Amyotrophic Lateral Sclerosis (ALS)

Also known as: Amyotrophic Lateral Sclerosis / ALS / Progressive muscular atrophy / ALS (Amyotrophic Lateral Sclerosis) / Sclerosis, Amyotrophic Lateral / Progressive spinal muscle atrophy / Lou Gehrig's disease

DrugDrug NameDrug Description
DB12243EdaravoneEdaravone is a free radical scavenger approved in May, 2017 for the treatment of amyotrophic lateral scleorosis (ALS). Clinical studies showed that the treatment attenuated deterioration of the disease when compared to placebo. It has been previously investigated for the treatment of ischemic stroke, reperfusion Injury, and myocardial Infarction as it possesses antioxidant and anti-apoptotic properties. Being a low molecular weight molecule with good water and lipid-soluble properies, it therapeutically advantageous in crossing the blood-brain barrier to mediate nootropic and neuroprotective effects. Oral formulation of edaravone is currently under development.
DB00740RiluzoleA glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis. Riluzole is marketed as Rilutek by Sanofi.
DrugDrug NamePhaseStatusCount
DB06774Capsaicin0Recruiting2
DB00201Caffeine1Recruiting1
DB01264Darunavir1Enrolling by Invitation1
DB04335Inosine1Completed1
DB05914Mesenchymal Stem Cells1Completed1
DB00683Midazolam1Recruiting1
DB00218Moxifloxacin1Completed1
DB12891Ozanezumab1Completed1
DB01129Rabeprazole1Recruiting2
DB06817Raltegravir1Enrolling by Invitation1
DB00503Ritonavir1Enrolling by Invitation1
DB12639Telbermin1Terminated1
DB00495Zidovudine1Enrolling by Invitation1
DB01048Abacavir1 / 2Recruiting1
DB09130Copper1 / 2Completed1
DB09131Cupric Chloride1 / 2Completed1
DB08930Dolutegravir1 / 2Recruiting1
DB05066Ibudilast1 / 2Recruiting1
DB05266Ibudilast1 / 2Recruiting1
DB00133L-Serine1 / 2Unknown Status1
DB06218Lacosamide1 / 2Not Yet Recruiting1
DB00709Lamivudine1 / 2Recruiting1
DB06819Phenylbutyric acid1 / 2Completed1
DB01132Pioglitazone1 / 2Completed1
DB00675Tamoxifen1 / 2Unknown Status1
DB00755Tretinoin1 / 2Completed1
DB01593Zinc1 / 2Completed1
DB00041Aldesleukin2Completed1
DB00026Anakinra2Unknown Status1
DB05025Arimoclomol2Completed1
DB05025Arimoclomol2Withdrawn1
DB11887Arundic acid2Completed2
DB00074Basiliximab2Completed1
DB00121Biotin2Active Not Recruiting1
DB00083Botulinum Toxin Type A2Completed1
DB00083Botulinum Toxin Type A2Withdrawn1
DB00482Celecoxib2Completed1
DB01285Corticotropin2Completed1
DB01285Corticotropin2Recruiting1
DB00148Creatine2Completed3
DB11846Creatinine2Completed1
DB08826Deferiprone2Completed1
DB00514Dextromethorphan2Completed1
DB04953Ezogabine2Recruiting1
DB12469Fasudil2Unknown Status1
DB00099Filgrastim2Completed1
DB08868Fingolimod2Completed1
DB05259Glatiramer Acetate2Completed1
DB00062Human Serum Albumin2Completed1
DB00062Human Serum Albumin2Recruiting1
DB05266Ibudilast2Active Not Recruiting1
DB04335Inosine2Not Yet Recruiting1
DB04465Lactose2Active Not Recruiting1
DB00007Leuprolide2Completed1
DB01202Levetiracetam2Completed1
DB00922Levosimendan2Active Not Recruiting1
DB01356Lithium2Completed1
DB01356Lithium2Unknown Status1
DB01043Memantine2Completed2
DB01043Memantine2Not Yet Recruiting1
DB00959Methylprednisolone2Completed1
DB01017Minocycline2Completed1
DB00688Mycophenolate mofetil2Completed1
DB12891Ozanezumab2Completed1
DB00082Pegvisomant2Completed1
DB08883Perampanel2Not Yet Recruiting1
DB06819Phenylbutyric acid2Recruiting1
DB01132Pioglitazone2Terminated1
DB00635Prednisone2Completed1
DB00908Quinidine2Completed1
DB01367Rasagiline2Active Not Recruiting1
DB01367Rasagiline2Completed1
DB01367Rasagiline2Unknown Status1
DB00740Riluzole2Completed1
DB00740Riluzole2Recruiting1
DB00052Somatotropin2Completed1
DB00864Tacrolimus2Completed1
DB04982Talampanel2Completed1
DB04982Talampanel2Terminated1
DB00675Tamoxifen2Completed2
DB08834Tauroursodeoxycholic acid2Completed1
DB08834Tauroursodeoxycholic acid2Recruiting1
DB00624Testosterone2Completed1
DB01041Thalidomide2Completed1
DB01041Thalidomide2Terminated1
DB12209Tirasemtiv2Completed3
DB06273Tocilizumab2Recruiting1
DB09270Ubidecarenone2Completed1
DB01586Ursodeoxycholic acid2Completed1
DB05025Arimoclomol2 / 3Completed1
DB00042Botulinum Toxin Type B2 / 3Completed1
DB09061Cannabidiol2 / 3Completed1
DB11121Chloroxylenol2 / 3Completed1
DB08826Deferiprone2 / 3Not Yet Recruiting1
DB00470Dronabinol2 / 3Completed1
DB00099Filgrastim2 / 3Completed1
DB00677Isoflurophate2 / 3Not Yet Recruiting1
DB01356Lithium2 / 3Terminated1
DB01043Memantine2 / 3Completed1
DB03614Methylcobalamin2 / 3Completed2
DB00334Olanzapine2 / 3Unknown Status1
DB00740Riluzole2 / 3Completed2
DB00740Riluzole2 / 3Terminated1
DB05185TRO196222 / 3Completed2
DB01212Ceftriaxone3Completed1
DB12243Edaravone3Completed4
DB01175Escitalopram3Completed1
DB08824Ioflupane I-1233Completed1
DB01277Mecasermin3Completed1
DB01017Minocycline3Completed1
DB12209Tirasemtiv3Active Not Recruiting1
DB12209Tirasemtiv3Enrolling by Invitation1
DB00313Valproic Acid3Completed1
DB00740Riluzole4Completed1
DB08826DeferiproneNot AvailableActive Not Recruiting1
DB00470DronabinolNot AvailableCompleted1
DB00099FilgrastimNot AvailableCompleted1
DB10551PeaNot AvailableCompleted1
DB08883PerampanelNot AvailableRecruiting1
DB00740RiluzoleNot AvailableCompleted1