Showing BioInteractions for Acyclovir (DB00787)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
Interacting GroupInteracting Drugs
Acyclovir is a DNA polymerase catalytic subunit inhibitor
1DNA polymerase catalytic subunit inhibitorsFamciclovir, Foscarnet, Ganciclovir, Penciclovir, Valaciclovir
2DNA polymerase catalytic subunit activatorsTalimogene laherparepvec
Interacting GroupInteracting Drugs
Acyclovir is a DNA polymerase catalytic subunit inhibitor
1DNA polymerase catalytic subunit inhibitorsFamciclovir
2DNA polymerase catalytic subunit activatorsTalimogene laherparepvec
Interacting GroupInteracting Drugs
Acyclovir is a Thymidine kinase potentiator
1Thymidine kinase inducersGanciclovir
Interacting GroupInteracting Drugs
Acyclovir is a Thymidine kinase substrate
1Thymidine kinase substratesValaciclovir
2Thymidine kinase inducersVidarabine
Interacting GroupInteracting Drugs
Acyclovir is a Guanylate kinase substrate
1Guanylate kinase substratesValaciclovir
Interacting GroupInteracting Drugs
Acyclovir is a Nucleoside diphosphokinase substrate
1Nucleoside diphosphokinase substratesTenofovir disoproxil
Interacting GroupInteracting Drugs
Acyclovir is a Pyruvate Kinases substrate
Interacting GroupInteracting Drugs
Acyclovir is a Creatine Kinases substrate
1Creatine Kinases substratesTenofovir disoproxil
2Creatine Kinases inducersTenofovir disoproxil
Interacting GroupInteracting Drugs
Acyclovir is a Phosphoglycerate Kinases substrate
Interacting GroupInteracting Drugs
Acyclovir is a Succinyl-CoA Synthetases substrate
Interacting GroupInteracting Drugs
Acyclovir is a Phosphoenolpyruvate Carboxykinases substrate
Interacting GroupInteracting Drugs
Acyclovir is a Adenylosuccinate Synthetases substrate
Interacting GroupInteracting Drugs
Acyclovir is a Solute carrier family 22 member 1 substrate
1Solute carrier family 22 member 1 substratesAcetylcholine, Agmatine, Amantadine, Buformin, Choline, Choline salicylate, Cimetidine, Codeine, Dexchlorpheniramine maleate, Dopamine, Epinephrine, Ganciclovir, Imatinib, Lamivudine, Metformin, Nafamostat, Nintedanib, Norepinephrine, Pancuronium, Phenformin, Pramipexole, Prazosin, Quinine, Ranitidine, Rocuronium, Spermidine, Spermine, Thiamine, Tubocurarine, Verapamil
2Solute carrier family 22 member 1 inhibitorsAmantadine, Chlorpheniramine, Choline, Choline salicylate, Cimetidine, Clopidogrel, Codeine, Dacomitinib, Desipramine, Dexchlorpheniramine maleate, Disopyramide, Doxazosin, Dronedarone, Efavirenz, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ganciclovir, Gilteritinib, Guanidine, Indinavir, Lasmiditan, Linagliptin, Nelfinavir, Nevirapine, Nicotine, Nintedanib, Palbociclib, Phenoxybenzamine, Pitolisant, Prazosin, Probenecid, Procainamide, Progesterone, Quinidine, Quinine, Reserpine, Rucaparib, Saquinavir, Verapamil
Interacting GroupInteracting Drugs
Acyclovir is a Solute carrier family 22 member 1 inhibitor
1Solute carrier family 22 member 1 substratesAcetylcholine, Agmatine, Amantadine, Buformin, Choline, Choline salicylate, Cimetidine, Codeine, Dexchlorpheniramine maleate, Dopamine, Epinephrine, Ganciclovir, Imatinib, Lamivudine, Metformin, Nafamostat, Nintedanib, Norepinephrine, Pancuronium, Phenformin, Pramipexole, Prazosin, Quinine, Ranitidine, Rocuronium, Spermidine, Spermine, Thiamine, Tubocurarine, Verapamil
2Solute carrier family 22 member 1 inhibitorsAmantadine, Chlorpheniramine, Choline, Choline salicylate, Cimetidine, Clopidogrel, Codeine, Dacomitinib, Desipramine, Dexchlorpheniramine maleate, Disopyramide, Doxazosin, Dronedarone, Efavirenz, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ganciclovir, Gilteritinib, Guanidine, Indinavir, Lasmiditan, Linagliptin, Nelfinavir, Nevirapine, Nicotine, Nintedanib, Palbociclib, Phenoxybenzamine, Pitolisant, Prazosin, Probenecid, Procainamide, Progesterone, Quinidine, Quinine, Reserpine, Rucaparib, Saquinavir, Verapamil
Interacting GroupInteracting Drugs
Acyclovir is a Solute carrier family 22 member 6 substrate
1Solute carrier family 22 member 6 inhibitorsAcetazolamide, Acetylsalicylic acid, Adefovir dipivoxil, Alprostadil, Aminohippuric acid, Aminophenazone, Amoxicillin, Antipyrine, Aspartame, Ataluren, Baricitinib, Benzylpenicillin, Bumetanide, Cabotegravir, Caprylic acid, Captopril, Carbenicillin, Carprofen, Caspofungin, Cefacetrile, Cefadroxil, Cefalotin, Cefamandole, Cefazolin, Cefoperazone, Cefotaxime, Cefotiam, Cefradine, Ceftazidime, Ceftriaxone, Cephalexin, Chloramphenicol, Chlorothiazide, Chlorpropamide, Cidofovir, Cilastatin, Cimetidine, Cinoxacin, Cloxacillin, Cyclosporine, Cyclothiazide, Dabrafenib, Diclofenac, Diflunisal, Dinoprostone, Dolutegravir, Doxycycline, Ellagic acid, Enalapril, Enasidenib, Etacrynic acid, Ethoxzolamide, Etodolac, Flufenamic acid, Fluorescein, Flurbiprofen, Folic acid, Foscarnet, Furosemide, Ganciclovir, Gentamicin, Glutaric Acid, Glyburide, Hydrochlorothiazide, Ibuprofen, Indomethacin, Istradefylline, Ketoprofen, Latanoprost, Lenvatinib, Losartan, Meclofenamic acid, Methazolamide, Methotrexate, Minocycline, Nafcillin, Nalidixic acid, Naproxen, Nateglinide, Norfloxacin, Novobiocin, Ofloxacin, Oxyphenbutazone, Oxytetracycline, Phenacetin, Phenylbutazone, Piperacillin, Piroxicam, Pravastatin, Probenecid, Riboflavin, Rifampicin, Rucaparib, Salicylic acid, Silibinin, Streptomycin, Sulindac, Taurocholic acid, Tazobactam, Tetracycline, Tolbutamide, Tolmetin, Topiroxostat, Trifluridine, Valproic acid
2Solute carrier family 22 member 6 inducersFurosemide
3Solute carrier family 22 member 6 substratesAdefovir dipivoxil, Alprostadil, Aminohippuric acid, Bumetanide, Captopril, Cefacetrile, Cefaloridine, Cefazolin, Cefdinir, Cefotiam, Ceftibuten, Ceftizoxime, Cephalexin, Cidofovir, Cimetidine, Citrulline, Conjugated estrogens, Cyclic adenosine monophosphate, Didanosine, Dinoprostone, Edaravone, Ellagic acid, Fluorescein, Glutaric Acid, Grepafloxacin, Hydrochlorothiazide, Indomethacin, Lamivudine, Latanoprost, Levofloxacin, Methotrexate, Probenecid, Silibinin, Stavudine, Taurocholic acid, Tazobactam, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Trifluridine, Zalcitabine, Zidovudine
Interacting GroupInteracting Drugs
Acyclovir is a Solute carrier family 22 member 6 inhibitor
1Solute carrier family 22 member 6 inhibitorsAcetazolamide, Acetylsalicylic acid, Adefovir dipivoxil, Alprostadil, Aminohippuric acid, Aminophenazone, Amoxicillin, Antipyrine, Aspartame, Ataluren, Baricitinib, Benzylpenicillin, Bumetanide, Cabotegravir, Caprylic acid, Captopril, Carbenicillin, Carprofen, Caspofungin, Cefacetrile, Cefadroxil, Cefalotin, Cefamandole, Cefazolin, Cefoperazone, Cefotaxime, Cefotiam, Cefradine, Ceftazidime, Ceftriaxone, Cephalexin, Chloramphenicol, Chlorothiazide, Chlorpropamide, Cidofovir, Cilastatin, Cimetidine, Cinoxacin, Cloxacillin, Cyclosporine, Cyclothiazide, Dabrafenib, Diclofenac, Diflunisal, Dinoprostone, Dolutegravir, Doxycycline, Ellagic acid, Enalapril, Enasidenib, Etacrynic acid, Ethoxzolamide, Etodolac, Flufenamic acid, Fluorescein, Flurbiprofen, Folic acid, Foscarnet, Furosemide, Ganciclovir, Gentamicin, Glutaric Acid, Glyburide, Hydrochlorothiazide, Ibuprofen, Indomethacin, Istradefylline, Ketoprofen, Latanoprost, Lenvatinib, Losartan, Meclofenamic acid, Methazolamide, Methotrexate, Minocycline, Nafcillin, Nalidixic acid, Naproxen, Nateglinide, Norfloxacin, Novobiocin, Ofloxacin, Oxyphenbutazone, Oxytetracycline, Phenacetin, Phenylbutazone, Piperacillin, Piroxicam, Pravastatin, Probenecid, Riboflavin, Rifampicin, Rucaparib, Salicylic acid, Silibinin, Streptomycin, Sulindac, Taurocholic acid, Tazobactam, Tetracycline, Tolbutamide, Tolmetin, Topiroxostat, Trifluridine, Valproic acid
2Solute carrier family 22 member 6 inducersFurosemide
3Solute carrier family 22 member 6 substratesAdefovir dipivoxil, Alprostadil, Aminohippuric acid, Bumetanide, Captopril, Cefacetrile, Cefaloridine, Cefazolin, Cefdinir, Cefotiam, Ceftibuten, Ceftizoxime, Cephalexin, Cidofovir, Cimetidine, Citrulline, Conjugated estrogens, Cyclic adenosine monophosphate, Didanosine, Dinoprostone, Edaravone, Ellagic acid, Fluorescein, Glutaric Acid, Grepafloxacin, Hydrochlorothiazide, Indomethacin, Lamivudine, Latanoprost, Levofloxacin, Methotrexate, Probenecid, Silibinin, Stavudine, Taurocholic acid, Tazobactam, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Trifluridine, Zalcitabine, Zidovudine
Interacting GroupInteracting Drugs
Acyclovir is a Solute carrier family 22 member 8 substrate
1Solute carrier family 22 member 8 inhibitorsAcetylsalicylic acid, Aminohippuric acid, Apalutamide, Aspartame, Ataluren, Avatrombopag, Baricitinib, Benzoic acid, Benzylpenicillin, Bumetanide, Cabotegravir, Caprylic acid, Cefacetrile, Cefaclor, Cefadroxil, Cefaloridine, Cefalotin, Cefamandole, Cefazolin, Cefoperazone, Cefotaxime, Cefotiam, Ceftibuten, Ceftizoxime, Ceftriaxone, Cephalexin, Cholic Acid, Cilastatin, Cimetidine, Conjugated estrogens, Dabrafenib, Diclofenac, Dinoprostone, Dolutegravir, Dronedarone, Enalapril, Enasidenib, Esomeprazole, Famotidine, Furosemide, Ganciclovir, Gemfibrozil, Glutaric Acid, Guanidine, Ibuprofen, Indomethacin, Ivosidenib, Ketoprofen, Lansoprazole, Latanoprost, Lenvatinib, Letermovir, Leucovorin, Liothyronine, Liotrix, Melatonin, Mercaptopurine, Methotrexate, Minocycline, Novobiocin, Ouabain, Oxytetracycline, Pantoprazole, Phenylbutazone, Piroxicam, Pradigastat, Pravastatin, Pretomanid, Probenecid, Quinidine, Rifampicin, Rosuvastatin, Rucaparib, Salicylic acid, Taurocholic acid, Tazobactam, Tenoxicam, Tetracycline, Topiroxostat, trans-2-hydroxycinnamic acid, Valproic acid, Zidovudine
2Solute carrier family 22 member 8 inducersMethyltestosterone, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate
3Solute carrier family 22 member 8 substratesAllopurinol, Aminohippuric acid, Avibactam, Baricitinib, Benzylpenicillin, Cefacetrile, Cefaclor, Cefaloridine, Cefdinir, Cefotiam, Ceftibuten, Ceftizoxime, Cholic Acid, Cimetidine, Conjugated estrogens, Cyclic adenosine monophosphate, Dinoprostone, Doripenem, Edaravone, Eluxadoline, Estradiol, Estrone, Famotidine, Fexofenadine, Glutaric Acid, Hydrochlorothiazide, Hydrocortisone, Leucovorin, Levocarnitine, Mercaptopurine, Methotrexate, Oseltamivir, Oxalic Acid, Pemetrexed, Piperacillin, Pravastatin, Quinapril, Ranitidine, Relebactam, Rosuvastatin, Saxagliptin, Sitagliptin, Succinic acid, Taurocholic acid, Tazobactam, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Tetracycline, Valaciclovir, Valproic acid, Zidovudine
Interacting GroupInteracting Drugs
Acyclovir is a Solute carrier family 22 member 8 inhibitor
1Solute carrier family 22 member 8 inhibitorsAcetylsalicylic acid, Aminohippuric acid, Apalutamide, Aspartame, Ataluren, Avatrombopag, Baricitinib, Benzoic acid, Benzylpenicillin, Bumetanide, Cabotegravir, Caprylic acid, Cefacetrile, Cefaclor, Cefadroxil, Cefaloridine, Cefalotin, Cefamandole, Cefazolin, Cefoperazone, Cefotaxime, Cefotiam, Ceftibuten, Ceftizoxime, Ceftriaxone, Cephalexin, Cholic Acid, Cilastatin, Cimetidine, Conjugated estrogens, Dabrafenib, Diclofenac, Dinoprostone, Dolutegravir, Dronedarone, Enalapril, Enasidenib, Esomeprazole, Famotidine, Furosemide, Ganciclovir, Gemfibrozil, Glutaric Acid, Guanidine, Ibuprofen, Indomethacin, Ivosidenib, Ketoprofen, Lansoprazole, Latanoprost, Lenvatinib, Letermovir, Leucovorin, Liothyronine, Liotrix, Melatonin, Mercaptopurine, Methotrexate, Minocycline, Novobiocin, Ouabain, Oxytetracycline, Pantoprazole, Phenylbutazone, Piroxicam, Pradigastat, Pravastatin, Pretomanid, Probenecid, Quinidine, Rifampicin, Rosuvastatin, Rucaparib, Salicylic acid, Taurocholic acid, Tazobactam, Tenoxicam, Tetracycline, Topiroxostat, trans-2-hydroxycinnamic acid, Valproic acid, Zidovudine
2Solute carrier family 22 member 8 inducersMethyltestosterone, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate
3Solute carrier family 22 member 8 substratesAllopurinol, Aminohippuric acid, Avibactam, Baricitinib, Benzylpenicillin, Cefacetrile, Cefaclor, Cefaloridine, Cefdinir, Cefotiam, Ceftibuten, Ceftizoxime, Cholic Acid, Cimetidine, Conjugated estrogens, Cyclic adenosine monophosphate, Dinoprostone, Doripenem, Edaravone, Eluxadoline, Estradiol, Estrone, Famotidine, Fexofenadine, Glutaric Acid, Hydrochlorothiazide, Hydrocortisone, Leucovorin, Levocarnitine, Mercaptopurine, Methotrexate, Oseltamivir, Oxalic Acid, Pemetrexed, Piperacillin, Pravastatin, Quinapril, Ranitidine, Relebactam, Rosuvastatin, Saxagliptin, Sitagliptin, Succinic acid, Taurocholic acid, Tazobactam, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Tetracycline, Valaciclovir, Valproic acid, Zidovudine
Interacting GroupInteracting Drugs
Acyclovir is a Ileal sodium/bile acid cotransporter substrate
1Ileal sodium/bile acid cotransporter substratesCholic Acid, Glycochenodeoxycholic Acid, Taurocholic acid, Valaciclovir
2Ileal sodium/bile acid cotransporter inducersCholic Acid, Taurocholic acid
3Ileal sodium/bile acid cotransporter inhibitorsCholic Acid, Cyclosporine, Deoxycholic acid, Ursodeoxycholic acid, Volixibat
Interacting GroupInteracting Drugs
Acyclovir is a Multidrug and toxin extrusion protein 1 substrate
1Multidrug and toxin extrusion protein 1 substratesCefradine, Cephalexin, Cimetidine, Ciprofloxacin, Estrone sulfate, Flecainide, Ganciclovir, Guanidine, Levofloxacin, Metformin, N-methylnicotinamide, Nadolol, Procainamide, Relebactam, Tetraethylammonium, Tipiracil, Topotecan
2Multidrug and toxin extrusion protein 1 inhibitorsAbemaciclib, Apalutamide, Bictegravir, Brigatinib, Cimetidine, Ciprofloxacin, Fedratinib, Flecainide, Gilteritinib, Glasdegib, Istradefylline, Lasmiditan, Levofloxacin, Lofexidine, Pexidartinib, Plazomicin, Pyrimethamine, Rifamycin, Rucaparib, Tafenoquine, Topotecan
3Multidrug and toxin extrusion protein 1 carriersTipiracil
Interacting GroupInteracting Drugs
Acyclovir is a Multidrug and toxin extrusion protein 2 substrate
1Multidrug and toxin extrusion protein 2 substratesBaricitinib, Cimetidine, Estrone sulfate, Ganciclovir, Metformin, N-methylnicotinamide, Nadolol, Procainamide, Relebactam, Topotecan
2Multidrug and toxin extrusion protein 2 inhibitorsAbemaciclib, Apalutamide, Baricitinib, Brigatinib, Cimetidine, Ciprofloxacin, Copanlisib, Fedratinib, Glasdegib, Istradefylline, Lasmiditan, Levofloxacin, Pexidartinib, Plazomicin, Pyrimethamine, Rucaparib, Tafenoquine