Pain, Neuropathic

Also known as: Neuropathic Pains / Neuropathic Pain / Neuralgia / Neuralgia NOS

DrugDrug NameDrug Description
DB00321AmitriptylineA tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety.
DB00286Conjugated estrogensA mixture of estrogens used in estrogen replacement therapy for menopause and hypoestrogenism, used in the treatment of various malignancies, and used in the treatment of postmenopausal osteoporosis.
DB01151DesipramineA tricyclic antidepressant used in the treatment of depression.
DB01142DoxepinA psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia.
DB00327HydromorphoneAn opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated.
DB00458ImipramineA tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis.
DB00230PregabalinAn anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants.
DB00285VenlafaxineA selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depression.
DrugDrug NameTargetType
DB00321AmitriptylineSodium-dependent serotonin transportertarget
DB00321AmitriptylineSodium-dependent noradrenaline transportertarget
DB00321AmitriptylinePotassium voltage-gated channel subfamily KQT member 2target
DB00321AmitriptylineAlpha-2A adrenergic receptortarget
DB00321AmitriptylineCytochrome P450 1A2enzyme
DB00321AmitriptylineCytochrome P450 2C19enzyme
DB00321AmitriptylineCytochrome P450 2D6enzyme
DB00321AmitriptylineSerum albumincarrier
DB00321AmitriptylineAlpha-1-acid glycoprotein 1carrier
DB00321AmitriptylineHistamine H1 receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 2Atarget
DB00321Amitriptyline5-hydroxytryptamine receptor 1Atarget
DB00321AmitriptylineAlpha-1A adrenergic receptortarget
DB00321AmitriptylineCytochrome P450 3A4enzyme
DB00321AmitriptylineCytochrome P450 3A5enzyme
DB00321AmitriptylinePotassium voltage-gated channel subfamily A member 1target
DB00321AmitriptylineAlpha-1D adrenergic receptortarget
DB00321AmitriptylineDelta-type opioid receptortarget
DB00321AmitriptylineKappa-type opioid receptortarget
DB00321AmitriptylineHigh affinity nerve growth factor receptortarget
DB00321AmitriptylineBDNF/NT-3 growth factors receptortarget
DB00321AmitriptylineCytochrome P450 2C9enzyme
DB00321AmitriptylineCytochrome P450 2B6enzyme
DB00321AmitriptylineCytochrome P450 2C8enzyme
DB00321AmitriptylineHistamine H2 receptortarget
DB00321AmitriptylineHistamine H4 receptortarget
DB00321AmitriptylineSigma non-opioid intracellular receptor 1target
DB00321Amitriptyline5-hydroxytryptamine receptor 2Ctarget
DB00321AmitriptylineAlpha-1B adrenergic receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 7target
DB00321Amitriptyline5-hydroxytryptamine receptor 1Dtarget
DB00321AmitriptylineMu-type opioid receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 1Btarget
DB00321Amitriptyline5-hydroxytryptamine receptor 6target
DB00321AmitriptylinePotassium voltage-gated channel subfamily KQT member 3target
DB00321AmitriptylineUDP-glucuronosyltransferase 2B10enzyme
DB00321Amitriptyline5-hydroxytryptamine receptor 1Ctarget
DB00321AmitriptylineMuscarinic acetylcholine receptortarget
DB00321AmitriptylineHERG human cardiac K+ channeltarget
DB00321AmitriptylineP-glycoprotein 1transporter
DB00321AmitriptylineUDP-glucuronosyltransferase 1-4enzyme
DB00286Conjugated estrogensEstrogen receptor alphatarget
DB00286Conjugated estrogensCytochrome P450 3A4enzyme
DB00286Conjugated estrogensCytochrome P450 1A2enzyme
DB00286Conjugated estrogensCatechol O-methyltransferaseenzyme
DB00286Conjugated estrogensCanalicular multispecific organic anion transporter 2transporter
DB00286Conjugated estrogensMultidrug resistance-associated protein 4transporter
DB00286Conjugated estrogensMultidrug resistance-associated protein 1transporter
DB00286Conjugated estrogensSolute carrier organic anion transporter family member 1A2transporter
DB00286Conjugated estrogensSodium/bile acid cotransportertransporter
DB00286Conjugated estrogensSolute carrier family 22 member 10transporter
DB00286Conjugated estrogensSolute carrier family 22 member 8transporter
DB00286Conjugated estrogensSolute carrier organic anion transporter family member 1C1transporter
DB00286Conjugated estrogensSolute carrier organic anion transporter family member 1B1transporter
DB00286Conjugated estrogensSolute carrier organic anion transporter family member 2B1transporter
DB00286Conjugated estrogensP-glycoprotein 1transporter
DB00286Conjugated estrogensSolute carrier family 22 member 6transporter
DB00286Conjugated estrogensOrganic solute transporter subunit alphatransporter
DB00286Conjugated estrogensOrganic solute transporter subunit betatransporter
DB00286Conjugated estrogensCanalicular multispecific organic anion transporter 1transporter
DB00286Conjugated estrogensSolute carrier organic anion transporter family member 4A1transporter
DB00286Conjugated estrogensATP-binding cassette sub-family C member 11transporter
DB00286Conjugated estrogensSolute carrier organic anion transporter family member 1B3transporter
DB00286Conjugated estrogensSolute carrier family 22 member 11transporter
DB00286Conjugated estrogensSolute carrier organic anion transporter family member 3A1transporter
DB00286Conjugated estrogensATP-binding cassette sub-family G member 2transporter
DB00286Conjugated estrogensThyroxine-binding globulincarrier
DB00286Conjugated estrogensSex hormone-binding globulincarrier
DB00286Conjugated estrogensSerum albumincarrier
DB00286Conjugated estrogensEstrogen receptor betatarget
DB01151DesipramineMuscarinic acetylcholine receptor M1target
DB01151DesipramineSodium-dependent noradrenaline transportertarget
DB01151DesipramineBeta-2 adrenergic receptortarget
DB01151DesipramineMuscarinic acetylcholine receptor M2target
DB01151DesipramineSodium-dependent serotonin transportertarget
DB01151DesipramineHistamine H1 receptortarget
DB01151DesipramineBeta-1 adrenergic receptortarget
DB01151DesipramineCytochrome P450 2D6enzyme
DB01151DesipramineMuscarinic acetylcholine receptor M3target
DB01151DesipramineMuscarinic acetylcholine receptor M4target
DB01151DesipramineMuscarinic acetylcholine receptor M5target
DB01151DesipramineAlpha-1 adrenergic receptorstarget
DB01151Desipramine5-hydroxytryptamine receptor 2Atarget
DB01151DesipramineAlpha-1-acid glycoprotein 1carrier
DB01151DesipramineCytochrome P450 2B6enzyme
DB01151DesipramineCytochrome P450 3A4enzyme
DB01151DesipramineSolute carrier family 22 member 2transporter
DB01151DesipramineSolute carrier family 22 member 1transporter
DB01151DesipramineSolute carrier family 22 member 3transporter
DB01151DesipramineSolute carrier family 22 member 5transporter
DB01151DesipramineP-glycoprotein 1transporter
DB01151DesipramineSolute carrier family 22 member 4transporter
DB01151DesipramineCytochrome P450 1A2enzyme
DB01151DesipramineCytochrome P450 2E1enzyme
DB01151DesipramineSphingomyelin phosphodiesterasetarget
DB01151Desipramine5-hydroxytryptamine receptor 1Atarget
DB01151Desipramine5-hydroxytryptamine receptor 2Ctarget
DB01151DesipramineDopamine D2 receptortarget
DB01151DesipramineAlpha-2 adrenergic receptorstarget
DB01142DoxepinSodium-dependent serotonin transportertarget
DB01142DoxepinSodium-dependent noradrenaline transportertarget
DB01142DoxepinHistamine H1 receptortarget
DB01142DoxepinHistamine H2 receptortarget
DB01142DoxepinCytochrome P450 2D6enzyme
DB01142DoxepinMuscarinic acetylcholine receptor M1target
DB01142DoxepinMuscarinic acetylcholine receptor M2target
DB01142DoxepinMuscarinic acetylcholine receptor M3target
DB01142DoxepinMuscarinic acetylcholine receptor M4target
DB01142DoxepinMuscarinic acetylcholine receptor M5target
DB01142DoxepinAlpha-1A adrenergic receptortarget
DB01142Doxepin5-hydroxytryptamine receptor 1Atarget
DB01142Doxepin5-hydroxytryptamine receptor 2Atarget
DB01142DoxepinCytochrome P450 2C19enzyme
DB01142DoxepinCytochrome P450 2C9enzyme
DB01142DoxepinCytochrome P450 1A2enzyme
DB01142DoxepinP-glycoprotein 1transporter
DB01142Doxepin5-hydroxytryptamine receptor 2Btarget
DB01142Doxepin5-hydroxytryptamine receptor 2Ctarget
DB01142DoxepinAlpha-1B adrenergic receptortarget
DB01142DoxepinAlpha-1D adrenergic receptortarget
DB01142DoxepinCytochrome P450 3A4enzyme
DB01142Doxepin5-hydroxytryptamine receptor 6target
DB01142DoxepinHistamine H4 receptortarget
DB01142DoxepinPotassium voltage-gated channel subfamily H member 2target
DB01142DoxepinSerum albumincarrier
DB01142DoxepinAlpha-1-acid glycoprotein 1carrier
DB00327HydromorphoneMu-type opioid receptortarget
DB00327HydromorphoneDelta-type opioid receptortarget
DB00327HydromorphoneKappa-type opioid receptortarget
DB00327HydromorphoneCytochrome P450 2C9enzyme
DB00327HydromorphoneUDP-glucuronosyltransferase 1-3enzyme
DB00327HydromorphoneUDP-glucuronosyltransferase 2B7enzyme
DB00327HydromorphoneSerum albumincarrier
DB00458ImipramineSodium-dependent noradrenaline transportertarget
DB00458ImipramineSodium-dependent serotonin transportertarget
DB00458ImipramineCytochrome P450 1A2enzyme
DB00458ImipramineCytochrome P450 2C19enzyme
DB00458ImipramineCytochrome P450 2D6enzyme
DB00458ImipramineHistamine H1 receptortarget
DB00458ImipramineAlpha-1A adrenergic receptortarget
DB00458Imipramine5-hydroxytryptamine receptor 2Atarget
DB00458ImipramineMuscarinic acetylcholine receptor M1target
DB00458ImipramineMuscarinic acetylcholine receptor M2target
DB00458ImipramineMuscarinic acetylcholine receptor M3target
DB00458ImipramineMuscarinic acetylcholine receptor M4target
DB00458ImipramineMuscarinic acetylcholine receptor M5target
DB00458ImipraminePotassium voltage-gated channel subfamily D member 2target
DB00458ImipraminePotassium voltage-gated channel subfamily D member 3target
DB00458ImipramineAlpha-1D adrenergic receptortarget
DB00458ImipramineAlpha-1-acid glycoprotein 1carrier
DB00458ImipramineSolute carrier family 22 member 2transporter
DB00458ImipramineSolute carrier family 22 member 3transporter
DB00458ImipramineP-glycoprotein 1transporter
DB00458ImipramineSolute carrier family 22 member 4transporter
DB00458ImipramineCytochrome P450 3A4enzyme
DB00458ImipramineCytochrome P450 2B6enzyme
DB00458ImipramineCytochrome P450 2C18enzyme
DB00458ImipramineCytochrome P450 2E1enzyme
DB00458ImipramineCytochrome P450 3A7enzyme
DB00458Imipramine5-hydroxytryptamine receptor 2Ctarget
DB00458ImipramineAlpha-1B adrenergic receptortarget
DB00458Imipramine5-hydroxytryptamine receptor 7target
DB00458ImipramineD(1) dopamine receptortarget
DB00458ImipramineDopamine D2 receptortarget
DB00458ImipraminePotassium voltage-gated channel subfamily H member 2target
DB00458ImipramineSodium-dependent dopamine transportertarget
DB00458Imipramine5-hydroxytryptamine receptor 1Atarget
DB00458Imipramine5-hydroxytryptamine receptor 6target
DB00458ImipraminePotassium voltage-gated channel subfamily H member 1target
DB00458ImipramineSerum albumincarrier
DB00458ImipramineAlpha-1-acid glycoprotein 2target
DB00230PregabalinExcitatory amino acid transporter 3transporter
DB00230PregabalinVoltage-dependent calcium channel subunit alpha-2/delta-1target
DB00230PregabalinLarge neutral amino acids transporter small subunit 1transporter
DB00285VenlafaxineSodium-dependent serotonin transportertarget
DB00285VenlafaxineSodium-dependent noradrenaline transportertarget
DB00285VenlafaxineCytochrome P450 2D6enzyme
DB00285VenlafaxineCytochrome P450 3A4enzyme
DB00285VenlafaxineSodium-dependent dopamine transportertarget
DB00285VenlafaxineP-glycoprotein 1transporter
DB00285VenlafaxineATP-binding cassette sub-family G member 2transporter
DrugDrug NamePhaseStatusCount
DB06690Nitrous oxide0Unknown Status1
DB09140Oxygen0Unknown Status1
DB12878AV-1011Completed1
DB06774Capsaicin1Enrolling by Invitation1
DB01068Clonazepam1Completed1
DB15198Dextromethadone1Completed2
DB00843Donepezil1Completed1
DB09119Eslicarbazepine acetate1Completed1
DB00996Gabapentin1Completed1
DB01167Itraconazole1Completed1
DB00281Lidocaine1Terminated1
DB00331Metformin1Completed1
DB14158Microcrystalline cellulose1Completed1
DB00904Ondansetron1Recruiting1
DB00230Pregabalin1Recruiting1
DB11706Raxatrigine1Completed2
DB11706Raxatrigine1Terminated1
DB06240Tariquidar1Recruiting1
DB00349Clobazam1 / 2Completed1
DB01068Clonazepam1 / 2Completed1
DB14009Medical Cannabis1 / 2Completed3
DB01036Tolterodine1 / 2Completed1
DB05050ADL58592Completed1
DB15333AZD-13862Terminated1
DB00316Acetaminophen2Recruiting2
DB06151Acetylcysteine2Completed1
DB00083Botulinum toxin type A2Recruiting1
DB00083Botulinum toxin type A2Terminated1
DB06774Capsaicin2Recruiting1
DB00482Celecoxib2Recruiting1
DB00514Dextromethorphan2Completed1
DB12140Dilmapimod2Completed1
DB00470Dronabinol2Recruiting1
DB00476Duloxetine2Completed1
DB00476Duloxetine2Recruiting1
DB00736Esomeprazole2Recruiting1
DB12760GW-4938382Completed1
DB00996Gabapentin2Completed1
DB00996Gabapentin2Withdrawn1
DB00028Immune globulin human2Unknown Status1
DB05214KD70402Completed1
DB15215KRN-55002Completed1
DB01221Ketamine2Completed1
DB01221Ketamine2Recruiting1
DB06218Lacosamide2Recruiting1
DB00281Lidocaine2Completed1
DB00281Lidocaine2Terminated1
DB14509Lithium carbonate2Completed1
DB12270Losmapimod2Completed1
DB00408Loxapine2Recruiting1
DB00653Magnesium sulfate2Recruiting1
DB14009Medical Cannabis2Recruiting1
DB01043Memantine2Completed1
DB01043Memantine2Not Yet Recruiting1
DB04896Milnacipran2Recruiting1
DB00295Morphine2Completed1
DB00295Morphine2Recruiting1
DB00486Nabilone2Completed1
DB01183Naloxone2Recruiting1
DB00788Naproxen2Recruiting1
DB00435Nitric Oxide2Completed1
DB00497Oxycodone2Recruiting1
DB00107Oxytocin2Recruiting1
DB00230Pregabalin2Completed1
DB00230Pregabalin2Terminated1
DB00230Pregabalin2Withdrawn1
DB06649Priralfinamide2Completed1
DB05232Tetrodotoxin2Terminated1
DB00193Tramadol2Recruiting1
DB00313Valproic acid2Completed1
DB06283Ziconotide2Active Not Recruiting1
DB00321Amitriptyline3Recruiting1
DB00083Botulinum toxin type A3Withdrawn1
DB00297Bupivacaine3Not Yet Recruiting1
DB00921Buprenorphine3Completed2
DB09061Cannabidiol3Completed2
DB00470Dronabinol3Completed2
DB00996Gabapentin3Not Yet Recruiting1
DB00281Lidocaine3Completed1
DB01043Memantine3Completed1
DB14011Nabiximols3Completed1
DB00526Oxaliplatin3Completed1
DB01192Oxymorphone3Completed1
DB00715Paroxetine3Completed1
DB00230Pregabalin3Completed6
DB00230Pregabalin3Recruiting1
DB00230Pregabalin3Terminated1
DB06204Tapentadol3Terminated1
DB00193Tramadol3Recruiting1
DB00316Acetaminophen4Not Yet Recruiting1
DB00316Acetaminophen4Recruiting1
DB00083Botulinum toxin type A4Completed1
DB00297Bupivacaine4Active Not Recruiting1
DB00297Bupivacaine4Not Yet Recruiting1
DB00297Bupivacaine4Recruiting1
DB06774Capsaicin4Recruiting1
DB06774Capsaicin4Unknown Status1
DB00564Carbamazepine4Completed1
DB00341Cetirizine4Completed1
DB01234Dexamethasone4Active Not Recruiting1
DB00843Donepezil4Active Not Recruiting1
DB00476Duloxetine4Completed1
DB00668Epinephrine4Active Not Recruiting1
DB00813Fentanyl4Completed1
DB00996Gabapentin4Completed2
DB00327Hydromorphone4Completed1
DB01221Ketamine4Completed1
DB01221Ketamine4Recruiting1
DB01221Ketamine4Unknown Status1
DB01009Ketoprofen4Not Yet Recruiting1
DB01009Ketoprofen4Recruiting1
DB00281Lidocaine4Completed2
DB00281Lidocaine4Recruiting1
DB00281Lidocaine4Terminated1
DB04817Metamizole4Not Yet Recruiting1
DB04817Metamizole4Recruiting1
DB00333Methadone4Completed1
DB00295Morphine4Recruiting1
DB00486Nabilone4Completed1
DB01183Naloxone4Completed1
DB00497Oxycodone4Completed1
DB00497Oxycodone4Terminated1
DB00230Pregabalin4Completed3
DB00230Pregabalin4Recruiting1
DB00230Pregabalin4Unknown Status3
DB00296Ropivacaine4Not Yet Recruiting1
DB06204Tapentadol4Completed2
DB00193Tramadol4Completed1
DB00181BaclofenNot AvailableRecruiting1
DB00083Botulinum toxin type ANot AvailableCompleted1
DB00921BuprenorphineNot AvailableCompleted1
DB09061CannabidiolNot AvailableCompleted1
DB06774CapsaicinNot AvailableActive Not Recruiting1
DB06774CapsaicinNot AvailableRecruiting3
DB06774CapsaicinNot AvailableUnknown Status1
DB14184CinnamaldehydeNot AvailableRecruiting1
DB01075DiphenhydramineNot AvailableCompleted1
DB00470DronabinolNot AvailableCompleted1
DB00476DuloxetineNot AvailableRecruiting1
DB00813FentanylNot AvailableCompleted1
DB00996GabapentinNot AvailableCompleted2
DB00327HydromorphoneNot AvailableCompleted1
DB00825LevomentholNot AvailableRecruiting1
DB00281LidocaineNot AvailableActive Not Recruiting1
DB00281LidocaineNot AvailableCompleted3
DB00653Magnesium sulfateNot AvailableCompleted1
DB14009Medical CannabisNot AvailableActive Not Recruiting1
DB00333MethadoneNot AvailableCompleted1
DB09241Methylene blueNot AvailableCompleted1
DB00295MorphineNot AvailableCompleted1
DB14011NabiximolsNot AvailableCompleted1
DB00497OxycodoneNot AvailableCompleted1
DB01192OxymorphoneNot AvailableUnknown Status1
DB01229PaclitaxelNot AvailableCompleted1
DB00230PregabalinNot AvailableActive Not Recruiting1
DB00230PregabalinNot AvailableCompleted4
DB00230PregabalinNot AvailableRecruiting2
DB00980RamelteonNot AvailableTerminated1
DB06204TapentadolNot AvailableCompleted1
DB00285VenlafaxineNot AvailableCompleted1