Showing BioInteractions for Carboplatin (DB00958)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

Enzyme Mediated Interactions 9
Transporter Mediated Interactions 6

	Interacting Group	Interacting Drugs
	Carboplatin is a Xanthine dehydrogenase/oxidase inducer
1	Xanthine dehydrogenase/oxidase inhibitors	Allopurinol, Carvedilol, Chlorphenesin, Deferoxamine, Eniluracil, Febuxostat, Spermine
2	Xanthine dehydrogenase/oxidase substrates	Adenosine, Azathioprine, Daunorubicin, Doxorubicin, Favipiravir, Inosine, Isosorbide mononitrate, Menadione, Mercaptopurine, NADH, Nitrofural, Porfiromycin, Procarbazine, Pyrazinamide
3	Xanthine dehydrogenase/oxidase conversion inhibitors	Trifluoperazine
4	Xanthine dehydrogenase/oxidase inducers	Aldesleukin, Cisplatin, Inosine

	Interacting Group	Interacting Drugs
	Carboplatin is a Myeloperoxidase substrate
1	Myeloperoxidase inhibitors	AB192, Aminosalicylic acid, Bivalirudin, Calcipotriol, Capsaicin, Cariporide, Cefdinir, Elafin, Melatonin, Nabumetone, Octreotide, Propylthiouracil, Tiopronin, Tolmetin
2	Myeloperoxidase substrates	Cysteamine, Dapsone, Melatonin, Oxaliplatin, Ticlopidine
3	Myeloperoxidase inducers	Cefaclor, Cisplatin, Urethane

	Interacting Group	Interacting Drugs
	Carboplatin is a Glutathione S-transferase theta-1 substrate
1	Glutathione S-transferase theta-1 substrates	Cisplatin, Etoposide, Oxaliplatin
2	Glutathione S-transferase theta-1 inducers	Polaprezinc

	Interacting Group	Interacting Drugs
	Carboplatin is a Metallothionein-1A substrate
1	Metallothionein-1A substrates	Cisplatin, Oxaliplatin
2	Metallothionein-1A binders	Zinc chloride, Zinc sulfate, unspecified form

	Interacting Group	Interacting Drugs
	Carboplatin is a Metallothionein-2 substrate
1	Metallothionein-2 substrates	Cisplatin, Oxaliplatin
2	Metallothionein-2 cofactors	Zinc chloride, Zinc sulfate, unspecified form

	Interacting Group	Interacting Drugs
	Carboplatin is a Superoxide dismutase [Cu-Zn] inhibitor
1	Superoxide dismutase [Cu-Zn] inducers	alpha-Tocopherol succinate, D-alpha-Tocopherol acetate, Polaprezinc, Vitamin E
2	Superoxide dismutase [Cu-Zn] substrates	Cisplatin, Oxaliplatin
3	Superoxide dismutase [Cu-Zn] inhibitors	Cannabidiol, Medical Cannabis, Nabiximols
4	Superoxide dismutase [Cu-Zn] cofactors	Copper, Zinc chloride, Zinc sulfate, unspecified form
5	Superoxide dismutase [Cu-Zn] ligands	Zinc acetate

	Interacting Group	Interacting Drugs
	Carboplatin is a Glutathione S-transferase P substrate
1	Glutathione S-transferase P inhibitors	alpha-Tocopherol succinate, Clomipramine, Curcumin, D-alpha-Tocopherol acetate, Etacrynic acid, Exisulind, Vitamin E
2	Glutathione S-transferase P substrates	Acetaminophen, Busulfan, Chlorambucil, Cisplatin, Etoposide, Oxaliplatin

	Interacting Group	Interacting Drugs
	Carboplatin is a Glutathione S-transferase Mu 1 substrate
1	Glutathione S-transferase Mu 1 substrates	Acetaminophen, Azathioprine, Busulfan, Cisplatin, Isosorbide mononitrate, Oxaliplatin
2	Glutathione S-transferase Mu 1 inhibitors	Chloroquine, Curcumin

	Interacting Group	Interacting Drugs
	Carboplatin is a NAD(P)H dehydrogenase [quinone] 1 substrate
1	NAD(P)H dehydrogenase [quinone] 1 inhibitors	Cannabidiol, Dicoumarol
2	NAD(P)H dehydrogenase [quinone] 1 inducers	alpha-Tocopherol succinate, D-alpha-Tocopherol acetate, Vitamin E
3	NAD(P)H dehydrogenase [quinone] 1 substrates	Cisplatin, Doxorubicin, Oxaliplatin, Phenytoin

	Interacting Group	Interacting Drugs
	Carboplatin is a High affinity copper uptake protein 1 substrate
1	High affinity copper uptake protein 1 substrates	Cisplatin, Copper, Oxaliplatin

	Interacting Group	Interacting Drugs
	Carboplatin is a Probable low affinity copper uptake protein 2 substrate
1	Probable low affinity copper uptake protein 2 substrates	Cisplatin

	Interacting Group	Interacting Drugs
	Carboplatin is a Copper-transporting ATPase 1 substrate
1	Copper-transporting ATPase 1 substrates	Cisplatin, Copper, Oxaliplatin

	Interacting Group	Interacting Drugs
	Carboplatin is a Copper-transporting ATPase 2 substrate
1	Copper-transporting ATPase 2 substrates	Cisplatin, Copper, Oxaliplatin

	Interacting Group	Interacting Drugs
	Carboplatin is a ATP-binding cassette sub-family G member 2 substrate
1	ATP-binding cassette sub-family G member 2 substrates	Abemaciclib, Afatinib, Allopurinol, Alpelisib, Alvocidib, Apixaban, Artesunate, Baricitinib, Berotralstat, Brigatinib, Cabotegravir, Camptothecin, Celecoxib, Cerivastatin, Cisplatin, Cladribine, Clofarabine, Conjugated estrogens, Copanlisib, Dabrafenib, Dacomitinib, Dactinomycin, Darolutamide, Dasatinib, Daunorubicin, Delafloxacin, Docetaxel, Dolutegravir, Donepezil, Doxorubicin, Duvelisib, Empagliflozin, Enasidenib, Ertugliflozin, Etoposide, Ezetimibe, Fimasartan, Fluorouracil, Folic acid, Fostemsavir, Gefitinib, Glasdegib, Glecaprevir, Glyburide, Idelalisib, Imatinib, Irinotecan, Ivermectin, Lamivudine, Larotrectinib, Leflunomide, Lenvatinib, Lusutrombopag, Methotrexate, Mitoxantrone, Mycophenolate mofetil, Nifurtimox, Nilotinib, Nitrofurantoin, Ombitasvir, Opicapone, Osimertinib, Oxaliplatin, Ozanimod, Palbociclib, Pantoprazole, Pazopanib, Pemigatinib, Pibrentasvir, Pitavastatin, Ponatinib, Pralatrexate, Pralsetinib, Prasterone, Pravastatin, Prazosin, Raloxifene, Revefenacin, Riluzole, Rimegepant, Riociguat, Ripretinib, Risdiplam, Rivaroxaban, Rosuvastatin, Rucaparib, Selpercatinib, Selumetinib, Simeprevir, Sofosbuvir, Sorafenib, Sulfasalazine, Sulpiride, Sumatriptan, Talazoparib, Tamoxifen, Tazemetostat, Tegaserod, Temozolomide, Teniposide, Tenofovir alafenamide, Teriflunomide, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tezacaftor, Topotecan, Trastuzumab deruxtecan, Trilaciclib, Tucatinib, Ubrogepant, Upadacitinib, Velpatasvir, Vemurafenib, Vericiguat, Vincristine, Voxilaprevir, Zidovudine
2	ATP-binding cassette sub-family G member 2 inhibitors	Abemaciclib, Afatinib, Alectinib, Avanafil, Avatrombopag, Baricitinib, Beclomethasone dipropionate, Brigatinib, Buprenorphine, Cabazitaxel, Caffeine, Cannabidiol, Capmatinib, Clofazimine, Cobicistat, Cyclosporine, Dabrafenib, Daclatasvir, Dacomitinib, Daidzin, Darolutamide, Dasabuvir, Dasatinib, Dexamethasone, Dexamethasone acetate, Diethylstilbestrol, Dovitinib, Dronabinol, Elacridar, Eltrombopag, Enasidenib, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Febuxostat, Fedratinib, Fostamatinib, Fostemsavir, Fusidic acid, Gefitinib, Genistein, Gilteritinib, Glasdegib, Glecaprevir, Hesperetin, Imatinib, Isavuconazole, Istradefylline, Lansoprazole, Lasmiditan, Letermovir, Lonafarnib, Medical Cannabis, Nabiximols, Naringenin, Nelfinavir, Nilotinib, Novobiocin, Olaparib, Omeprazole, Palbociclib, Pantoprazole, Paritaprevir, Pibrentasvir, Ponatinib, Pralsetinib, Progesterone, Quercetin, Rabeprazole, Regorafenib, Relugolix, Rilpivirine, Ripretinib, Ritonavir, Rolapitant, Rucaparib, Safinamide, Saquinavir, Selpercatinib, Simeprevir, Sorafenib, Sulfasalazine, Sunitinib, Tafamidis, Taurocholic acid, Telmisartan, Tepotinib, Teriflunomide, Topiroxostat, Upadacitinib, Vandetanib, Velpatasvir, Vemurafenib, Venetoclax, Vismodegib, Voxilaprevir
3	ATP-binding cassette sub-family G member 2 inducers	Apalutamide, Cholesterol, Dovitinib, Progesterone, Venlafaxine
4	ATP-binding cassette sub-family G member 2 antagonists	Zafirlukast
5	ATP-binding cassette sub-family G member 2 weak inhibitors	Cobimetinib
6	ATP-binding cassette sub-family G member 2 transporters	Ledipasvir
7	ATP-binding cassette sub-family G member 2 modulators	Avapritinib

	Interacting Group	Interacting Drugs
	Carboplatin is a Canalicular multispecific organic anion transporter 1 substrate
1	Canalicular multispecific organic anion transporter 1 inhibitors	5-methyltetrahydrofolic acid, Aminohippuric acid, Azithromycin, Cyclosporine, Daunorubicin, Ethinylestradiol, Etoposide, Furosemide, Fusidic acid, Glutathione, Glyburide, Grepafloxacin, Indomethacin, Ivermectin, Letermovir, Lomefloxacin, Lonafarnib, Methotrexate, Norgestimate, Octreotide, Ofloxacin, Pranlukast, Probenecid, Quinidine, Reserpine, Simeprevir, Sorafenib, Sparfloxacin, Sulfinpyrazone, Sunitinib, Telmisartan, Tetrahydrofolic acid, Tricarbonyl(1,10-phenanthroline)rhenium(1+), Vinblastine, Vincristine
2	Canalicular multispecific organic anion transporter 1 substrates	Aminohippuric acid, Atorvastatin, Avibactam, Azithromycin, Belantamab mafodotin, Canagliflozin, Carbamazepine, Cerivastatin, Conjugated estrogens, Docetaxel, Doxorubicin, Eluxadoline, Erythromycin, Etoposide, Ezetimibe, Fexofenadine, Fluvastatin, Gadoxetic acid, Glutathione, Indinavir, Indomethacin, Irinotecan, Lovastatin, Methotrexate, Octreotide, Olmesartan, Oxaliplatin, Paclitaxel, Phenytoin, Pitavastatin, Pralatrexate, Pravastatin, Probenecid, Raloxifene, Ritonavir, Rosuvastatin, Saquinavir, Simeprevir, Simvastatin, Sulfasalazine, Sulfinpyrazone, Talinolol, Tamoxifen, Tenofovir disoproxil, Valsartan, Vasopressin, Vinblastine, Vincristine
3	Canalicular multispecific organic anion transporter 1 inducers	Arsenic trioxide, Cholic Acid, Cisplatin, Dexamethasone, Dexamethasone acetate, Eprosartan, Ethinylestradiol, Hyperforin, Nifedipine, Olmesartan, Phenobarbital, Quercetin, Rifampicin, Spironolactone, Taurocholic acid, Ursodeoxycholic acid, Vinblastine
4	Canalicular multispecific organic anion transporter 1 transporters	Indocyanine green acid form