Alcohol Dependence

Also known as: Alcoholism / Alcohol Addiction / Alcoholic / Addiction, Alcohol / Chronic alcohol abuse / Alcohol abuse chronic / Dipsomania / Chronic alcoholism / Alcohol abuse, continuous drinking behaviour / Alcohol abuse, continuous drinking behavior / Alcohol dependence syndrome

DrugDrug NameDrug Description
DB00659AcamprosateA medication used to maintain alcohol abstinence in patients with alcohol dependence.
DB01142DoxepinA psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia.
DB00472FluoxetineA selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I.
DB06230NalmefeneAn opioid antagonist used in conjunction with psychosocial support to help adults with alcohol dependence reduce alcohol consumption.
DB00704NaltrexoneA narcotic antagonist used in opioid overdose.
DB00273TopiramateAn anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines.
DB00656TrazodoneA serotonin uptake inhibitor used to treat major depressive disorder.
DrugDrug NameTargetType
DB00659AcamprosateMetabotropic glutamate receptor 5target
DB00659AcamprosateProton-coupled amino acid transporter 1transporter
DB00659AcamprosateGABA-A receptor (anion channel)target
DB00659AcamprosateGlutamate (NMDA) receptortarget
DB01142DoxepinSodium-dependent serotonin transportertarget
DB01142DoxepinSodium-dependent noradrenaline transportertarget
DB01142DoxepinHistamine H1 receptortarget
DB01142DoxepinHistamine H2 receptortarget
DB01142DoxepinCytochrome P450 2D6enzyme
DB01142DoxepinMuscarinic acetylcholine receptor M1target
DB01142DoxepinMuscarinic acetylcholine receptor M2target
DB01142DoxepinMuscarinic acetylcholine receptor M3target
DB01142DoxepinMuscarinic acetylcholine receptor M4target
DB01142DoxepinMuscarinic acetylcholine receptor M5target
DB01142DoxepinAlpha-1A adrenergic receptortarget
DB01142Doxepin5-hydroxytryptamine receptor 1Atarget
DB01142Doxepin5-hydroxytryptamine receptor 2Atarget
DB01142DoxepinCytochrome P450 2C19enzyme
DB01142DoxepinCytochrome P450 2C9enzyme
DB01142DoxepinCytochrome P450 1A2enzyme
DB01142DoxepinP-glycoprotein 1transporter
DB01142Doxepin5-hydroxytryptamine receptor 2Btarget
DB01142Doxepin5-hydroxytryptamine receptor 2Ctarget
DB01142DoxepinAlpha-1B adrenergic receptortarget
DB01142DoxepinAlpha-1D adrenergic receptortarget
DB01142DoxepinCytochrome P450 3A4enzyme
DB01142Doxepin5-hydroxytryptamine receptor 6target
DB01142DoxepinHistamine H4 receptortarget
DB01142DoxepinPotassium voltage-gated channel subfamily H member 2target
DB01142DoxepinSerum albumincarrier
DB01142DoxepinAlpha-1-acid glycoprotein 1carrier
DB00472FluoxetineSodium-dependent serotonin transportertarget
DB00472FluoxetineCytochrome P450 2C9enzyme
DB00472FluoxetineCytochrome P450 2D6enzyme
DB00472FluoxetineCYP2B proteinenzyme
DB00472FluoxetineCytochrome P450 1A2enzyme
DB00472FluoxetineCytochrome P450 3A4enzyme
DB00472FluoxetineCytochrome P450 2C19enzyme
DB00472FluoxetineP-glycoprotein 1transporter
DB00472FluoxetineCytochrome P450 2B6enzyme
DB00472FluoxetineCytochrome P450 3A5enzyme
DB00472FluoxetineSerum albumincarrier
DB00472FluoxetineAlpha-1-acid glycoprotein 1carrier
DB00472FluoxetinePotassium voltage-gated channel subfamily H member 2target
DB00472Fluoxetine5-hydroxytryptamine receptor 2Ctarget
DB00472FluoxetineCyclin-dependent kinases regulatory subunit 1target
DB00472FluoxetineNeuronal acetylcholine receptor subunit alpha-2target
DB00472FluoxetineNeuronal acetylcholine receptor subunit alpha-3target
DB00472FluoxetineNeuronal acetylcholine receptor subunit beta-4target
DB06230NalmefeneMu-type opioid receptortarget
DB06230NalmefeneKappa-type opioid receptortarget
DB06230NalmefeneDelta-type opioid receptortarget
DB06230NalmefeneUDP-glucuronosyltransferase 2B7enzyme
DB06230NalmefeneUDP-glucuronosyltransferase 1-3enzyme
DB06230NalmefeneUDP-glucuronosyltransferase 1-8enzyme
DB00704NaltrexoneMu-type opioid receptortarget
DB00704NaltrexoneKappa-type opioid receptortarget
DB00704NaltrexoneDelta-type opioid receptortarget
DB00704NaltrexoneHCG20471, isoform CRA_ctarget
DB00704NaltrexoneUDP-glucuronosyltransferase 1-1enzyme
DB00273TopiramateGamma-aminobutyric acid receptor subunit alpha-1target
DB00273TopiramateSodium channel protein type 1 subunit alphatarget
DB00273TopiramateCarbonic anhydrase 2target
DB00273TopiramateCarbonic anhydrase 4target
DB00273TopiramateGlutamate receptor ionotropic, kainate 1target
DB00273TopiramateCytochrome P450 2C19enzyme
DB00273TopiramateCytochrome P450 3A4enzyme
DB00273TopiramateGABA-A receptor (anion channel)target
DB00273TopiramateCarbonic anhydrase 1target
DB00273TopiramateCarbonic anhydrase 3target
DB00273TopiramateGlutamate receptor 1target
DB00656Trazodone5-hydroxytryptamine receptor 2Atarget
DB00656TrazodoneSodium-dependent serotonin transportertarget
DB00656TrazodoneAlpha-1A adrenergic receptortarget
DB00656TrazodoneAlpha-2A adrenergic receptortarget
DB00656TrazodoneHistamine H1 receptortarget
DB00656Trazodone5-hydroxytryptamine receptor 1Atarget
DB00656TrazodoneCytochrome P450 2D6enzyme
DB00656TrazodoneCytochrome P450 3A4enzyme
DB00656Trazodone5-hydroxytryptamine receptor 2Ctarget
DB00656TrazodoneCytochrome P450 3A5enzyme
DB00656TrazodoneCytochrome P450 3A7enzyme
DB00656TrazodoneP-glycoprotein 1transporter
DB00656Trazodone5-hydroxytryptamine receptor 1Ctarget
DrugDrug NamePhaseStatusCount
DB00898Ethanol0Recruiting1
DB01276Exenatide0Recruiting1
DB11895Lenomorelin0Recruiting1
DB06230Nalmefene0Terminated1
DB00704Naltrexone0Completed1
DB00107Oxytocin0Completed1
DB00181Baclofen1Completed1
DB11105Benzalkonium1Completed1
DB06770Benzyl alcohol1Completed1
DB00215Citalopram1Completed1
DB00470Dronabinol1Active Not Recruiting1
DB00898Ethanol1Completed1
DB00898Ethanol1Terminated1
DB12886GSK-15214981Completed2
DB01221Ketamine1Completed1
DB12341LY-24563021Completed1
DB01017Minocycline1Completed1
DB06230Nalmefene1Completed2
DB00704Naltrexone1Completed3
DB00704Naltrexone1Terminated1
DB05423ORG-345171Completed1
DB00904Ondansetron1Completed1
DB00107Oxytocin1Completed1
DB00107Oxytocin1Withdrawn1
DB14870PF-51904571Completed1
DB06663Pasireotide1Completed1
DB00457Prazosin1Completed1
DB12543Samidorphan1Completed1
DB11805Saracatinib1Recruiting1
DB01104Sertraline1Completed1
DB00877Sirolimus1Recruiting1
DB00906Tiagabine1Terminated1
DB00273Topiramate1Completed1
DB00659Acamprosate1 / 2Completed1
DB06151Acetylcysteine1 / 2Completed1
DB12338Carisbamate1 / 2Active Not Recruiting1
DB00704Naltrexone1 / 2Active Not Recruiting1
DB00704Naltrexone1 / 2Completed1
DB00457Prazosin1 / 2Completed1
DB00313Valproic acid1 / 2Completed1
DB00659Acamprosate2Completed4
DB06151Acetylcysteine2Completed1
DB00714Apomorphine2Unknown Status1
DB00673Aprepitant2Completed2
DB00673Aprepitant2Terminated1
DB01238Aripiprazole2Completed2
DB00181Baclofen2Completed3
DB00181Baclofen2Terminated1
DB12299Bavisant2Withdrawn1
DB01156Bupropion2Completed1
DB12196CP-8660872Completed1
DB00215Citalopram2Completed1
DB00434Cyproheptadine2Completed1
DB01151Desipramine2Completed1
DB01075Diphenhydramine2Recruiting1
DB00822Disulfiram2Completed1
DB00590Doxazosin2Completed1
DB00590Doxazosin2Recruiting1
DB00476Duloxetine2Completed1
DB00898Ethanol2Completed1
DB00898Ethanol2Recruiting1
DB01276Exenatide2Active Not Recruiting1
DB01039Fenofibrate2Completed1
DB13873Fenofibric acid2Completed1
DB00472Fluoxetine2Completed1
DB00996Gabapentin2Completed2
DB00145Glycine2Completed1
DB01221Ketamine2Suspended1
DB04465Lactose2Completed1
DB11895Lenomorelin2Completed1
DB01202Levetiracetam2Completed2
DB01202Levetiracetam2Terminated1
DB00186Lorazepam2Completed1
DB00657Mecamylamine2Completed1
DB00834Mifepristone2Active Not Recruiting1
DB00834Mifepristone2Completed1
DB00370Mirtazapine2Completed2
DB00745Modafinil2Completed1
DB00704Naltrexone2Completed14
DB12220ORG-259352Terminated1
DB00334Olanzapine2Completed1
DB00904Ondansetron2Completed5
DB00904Ondansetron2Terminated1
DB00904Ondansetron2Unknown Status1
DB12585Ondelopran2Completed1
DB00107Oxytocin2Completed1
DB00107Oxytocin2Recruiting1
DB00107Oxytocin2Withdrawn1
DB14870PF-51904572Recruiting1
DB08883Perampanel2Recruiting1
DB12572Pexacerfont2Completed1
DB01132Pioglitazone2Recruiting1
DB01132Pioglitazone2Terminated1
DB00457Prazosin2Unknown Status1
DB00230Pregabalin2Completed1
DB00571Propranolol2Completed1
DB11664Psilocybine2Recruiting1
DB11664Psilocybine2Unknown Status1
DB01224Quetiapine2Completed4
DB00734Risperidone2Completed1
DB12543Samidorphan2Completed1
DB12973Serlopitant2Terminated1
DB01104Sertraline2Completed4
DB01104Sertraline2Terminated1
DB09153Sodium chloride2Completed1
DB00273Topiramate2Active Not Recruiting1
DB00273Topiramate2Completed5
DB00273Topiramate2Terminated2
DB00273Topiramate2Unknown Status1
DB12580Tradipitant2Completed2
DB00656Trazodone2Completed1
DB00313Valproic acid2Completed1
DB01273Varenicline2Completed5
DB01273Varenicline2Unknown Status1
DB12512Verucerfont2Completed1
DB01080Vigabatrin2Terminated1
DB01392Yohimbine2Completed1
DB00909Zonisamide2Completed2
DB00909Zonisamide2Terminated1
DB12110m-Chlorophenylpiperazine2Completed1
DB01238Aripiprazole2 / 3Completed1
DB00181Baclofen2 / 3Completed3
DB01205Flumazenil2 / 3Completed1
DB00996Gabapentin2 / 3Completed2
DB00704Naltrexone2 / 3Completed1
DB00904Ondansetron2 / 3Not Yet Recruiting1
DB00396Progesterone2 / 3Recruiting1
DB00273Topiramate2 / 3Completed2
DB00273Topiramate2 / 3Unknown Status1
DB00313Valproic acid2 / 3Completed1
DB01273Varenicline2 / 3Completed1
DB00659Acamprosate3Completed2
DB00659Acamprosate3Not Yet Recruiting1
DB01238Aripiprazole3Completed1
DB01238Aripiprazole3Recruiting1
DB00181Baclofen3Completed2
DB00181Baclofen3Recruiting1
DB11093Calcium Citrate3Not Yet Recruiting1
DB00475Chlordiazepoxide3Completed1
DB01151Desipramine3Completed1
DB00996Gabapentin3Completed1
DB00555Lamotrigine3Withdrawn1
DB01202Levetiracetam3Completed1
DB14509Lithium carbonate3Completed1
DB00657Mecamylamine3Completed1
DB06230Nalmefene3Completed5
DB06230Nalmefene3Not Yet Recruiting1
DB01183Naloxone3Completed1
DB00704Naltrexone3Completed16
DB00704Naltrexone3Recruiting1
DB00704Naltrexone3Terminated1
DB00704Naltrexone3Unknown Status1
DB00334Olanzapine3Completed1
DB00904Ondansetron3Completed2
DB12585Ondelopran3Completed1
DB00107Oxytocin3Completed2
DB00715Paroxetine3Completed1
DB00457Prazosin3Completed1
DB01224Quetiapine3Completed3
DB00273Topiramate3Recruiting1
DB00273Topiramate3Unknown Status1
DB00273Topiramate3Withdrawn2
DB00313Valproic acid3Completed2
DB01273Varenicline3Terminated1
DB00909Zonisamide3Recruiting1
DB00659Acamprosate4Completed9
DB00659Acamprosate4Terminated1
DB00659Acamprosate4Unknown Status2
DB06151Acetylcysteine4Recruiting1
DB01238Aripiprazole4Completed1
DB00181Baclofen4Completed1
DB11748Benfotiamine4Completed1
DB01156Bupropion4Completed1
DB01156Bupropion4Unknown Status1
DB03568Butyric Acid4Completed1
DB00564Carbamazepine4Completed1
DB00122Choline4Completed1
DB12153Citicoline4Completed1
DB00907Cocaine4Recruiting1
DB02097Cytidine4Completed1
DB00822Disulfiram4Completed2
DB00822Disulfiram4Unknown Status1
DB01126Dutasteride4Completed2
DB01175Escitalopram4Completed2
DB00898Ethanol4Completed1
DB00898Ethanol4Recruiting1
DB00472Fluoxetine4Completed1
DB00472Fluoxetine4Unknown Status1
DB00996Gabapentin4Recruiting1
DB04465Lactose4Completed1
DB00555Lamotrigine4Completed1
DB01202Levetiracetam4Completed1
DB00186Lorazepam4Completed2
DB00186Lorazepam4Recruiting1
DB01043Memantine4Completed1
DB00422Methylphenidate4Completed2
DB00683Midazolam4Withdrawn1
DB06230Nalmefene4Completed1
DB06230Nalmefene4Terminated1
DB00704Naltrexone4Active Not Recruiting1
DB00704Naltrexone4Completed31
DB00704Naltrexone4Enrolling by Invitation1
DB00704Naltrexone4Recruiting1
DB00704Naltrexone4Terminated3
DB00704Naltrexone4Unknown Status1
DB00184Nicotine4Completed5
DB00842Oxazepam4Completed1
DB00715Paroxetine4Completed1
DB00457Prazosin4Completed1
DB00230Pregabalin4Active Not Recruiting1
DB00818Propofol4Withdrawn1
DB01224Quetiapine4Completed2
DB00811Ribavirin4Completed1
DB01104Sertraline4Completed2
DB09072Sodium oxybate4Completed1
DB00421Spironolactone4Suspended1
DB00273Topiramate4Completed3
DB00273Topiramate4Recruiting1
DB00273Topiramate4Unknown Status1
DB00313Valproic acid4Recruiting1
DB01273Varenicline4Terminated1
DB00909Zonisamide4Completed1
DB00659AcamprosateNot AvailableTerminated1
DB00201CaffeineNot AvailableActive Not Recruiting1
DB00190CarbidopaNot AvailableRecruiting1
DB00215CitalopramNot AvailableCompleted1
DB00260CycloserineNot AvailableCompleted1
DB01576DextroamphetamineNot AvailableRecruiting1
DB00829DiazepamNot AvailableCompleted1
DB01075DiphenhydramineNot AvailableActive Not Recruiting1
DB01126DutasterideNot AvailableCompleted2
DB00898EthanolNot AvailableActive Not Recruiting2
DB00898EthanolNot AvailableCompleted4
DB00898EthanolNot AvailableRecruiting1
DB00996GabapentinNot AvailableCompleted1
DB00145GlycineNot AvailableCompleted1
DB01221KetamineNot AvailableCompleted1
DB11895LenomorelinNot AvailableCompleted1
DB01235LevodopaNot AvailableRecruiting1
DB00745ModafinilNot AvailableRecruiting1
DB06230NalmefeneNot AvailableCompleted1
DB06230NalmefeneNot AvailableRecruiting1
DB00704NaltrexoneNot AvailableCompleted1
DB00704NaltrexoneNot AvailableRecruiting1
DB00457PrazosinNot AvailableTerminated1
DB00795SulfasalazineNot AvailableCompleted1
DB00599ThiopentalNot AvailableCompleted1
DB00273TopiramateNot AvailableTerminated1
DB00313Valproic acidNot AvailableCompleted1
DB01273VareniclineNot AvailableCompleted1
DB00909ZonisamideNot AvailableCompleted1