Multidrug resistance protein 1

Details

Name
Multidrug resistance protein 1
Synonyms
  • 3.6.3.44
  • ATP-binding cassette sub-family B member 1
  • MDR1
  • P-glycoprotein 1
  • PGY1
Gene Name
ABCB1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0037114|Multidrug resistance protein 1
MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAII
HGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSG
IGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS
KINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFT
DKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIG
AAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARG
AAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSG
QTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLF
ATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIA
IARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAG
FDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRS
SLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAII
NGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKA
GEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNI
ANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEA
IENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFG
AYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDS
YSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVV
QLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVV
SQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLD
EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQL
LAQKGIYFSMVSVQAGTKRQ
Number of residues
1280
Molecular Weight
141477.255
Theoretical pI
9.44
GO Classification
Functions
ATP binding / ATPase activity, coupled to transmembrane movement of substances / transporter activity / xenobiotic-transporting ATPase activity
Processes
drug transmembrane transport / G2/M transition of mitotic cell cycle / response to drug / small molecule metabolic process / stem cell proliferation / transmembrane transport / transport
Components
cell surface / extracellular exosome / integral component of membrane / membrane / plasma membrane
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Pfam Domain Function
Transmembrane Regions
45-67 117-137 187-208 216-236 293-316 331-352 712-732 757-777 833-853 855-874 935-957 974-995
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0016291|Multidrug resistance protein 1 (ABCB1)
ATGGATCTTGAAGGGGACCGCAATGGAGGAGCAAAGAAGAAGAACTTTTTTAAACTGAAC
AATAAAAGTGAAAAAGATAAGAAGGAAAAGAAACCAACTGTCAGTGTATTTTCAATGTTT
CGCTATTCAAATTGGCTTGACAAGTTGTATATGGTGGTGGGAACTTTGGCTGCCATCATC
CATGGGGCTGGACTTCCTCTCATGATGCTGGTGTTTGGAGAAATGACAGATATCTTTGCA
AATGCAGGAAATTTAGAAGATCTGATGTCAAACATCACTAATAGAAGTGATATCAATGAT
ACAGGGTTCTTCATGAATCTGGAGGAAGACATGACCAGGTATGCCTATTATTACAGTGGA
ATTGGTGCTGGGGTGCTGGTTGCTGCTTACATTCAGGTTTCATTTTGGTGCCTGGCAGCT
GGAAGACAAATACACAAAATTAGAAAACAGTTTTTTCATGCTATAATGCGACAGGAGATA
GGCTGGTTTGATGTGCACGATGTTGGGGAGCTTAACACCCGACTTACAGATGATGTCTCC
AAGATTAATGAAGGAATTGGTGACAAAATTGGAATGTTCTTTCAGTCAATGGCAACATTT
TTCACTGGGTTTATAGTAGGATTTACACGTGGTTGGAAGCTAACCCTTGTGATTTTGGCC
ATCAGTCCTGTTCTTGGACTGTCAGCTGCTGTCTGGGCAAAGATACTATCTTCATTTACT
GATAAAGAACTCTTAGCGTATGCAAAAGCTGGAGCAGTAGCTGAAGAGGTCTTGGCAGCA
ATTAGAACTGTGATTGCATTTGGAGGACAAAAGAAAGAACTTGAAAGGTACAACAAAAAT
TTAGAAGAAGCTAAAAGAATTGGGATAAAGAAAGCTATTACAGCCAATATTTCTATAGGT
GCTGCTTTCCTGCTGATCTATGCATCTTATGCTCTGGCCTTCTGGTATGGGACCACCTTG
GTCCTCTCAGGGGAATATTCTATTGGACAAGTACTCACTGTATTCTTTTCTGTATTAATT
GGGGCTTTTAGTGTTGGACAGGCATCTCCAAGCATTGAAGCATTTGCAAATGCAAGAGGA
GCAGCTTATGAAATCTTCAAGATAATTGATAATAAGCCAAGTATTGACAGCTATTCGAAG
AGTGGGCACAAACCAGATAATATTAAGGGAAATTTGGAATTCAGAAATGTTCACTTCAGT
TACCCATCTCGAAAAGAAGTTAAGATCTTGAAGGGTCTGAACCTGAAGGTGCAGAGTGGG
CAGACGGTGGCCCTGGTTGGAAACAGTGGCTGTGGGAAGAGCACAACAGTCCAGCTGATG
CAGAGGCTCTATGACCCCACAGAGGGGATGGTCAGTGTTGATGGACAGGATATTAGGACC
ATAAATGTAAGGTTTCTACGGGAAATCATTGGTGTGGTGAGTCAGGAACCTGTATTGTTT
GCCACCACGATAGCTGAAAACATTCGCTATGGCCGTGAAAATGTCACCATGGATGAGATT
GAGAAAGCTGTCAAGGAAGCCAATGCCTATGACTTTATCATGAAACTGCCTCATAAATTT
GACACCCTGGTTGGAGAGAGAGGGGCCCAGTTGAGTGGTGGGCAGAAGCAGAGGATCGCC
ATTGCACGTGCCCTGGTTCGCAACCCCAAGATCCTCCTGCTGGATGAGGCCACGTCAGCC
TTGGACACAGAAAGCGAAGCAGTGGTTCAGGTGGCTCTGGATAAGGCCAGAAAAGGTCGG
ACCACCATTGTGATAGCTCATCGTTTGTCTACAGTTCGTAATGCTGACGTCATCGCTGGT
TTCGATGATGGAGTCATTGTGGAGAAAGGAAATCATGATGAACTCATGAAAGAGAAAGGC
ATTTACTTCAAACTTGTCACAATGCAGACAGCAGGAAATGAAGTTGAATTAGAAAATGCA
GCTGATGAATCCAAAAGTGAAATTGATGCCTTGGAAATGTCTTCAAATGATTCAAGATCC
AGTCTAATAAGAAAAAGATCAACTCGTAGGAGTGTCCGTGGATCACAAGCCCAAGACAGA
AAGCTTAGTACCAAAGAGGCTCTGGATGAAAGTATACCTCCAGTTTCCTTTTGGAGGATT
ATGAAGCTAAATTTAACTGAATGGCCTTATTTTGTTGTTGGTGTATTTTGTGCCATTATA
AATGGAGGCCTGCAACCAGCATTTGCAATAATATTTTCAAAGATTATAGGGGTTTTTACA
AGAATTGATGATCCTGAAACAAAACGACAGAATAGTAACTTGTTTTCACTATTGTTTCTA
GCCCTTGGAATTATTTCTTTTATTACATTTTTCCTTCAGGGTTTCACATTTGGCAAAGCT
GGAGAGATCCTCACCAAGCGGCTCCGATACATGGTTTTCCGATCCATGCTCAGACAGGAT
GTGAGTTGGTTTGATGACCCTAAAAACACCACTGGAGCATTGACTACCAGGCTCGCCAAT
GATGCTGCTCAAGTTAAAGGGGCTATAGGTTCCAGGCTTGCTGTAATTACCCAGAATATA
GCAAATCTTGGGACAGGAATAATTATATCCTTCATCTATGGTTGGCAACTAACACTGTTA
CTCTTAGCAATTGTACCCATCATTGCAATAGCAGGAGTTGTTGAAATGAAAATGTTGTCT
GGACAAGCACTGAAAGATAAGAAAGAACTAGAAGGTTCTGGGAAGATCGCTACTGAAGCA
ATAGAAAACTTCCGAACCGTTGTTTCTTTGACTCAGGAGCAGAAGTTTGAACATATGTAT
GCTCAGAGTTTGCAGGTACCATACAGAAACTCTTTGAGGAAAGCACACATCTTTGGAATT
ACATTTTCCTTCACCCAGGCAATGATGTATTTTTCCTATGCTGGATGTTTCCGGTTTGGA
GCCTACTTGGTGGCACATAAACTCATGAGCTTTGAGGATGTTCTGTTAGTATTTTCAGCT
GTTGTCTTTGGTGCCATGGCCGTGGGGCAAGTCAGTTCATTTGCTCCTGACTATGCCAAA
GCCAAAATATCAGCAGCCCACATCATCATGATCATTGAAAAAACCCCTTTGATTGACAGC
TACAGCACGGAAGGCCTAATGCCGAACACATTGGAAGGAAATGTCACATTTGGTGAAGTT
GTATTCAACTATCCCACCCGACCGGACATCCCAGTGCTTCAGGGACTGAGCCTGGAGGTG
AAGAAGGGCCAGACGCTGGCTCTGGTGGGCAGCAGTGGCTGTGGGAAGAGCACAGTGGTC
CAGCTCCTGGAGCGGTTCTACGACCCCTTGGCAGGGAAAGTGCTGCTTGATGGCAAAGAA
ATAAAGCGACTGAATGTTCAGTGGCTCCGAGCACACCTGGGCATCGTGTCCCAGGAGCCC
ATCCTGTTTGACTGCAGCATTGCTGAGAACATTGCCTATGGAGACAACAGCCGGGTGGTG
TCACAGGAAGAGATTGTGAGGGCAGCAAAGGAGGCCAACATACATGCCTTCATCGAGTCA
CTGCCTAATAAATATAGCACTAAAGTAGGAGACAAAGGAACTCAGCTCTCTGGTGGCCAG
AAACAACGCATTGCCATAGCTCGTGCCCTTGTTAGACAGCCTCATATTTTGCTTTTGGAT
GAAGCCACGTCAGCTCTGGATACAGAAAGTGAAAAGGTTGTCCAAGAAGCCCTGGACAAA
GCCAGAGAAGGCCGCACCTGCATTGTGATTGCTCACCGCCTGTCCACCATCCAGAATGCA
GACTTAATAGTGGTGTTTCAGAATGGCAGAGTCAAGGAGCATGGCACGCATCAGCAGCTG
CTGGCACAGAAAGGCATCTATTTTTCAATGGTCAGTGTCCAGGCTGGAACAAAGCGCCAG
TGA
Chromosome Location
7
Locus
7q21.1
External Identifiers
ResourceLink
UniProtKB IDP08183
UniProtKB Entry NameMDR1_HUMAN
GenBank Protein ID307180
GenBank Gene IDM14758
GenAtlas IDABCB1
HGNC IDHGNC:40
General References
  1. Chen CJ, Chin JE, Ueda K, Clark DP, Pastan I, Gottesman MM, Roninson IB: Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell. 1986 Nov 7;47(3):381-9. [PubMed:2876781]
  2. Chen CJ, Clark D, Ueda K, Pastan I, Gottesman MM, Roninson IB: Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins. J Biol Chem. 1990 Jan 5;265(1):506-14. [PubMed:1967175]
  3. Chen G, Duran GE, Steger KA, Lacayo NJ, Jaffrezou JP, Dumontet C, Sikic BI: Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins. J Biol Chem. 1997 Feb 28;272(9):5974-82. [PubMed:9038218]
  4. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039]
  5. Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O'Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, Vanbrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam AM, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang SP, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, Wilson RK: The DNA sequence of human chromosome 7. Nature. 2003 Jul 10;424(6945):157-64. [PubMed:12853948]
  6. Gekeler V, Weger S, Probst H: mdr1/P-glycoprotein gene segments analyzed from various human leukemic cell lines exhibiting different multidrug resistance profiles. Biochem Biophys Res Commun. 1990 Jun 15;169(2):796-802. [PubMed:1972623]
  7. Kioka N, Tsubota J, Kakehi Y, Komano T, Gottesman MM, Pastan I, Ueda K: P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance. Biochem Biophys Res Commun. 1989 Jul 14;162(1):224-31. [PubMed:2568832]
  8. Kerb R, Hoffmeyer S, Brinkmann U: ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2. Pharmacogenomics. 2001 Feb;2(1):51-64. [PubMed:11258197]
  9. Begley GS, Horvath AR, Taylor JC, Higgins CF: Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome. Mol Immunol. 2005 Jan;42(1):137-41. [PubMed:15488952]
  10. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648]
  11. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [PubMed:21269460]
  12. Katayama K, Yamaguchi M, Noguchi K, Sugimoto Y: Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function. Cancer Lett. 2014 Apr 1;345(1):124-31. doi: 10.1016/j.canlet.2013.12.007. Epub 2013 Dec 11. [PubMed:24333728]
  13. Choi KH, Chen CJ, Kriegler M, Roninson IB: An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene. Cell. 1988 May 20;53(4):519-29. [PubMed:2897240]
  14. Mickley LA, Lee JS, Weng Z, Zhan Z, Alvarez M, Wilson W, Bates SE, Fojo T: Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors. Blood. 1998 Mar 1;91(5):1749-56. [PubMed:9473242]
  15. Decleves X, Chevillard S, Charpentier C, Vielh P, Laplanche JL: A new polymorphism (N21D) in the exon 2 of the human MDR1 gene encoding the P-glycoprotein. Hum Mutat. 2000 May;15(5):486. [PubMed:10790226]
  16. Hoffmeyer S, Burk O, von Richter O, Arnold HP, Brockmoller J, Johne A, Cascorbi I, Gerloff T, Roots I, Eichelbaum M, Brinkmann U: Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3473-8. [PubMed:10716719]
  17. Cascorbi I, Gerloff T, Johne A, Meisel C, Hoffmeyer S, Schwab M, Schaeffeler E, Eichelbaum M, Brinkmann U, Roots I: Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects. Clin Pharmacol Ther. 2001 Mar;69(3):169-74. [PubMed:11240981]
  18. Honda T, Dan Y, Koyabu N, Ieiri I, Otsubo K, Higuchi S, Ohtani H, Sawada Y: Polymorphism of MDR1 gene in healthy japanese subjects: a novel SNP with an amino acid substitution (Glu108Lys). Drug Metab Pharmacokinet. 2002;17(5):479-81. [PubMed:15618700]
  19. Itoda M, Saito Y, Komamura K, Ueno K, Kamakura S, Ozawa S, Sawada J: Twelve novel single nucleotide polymorphisms in ABCB1/MDR1 among Japanese patients with ventricular tachycardia who were administered amiodarone. Drug Metab Pharmacokinet. 2002;17(6):566-71. [PubMed:15618713]
  20. Saito S, Iida A, Sekine A, Miura Y, Ogawa C, Kawauchi S, Higuchi S, Nakamura Y: Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population. J Hum Genet. 2002;47(1):38-50. [PubMed:11829140]
  21. Brant SR, Panhuysen CI, Nicolae D, Reddy DM, Bonen DK, Karaliukas R, Zhang L, Swanson E, Datta LW, Moran T, Ravenhill G, Duerr RH, Achkar JP, Karban AS, Cho JH: MDR1 Ala893 polymorphism is associated with inflammatory bowel disease. Am J Hum Genet. 2003 Dec;73(6):1282-92. Epub 2003 Nov 7. [PubMed:14610718]
  22. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [PubMed:16959974]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00171ATPinvestigational, nutraceuticalunknownDetails
DB00778Roxithromycinapproved, investigational, withdrawnunknownDetails
DB04881ElacridarinvestigationalunknownDetails
DB04905TesmilifeneinvestigationalyesinducerDetails
DB05449FM-VP4investigationalunknownDetails
DB06240TariquidarinvestigationalunknownDetails
DB06191ZosuquidarinvestigationalunknownDetails
DB00661VerapamilapprovedunknownsubstrateinhibitorinducerDetails
DB01232Saquinavirapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB00220NelfinavirapprovedunknownsubstrateinhibitorinducerDetails
DB00224IndinavirapprovedunknownsubstrateinhibitorinducerDetails
DB00701Amprenavirapproved, investigationalunknownsubstrateinducerDetails
DB01045RifampicinapprovedunknowninducerDetails
DB00206Reserpineapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB01115NifedipineapprovedunknownsubstrateinhibitorinducerDetails
DB00834Mifepristoneapproved, investigationalunknowninhibitorinducerDetails
DB01234Dexamethasoneapproved, investigational, vet_approvedunknownsubstrateinhibitorinducerDetails
DB00257Clotrimazoleapproved, vet_approvedunknowninhibitorinducerDetails
DB00564Carbamazepineapproved, investigationalunknowninducerDetails
DB00656Trazodoneapproved, investigationalunknowninducerDetails
DB01149Nefazodoneapproved, withdrawnunknowninhibitorinducerDetails
DB00503Ritonavirapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB00390DigoxinapprovedunknownsubstrateinhibitorinducerDetails
DB00279Liothyronineapproved, vet_approvedunknowninducerDetails
DB00451LevothyroxineapprovedunknowninducerDetails
DB00440Trimethoprimapproved, vet_approvedunknowninhibitorinducerDetails
DB00396Progesteroneapproved, vet_approvedunknownsubstrateinhibitorinducerDetails
DB02261Platelet Activating FactorexperimentalunknowninducerDetails
DB00091Cyclosporineapproved, investigational, vet_approvedunknownsubstrateinhibitorinducerDetails
DB00501Cimetidineapproved, investigationalunknownsubstrateinducerDetails
DB04630Aldosteroneexperimental, investigationalunknownsubstrateinducerDetails
DB00864Tacrolimusapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB00877Sirolimusapproved, investigationalunknowninhibitorinducerDetails
DB01174Phenobarbitalapproved, investigationalunknownsubstrateinducerDetails
DB00199Erythromycinapproved, investigational, vet_approvednosubstrateinhibitorDetails
DB01118Amiodaroneapproved, investigationalunknowninhibitorinducerDetails
DB01323St. John's Wortapproved, investigational, nutraceuticalunknowninducerDetails
DB00541Vincristineapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB00570VinblastineapprovedunknownsubstrateinhibitorinducerDetails
DB02659Cholic AcidapprovedunknowninducerDetails
DB00675TamoxifenapprovedunknownsubstrateinhibitorinducerDetails
DB00428Streptozocinapproved, investigationalunknowninducerDetails
DB01204Mitoxantroneapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB00997Doxorubicinapproved, investigationalunknownsubstrateinhibitorinducerDetails
DB00694DaunorubicinapprovedunknownsubstrateinhibitorinducerDetails
DB00908Quinidineapproved, investigationalunknownsubstrateinhibitorDetails
DB01026Ketoconazoleapproved, investigationalunknowninhibitorDetails
DB01388Mibefradilinvestigational, withdrawnunknowninhibitorDetails
DB04540Cholesterolapproved, investigationalunknowninhibitorDetails
DB00358Mefloquineapproved, investigationalunknowninhibitorDetails
DB00622Nicardipineapproved, investigationalunknownsubstrateinhibitorDetails
DB00381AmlodipineapprovedunknownsubstrateinhibitorDetails
DB00972AzelastineapprovedunknowninhibitorDetails
DB00863RanitidineapprovedunknownsubstrateinhibitorDetails
DB00773EtoposideapprovedunknownsubstrateinhibitorDetails
DB00333MethadoneapprovedunknowninhibitorDetails
DB00641SimvastatinapprovedunknowninhibitorDetails
DB00227Lovastatinapproved, investigationalunknowninhibitorDetails
DB01076AtorvastatinapprovednosubstrateinhibitorDetails
DB00361Vinorelbineapproved, investigationalunknownsubstrateDetails
DB01229Paclitaxelapproved, vet_approvedunknownsubstrateinhibitorDetails
DB00457PrazosinapprovedunknownsubstrateinhibitormodulatorDetails
DB01054Nitrendipineapproved, investigationalunknowninhibitorDetails
DB00975DipyridamoleapprovedunknownsubstrateinhibitorDetails
DB00343Diltiazemapproved, investigationalunknownsubstrateinhibitorDetails
DB01394ColchicineapprovedunknownsubstrateinducerDetails
DB01211ClarithromycinapprovedunknownsubstrateinhibitorDetails
DB00477Chlorpromazineapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB00970Dactinomycinapproved, investigationalunknownsubstrateinhibitorDetails
DB13179TroleandomycinapprovedunknowninhibitorDetails
DB00831Trifluoperazineapproved, investigationalunknowninhibitorDetails
DB00342Terfenadineapproved, withdrawnunknowninhibitorDetails
DB00468QuinineapprovedunknownsubstrateinhibitorDetails
DB01167Itraconazoleapproved, investigationalunknowninhibitorDetails
DB00328Indomethacinapproved, investigationalunknownsubstrateinhibitorDetails
DB02587Colforsinexperimental, investigationalunknowninhibitorDetails
DB00623FluphenazineapprovedunknowninhibitorDetails
DB01023Felodipineapproved, investigationalunknowninhibitorDetails
DB00845Clofazimineapproved, investigationalunknowninhibitorDetails
DB01136Carvedilolapproved, investigationalunknowninhibitorDetails
DB00421SpironolactoneapprovedunknowninducerDetails
DB00281Lidocaineapproved, vet_approvedunknowninhibitorDetails
DB00537Ciprofloxacinapproved, investigationalunknownsubstrateDetails
DB00207AzithromycinapprovedunknownsubstrateinhibitorDetails
DB00316AcetaminophenapprovedunknowninhibitorDetails
DB00196Fluconazoleapproved, investigationalunknowninhibitorDetails
DB00213PantoprazoleapprovedunknownsubstrateinhibitorDetails
DB00338Omeprazoleapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB00448Lansoprazoleapproved, investigationalunknownsubstrateinhibitorDetails
DB00264Metoprololapproved, investigationalunknownsubstrateDetails
DB00678LosartanapprovedunknownsubstrateinhibitorDetails
DB00584Enalaprilapproved, vet_approvedunknowninhibitorDetails
DB00590DoxazosinapprovedunknowninhibitorDetails
DB01340CilazaprilapprovedunknowninhibitorDetails
DB01197CaptoprilapprovedunknowninhibitorDetails
DB00796Candesartan cilexetilapprovedunknowninhibitorDetails
DB01110Miconazoleapproved, investigational, vet_approvedunknowninhibitorDetails
DB00696ErgotamineapprovedunknowninhibitorDetails
DB01253ErgometrineapprovedunknowninhibitorDetails
DB00320Dihydroergotamineapproved, investigationalunknowninhibitorDetails
DB01200Bromocriptineapproved, investigationalunknownsubstrateinhibitorDetails
DB00836LoperamideapprovedunknownsubstrateDetails
DB00813Fentanylapproved, illicit, investigational, vet_approvedunknowninhibitorDetails
DB00802Alfentanilapproved, illicitunknowninhibitorDetails
DB00401NisoldipineapprovedunknowninhibitorDetails
DB04832Zimelidineapproved, withdrawnunknowninhibitorDetails
DB00382Tacrineapproved, investigational, withdrawnunknownsubstrateDetails
DB00669Sumatriptanapproved, investigationalunknownsubstrateDetails
DB01037Selegilineapproved, investigational, vet_approvedunknowninhibitorDetails
DB00747Scopolamineapproved, investigationalunknowninhibitorDetails
DB00458ImipramineapprovedunknownsubstrateDetails
DB00502HaloperidolapprovedunknownsubstrateinhibitorDetails
DB00176Fluvoxamineapproved, investigationalunknowninhibitorDetails
DB00690Flurazepamapproved, illicit, investigationalunknowninhibitorDetails
DB00472Fluoxetineapproved, vet_approvedunknowninhibitorDetails
DB01142Doxepinapproved, investigationalunknownsubstrateDetails
DB01151Desipramineapproved, investigationalunknowninhibitorDetails
DB01242Clomipramineapproved, investigational, vet_approvedunknowninhibitorDetails
DB01239Chlorprothixeneapproved, experimental, investigational, withdrawnunknowninhibitorDetails
DB00490Buspironeapproved, investigationalunknowninhibitorDetails
DB01100PimozideapprovedunknowninhibitorDetails
DB00295Morphineapproved, investigationalnosubstrateDetails
DB00602Ivermectinapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB00741Hydrocortisoneapproved, vet_approvedunknownsubstrateDetails
DB00637Astemizoleapproved, withdrawnunknowninhibitorDetails
DB00508Triflupromazineapproved, vet_approvedunknowninhibitorDetails
DB00344ProtriptylineapprovedunknowninhibitorDetails
DB01069Promethazineapproved, investigationalunknowninhibitorDetails
DB01244Bepridilapproved, withdrawnunknowninhibitorDetails
DB00455Loratadineapproved, investigationalnosubstrateinhibitorDetails
DB00967Desloratadineapproved, investigationalunknowninhibitorDetails
DB00285VenlafaxineapprovedunknownsubstrateinhibitorDetails
DB01104SertralineapprovedunknowninhibitorDetails
DB00234Reboxetineapproved, experimentalunknowninhibitorDetails
DB00715Paroxetineapproved, investigationalunknowninhibitorDetails
DB00215CitalopramapprovedunknownsubstrateinhibitorDetails
DB01196Estramustineapproved, investigationalunknowninhibitorDetails
DB04348Taurocholic acidapproved, experimentalunknownsubstrateinhibitorDetails
DB00875Flupentixolapproved, investigational, withdrawnunknowninhibitorDetails
DB00351Megestrol acetateapproved, investigational, vet_approvedunknowninhibitorDetails
DB02010StaurosporineexperimentalunknowninhibitorDetails
DB01103QuinacrineinvestigationalunknowninhibitorDetails
DB01645GenisteininvestigationalunknowninhibitorDetails
DB04216Quercetinexperimental, investigationalunknowninhibitorDetails
DB01137Levofloxacinapproved, investigationalunknownsubstrateinhibitorDetails
DB03467NaringeninexperimentalunknowndownregulatorDetails
DB01016GlyburideapprovedunknowninhibitorDetails
DB00950Fexofenadineapproved, investigationalunknownsubstrateinhibitorDetails
DB00726TrimipramineapprovedunknownsubstrateDetails
DB00571Propranololapproved, investigationalunknownsubstrateDetails
DB00635Prednisoneapproved, vet_approvedunknownsubstrateDetails
DB00276Amsacrineapproved, investigationalunknowninhibitorDetails
DB00027Gramicidin DapprovedunknowninhibitorDetails
DB01086Benzocaineapproved, investigationalunknowninhibitorDetails
DB01601LopinavirapprovedunknowninhibitorDetails
DB00520CaspofunginapprovedunknowninhibitorDetails
DB00175PravastatinapprovednosubstrateDetails
DB00619ImatinibapprovedunknownsubstrateinhibitorDetails
DB00398Sorafenibapproved, investigationalunknownsubstrateinhibitorDetails
DB01268Sunitinibapproved, investigationalunknowninhibitorDetails
DB01162TerazosinapprovedunknowninhibitorDetails
DB00470Dronabinolapproved, illicitunknowninhibitorDetails
DB00921Buprenorphineapproved, illicit, investigational, vet_approvedunknowninhibitorDetails
DB00966Telmisartanapproved, investigationalunknowninhibitorDetails
DB01254Dasatinibapproved, investigationalunknownsubstrateinhibitorDetails
DB00317Gefitinibapproved, investigationalunknownsubstrateinhibitorDetails
DB04868Nilotinibapproved, investigationalunknownsubstrateinhibitorDetails
DB00655EstroneapprovedunknownsubstrateinducerDetails
DB01259Lapatinibapproved, investigationalunknowninhibitorDetails
DB01263Posaconazoleapproved, investigational, vet_approvedunknowninhibitorDetails
DB00365Grepafloxacinapproved, investigational, withdrawnunknownsubstrateinhibitorDetails
DB00829Diazepamapproved, illicit, investigational, vet_approvedunknownsubstrateDetails
DB01396Digitoxinapproved, investigationalunknownsubstrateDetails
DB01208Sparfloxacinapproved, investigational, withdrawnunknownsubstrateDetails
DB00959Methylprednisoloneapproved, vet_approvedunknownsubstrateDetails
DB01224QuetiapineapprovedunknownsubstrateDetails
DB00334Olanzapineapproved, investigationalnosubstrateDetails
DB00363ClozapineapprovedunknownsubstrateDetails
DB01183Naloxoneapproved, vet_approvedunknownsubstrateDetails
DB00515CisplatinapprovedunknownsubstrateDetails
DB04690CamptothecinexperimentalunknownsubstrateDetails
DB00860Prednisoloneapproved, vet_approvedunknownsubstrateDetails
DB01193Acebutololapproved, investigationalunknownsubstrateDetails
DB01050IbuprofenapprovedunknownsubstrateDetails
DB00945Acetylsalicylic acidapproved, vet_approvedunknownsubstrateinducermodulatorDetails
DB00575ClonidineapprovedunknownsubstrateDetails
DB01184Domperidoneapproved, investigational, vet_approvedunknownsubstrateDetails
DB00742Mannitolapproved, investigationalunknownsubstrateDetails
DB00443Betamethasoneapproved, vet_approvedunknownsubstrateDetails
DB00539Toremifeneapproved, investigationalunknownsubstrateDetails
DB00255Diethylstilbestrolapproved, investigationalunknownsubstrateDetails
DB00882Clomifeneapproved, investigationalunknownsubstrateDetails
DB00783Estradiolapproved, investigational, vet_approvedunknownsubstrateDetails
DB01248Docetaxelapproved, investigationalunknownsubstrateDetails
DB00563MethotrexateapprovedunknownsubstrateDetails
DB00373TimololapprovedunknownsubstrateDetails
DB01203NadololapprovedunknownsubstrateDetails
DB00523Alitretinoinapproved, investigationalunknownsubstrateDetails
DB01339Vecuroniumapproved, investigationalunknownsubstrateDetails
DB04840Debrisoquineapproved, investigationalunknownsubstrateDetails
DB00441GemcitabineapprovedunknownsubstrateDetails
DB01030Topotecanapproved, investigationalunknownsubstrateDetails
DB02901Stanoloneillicit, investigationalunknownsubstrateDetails
DB00751Epinastineapproved, investigationalunknownsubstrateDetails
DB00717NorethisteroneapprovedunknowninducerDetails
DB04573Estriolapproved, investigational, vet_approvedunknownsubstrateinducerDetails
DB03203SphingosineexperimentalunknownsubstrateDetails
DB00439Cerivastatinapproved, withdrawnunknownsubstrateDetails
DB00286Conjugated estrogensapprovedunknownsubstrateDetails
DB01202LevetiracetamapprovedunknownsubstrateDetails
DB00252Phenytoinapproved, vet_approvedunknownsubstrateDetails
DB00585NizatidineapprovedunknownsubstrateDetails
DB00530Erlotinibapproved, investigationalunknownsubstrateDetails
DB00555Lamotrigineapproved, investigationalunknownsubstrateDetails
DB01261Sitagliptinapproved, investigationalunknownsubstrateDetails
DB01072Atazanavirapproved, investigationalunknownsubstrateinhibitorDetails
DB01169Arsenic trioxideapproved, investigationalunknownsubstrateDetails
DB06772CabazitaxelapprovedunknownsubstrateinhibitorDetails
DB01583LiotrixapprovedunknowninducerDetails
DB06287TemsirolimusapprovedunknownsubstrateinhibitorDetails
DB01587KetazolamapprovedunknownsubstrateDetails
DB04877VoacamineexperimentalunknowninhibitorDetails
DB00977EthinylestradiolapprovedunknownsubstrateDetails
DB01182PropafenoneapprovedunknowninhibitorDetails
DB00216Eletriptanapproved, investigationalunknownsubstrateDetails
DB04855DronedaroneapprovednoinhibitorDetails
DB06176Romidepsinapproved, investigationalunknownsubstrateDetails
DB06207SilodosinapprovedunknownsubstrateDetails
DB06414EtravirineapprovedunknowninducerDetails
DB06228RivaroxabanapprovedunknownsubstrateDetails
DB06695Dabigatran etexilateapprovedunknownsubstrateDetails
DB00973EzetimibeapprovedunknownsubstrateDetails
DB06702FesoterodineapprovedunknownsubstrateDetails
DB06212TolvaptanapprovednosubstrateinhibitorDetails
DB08860PitavastatinapprovedunknownsubstrateDetails
DB06589PazopanibapprovedunknownsubstrateDetails
DB08864RilpivirineapprovedunknowninhibitorDetails
DB08873Boceprevirapproved, withdrawnunknowninhibitorDetails
DB05521Telaprevirapproved, withdrawnunknownsubstrateinhibitorDetails
DB08874FidaxomicinapprovedunknownsubstrateinhibitorDetails
DB05039IndacaterolapprovedunknownsubstrateDetails
DB00349Clobazamapproved, illicitunknownsubstrateDetails
DB08882LinagliptinapprovedunknownsubstrateDetails
DB08827Lomitapideapproved, investigationalnoinhibitorDetails
DB08816TicagrelorapprovedunknownsubstrateinhibitorDetails
DB08865CrizotinibapprovedunknownsubstrateinhibitorDetails
DB06605ApixabanapprovedunknownsubstrateDetails
DB06626Axitinibapproved, investigationalnosubstrateDetails
DB08828Vismodegibapproved, investigationalunknownsubstrateDetails
DB08889Carfilzomibapproved, investigationalunknownsubstrateDetails
DB08893MirabegronapprovedunknownsubstrateinhibitorDetails
DB08896RegorafenibapprovedunknownsubstrateinhibitorDetails
DB08899EnzalutamideapprovedunknowninhibitorDetails
DB08820IvacaftorapprovednoinhibitorDetails
DB06616BosutinibapprovedunknownsubstrateinhibitorDetails
DB08901Ponatinibapproved, investigationalunknownsubstrateinhibitorDetails
DB08906Fluticasone furoateapprovedunknownsubstrateDetails
DB08907CanagliflozinapprovedunknownsubstrateinhibitorDetails
DB08910PomalidomideapprovedunknownsubstrateDetails
DB00480LenalidomideapprovedunknownsubstrateDetails
DB08912Dabrafenibapproved, investigationalunknownsubstrateDetails
DB05773Trastuzumab emtansineapproved, investigationalunknownsubstrateDetails
DB00495ZidovudineapprovedunknownsubstrateDetails
DB00758ClopidogrelapprovedunknownsubstrateDetails
DB08916AfatinibapprovedunknownsubstrateinhibitorDetails
DB00762Irinotecanapproved, investigationalunknownsubstrateDetails
DB00709Lamivudineapproved, investigationalunknownsubstrateDetails
DB00688Mycophenolate mofetilapproved, investigationalunknownsubstrateDetails
DB08918Levomilnacipranapproved, investigationalunknownsubstrateDetails
DB06290SimeprevirapprovedunknownsubstrateinhibitorDetails
DB08934SofosbuvirapprovednosubstrateDetails
DB06292DapagliflozinapprovedunknownsubstrateDetails
DB09076UmeclidiniumapprovednosubstrateDetails
DB09075EdoxabanapprovednosubstrateDetails
DB09063CeritinibapprovednosubstrateDetails
DB09078Lenvatinibapproved, investigationalnosubstrateDetails
DB09079NintedanibapprovednosubstrateinhibitorDetails
DB09054IdelalisibapprovednosubstrateinhibitorDetails
DB09065CobicistatapprovedyesinhibitorDetails
DB09291Rolapitantapproved, investigationalnoinhibitorDetails
DB09102Daclatasvirapproved, investigationalunknowninhibitorDetails
DB06636Isavuconazoniumapproved, investigationalyesinhibitorDetails
DB06603Panobinostatapproved, investigationalyessubstrateDetails
DB05239Cobimetinibapproved, investigationalunknownsubstrateDetails
DB09330OsimertinibapprovednosubstrateDetails
DB11362SelexipagapprovednosubstrateDetails
DB11363Alectinibapproved, investigationalnoinhibitorDetails
DB06403Ambrisentanapproved, investigationalunknownsubstrateDetails
DB09296Ombitasvirapproved, investigationalnosubstrateDetails
DB11574ElbasvirapprovednosubstrateDetails
DB11575GrazoprevirapprovednosubstrateDetails
DB09161Technetium Tc-99m sestamibiapproved, investigationalnosubstrateDetails
DB11581Venetoclaxapproved, investigationalnosubstrateinhibitorDetails
DB05015Belinostatapproved, investigationalunknownsubstrateDetails
DB11613Velpatasvirapproved, investigationalnosubstrateinhibitorDetails
DB06670OdanacatibinvestigationalnosubstrateDetails
DB09027LedipasvirapprovednosubstratetransporterDetails
DB09198LobeglitazoneexperimentalnoDetails
DB09031Miltefosineapproved, investigationalunknownDetails
DB09280LumacaftorapprovednoinhibitorinducerDetails
DB11828Neratinibapproved, investigationalunknowninhibitorDetails
DB12026Voxilaprevirapproved, investigationalnosubstrateinhibitorDetails
DB13874Enasidenibapproved, investigationalunknowninhibitorDetails
DB05889Inotuzumab ozogamicinapproved, investigationalunknownsubstrateDetails
DB13878Pibrentasvirapproved, investigationalunknownsubstrateinhibitorDetails
DB13879Glecaprevirapproved, investigationalunknownsubstrateinhibitorDetails
DB12483Copanlisibapproved, investigationalunknownsubstrateDetails
DB12001Abemaciclibapproved, investigationalunknownsubstrateinhibitorDetails
DB12364Betrixabanapproved, investigationalnosubstrateDetails
DB13919CandesartanexperimentalunknowninhibitorDetails
DB12070Letermovirapproved, investigationalnosubstrateinhibitorDetails
DB08930DolutegravirapprovednosubstrateDetails
DB12332Rucaparibapproved, investigationalunknownsubstrateinhibitorDetails
DB13146Fluciclovine (18F)approvednosubstrateDetails
DB09270Ubidecarenoneapproved, investigational, nutraceuticalnosubstrateDetails
DB11827Ertugliflozinapproved, investigationalnosubstrateDetails
DB13943Testosterone cypionateapprovedunknowninhibitorDetails
DB13944Testosterone enanthateapprovedunknowninhibitorDetails
DB13946Testosterone undecanoateapproved, investigationalunknowninhibitorDetails
DB09160Technetium Tc-99m tetrofosminapprovednobinderDetails
DB13951Stanolone acetateexperimentalunknownsubstrateDetails
DB13952Estradiol acetateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13953Estradiol benzoateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13954Estradiol cypionateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13955Estradiol dienanthateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13956Estradiol valerateapproved, investigational, vet_approvedunknownsubstrateDetails
DB01420Testosterone propionateapproved, investigational, vet_approved, withdrawnnosubstrateDetails
DB11901Apalutamideapproved, investigationalunknowninducerDetails
DB11633Isavuconazoleapproved, investigationalunknowninhibitorDetails
DB11251Tocopherolapproved, investigationalnotransporterDetails
DB14003alpha-Tocopherol acetateapprovednosubstrateDetails
DB09099Somatostatinapproved, investigationalunknownsubstrateDetails
DB11635TocofersolanapprovedunknownantagonistDetails
DB11641Vinflunineapproved, investigationalnosubstrateDetails
DB11672Curcuminapproved, experimental, investigationalunknowninhibitorDetails
DB11995Avatrombopagapproved, investigationalunknownsubstrateDetails
DB09297Paritaprevirapproved, investigationalunknownsubstrateDetails
DB09183DasabuvirapprovedunknownsubstrateDetails
DB00813Fentanylapproved, illicit, investigational, vet_approvedunknownDetails
DB14062Concanamycin AexperimentalyesinhibitorDetails
DB14061HycanthoneexperimentalyesinhibitorDetails
DB14063DexverapamilexperimentalyesinhibitorDetails
DB14064EmopamilexperimentalyesinhibitorDetails
DB14065LomerizineexperimentalyesinhibitorDetails
DB14066TetrandrineexperimentalunknowninhibitorDetails
DB14067Dofequidarexperimental, investigationalunknowninhibitorDetails
DB11431Moxidectininvestigational, vet_approvednosubstrateDetails
DB14068DexniguldipineexperimentalunknowninhibitorDetails
DB14069ONT-093investigationalyesinhibitorDetails
DB14070HM-30181experimentalyesinhibitorDetails
DB14071DesmethylsertralineexperimentalunknowninhibitorDetails
DB14072Reversin 121experimentalyesinhibitorDetails
DB14146LoxicodegolinvestigationalunknownDetails
DB14538Hydrocortisone aceponateexperimental, vet_approvedunknownDetails
DB14539Hydrocortisone acetateapproved, vet_approvedunknownDetails
DB14540Hydrocortisone butyrateapproved, vet_approvedunknownDetails
DB14541Hydrocortisone cypionateapproved, investigational, vet_approvedunknownDetails
DB14542Hydrocortisone phosphateapproved, vet_approvedunknownDetails
DB14543Hydrocortisone probutateapproved, vet_approvedunknownDetails
DB14544Hydrocortisone valerateapproved, vet_approvedunknownDetails
DB14568Ivosidenibapproved, investigationalunknownsubstrateinhibitorDetails
DB11979Elagolixapproved, investigationalunknownsubstrateDetails
DB13867Fluticasoneapproved, experimentalnosubstrateDetails
DB00588Fluticasone propionateapprovednosubstrateDetails
DB00608Chloroquineapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB00613Amodiaquineapproved, investigationalunknowninhibitorDetails
DB01087PrimaquineapprovedunknowninhibitorDetails
DB01611HydroxychloroquineapprovedunknowninhibitorDetails
DB01267PaliperidoneapprovedunknownsubstrateinhibitorDetails
DB05928DovitinibinvestigationalunknowninhibitorDetails
DB13125Lusutrombopagapproved, investigationalunknownsubstrateinhibitorDetails
DB14635Curcumin sulfateexperimentalunknownDetails
DB14641Estriol tripropionateexperimentalunknownDetails
DB11952Duvelisibapproved, investigationalnosubstrateDetails
DB09213Dexibuprofenapproved, investigationalunknownDetails
DB11760Talazoparibapproved, investigationalunknownsubstrateDetails
DB12455Omadacyclineapproved, investigationalunknownsubstrateDetails
DB12836Grapiprantinvestigational, vet_approvednosubstrateDetails
DB12035Sarecyclineapproved, investigationalunknowninhibitorDetails
DB11753Rifamycinapproved, investigationalnosubstrateinhibitorDetails
DB11963Dacomitinibapproved, investigationalnosubstrateinhibitorDetails
DB11855Revefenacinapproved, investigationalnosubstrateDetails
DB12141Gilteritinibapproved, investigationalnosubstrateDetails
DB14126Tenofovirexperimental, investigationalnosubstrateDetails
DB00300Tenofovir disoproxilapproved, investigationalunknownsubstrateinhibitorDetails
DB09299Tenofovir alafenamideapprovedunknownsubstrateDetails
DB01264DarunavirapprovedunknowninhibitorDetails
DB00203Sildenafilapproved, investigationalunknownsubstrateinhibitorDetails
DB00862VardenafilapprovedunknownsubstrateinhibitorDetails
DB00776OxcarbazepineapprovedunknownsubstrateDetails
DB00248CabergolineapprovednosubstrateDetails
DB06480PrucaloprideapprovednosubstrateDetails
DB00734Risperidoneapproved, investigationalunknownsubstrateDetails
DB01117AtovaquoneapprovednoinhibitorDetails
DB00788Naproxenapproved, vet_approvednoinhibitorDetails
DB00615Rifabutinapproved, investigationalunknowninducerDetails
DB12582PiperineinvestigationalunknowninhibitorDetails
DB11978Glasdegibapproved, investigationalnosubstrateinhibitorDetails
DB09074OlaparibapprovednosubstrateDetails
DB00193Tramadolapproved, investigationalnosubstrateDetails
DB00243Ranolazineapproved, investigationalnosubstrateinhibitorDetails
DB00321AmitriptylineapprovedunknownsubstrateDetails
DB00341CetirizineapprovedyessubstrateinhibitorDetails
DB09073Palbociclibapproved, investigationalnosubstrateinhibitorDetails
DB01079Tegaserodapproved, investigational, withdrawnunknownsubstrateDetails
DB13867Fluticasoneapproved, experimentalunknownsubstrateDetails
DB08906Fluticasone furoateapprovedunknownDetails
DB12147Erdafitinibapproved, investigationalunknownsubstrateinhibitorDetails
DB00736Esomeprazoleapproved, investigationalunknownsubstrateinhibitorDetails
DB00476DuloxetineapprovedunknowninhibitorDetails
DB00481Raloxifeneapproved, investigationalunknownsubstrateDetails
DB12015Alpelisibapproved, investigationalunknownsubstrateinhibitorDetails
DB11712Tezacaftorapproved, investigationalunknownsubstrateinhibitorDetails
DB00768OlopatadineapprovednosubstrateDetails
DB00698Nitrofurantoinapproved, vet_approvedunknownsubstrateDetails
DB00451LevothyroxineapprovednoregulatorDetails
DB00394Beclomethasone dipropionateapproved, investigationalunknownsubstrateinducerDetails
DB00612BisoprololapprovedunknownsubstrateinhibitorDetails
DB00916MetronidazoleapprovedunknowninhibitorDetails
DB00482Celecoxibapproved, investigationalunknownsubstrateDetails
DB00843DonepezilapprovedunknownsubstrateDetails
DB11986Entrectinibapproved, investigationalunknownsubstrateinhibitorDetails
DB12500Fedratinibapproved, investigationalunknownsubstrateinhibitorDetails
DB12825Lefamulinapproved, investigationalunknownsubstrateDetails
DB01222BudesonideapprovednosubstrateDetails
DB11757Istradefyllineapproved, investigationalunknowninhibitorDetails
DB01233Metoclopramideapproved, investigationalunknownsubstrateDetails
DB01175EscitalopramapprovedunknownsubstrateDetails
DB00603Medroxyprogesterone acetateapproved, investigationalunknowninhibitorDetails
DB01217Anastrozoleapproved, investigationalunknownsubstrateDetails
DB01195Flecainideapproved, withdrawnunknownsubstrateDetails
DB01418Acenocoumarolapproved, investigationalunknownsubstrateDetails
DB05676Apremilastapproved, investigationalunknownsubstrateDetails
DB11732Lasmiditanapproved, investigationalunknownsubstrateinhibitorDetails
DB11586Asunaprevirapproved, investigational, withdrawnunknownsubstrateinhibitorDetails
DB15444Elexacaftorapproved, investigationalunknownsubstrateinhibitorDetails
DB15566Prednisolone acetateapproved, vet_approvedunknownsubstrateDetails