Pain, Acute

Also known as: Pain Acute / Acute Pain / Pain NOS / Pain finding / Acute pain NOS / Pain

DrugDrug NameDrug Description
DB15465BenzhydrocodoneBenzyhydrocodone is indicated, in combination with acetaminophen, for the short-term management of acute pain requiring opioid therapy.
DB00395CarisoprodolA centrally acting muscle relaxant used to relieve the discomfort associated with various musculoskeletal conditions.
DB00482CelecoxibAn NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis.
DB00749EtodolacAn NSAID used to treat osteoarthritis and rheumatoid arthritis, as well as acute pain.
DB00956HydrocodoneAn opioid agonist used as an analgesic and antitussive agent.
DB01050IbuprofenAn NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation.
DB00328IndomethacinA nonsteroidal anti-inflammatory (NSAID) used for symptomatic management of chronic musculoskeletal pain conditions and to induce closure of a hemodynamically significant patent ductus arteriosus in premature infants.
DB00465KetorolacAn NSAID used to treat moderate to severe pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders, and headaches.
DB00296RopivacaineAn analgesic drug used for local or regional anesthesia for surgery and short-term management of pain.
DB00708SufentanilAn opioid used to induce and maintain anesthesia, to act as an analgesic in labor and delivery, and to treat severe, acute pain.
DB00193TramadolA centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults.
DrugDrug NameTargetType
DB00395CarisoprodolCytochrome P450 2C19enzyme
DB00395CarisoprodolGamma-aminobutyric acid receptor subunit alpha-1target
DB00395CarisoprodolGamma-aminobutyric acid receptor subunit beta-2target
DB00395CarisoprodolGamma-aminobutyric acid receptor subunit gamma-2target
DB00395CarisoprodolGamma-aminobutyric acid receptor subunit alpha-5target
DB00395CarisoprodolGamma-aminobutyric acid receptor subunit alpha-3target
DB00482CelecoxibProstaglandin G/H synthase 2target
DB00482Celecoxib3-phosphoinositide-dependent protein kinase 1target
DB00482CelecoxibCytochrome P450 2C9enzyme
DB00482CelecoxibCytochrome P450 2D6enzyme
DB00482CelecoxibMultidrug resistance-associated protein 4transporter
DB00482CelecoxibCytochrome P450 3A4enzyme
DB00482CelecoxibCytochrome P450 2C8enzyme
DB00482CelecoxibCarbonic anhydrase 2target
DB00482CelecoxibCarbonic anhydrase 3target
DB00482CelecoxibBile salt export pumptransporter
DB00482CelecoxibCadherin-11target
DB00482CelecoxibP-glycoprotein 1transporter
DB00482CelecoxibATP-binding cassette sub-family G member 2transporter
DB00749EtodolacProstaglandin G/H synthase 1target
DB00749EtodolacProstaglandin G/H synthase 2target
DB00749EtodolacCytochrome P450 2C9enzyme
DB00749EtodolacUDP-glucuronosyltransferase 1-9enzyme
DB00749EtodolacRetinoic acid receptor RXR-alphatarget
DB00749EtodolacSerum albumincarrier
DB00749EtodolacSolute carrier family 22 member 6transporter
DB00749EtodolacUDP-glucuronosyltransferase 1-3enzyme
DB00749EtodolacUDP-glucuronosyltransferase 1-10enzyme
DB00749EtodolacUDP-glucuronosyltransferase 2B7enzyme
DB00956HydrocodoneMu-type opioid receptortarget
DB00956HydrocodoneDelta-type opioid receptortarget
DB00956HydrocodoneCytochrome P450 3A4enzyme
DB00956HydrocodoneCytochrome P450 2D6enzyme
DB00956HydrocodoneCytochrome P450 2B6enzyme
DB00956HydrocodoneCytochrome P450 2C19enzyme
DB00956HydrocodoneSigma non-opioid intracellular receptor 1target
DB01050IbuprofenProstaglandin G/H synthase 1target
DB01050IbuprofenProstaglandin G/H synthase 2target
DB01050IbuprofenCytochrome P450 2C9enzyme
DB01050IbuprofenSerum albumincarrier
DB01050IbuprofenMultidrug resistance-associated protein 4transporter
DB01050IbuprofenMultidrug resistance-associated protein 1transporter
DB01050IbuprofenSolute carrier organic anion transporter family member 1A2transporter
DB01050IbuprofenSolute carrier family 22 member 6transporter
DB01050IbuprofenSolute carrier family 22 member 8transporter
DB01050IbuprofenSolute carrier family 22 member 11transporter
DB01050IbuprofenSolute carrier organic anion transporter family member 2B1transporter
DB01050IbuprofenP-glycoprotein 1transporter
DB01050IbuprofenUDP-glucuronosyltransferase 1-3enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 1-9enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 2B4enzyme
DB01050IbuprofenUDP-glucuronosyltransferase 2B7enzyme
DB01050IbuprofenCytochrome P450 2C8enzyme
DB01050IbuprofenCytochrome P450 2C19enzyme
DB01050IbuprofenApoptosis regulator Bcl-2target
DB01050IbuprofenThrombomodulintarget
DB01050IbuprofenFatty acid-binding protein, intestinaltarget
DB01050IbuprofenPeroxisome proliferator-activated receptor gammatarget
DB01050IbuprofenCystic fibrosis transmembrane conductance regulatortarget
DB01050IbuprofenPeroxisome proliferator-activated receptor alphatarget
DB01050IbuprofenPlatelet glycoprotein Ib alpha chaintarget
DB01050IbuprofenProtein S100-A7target
DB01050IbuprofenAlpha-methylacyl-CoA racemaseenzyme
DB01050IbuprofenCytochrome P450 3A4enzyme
DB00328IndomethacinProstaglandin G/H synthase 1target
DB00328IndomethacinProstaglandin G/H synthase 2target
DB00328IndomethacinCytochrome P450 2C19enzyme
DB00328IndomethacinUDP-glucuronosyltransferase 1-9enzyme
DB00328IndomethacinPhospholipase A2, membrane associatedtarget
DB00328IndomethacinProstaglandin reductase 2target
DB00328IndomethacinLactoylglutathione lyasetarget
DB00328IndomethacinProstaglandin D2 receptor 2target
DB00328IndomethacinPeroxisome proliferator-activated receptor gammatarget
DB00328IndomethacinSerum albumincarrier
DB00328IndomethacinCanalicular multispecific organic anion transporter 2transporter
DB00328IndomethacinMultidrug resistance-associated protein 4transporter
DB00328IndomethacinMultidrug resistance-associated protein 6transporter
DB00328IndomethacinP-glycoprotein 1transporter
DB00328IndomethacinMultidrug resistance-associated protein 1transporter
DB00328IndomethacinSolute carrier organic anion transporter family member 1A2transporter
DB00328IndomethacinSolute carrier family 22 member 6transporter
DB00328IndomethacinSolute carrier family 22 member 8transporter
DB00328IndomethacinCanalicular multispecific organic anion transporter 1transporter
DB00328IndomethacinATP-binding cassette sub-family C member 11transporter
DB00328IndomethacinSolute carrier family 22 member 11transporter
DB00328IndomethacinSodium/bile acid cotransportertransporter
DB00328IndomethacinSolute carrier family 22 member 7transporter
DB00328IndomethacinCytochrome P450 2C9enzyme
DB00328IndomethacinUDP-glucuronosyltransferase 1-1enzyme
DB00328IndomethacinLiver carboxylesterase 1enzyme
DB00328IndomethacinUDP-glucuronosyltransferase 2B7enzyme
DB00328IndomethacinPeroxisome proliferator-activated receptor alphatarget
DB00328IndomethacinAldo-keto reductase family 1 member C3target
DB00328IndomethacinSolute carrier organic anion transporter family member 1B1transporter
DB00328IndomethacinBile salt export pumptransporter
DB00465KetorolacProstaglandin G/H synthase 1target
DB00465KetorolacProstaglandin G/H synthase 2target
DB00465KetorolacUDP-glucuronosyltransferase 2B7enzyme
DB00465KetorolacCytochrome P450 2C8enzyme
DB00465KetorolacCytochrome P450 2C9enzyme
DB00296RopivacaineSodium channel protein type 10 subunit alphatarget
DB00296RopivacaineCytochrome P450 1A2enzyme
DB00296RopivacaineCytochrome P450 2B6enzyme
DB00296RopivacaineCytochrome P450 3A4enzyme
DB00708SufentanilMu-type opioid receptortarget
DB00708SufentanilDelta-type opioid receptortarget
DB00708SufentanilKappa-type opioid receptortarget
DB00708SufentanilCytochrome P450 3A4enzyme
DB00193TramadolMu-type opioid receptortarget
DB00193TramadolSodium-dependent noradrenaline transportertarget
DB00193Tramadol5-hydroxytryptamine receptor 2Ctarget
DB00193TramadolKappa-type opioid receptortarget
DB00193TramadolSodium-dependent serotonin transportertarget
DB00193TramadolCytochrome P450 2D6enzyme
DB00193TramadolDelta-type opioid receptortarget
DB00193TramadolCytochrome P450 3A4enzyme
DB00193TramadolCytochrome P450 2B6enzyme
DB00193TramadolAlpha-7 nicotinic cholinergic receptor subunittarget
DB00193TramadolMuscarinic acetylcholine receptor M3target
DB00193TramadolMuscarinic acetylcholine receptor M1target
DB00193TramadolUDP-glucuronosyltransferase 1-1enzyme
DB00193TramadolP-glycoprotein 1transporter
DB00193TramadolNeurokinin 1 receptortarget
DB00193TramadolSodium channel protein type 2 subunit alphatarget
DB00193TramadolTransient receptor potential cation channel subfamily V member 1target
DB00193TramadolNMDA receptortarget
DB00193TramadolAdenosine receptor A1target
DB00193TramadolAlpha-2 adrenergic receptorstarget
DrugDrug NamePhaseStatusCount
DB00996Gabapentin0Completed1
DB00333Methadone0Completed1
DB00295Morphine0Completed1
DB06690Nitrous oxide0Recruiting1
DB00296Ropivacaine0Completed1
DB00316Acetaminophen1Recruiting1
DB00316Acetaminophen1Withdrawn2
DB00297Bupivacaine1Completed1
DB09214Dexketoprofen1Completed1
DB08818Hyaluronic acid1Completed1
DB00956Hydrocodone1Withdrawn2
DB00327Hydromorphone1Completed1
DB00327Hydromorphone1Recruiting1
DB01050Ibuprofen1Completed1
DB01050Ibuprofen1Recruiting1
DB01221Ketamine1Recruiting1
DB00295Morphine1Completed1
DB00788Naproxen1Completed1
DB00497Oxycodone1Completed1
DB00497Oxycodone1Recruiting1
DB12012PF-044578451Completed1
DB00230Pregabalin1Completed1
DB00852Pseudoephedrine1Completed1
DB00575Clonidine1 / 2Completed1
DB00633Dexmedetomidine1 / 2Active Not Recruiting1
DB00813Fentanyl1 / 2Completed1
DB01221Ketamine1 / 2Completed1
DB00295Morphine1 / 2Active Not Recruiting1
DB00295Morphine1 / 2Completed2
DB00388Phenylephrine1 / 2Completed1
DB00899Remifentanil1 / 2Completed1
DB01638Sorbitol1 / 2Completed1
DB05050ADL58592Completed1
DB00316Acetaminophen2Completed1
DB00316Acetaminophen2Recruiting1
DB00297Bupivacaine2Completed1
DB00297Bupivacaine2Recruiting1
DB11131Capsicum oleoresin2Withdrawn1
DB00190Carbidopa2Withdrawn1
DB00482Celecoxib2Completed2
DB11938Difelikefalin2Completed2
DB00813Fentanyl2Not Yet Recruiting1
DB00956Hydrocodone2Completed1
DB00327Hydromorphone2Completed1
DB00327Hydromorphone2Recruiting1
DB01050Ibuprofen2Completed2
DB01221Ketamine2Completed1
DB01221Ketamine2Not Yet Recruiting1
DB01221Ketamine2Recruiting1
DB01235Levodopa2Withdrawn1
DB00825Levomenthol2Withdrawn1
DB00186Lorazepam2Terminated1
DB14009Medical Cannabis2Recruiting1
DB09543Methyl salicylate2Withdrawn1
DB01017Minocycline2Completed1
DB00295Morphine2Completed3
DB00295Morphine2Not Yet Recruiting2
DB01183Naloxone2Recruiting1
DB00788Naproxen2Withdrawn1
DB00497Oxycodone2Completed1
DB00899Remifentanil2Recruiting1
DB00708Sufentanil2Completed1
DB06204Tapentadol2Completed1
DB06264Tolperisone2Completed1
DB00193Tramadol2Completed1
DB00297Bupivacaine2 / 3Completed1
DB00633Dexmedetomidine2 / 3Completed1
DB00586Diclofenac2 / 3Recruiting1
DB11823Esketamine2 / 3Completed1
DB00327Hydromorphone2 / 3Completed1
DB01221Ketamine2 / 3Completed3
DB01221Ketamine2 / 3Not Yet Recruiting1
DB00465Ketorolac2 / 3Recruiting1
DB00281Lidocaine2 / 3Completed1
DB00281Lidocaine2 / 3Enrolling by Invitation1
DB09337Medical air2 / 3Terminated1
DB00683Midazolam2 / 3Not Yet Recruiting1
DB00295Morphine2 / 3Completed1
DB06690Nitrous oxide2 / 3Terminated1
DB03754Tromethamine2 / 3Recruiting1
DB00316Acetaminophen3Completed3
DB00316Acetaminophen3Recruiting1
DB06774Capsaicin3Completed1
DB00482Celecoxib3Completed2
DB00924Cyclobenzaprine3Not Yet Recruiting1
DB09214Dexketoprofen3Completed2
DB00586Diclofenac3Completed5
DB00749Etodolac3Not Yet Recruiting1
DB00813Fentanyl3Recruiting1
DB00327Hydromorphone3Completed2
DB00327Hydromorphone3Recruiting1
DB00327Hydromorphone3Terminated1
DB01050Ibuprofen3Recruiting1
DB01221Ketamine3Not Yet Recruiting1
DB01221Ketamine3Terminated1
DB00281Lidocaine3Completed1
DB00281Lidocaine3Recruiting1
DB01028Methoxyflurane3Recruiting1
DB00295Morphine3Completed4
DB00295Morphine3Not Yet Recruiting1
DB00295Morphine3Recruiting1
DB14881Oliceridine3Completed3
DB01192Oxymorphone3Completed1
DB01192Oxymorphone3Suspended1
DB00230Pregabalin3Enrolling by Invitation1
DB02772Sucrose3Recruiting1
DB00708Sufentanil3Completed1
DB06204Tapentadol3Completed2
DB00193Tramadol3Completed5
DB00316Acetaminophen4Active Not Recruiting1
DB00316Acetaminophen4Completed5
DB00316Acetaminophen4Not Yet Recruiting1
DB00316Acetaminophen4Recruiting2
DB00316Acetaminophen4Withdrawn1
DB06274Alvimopan4Withdrawn1
DB00297Bupivacaine4Active Not Recruiting1
DB00297Bupivacaine4Completed6
DB00297Bupivacaine4Not Yet Recruiting1
DB00297Bupivacaine4Recruiting4
DB00921Buprenorphine4Completed1
DB00921Buprenorphine4Not Yet Recruiting1
DB01234Dexamethasone4Completed1
DB01234Dexamethasone4Not Yet Recruiting1
DB01234Dexamethasone4Recruiting1
DB14649Dexamethasone acetate4Completed1
DB09214Dexketoprofen4Completed1
DB00633Dexmedetomidine4Withdrawn1
DB09341Dextrose, unspecified form4Completed1
DB00476Duloxetine4Enrolling by Invitation1
DB00668Epinephrine4Completed1
DB00668Epinephrine4Recruiting1
DB01628Etoricoxib4Unknown Status1
DB12728Fenpropidin4Recruiting1
DB00813Fentanyl4Completed1
DB00813Fentanyl4Not Yet Recruiting2
DB00813Fentanyl4Recruiting1
DB00813Fentanyl4Terminated1
DB00996Gabapentin4Completed1
DB00996Gabapentin4Not Yet Recruiting1
DB08872Gabapentin enacarbil4Not Yet Recruiting1
DB00327Hydromorphone4Completed3
DB00327Hydromorphone4Not Yet Recruiting1
DB00327Hydromorphone4Withdrawn1
DB01050Ibuprofen4Completed2
DB01050Ibuprofen4Not Yet Recruiting2
DB01050Ibuprofen4Recruiting1
DB01221Ketamine4Active Not Recruiting1
DB01221Ketamine4Completed5
DB01221Ketamine4Not Yet Recruiting1
DB01221Ketamine4Recruiting3
DB01221Ketamine4Terminated1
DB01221Ketamine4Withdrawn1
DB00465Ketorolac4Completed1
DB00465Ketorolac4Recruiting1
DB01002Levobupivacaine4Recruiting1
DB00281Lidocaine4Completed1
DB00281Lidocaine4Recruiting4
DB09337Medical air4Completed1
DB01028Methoxyflurane4Completed2
DB01028Methoxyflurane4Not Yet Recruiting1
DB01028Methoxyflurane4Recruiting1
DB00295Morphine4Active Not Recruiting1
DB00295Morphine4Completed4
DB00295Morphine4Recruiting2
DB00295Morphine4Withdrawn1
DB01183Naloxone4Not Yet Recruiting1
DB06690Nitrous oxide4Completed1
DB00497Oxycodone4Completed2
DB00497Oxycodone4Recruiting1
DB00230Pregabalin4Completed1
DB00750Prilocaine4Recruiting1
DB00818Propofol4Active Not Recruiting1
DB00899Remifentanil4Active Not Recruiting1
DB00533Rofecoxib4Terminated1
DB00296Ropivacaine4Recruiting1
DB00296Ropivacaine4Withdrawn1
DB01236Sevoflurane4Active Not Recruiting1
DB00708Sufentanil4Not Yet Recruiting1
DB00708Sufentanil4Recruiting1
DB06204Tapentadol4Completed1
DB00193Tramadol4Active Not Recruiting1
DB00193Tramadol4Completed1
DB00580Valdecoxib4Terminated1
DB00316AcetaminophenNot AvailableCompleted2
DB00297BupivacaineNot AvailableCompleted1
DB00297BupivacaineNot AvailableRecruiting2
DB00318CodeineNot AvailableTerminated1
DB01234DexamethasoneNot AvailableCompleted1
DB00633DexmedetomidineNot AvailableCompleted1
DB00476DuloxetineNot AvailableNot Yet Recruiting1
DB00476DuloxetineNot AvailableRecruiting2
DB00898EthanolNot AvailableRecruiting1
DB00813FentanylNot AvailableNot Yet Recruiting1
DB00327HydromorphoneNot AvailableTerminated1
DB01221KetamineNot AvailableCompleted1
DB01221KetamineNot AvailableNot Yet Recruiting1
DB01221KetamineNot AvailableTerminated1
DB01221KetamineNot AvailableUnknown Status2
DB00281LidocaineNot AvailableRecruiting1
DB00683MidazolamNot AvailableCompleted1
DB00683MidazolamNot AvailableNot Yet Recruiting1
DB00295MorphineNot AvailableActive Not Recruiting1
DB00295MorphineNot AvailableCompleted2
DB00295MorphineNot AvailableNot Yet Recruiting2
DB00295MorphineNot AvailableRecruiting1
DB00295MorphineNot AvailableTerminated1
DB00295MorphineNot AvailableUnknown Status1
DB00497OxycodoneNot AvailableTerminated1
DB01229PaclitaxelNot AvailableCompleted1
DB00818PropofolNot AvailableActive Not Recruiting1
DB00296RopivacaineNot AvailableCompleted2
DB00296RopivacaineNot AvailableNot Yet Recruiting1
DB00747ScopolamineNot AvailableCompleted1
DB00193TramadolNot AvailableActive Not Recruiting1
DB00193TramadolNot AvailableCompleted1