Amyotrophic Lateral Sclerosis (ALS)

Also known as: Motor Neuron Disease, Amyotrophic Lateral Sclerosis / Amyotrophic Lateral Sclerosis / Lateral Amyotrophic Sclerosis / Lou Gehrig Disease / ALS / Lou-Gehrigs Disease / Lou Gehrig's Disease / ALS (Amyotrophic Lateral Sclerosis) / Amyotrophic lateral sclerosis(ALS) / Lou Gehrigs Disease / Amyotrophic lateral sclerosis (disorder)

DrugDrug NameDrug Description
DB12243EdaravoneA free radical scavenger used to delay the progression of ALS.
DB06819Phenylbutyric acidAn agent indicated for the adjunctive therapy for the management of chronic urea cycle disorders due to deficiencies in specific enzymes, including the neonatal-onset deficiency and late-onset disease with a history of hyperammonemic encephalopathy.
DB00740RiluzoleA glutamate antagonist used to treat amyotrophic lateral sclerosis.
DB08834Tauroursodeoxycholic acidThe taurine conjugate of ursodeoxycholic acid with antiapoptotic and ER stress response dampening effects used in some countries to treat gallstones. It is also being investigated for a wide variety of other conditions.
DB14782TofersenAn antisense oligonucleotide indicated for the treatment of adult amyotrophic lateral sclerosis caused by SOD1 mutation.
DrugDrug NameTargetType
DB12243EdaravoneSolute carrier family 22 member 6transporter
DB12243EdaravoneSolute carrier family 22 member 8transporter
DB12243EdaravoneUDP-glucuronosyltransferase 1-1enzyme
DB12243EdaravoneUDP-glucuronosyltransferase 1-6enzyme
DB12243EdaravoneUDP-glucuronosyltransferase 1-7enzyme
DB12243EdaravoneUDP-glucuronosyltransferase 1-8enzyme
DB12243EdaravoneUDP-glucuronosyltransferase 1-9enzyme
DB12243EdaravoneUDP-glucuronosyltransferase 1-10enzyme
DB12243EdaravoneUDP-glucuronosyltransferase 2B7enzyme
DB12243EdaravoneUDP-glucuronosyltransferase 2B17enzyme
DB12243EdaravoneSulfotransferaseenzyme
DB12243EdaravoneSerum albumincarrier
DB06819Phenylbutyric acidAromatic-amino-acid aminotransferasetarget
DB06819Phenylbutyric acidHistone deacetylasetarget
DB00740RiluzoleSodium channel protein type 5 subunit alphatarget
DB00740RiluzoleCytochrome P450 1A2enzyme
DB00740RiluzoleCystine/glutamate transportertarget
DB00740RiluzoleATP-binding cassette sub-family G member 2transporter
DB00740RiluzoleCytochrome P450 1A1enzyme
DB08834Tauroursodeoxycholic acidSolute carrier organic anion transporter family member 1A2transporter
DB08834Tauroursodeoxycholic acidCystine/glutamate transportertransporter
DB08834Tauroursodeoxycholic acidCytochrome P450 3A1enzyme
DB08834Tauroursodeoxycholic acidCytochrome P450 3A2enzyme
DB08834Tauroursodeoxycholic acidATP-binding cassette sub-family G member 5transporter
DB08834Tauroursodeoxycholic acidATP-binding cassette sub-family G member 8transporter
DB08834Tauroursodeoxycholic acidBile salt export pumptransporter
DB08834Tauroursodeoxycholic acidIntegrin alpha-5target
DB14782TofersenSuperoxide dismutase 1 (SOD1)target
DrugDrug NamePhaseStatusCount
DB06774Capsaicin0Completed2
DB01175Escitalopram0Completed1
DB08883Perampanel0Completed1
DB14759Red pepper0Completed2
DB00740Riluzole0Completed1
DB08839Serotonin0Completed1
DB18407ABBV-CLS-72621Active Not Recruiting1
DB17947AP-1011Unknown Status1
DB00201Caffeine1Completed1
DB00190Carbidopa1Completed1
DB00482Celecoxib1Completed1
DB00501Cimetidine1Completed1
DB00537Ciprofloxacin1Completed1
DB09130Copper1Completed1
DB16963Copper(II) dithiosemicarbazone1Completed1
DB18678DNL3431Active Not Recruiting1
DB01264Darunavir1Completed1
DB15130Dexpramipexole1Completed4
DB08930Dolutegravir1Completed1
DB09148Florbetaben F-181Recruiting1
DB17079GDC-01341Completed2
DB14865Human interleukin-21Unknown Status1
DB04335Inosine1Completed1
DB01235Levodopa1Completed1
DB00683Midazolam1Completed1
DB00218Moxifloxacin1Completed1
DB16921Oxaloacetic acid1Unknown Status1
DB12891Ozanezumab1Completed1
DB18649Prosetin1Recruiting1
DB01129Rabeprazole1Completed2
DB00503Ritonavir1Completed1
DB18103SPG3021Recruiting1
DB12639Telbermin1Terminated2
DB09299Tenofovir alafenamide1Completed1
DB17922AMT-1621 / 2Not Yet Recruiting1
DB11817Baricitinib1 / 2Recruiting1
DB06616Bosutinib1 / 2Recruiting1
DB09130Copper1 / 2Active Not Recruiting1
DB09130Copper1 / 2Completed1
DB16963Copper(II) dithiosemicarbazone1 / 2Active Not Recruiting1
DB00514Dextromethorphan1 / 2Completed1
DB17931Engensis1 / 2Completed1
DB00467Enoxacin1 / 2Completed1
DB00016Erythropoietin1 / 2Recruiting1
DB17953Human Embryonic Stem Cell-derived Astrocytes1 / 2Completed1
DB18265Human glial progenitor cells1 / 2Not Yet Recruiting1
DB16958IPL-3441 / 2Suspended1
DB05066Ibudilast1 / 2Completed1
DB11757Istradefylline1 / 2Recruiting1
DB06218Lacosamide1 / 2Completed1
DB06819Phenylbutyric acid1 / 2Completed1
DB01132Pioglitazone1 / 2Completed1
DB00413Pramipexole1 / 2Completed2
DB00908Quinidine1 / 2Completed1
DB00740Riluzole1 / 2Terminated1
DB00133Serine1 / 2Unknown Status1
DB00675Tamoxifen1 / 2Completed1
DB12639Telbermin1 / 2Completed1
DB12639Telbermin1 / 2Terminated1
DB08911Trametinib1 / 2Terminated1
DB00755Tretinoin1 / 2Completed1
DB11677Triheptanoin1 / 2Completed1
DB01593Zinc1 / 2Completed1
DB16977ANX-0052Recruiting1
DB17947AP-1012Recruiting1
DB01048Abacavir2Completed1
DB00062Albumin human2Completed2
DB00041Aldesleukin2Active Not Recruiting1
DB00041Aldesleukin2Completed1
DB17007Alirinetide2Completed1
DB06742Ambroxol2Recruiting1
DB00026Anakinra2Completed1
DB05025Arimoclomol2Completed1
DB05025Arimoclomol2Withdrawn1
DB11887Arundic acid2Completed2
DB00572Atropine2Not Yet Recruiting1
DB16838BLZ-9452Active Not Recruiting1
DB00074Basiliximab2Completed1
DB00121Biotin2Completed2
DB00083Botulinum toxin type A2Completed1
DB00083Botulinum toxin type A2Withdrawn1
DB17952CNM-Au82Completed1
DB17952CNM-Au82Withdrawn1
DB00482Celecoxib2Completed2
DB00537Ciprofloxacin2Completed1
DB01407Clenbuterol2Completed1
DB01394Colchicine2Completed1
DB09130Copper2Completed1
DB16963Copper(II) dithiosemicarbazone2Completed1
DB01285Corticotropin2Completed1
DB00148Creatine2Completed3
DB11846Creatinine2Completed1
DB01003Cromoglicic acid2Terminated1
DB00496Darifenacin2Not Yet Recruiting1
DB18025Dazucorilant2Recruiting1
DB17934Debamestrocel2Completed1
DB08826Deferiprone2Completed1
DB16949Deulinoleate ethyl2Recruiting1
DB00633Dexmedetomidine2Not Yet Recruiting1
DB15130Dexpramipexole2Completed2
DB09255Dextran2Completed1
DB00514Dextromethorphan2Completed1
DB08930Dolutegravir2Completed1
DB16041EPI-5892Completed1
DB12243Edaravone2Not Yet Recruiting1
DB17931Engensis2Completed2
DB00016Erythropoietin2Completed1
DB04953Ezogabine2Completed1
DB08162Fasudil2Active Not Recruiting1
DB08162Fasudil2Completed1
DB12469Fasudil2Unknown Status1
DB00099Filgrastim2Completed2
DB08868Fingolimod2Completed1
DB05259Glatiramer2Completed1
DB14154Gold2Withdrawn1
DB15726Human Umbilical Cord Mesenchymal Stem Cells2Active Not Recruiting1
DB14865Human interleukin-22Completed1
DB16958IPL-3442Suspended1
DB05266Ibudilast2Completed1
DB16932Icerguastat2Active Not Recruiting1
DB04335Inosine2Completed1
DB16956L-Acetylleucine2Active Not Recruiting1
DB00709Lamivudine2Completed1
DB16978Latozinemab2Terminated1
DB00007Leuprolide2Completed1
DB01202Levetiracetam2Completed1
DB00922Levosimendan2Completed1
DB14509Lithium carbonate2Completed2
DB16223Lunasine2Completed1
DB14009Medical Cannabis2Recruiting1
DB01043Memantine2Completed3
DB00959Methylprednisolone2Completed1
DB01017Minocycline2Completed1
DB00688Mycophenolate mofetil2Completed1
DB00336Nitrofural2Recruiting1
DB12891Ozanezumab2Completed1
DB16694Pegcetacoplan2Terminated1
DB08883Perampanel2Completed1
DB08883Perampanel2Terminated1
DB06819Phenylbutyric acid2Completed1
DB01100Pimozide2Unknown Status2
DB01132Pioglitazone2Terminated1
DB00635Prednisone2Completed1
DB00908Quinidine2Completed1
DB00243Ranolazine2Unknown Status1
DB01367Rasagiline2Completed3
DB15256Reldesemtiv2Completed1
DB00740Riluzole2Active Not Recruiting1
DB00740Riluzole2Completed6
DB00740Riluzole2Terminated1
DB00740Riluzole2Withdrawn1
DB09446Safflower oil2Recruiting1
DB01001Salbutamol2Not Yet Recruiting1
DB00747Scopolamine2Not Yet Recruiting1
DB00133Serine2Terminated1
DB00877Sirolimus2Completed1
DB00052Somatotropin2Completed1
DB00864Tacrolimus2Completed1
DB04982Talampanel2Completed1
DB04982Talampanel2Terminated1
DB00675Tamoxifen2Completed2
DB08834Tauroursodeoxycholic acid2Completed2
DB16974Tegoprubart2Completed1
DB00624Testosterone2Completed1
DB01041Thalidomide2Completed1
DB01041Thalidomide2Terminated1
DB12129Tideglusib2Not Yet Recruiting1
DB12209Tirasemtiv2Completed4
DB06273Tocilizumab2Completed1
DB09069Trimetazidine2Completed1
DB09270Ubidecarenone2Completed1
DB01586Ursodeoxycholic acid2Completed1
DB18184ZYIL-12Recruiting1
DB18407ABBV-CLS-72622 / 3Enrolling by Invitation1
DB18407ABBV-CLS-72622 / 3Recruiting1
DB08842Acetylcarnitine2 / 3Not Yet Recruiting1
DB00915Amantadine2 / 3Recruiting1
DB05025Arimoclomol2 / 3Completed1
DB00042Botulinum toxin type B2 / 3Completed1
DB17952CNM-Au82 / 3Completed1
DB17952CNM-Au82 / 3Recruiting1
DB09061Cannabidiol2 / 3Completed1
DB16963Copper(II) dithiosemicarbazone2 / 3Unknown Status1
DB01285Corticotropin2 / 3Terminated1
DB18678DNL3432 / 3Enrolling by Invitation1
DB18678DNL3432 / 3Recruiting1
DB08826Deferiprone2 / 3Active Not Recruiting1
DB00470Dronabinol2 / 3Completed1
DB00099Filgrastim2 / 3Completed1
DB05266Ibudilast2 / 3Recruiting1
DB14509Lithium carbonate2 / 3Terminated1
DB11526Masitinib2 / 3Completed1
DB03614Mecobalamin2 / 3Completed2
DB14009Medical Cannabis2 / 3Completed1
DB01043Memantine2 / 3Completed1
DB01043Memantine2 / 3Recruiting1
DB00334Olanzapine2 / 3Completed1
DB05185Olesoxime2 / 3Completed1
DB11947Pridopidine2 / 3Completed1
DB11947Pridopidine2 / 3Recruiting1
DB00740Riluzole2 / 3Completed2
DB00740Riluzole2 / 3Recruiting1
DB00740Riluzole2 / 3Terminated1
DB00656Trazodone2 / 3Recruiting1
DB12310Trehalose2 / 3Recruiting1
DB12440Verdiperstat2 / 3Completed1
DB12440Verdiperstat2 / 3Recruiting1
DB15636Zilucoplan2 / 3Completed1
DB15636Zilucoplan2 / 3Recruiting1
DB01048Abacavir3Recruiting1
DB05025Arimoclomol3Completed1
DB05025Arimoclomol3Terminated1
DB01212Ceftriaxone3Completed1
DB17934Debamestrocel3Completed1
DB15130Dexpramipexole3Completed1
DB15130Dexpramipexole3Terminated1
DB08930Dolutegravir3Recruiting1
DB12243Edaravone3Completed7
DB12243Edaravone3Terminated2
DB01175Escitalopram3Completed1
DB08824Ioflupane I-1233Completed1
DB00709Lamivudine3Recruiting1
DB16960Lenzumestrocel3Active Not Recruiting1
DB00922Levosimendan3Completed1
DB00922Levosimendan3Terminated1
DB14509Lithium carbonate3Recruiting1
DB11526Masitinib3Recruiting1
DB03614Mecobalamin3Unknown Status1
DB01017Minocycline3Completed1
DB05185Olesoxime3Completed1
DB06819Phenylbutyric acid3Active Not Recruiting1
DB06819Phenylbutyric acid3Enrolling by Invitation1
DB11580Ravulizumab3Terminated1
DB15256Reldesemtiv3Terminated2
DB00740Riluzole3Active Not Recruiting1
DB00740Riluzole3Completed1
DB00740Riluzole3Recruiting1
DB08834Tauroursodeoxycholic acid3Active Not Recruiting2
DB08834Tauroursodeoxycholic acid3Enrolling by Invitation1
DB08834Tauroursodeoxycholic acid3Recruiting1
DB12209Tirasemtiv3Completed2
DB14782Tofersen3Completed1
DB18677Ulefnersen3Recruiting1
DB01586Ursodeoxycholic acid3Active Not Recruiting1
DB01586Ursodeoxycholic acid3Recruiting1
DB00313Valproic acid3Completed1
DB00740Riluzole4Completed1
DB15729Adipose-Derived Mesenchymal Stem Cells: Autologous or Allogeneic OriginsNot AvailableNo Longer Available1
DB17952CNM-Au8Not AvailableAvailable2
DB06774CapsaicinNot AvailableCompleted1
DB17934DebamestrocelNot AvailableNo Longer Available1
DB08826DeferiproneNot AvailableCompleted1
DB00470DronabinolNot AvailableCompleted1
DB12243EdaravoneNot AvailableActive Not Recruiting1
DB17743Fecal microbiotaNot AvailableActive Not Recruiting1
DB00099FilgrastimNot AvailableCompleted1
DB14914Flortaucipir F-18Not AvailableCompleted1
DB14154GoldNot AvailableAvailable1
DB00166Lipoic acidNot AvailableUnknown Status1
DB14043PalmidrolNot AvailableCompleted1
DB08883PerampanelNot AvailableTerminated1
DB00413PramipexoleNot AvailableTemporarily Not Available1
DB11947PridopidineNot AvailableAvailable1
DB00740RiluzoleNot AvailableCompleted1
DB00740RiluzoleNot AvailableNo Longer Available1
DB12310TrehaloseNot AvailableAvailable1