruiting2
DB00802AlfentanilNot AvailableCompleted1
DB00673AprepitantNot AvailableCompleted3
DB00673AprepitantNot AvailableWithdrawn3
DB13295AtracuriumNot AvailableCompleted1
DB00572AtropineNot AvailableCompleted1
DB00297BupivacaineNot AvailableCompleted1
DB00297BupivacaineNot AvailableRecruiting1
DB00201CaffeineNot AvailableCompleted1
DB01112CefuroximeNot AvailableCompleted1
DB01189DesfluraneNot AvailableCompleted1
DB01234DexamethasoneNot AvailableActive Not Recruiting1
DB01234DexamethasoneNot AvailableCompleted12
DB01234DexamethasoneNot AvailableRecruiting1
DB00633DexmedetomidineNot AvailableCompleted1
DB00633DexmedetomidineNot AvailableRecruiting1
DB00757DolasetronNot AvailableCompleted1
DB00470DronabinolNot AvailableCompleted1
DB00450DroperidolNot AvailableCompleted2
DB00668EpinephrineNot AvailableActive Not Recruiting1
DB00187EsmololNot AvailableCompleted1
DB00927FamotidineNot AvailableActive Not Recruiting1
DB00813FentanylNot AvailableCompleted2
DB00813FentanylNot AvailableRecruiting1
DB00996GabapentinNot AvailableCompleted1
DB00996GabapentinNot AvailableNot Yet Recruiting1
DB00996GabapentinNot AvailableRecruiting1
DB00889GranisetronNot AvailableCompleted1
DB01018GuanfacineNot AvailableCompleted1
DB00502HaloperidolNot AvailableCompleted1
DB00956HydrocodoneNot AvailableCompleted1
DB00327HydromorphoneNot AvailableCompleted1
DB00753IsofluraneNot AvailableCompleted1
DB01221KetamineNot AvailableCompleted1
DB00465KetorolacNot AvailableCompleted1
DB01002LevobupivacaineNot AvailableCompleted1
DB00281LidocaineNot AvailableActive Not Recruiting1
DB00281LidocaineNot AvailableCompleted1
DB00281LidocaineNot AvailableRecruiting2
DB00186LorazepamNot AvailableWithdrawn1
DB00737MeclizineNot AvailableCompleted1
DB00454MeperidineNot AvailableCompleted1
DB04817MetamizoleNot AvailableCompleted1
DB04817MetamizoleNot AvailableRecruiting1
DB00333MethadoneNot AvailableCompleted1
DB01233MetoclopramideNot AvailableCompleted1
DB00683MidazolamNot AvailableCompleted3
DB00683MidazolamNot AvailableRecruiting1
DB00295MorphineNot AvailableCompleted2
DB00844NalbuphineNot AvailableRecruiting1
DB01183NaloxoneNot AvailableCompleted2
DB00184NicotineNot AvailableWithdrawn1
DB00904OndansetronNot AvailableActive Not Recruiting1
DB00904OndansetronNot AvailableCompleted9
DB00904OndansetronNot AvailableRecruiting1
DB00904OndansetronNot AvailableWithdrawn2
DB00497OxycodoneNot AvailableCompleted2
DB01192OxymorphoneNot AvailableCompleted1
DB00377PalonosetronNot AvailableCompleted6
DB00377PalonosetronNot AvailableUnknown Status1
DB00981PhysostigmineNot AvailableUnknown Status1
DB00230PregabalinNot AvailableRecruiting1
DB01069PromethazineNot AvailableActive Not Recruiting1
DB01069PromethazineNot AvailableCompleted1
DB09288PropacetamolNot AvailableCompleted1
DB00807ProparacaineNot AvailableCompleted1
DB00818PropofolNot AvailableCompleted2
DB09290RamosetronNot AvailableCompleted6
DB09290RamosetronNot AvailableNot Yet Recruiting1
DB00863RanitidineNot AvailableCompleted1
DB00899RemifentanilNot AvailableCompleted1
DB00899RemifentanilNot AvailableRecruiting1
DB00296RopivacaineNot AvailableRecruiting1
DB00747ScopolamineNot AvailableCompleted1
DB01236SevofluraneNot AvailableCompleted2
DB09153Sodium chlorideNot AvailableCompleted1
DB09153Sodium chlorideNot AvailableUnknown Status1
DB00708SufentanilNot AvailableCompleted1
DB00193TramadolNot AvailableCompleted1
DB11699TropisetronNot AvailableCompleted2