Alcoholism

Also known as: Chronic alcohol abuse / Alcohol addiction / Alcohol abuse chronic / Alcohol dependence / Dipsomania / Chronic alcoholism / Alcohol abuse, continuous drinking behaviour / Alcohol abuse, continuous drinking behavior / Alcohol dependence syndrome

DrugDrug NameDrug Description
DB01142DoxepinDoxepin is a dibenzoxepin-derivative tricyclic antidepressant (TCA). Structurally similar to phenothiazines, TCAs contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, doxepin does not affect mood or arousal, but may cause sedation. In depressed individuals, doxepin exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as doxepin and amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. Doxepin has less sedative and anticholinergic effects than amitriptyline. See toxicity section below for a complete listing of side effects. When orally administered, doxepin may be used to treat depression and insomnia. Unlabeled indications of oral doxepin also include chronic and neuropathic pain, and anxiety. Doxepin may also be used as a second line agent to treat idiopathic urticaria. As a topical agent, doxepin may be used relieve itching in patients with certain types of eczema. It may be used for the management of moderate pruritus in adult patients with atopic dermatitis or lichen simplex chronicus.
DrugDrug NameTargetType
DB01142DoxepinSodium-dependent serotonin transportertarget
DB01142DoxepinSodium-dependent noradrenaline transportertarget
DB01142DoxepinHistamine H1 receptortarget
DB01142DoxepinHistamine H2 receptortarget
DB01142DoxepinCytochrome P450 2D6enzyme
DB01142DoxepinMuscarinic acetylcholine receptor M1target
DB01142DoxepinMuscarinic acetylcholine receptor M2target
DB01142DoxepinMuscarinic acetylcholine receptor M3target
DB01142DoxepinMuscarinic acetylcholine receptor M4target
DB01142DoxepinMuscarinic acetylcholine receptor M5target
DB01142DoxepinAlpha-1A adrenergic receptortarget
DB01142Doxepin5-hydroxytryptamine receptor 1Atarget
DB01142Doxepin5-hydroxytryptamine receptor 2Atarget
DB01142DoxepinD(2) dopamine receptortarget
DB01142DoxepinCytochrome P450 2C19enzyme
DB01142DoxepinCytochrome P450 2C9enzyme
DB01142DoxepinCytochrome P450 1A2enzyme
DB01142DoxepinAlpha-1-acid glycoprotein 1carrier
DB01142DoxepinMultidrug resistance protein 1transporter
DB01142Doxepin5-hydroxytryptamine receptor 2Btarget
DB01142Doxepin5-hydroxytryptamine receptor 2Ctarget
DB01142DoxepinAlpha-1B adrenergic receptortarget
DB01142DoxepinAlpha-1D adrenergic receptortarget
DB01142DoxepinAlpha-2A adrenergic receptortarget
DB01142DoxepinAlpha-2B adrenergic receptortarget
DB01142DoxepinAlpha-2C adrenergic receptortarget
DB01142DoxepinCytochrome P450 3A4enzyme
DB01142Doxepin5-hydroxytryptamine receptor 6target
DB01142DoxepinHistamine H4 receptortarget
DB01142DoxepinPotassium voltage-gated channel subfamily H member 2target
DrugDrug NamePhaseStatusCount
DB00898Ethanol0Recruiting1
DB01276Exenatide0Recruiting1
DB02325Isopropyl Alcohol0Recruiting1
DB06230Nalmefene0Terminated1
DB00704Naltrexone0Completed1
DB00107Oxytocin0Recruiting1
DB09153Sodium Chloride0Recruiting1
DB00898Ethanol1Terminated1
DB12886GSK-15214981Completed2
DB00704Naltrexone1Completed2
DB00904Ondansetron1Completed1
DB00107Oxytocin1Completed1
DB00107Oxytocin1Not Yet Recruiting1
DB06663Pasireotide1Completed1
DB11805Saracatinib1Recruiting1
DB01104Sertraline1Completed1
DB00906Tiagabine1Terminated1
DB00273Topiramate1Completed1
DB06151Acetylcysteine1 / 2Completed1
DB00704Naltrexone1 / 2Recruiting1
DB00457Prazosin1 / 2Completed1
DB00659Acamprosate2Completed4
DB00714Apomorphine2Unknown Status1
DB00673Aprepitant2Completed1
DB00181Baclofen2Completed3
DB00181Baclofen2Terminated1
DB12299Bavisant2Withdrawn1
DB01156Bupropion2Completed1
DB12196CP-8660872Completed1
DB00215Citalopram2Completed1
DB00434Cyproheptadine2Completed1
DB01151Desipramine2Completed1
DB00822Disulfiram2Completed1
DB00590Doxazosin2Recruiting1
DB00898Ethanol2Completed1
DB01039Fenofibrate2Completed1
DB00472Fluoxetine2Completed1
DB06717Fosaprepitant2Completed1
DB00996Gabapentin2Completed2
DB11895Ghrelin2Completed1
DB00145Glycine2Completed1
DB02325Isopropyl Alcohol2Completed1
DB01221Ketamine2Terminated1
DB04465Lactose2Completed1
DB01202Levetiracetam2Completed1
DB01202Levetiracetam2Terminated1
DB00186Lorazepam2Completed1
DB12111MK-2122Completed1
DB00657Mecamylamine2Completed1
DB00834Mifepristone2Completed1
DB00834Mifepristone2Recruiting1
DB00745Modafinil2Completed1
DB00704Naltrexone2Completed7
DB12220ORG-259352Terminated1
DB00904Ondansetron2Active Not Recruiting1
DB00904Ondansetron2Completed2
DB00904Ondansetron2Unknown Status1
DB08883Perampanel2Suspended1
DB12572Pexacerfont2Completed1
DB01132Pioglitazone2Recruiting1
DB00457Prazosin2Unknown Status1
DB01224Quetiapine2Completed3
DB00734Risperidone2Completed1
DB01104Sertraline2Completed4
DB01104Sertraline2Terminated1
DB09153Sodium Chloride2Completed1
DB00273Topiramate2Completed3
DB00273Topiramate2Recruiting1
DB00273Topiramate2Terminated1
DB00273Topiramate2Unknown Status1
DB12580Tradipitant2Completed1
DB00656Trazodone2Completed1
DB00313Valproic Acid2Completed1
DB01273Varenicline2Completed3
DB01080Vigabatrin2Terminated1
DB01392Yohimbine2Completed1
DB00909Zonisamide2Completed1
DB00909Zonisamide2Terminated1
DB00181Baclofen2 / 3Completed1
DB00904Ondansetron2 / 3Not Yet Recruiting1
DB00313Valproic Acid2 / 3Completed1
DB00659Acamprosate3Completed1
DB00659Acamprosate3Not Yet Recruiting1
DB01238Aripiprazole3Recruiting1
DB00181Baclofen3Recruiting1
DB01373Calcium3Not Yet Recruiting1
DB11093Calcium Citrate3Not Yet Recruiting1
DB00475Chlordiazepoxide3Completed1
DB01151Desipramine3Completed1
DB00514Dextromethorphan3Not Yet Recruiting1
DB01183Naloxone3Completed1
DB00704Naltrexone3Completed10
DB00704Naltrexone3Terminated1
DB00904Ondansetron3Completed1
DB00107Oxytocin3Completed1
DB00107Oxytocin3Enrolling by Invitation1
DB00715Paroxetine3Completed1
DB01224Quetiapine3Completed2
DB01273Varenicline3Terminated1
DB00659Acamprosate4Completed3
DB00659Acamprosate4Unknown Status1
DB01238Aripiprazole4Completed1
DB11748Benfotiamine4Completed1
DB01156Bupropion4Completed1
DB01156Bupropion4Unknown Status1
DB00564Carbamazepine4Completed1
DB00822Disulfiram4Unknown Status1
DB01126Dutasteride4Completed2
DB01175Escitalopram4Completed1
DB00472Fluoxetine4Completed1
DB00472Fluoxetine4Unknown Status1
DB04465Lactose4Completed1
DB01202Levetiracetam4Completed1
DB00186Lorazepam4Completed1
DB01043Memantine4Completed1
DB00422Methylphenidate4Completed1
DB00683Midazolam4Withdrawn1
DB00704Naltrexone4Completed22
DB00704Naltrexone4Unknown Status1
DB00184Nicotine4Completed2
DB00457Prazosin4Completed1
DB00230Pregabalin4Active Not Recruiting1
DB00818Propofol4Withdrawn1
DB01224Quetiapine4Completed1
DB00811Ribavirin4Completed1
DB01104Sertraline4Completed2
DB00421Spironolactone4Suspended1
DB00273Topiramate4Completed3
DB00909Zonisamide4Completed1
DB00201CaffeineNot AvailableActive Not Recruiting1
DB00215CitalopramNot AvailableCompleted1
DB00829DiazepamNot AvailableCompleted1
DB01075DiphenhydramineNot AvailableActive Not Recruiting1
DB01126DutasterideNot AvailableCompleted2
DB00898EthanolNot AvailableActive Not Recruiting2
DB00898EthanolNot AvailableCompleted4
DB00898EthanolNot AvailableRecruiting1
DB11895GhrelinNot AvailableCompleted1
DB02325Isopropyl AlcoholNot AvailableActive Not Recruiting1
DB02325Isopropyl AlcoholNot AvailableCompleted1
DB02325Isopropyl AlcoholNot AvailableRecruiting1
DB01221KetamineNot AvailableCompleted1
DB00457PrazosinNot AvailableTerminated1
DB09153Sodium ChlorideNot AvailableCompleted1
DB00599ThiopentalNot AvailableCompleted1
DB00273TopiramateNot AvailableTerminated1
DB00313Valproic AcidNot AvailableCompleted1
DB01593ZincNot AvailableActive Not Recruiting1
DB00909ZonisamideNot AvailableCompleted1