Showing BioInteractions for Loxoprofen (DB09212)
BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Loxoprofen is a Carbonyl reductase [NADPH] 1 substrate | ||
| 1 | Carbonyl reductase [NADPH] 1 ligands | 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol |
| 2 | Carbonyl reductase [NADPH] 1 substrates | Acetohexamide, Amrubicin, Deutetrabenazine, Doxorubicin, Fenofibrate, Haloperidol, Lubiprostone, Oxcarbazepine, Tetrabenazine |
| 3 | Carbonyl reductase [NADPH] 1 binders | 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol |
| 4 | Carbonyl reductase [NADPH] 1 inhibitors | Resveratrol, Sofalcone |
| Interacting Group | Interacting Drugs | |
|---|---|---|
| Loxoprofen is a Cytochrome P450 3A Subfamily substrate | ||
| 1 | Cytochrome P450 3A Subfamily inhibitors | Crizotinib, Diacerein, Fluvoxamine, Glecaprevir, Istradefylline, Lemborexant, Lonafarnib, Lopinavir, Lorlatinib, Midostaurin, Nefazodone, Olanzapine, Phenelzine, Pibrentasvir, Remoxipride, Rhein, Risdiplam, Selpercatinib |
| 2 | Cytochrome P450 3A Subfamily substrates | Acalabrutinib, Ambroxol acefyllinate, Budesonide, Dolutegravir, Elagolix, Ethosuximide, Foretinib, Glecaprevir, Lonafarnib, Lorlatinib, Mebendazole, Methylprednisolone, Midostaurin, Mirodenafil, Moxisylyte, Naldemedine, Omega-3-carboxylic acids, Relugolix, Tazemetostat, Thiopental, Tucatinib, Zanubrutinib |
| 3 | Cytochrome P450 3A Subfamily inducers | Brigatinib, Budesonide, Lemborexant, Methylprednisolone, Midostaurin, Myrrh, Prednisolone phosphate, Prednisone, Relugolix, Rifapentine |