Obstructive Sleep Apnea (OSA)

Also known as: Apnea, Obstructive Sleep / Obstructive Sleep Apnea / Obstructive sleep apnoea syndrome / Obstructive sleep apnea syndrome / Obstructive sleep apnea (adult) (pediatric) / Sleep Apnea, Obstructive

DrugDrug NameDrug Description
DB00745ModafinilModafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactivation and euphoria. The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Modafinil activates glutamatergic circuits while inhibiting GABA.
DB14754SolriamfetolSolriamfetol marketed under the brand name Sunosi by Jazz Pharmaceuticals in the United States is a dopamine and norepinephrine reuptake inhibitor (DNRI) indicated in treating daytime sleepiness associated with narcolepsy or obstructive sleep apnea[FDA Label]. Solriamfetol was given FDA approval in 2019[FDA Label].
DrugDrug NamePhaseStatusCount
DB00556Perflutren0Not Yet Recruiting1
DB11104Sulfur hexafluoride0Not Yet Recruiting1
DB11951Lemborexant1Completed1
DB00370Mirtazapine1Completed1
DB00338Omeprazole1Withdrawn1
DB00289Atomoxetine1 / 2Completed1
DB00136Calcitriol1 / 2Completed1
DB00482Celecoxib1 / 2Completed1
DB00633Dexmedetomidine1 / 2Withdrawn1
DB00328Indometacin1 / 2Completed1
DB09496Octinoxate1 / 2Completed1
DB01062Oxybutynin1 / 2Completed1
DB09536Titanium dioxide1 / 2Completed1
DB00819Acetazolamide2Completed1
DB00559Bosentan2Completed1
DB01083Orlistat2Recruiting1
DB09140Oxygen2Recruiting1
DB00571Propranolol2Enrolling by Invitation1
DB14754Solriamfetol2Recruiting1
DB00909Zonisamide2Completed1
DB00633Dexmedetomidine2 / 3Withdrawn1
DB01221Ketamine2 / 3Completed1
DB00594Amiloride3Completed1
DB00381Amlodipine3Completed1
DB06413Armodafinil3Completed3
DB01222Budesonide3Completed1
DB00310Chlorthalidone3Completed1
DB00633Dexmedetomidine3Completed1
DB00813Fentanyl3Completed1
DB00471Montelukast3Completed1
DB11642Pitolisant3Completed2
DB11642Pitolisant3Recruiting1
DB11642Pitolisant3Withdrawn1
DB00980Ramelteon3Completed1
DB14754Solriamfetol3Completed3
DB01198Zopiclone3Completed1
DB00316Acetaminophen4Terminated1
DB00316Acetaminophen4Withdrawn1
DB00381Amlodipine4Active Not Recruiting1
DB06413Armodafinil4Completed2
DB01222Budesonide4Unknown Status1
DB00190Carbidopa4Recruiting1
DB11121Chloroxylenol4Completed1
DB11121Chloroxylenol4Terminated1
DB01234Dexamethasone4Recruiting1
DB00633Dexmedetomidine4Not Yet Recruiting1
DB00633Dexmedetomidine4Recruiting1
DB00633Dexmedetomidine4Terminated1
DB00843Donepezil4Completed1
DB00843Donepezil4Unknown Status1
DB00402Eszopiclone4Completed2
DB01018Guanfacine4Active Not Recruiting1
DB00999Hydrochlorothiazide4Active Not Recruiting1
DB00956Hydrocodone4Terminated1
DB01050Ibuprofen4Terminated1
DB00465Ketorolac4Recruiting1
DB00007Leuprolide4Terminated1
DB01235Levodopa4Recruiting1
DB00745Modafinil4Completed1
DB00764Mometasone4Completed1
DB00764Mometasone4Withdrawn1
DB00471Montelukast4Terminated1
DB00295Morphine4Recruiting1
DB04861Nebivolol4Unknown Status1
DB01400Neostigmine4Completed1
DB01400Neostigmine4Recruiting1
DB00904Ondansetron4Recruiting1
DB00213Pantoprazole4Completed1
DB00715Paroxetine4Completed1
DB01132Pioglitazone4Terminated1
DB00818Propofol4Completed1
DB00818Propofol4Recruiting1
DB01236Sevoflurane4Recruiting1
DB01105Sibutramine4Completed1
DB09153Sodium chloride4Terminated1
DB06206Sugammadex4Completed1
DB06206Sugammadex4Recruiting1
DB11815Tilarginine4Completed1
DB00177Valsartan4Active Not Recruiting1
DB00285Venlafaxine4Active Not Recruiting1
DB00437AllopurinolNot AvailableWithdrawn1
DB06413ArmodafinilNot AvailableRecruiting1
DB09230AzelnidipineNot AvailableCompleted1
DB00201CaffeineNot AvailableTerminated1
DB00633DexmedetomidineNot AvailableCompleted1
DB08908Dimethyl fumarateNot AvailableCompleted1
DB00783EstradiolNot AvailableCompleted1
DB00402EszopicloneNot AvailableCompleted2
DB00813FentanylNot AvailableCompleted1
DB00813FentanylNot AvailableNot Yet Recruiting1
DB00448LansoprazoleNot AvailableWithdrawn1
DB00745ModafinilNot AvailableRecruiting1
DB00295MorphineNot AvailableSuspended1
DB00275OlmesartanNot AvailableCompleted1
DB01132PioglitazoneNot AvailableUnknown Status1
DB00396ProgesteroneNot AvailableCompleted1
DB00818PropofolNot AvailableCompleted1
DB00980RamelteonNot AvailableCompleted1
DB01001SalbutamolNot AvailableRecruiting1
DB09153Sodium chlorideNot AvailableRecruiting1
DB00421SpironolactoneNot AvailableCompleted1
DB00624TestosteroneNot AvailableCompleted1
DB06694XylometazolineNot AvailableRecruiting1